Katharina Inholz, Janet L Anderl, Moritz Klawitter, Heike Goebel, Elmer Maurits, Christopher J Kirk, R Andrea Fan, Michael Basler
Immunoproteasomes are a special class of proteasomes, which can be induced with IFN-γ in an inflammatory environment. In recent years, it became evident that certain immune cell types constitutively express high levels of immunoproteasomes. However, information regarding the basal expression of proteolytically active immunoproteasome subunits in different types of immune cells is still rare. Hence, we quantified standard proteasome subunits (β1c, β2c, β5c) and immunoproteasome subunits (LMP2, MECL-1, LMP7) in the major murine (CD4+ T cells, CD8+ T cells, CD19+ B cells, CD11c+ dendritic cells, CD49d+ natural killer cells, Ly-6G+ neutrophils) and human immune cell (CD4+ T cells, CD8+ T cells, CD19+ B cells, CD1c+ CD141+ myeloid dendritic cells, CD56+ natural killer cells, granulocytes) subsets...
March 8, 2024: European Journal of Immunology