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Pathology of esophagus

Masuyo Miyake, Akimitsu Yamada, Kentaro Miyake, Itaru Endo
BACKGROUND: The esophageal metastasis of breast cancer is rare. Moreover, it is extremely unusual for patients to experience the symptoms of esophageal metastasis during their lifetimes. We present a case of dysphagia caused by esophageal metastasis after a long interval following a primary mastectomy. CASE PRESENTATION: A 77-year-old woman with a history of heterochronous bilateral breast cancer and under treatment for pleural dissemination recurrence originating from right breast cancer complained of dysphagia...
February 15, 2019: Surgical Case Reports
Hiroki Kudo, Yasuji Seyama, Hiroyuki Kanomata, Masamichi Takahashi, Tachen Chang, Yujiro Matsuoka, Tomoyo Machida, Yohei Furumoto, Masahiro Warabi, Tooru Tanizawa, Ikuo Wada, Tsuyoshi Maeshiro, Sachio Miyamoto, Nobutaka Umekita
A 72-year-old man with general fatigue was referred, and CT and MRI revealed a pancreatic mass with necrosis that was suspected of invading the stomach, splenic artery, celiac artery, liver, and portal vein. Upper gastrointestinal endoscopy showed an extrinsic mass with ulcer formation in the posterior wall of the upper gastric corpus and irregular mucosa in the lower esophagus incidentally. Biopsy showed squamous cell carcinoma from both lesions, leading to the diagnosis of pancreatic adenosquamous carcinoma and early esophageal cancer...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Amandine Crombé, Nicolas Alberti, Nicolas Villard, Frank Pilleul, Xavier Buy, François Le Loarer, Michèle Kind
OBJECTIVES: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS. METHODS: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. The locations, sizes, heterogeneity, margin definitions, and local extensions of the tumors were reported together with their impact on surrounding organs and regional and distant metastases...
February 14, 2019: European Radiology
Kai-Chen Chung, Chih-Hung Lin, Chung-Lin Tsai, Yu-Hsuan Li, Chih-Hsiang Liao
BACKGROUND: and Importance: Esophageal injury is a severe surgical complication of a transsternal approach to the high thoracic vertebral metastasis, which can result in mediastinitis and life-threatening consequences. A covered stent can be placed in the esophagus to prevent mediastinal leakage. However, tracheomalacia is a very rare complication following esophageal stenting. CLINICAL PRESENTATION: A 56-year-old man had a pathologic fracture of the T3 vertebral body with spinal cord compression, myelopathy, and neurogenic bladder...
February 2, 2019: World Neurosurgery
Dhyanesh A Patel, Tina Higginbotham, James C Slaughter, Muhammad Aslam, Elif Yuksel, David Katzka, C Prakash Gyawali, Melina Mashi, John Pandolfino, Michael F Vaezi
BACKGROUND: Diagnostic testing for chronic esophageal disorders rely on histopathology analysis of biopsies or uncomfortable transnasal catheters or wireless pH monitoring, which capture abnormal intraluminal refluxate. We therefore developed a balloon mucosal impedance (MI) catheter system that instantly detects changes in esophageal mucosal integrity during endoscopy over a long segment of the esophagus. We performed a prospective study to evaluate the ability of a balloon-incorporated MI catheter to detect and evaluate esophageal disorders, including gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE)...
January 31, 2019: Gastroenterology
Alexander Tarek El Gammal, Nathaniel Melling, Matthias Reeh, Florian Gebauer, Oliver Mann, Daniel Perez, Maximillian Bockhorn, Kai Bachmann, Jakob Robert Izbicki, Katharina Grupp
Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in esophageal cancers remains unclear. Immunohistochemical RAI3 staining was analyzed on tissue microarrays containing 359 esophageal adenocarcinomas (EAC) and 254 esophageal squamous cell carcinomas (ESCC). RAI3 immunostaining was typically absent or weakly detectable in the membranes in benign esophageal tissues. RAI3 staining was higher in malignant than in benign esophagus epithelium...
January 29, 2019: Experimental and Molecular Pathology
Umesha Boregowda, Chandraprakash Umapathy, Nasir Halim, Madhav Desai, Arpitha Nanjappa, Subramanyeswara Arekapudi, Thimmaiah Theethira, Helen Wong, Marina Roytman, Shreyas Saligram
Cirrhosis of liver is a major problem in the western world. Portal hypertension is a complication of cirrhosis and can lead to a myriad of pathology of which include the development of porto-systemic collaterals. Gastrointestinal varices are dilated submucosal veins, which often develop at sites near the formation of gastroesophageal collateral circulation. The incidence of varices is on the rise due to alcohol and obesity. The most significant complication of portal hypertension is life-threatening bleeding from gastrointestinal varices, which is associated with substantial morbidity and mortality...
January 21, 2019: World Journal of Gastrointestinal Pharmacology and Therapeutics
Yohei Hosoda, Yu Sasaki, Takashi Sugimoto, Kazuhiro Nishiyama, Hokahiro Katayama, Nobuko Ogura, Izumi Komoto, Hidenori Kiyochi, Shoji Tsunekawa, Yoshiro Taki, Masayuki Imamura
We report a rare case of esophageal carcinoma with gastric wall metastasis. A 73-year-old man with dysphagia underwent endoscopy and upper GI series and chest-abdominal computed tomography, revealing esophageal carcinoma and gastric cancer, which was diagnosed as squamous cell carcinoma by biopsy. The esophageal carcinoma was located in the lower thoracic esophagus(Lt). Total gastrectomy was performed. The resected specimen showed a type 3 tumor measuring 7×7 cm in the anterior wall of the stomach. Pathologically, the depth of invasion of the stomach was SE...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yosuke Ariyoshi, Noriaki Koizumi, Rie Yasuoka, Kenji Nakamura, Hiroshi Fujiki, Atsushi Shiozaki, Hitoshi Fujiwara, Chouhei Sakakura
A 58-year-old man was followed up for esophageal submucosal tumor at our hospital. Esophagogastroduodenoscopy showed the tumor was located on the left side of the thoracic esophagus and had gradually increased in size. Endoscopic ultrasonography revealed an 18×11.5mm hypoechoic tumor connected to the fourth layer of the esophagus and fine needle biopsy revealed c-kit(+), desmin(-)and a-SMA(-). Double-contrast barium study detected a tumor of diameter 20 mm in the middle-lower thoracic esophagus. We diagnosed an esophageal gastrointestinal stromal tumor(GIST)and performed mediastinoscope-assisted transhiatal esophagectomy with gastric tube reconstruction...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yusuke Akamaru, Noriko Wada, Ryohei Wada, Koji Munakata, Daisuke Takiuchi, Osakuni Morimoto, Hirofumi Ota, Kunitaka Shibata, Hirotsugu Ohashi
We experienced a case of multiple esophageal intramural metastasis from adenocarcinoma of the esophagogastric junction. A 58-year-old man was admitted complaining of dysphagia. Upper gastrointestinal endoscopy revealed a type 3 tumor at the esophagogastric junction. Biopsy showed Group 5, poorly differentiated adenocarcinoma. Abdominal CT indicated regional and para-aortic lymph node metastasis. Then the clinical diagnosis was established as Siewert type Ⅲ adenocarcinoma and cT4aN2M1(LYM), cStage Ⅳ. After conducting 4 courses of SP(S-1/cisplatin)therapy, endoscopy showed partial response of the primary tumor and the submucosal nodules in the lower esophagus...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hiroki Harada, Kei Hosoda, Hiromitsu Moriya, Hiroaki Mieno, Akira Ema, Marie Washio, Mariko Kikuchi, Yoshimasa Kosaka, Masahiko Watanabe, Keishi Yamashita
Esophageal carcinosarcoma (ECS) has been suggested to result from an epithelial mesenchymal transition (EMT) phenomenon. However, knowledge on its underlying molecular features is limited. The clinical and pathological features, and the prognosis of ECS require further investigation. In the present study, a total of 325 patients with esophageal tumors were observed between January 2004 and December 2014, of which 6 patients were diagnosed pathologically with ECS. The clinicopathological features were compared with those of corresponding cases with the identical pathological T stage (pT) of esophageal squamous cell carcinoma (ESCC)...
January 2019: Oncology Letters
Keiichi Kimura, Yoshito Hayashi, Keisuke Otani, Yoshiki Tsujii, Hideki Iijima, Fumiaki Isohashi, Kazuhiko Ogawa, Tetsuo Takehara
Only a few cases of esophageal granulocyte-colony-stimulating-factor (G-CSF)-producing esophageal carcinosarcoma are reported, and patients with G-CSF-producing tumors are typically considered to have poor prognosis. An 89-year-old man was examined for low-grade fever and dysphagia. Chest computed tomography revealed a huge 80-mm tumor on the thoracic esophagus without direct invasion to surrounding organs. Esophagogastroduodenoscopy (EGD) showed a huge mass occupying the esophageal lumen with a superficial flat lesion...
January 16, 2019: Clinical Journal of Gastroenterology
Wojciech Latos, Andrzej M Bugaj, Aleksander Sieroń, Aleksandra Kawczyk-Krupka
BACKGROUND: This study assessed the efficacy of autofluorescence endoscopy (AFE) using the Onco-LIFE system and numerical color value (NCV) estimation in comparison to white light endoscopy (WLE) in endoscopic surveillance for identification of early dysplasia in Barrett's esophagus (BE) to aid in real-time image elucidation and minimize the overreliance on biopsy and histology. METHODS: AFE, performed simultaneously during WLE, with biopsy was performed among 24 patients with BE...
January 12, 2019: Photodiagnosis and Photodynamic Therapy
Sung Bum Kim, Si Hyung Lee, Da Eun Jeong, Kyeong Ok Kim, Mi Jin Gu
Esophageal basaloid squamous carcinoma (BSC) is a rare, aggressive variant of squamous cell carcinoma. BSC is usually diagnosed in advanced stage and its prognosis is relatively poor. A 59-year-old male with subepithelial lesion of the esophagus that was incidentally discovered during health promotion examination was referred to our hospital. Esophagogastroduodenoscopy showed a 10-mm bulging mucosa with an intact surface at 34 cm from incisor teeth. Endoscopic ultrasonography revealed a smooth margined homogenous hypoechoic lesion, measuring 11...
November 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Katharina Puetz, Elfriede Bollschweiler, Robert Semrau, Stefan P Mönig, Arnulf H Hölscher, Uta Drebber
AIM: Neoadjuvant chemoradiation reduces tumor volume and improves R0 resection rate, followed by extended survival for patients with advanced esophageal cancer. The degree of tumor regression has high prognostic relevance. To date, there is still no generally accepted tumor regression grading system. The aim of this study was to compare the prognostic discrimination power of different histological regression grading systems: a. the fibrosis/tumor ratio within the primary tumor (Mandard), b...
January 12, 2019: Histopathology
Naomichi Koga, Nobuhide Kubo, Hiroshi Saeki, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Yuichiro Nakashima, Eiji Oki, Yutaka Koga, Yoshinao Oda, Hisao Oiwa, Toshio Oiwa, Yoshihiko Maehara
BACKGROUND: Primary amelanotic malignant melanoma of esophagus, which is a subtype of primary malignant melanoma of the esophagus (PMME), is a very rare disease with a poor prognosis. We herein report a case of the amelanotic type of PMME. CASE PRESENTATION: An 86-year-old woman was admitted to our hospital with symptoms of dysphagia. An endoscopic examination and constructed radiography revealed an elevated and semipedunculated lesion with an ulcer in the lower thoracic esophagus accompanied by another submucosal lesion of the esophagus...
January 11, 2019: Surgical Case Reports
Ming Hu, Weidong Liu, Feng Yin, Dongwei Zhang, Xiuli Liu, Jinping Lai
Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. It is an important variant of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma and carries exceedingly poor prognosis. HAC most commonly originates in the stomach, and less commonly in the ovary, esophagus, lung, among other organs. HAC originating in the colon is exceedingly rare. Here we report such a case of a 63-year-old man presented as decompensated liver failure with jaundice and weakness...
December 2018: Gastroenterology Research
Daryl Ramai, Alexis Bivona, William Latson, Andrew Ofosu, Emmanuel Ofori, Madhavi Reddy, Douglas G Adler
Tracheoesophageal fistulas (TEF) are pathologic communications between the trachea and esophagus. TEF can lead to significant respiratory distress that may result in lethal respiratory compromise, often due to recurrent and intractable infections. Through the use of endoscopy, some TEF can be successfully repaired using different approaches depending on the size, location, availability, and experience of the treating endoscopist. The aim of this manuscript is to provide an up-to-date review of the endoscopic management of TEF for gastroenterologists...
January 2019: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
A Pinto, B Abastado, P Cattan
A fibrovascular polyp is a rare benign pseudotumor of the esophagus or the hypopharynx. It comes to light through dysphagia and can lead to death by asphyxiation. CT scan and MRI suggest this diagnosis by highlighting a lobed endoluminal tumor primarily composed of adipose tissue and pedicled on a vessel. Anatomo-pathological analysis of biopsies can exclude liposarcoma, the main differential diagnosis. Treatment consists in complete reconstruction by cervicotomy.
December 20, 2018: Journal of Visceral Surgery
Vignesh Shanmugam, Richard N Mitchell, Robert F Padera, Ory Wiesel
BACKGROUND AND OBJECTIVES: The formation of a fistula between the gastrointestinal tract and cardiovascular system is a rare but devastating condition. Although clinical diagnosis is suspected, autopsy confirmation is rarely obtained. Advancement in the treatment of esophageal cancer could result in an increased risk of enterovascular fistula formation. We describe autopsy-proven series of enterovascular fistulas with particular focus on this complication developing as a consequence of esophageal cancer therapy...
December 18, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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