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Debajit Bhuyan, Ankur Das, Saurabh Kumar Laskar, Durlav Prasad Bora, Shantanu Tamuli, Mineswar Hazarika
Aim: An experiment was conducted to evaluate the nutritional, physicochemical, microbiological, and sensory attributes of pork sausages treated with conventional smoking (CS) and liquid smoke (LS). Materials and Methods: Pork sausages were prepared by employing CS (T1 ) and by addition of LS at 3% (T2A ), 5% (T2B ), and 7% (T2C ) while smoking was not done in control (C) sausages. The ready-to-eat pork sausages were evaluated in terms of proximate composition, emulsion stability (ES), cooking loss (CL), pH, water activity (aw ), texture profile analysis (TPA), and shear force on the day of preparation and the shelf life of the sausages was evaluated on the basis of thiobarbituric acid reactive substance (TBARS) value, organoleptic qualities, total viable plate count, total psychrophilic count, and yeast and mold counts at 5-day interval up to 15 days under refrigerated storage (6±1°C)...
December 2018: Veterinary World
Assaf Hoofien, Yael Mozer, Anat Guz-Mark, Vered Hoffer, Daniel Landau, Raanan Shamir
No abstract text is available yet for this article.
February 2019: Israel Medical Association Journal: IMAJ
Joel Lim, Alexandra Oschman, Kayla Curiel
PURPOSE OF REVIEW: The current review provides a summary of available lipid products and discusses current literature and the limitations to the use of various lipid products for treatment and prevention of intestinal failure-associated liver disease (IFALD) in pediatric patients dependent on parenteral nutrition. RECENT FINDINGS: Improvements in markers of cholestasis and liver function have been seen with minimizing soybean lipid, fish oil lipid, and mixed fish oil-containing lipid emulsions...
February 11, 2019: Current Opinion in Organ Transplantation
Debjyoti Paul, Krishnendu Manna, Aaveri Sengupta, Sayani Mukherjee, Sanjit Dey, Prasanta K Bag, Pubali Dhar
AIM: The present work provides first-time empirical and molecular interaction evidence to establish the higher biofunctionality of a therapeutic lipid, α-eleostearic acid (ESA), encapsulated in a novel and thoroughly characterized biocompatible nanoemulsion (NE) system (particle size <200 nm). MATERIALS & METHODS: A novel methodology was employed to fabricate novel formulations of ESA. Molecular biological tools and assays were used to arrive at definite conclusions...
February 12, 2019: Nanomedicine
Kee Woong Kwon, Hong-Hee Choi, Seung Jung Han, Jong-Seok Kim, Woo Sik Kim, Hongmin Kim, Lee-Han Kim, Soon Myung Kang, Jaehun Park, Sung Jae Shin
Bacillus Calmette-Guerin vaccine confers insufficient pulmonary protection against tuberculosis (TB), particularly the Mycobacterium tuberculosis (Mtb) Beijing strain infection. Identification of vaccine antigens (Ags) by considering Mtb genetic diversity is crucial for the development of improved TB vaccine. MTBK_20640, a new Beijing genotype-specific proline-glutamic acid-family Ag, was identified by comparative genomic analysis. Its immunologic features were characterized by evaluating interactions with dendritic cells (DCs), and immunogenicity and vaccine efficacy were determined against highly virulent Mtb Beijing outbreak Korean Beijing (K) strain and HN878 strain in murine infection model...
February 12, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Maria B C de Matos, Bárbara S Miranda, Yudha Rizky Nuari, Gert Storm, Gero Leneweit, Raymond M Schiffelers, Robbert J Kok
Asymmetrical lipid nanoparticles are interesting nanocarriers for charged molecules, like nucleic acids. They promise control over inner and outer charge. High charge density on the inside is favorable for efficient condensation and charge neutralization of highly charged biopharmaceuticals, while a neutral or slightly negative outer layer promotes biocompatibility. The main goal of this work was the development and characterization of asymmetric liposomes, prepared using water in oil (w/o) nanoemulsions of phospholipids and squalene in a centrifugal field...
February 12, 2019: Journal of Drug Targeting
Hilal Ozkan, Nilgün Köksal, Bayram Ali Dorum, Fatma Kocael, Yesim Ozarda, Pelin Doğan, Ipek Guney Varal, Onur Bagci
BACKGROUND: Parenteral nutrition (PN) has been widely used in preterm infants. Lipid solutions used for PN were reported to be associated with oxidative stress and related morbidities. The aim of this study was to compare the effectiveness of new generation lipid emulsion (SMOFLipid) and olive-oil based lipid emulsion for prevention of PN associated oxidative damage. METHODS: Preterm infants <32 gestational age were included to this prospective randomized study...
February 10, 2019: Pediatrics International: Official Journal of the Japan Pediatric Society
Hadis Rostamabadi, Seid Reza Falsafi, Seid Mahdi Jafari
Carotenoids, as promising functional components in human diet, are gaining immense importance todays. Apart from their pivotal importance in photosynthetic organisms or as natural pigments, they are typically referred to as health-promotional ingredients, which offer several beneficial attributes. However, their sensitivity against environmental and process stresses, low-water solubility, as well as low-bioavailability are the most shortfalls restricting pharmaceutical/food carotenoid applications. In this regard, lipid-based nano-delivery cargos i...
February 7, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Jie Luo, Ziwei Wang, Yiran Li, Chong Chen, Fazheng Ren, Huiyuan Guo
Milk fat globule membrane polar lipids (MPL) are increasingly used as the surface-active components for emulsions in many infant food products. However, the precise effect of the emulsifier MPL on the digestion of lipids during gastrointestinal digestion has not been elucidated. This study investigated the lipid digestion of droplets covered with MPL with different sizes in a simulated in vitro infant gastrointestinal digestion assay. The well-used surface-active component casein was used as a control. Four types of emulsions were formulated: small and large droplets covered with MPL concentrate (MPL-S and MPL-L, with volumetric means of 0...
February 6, 2019: Journal of Dairy Science
Noha F Hassan, Somaia A Nada, Azza Hassan, Mona R El-Ansary, Muhammad Y Al-Shorbagy, Rania M Abdelsalam
The most epidemic liver disorder non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis and inflammation with hepatocellular damage. Recently, it is predictable to be the extensive cause for liver transplantation. The absence of an approved therapeutic agent for NASH is the reason for investigating saroglitazar (SAR) which showed promising effects as a dual PPAR-α/γ agonist in recent studies on NASH. Here, we aimed to investigate the effect of SAR on NASH induced in rats by the administration of high-fat emulsion (HFE) and small doses of lipopolysaccharides (LPS) for 5 weeks...
February 9, 2019: Inflammation
Tanmoy Kumar Dey, Hemanta Koley, Mahua Ghosh, Sanjit Dey, Pubali Dhar
The physiological efficacy of nutraceuticals is dependent on their physicochemical nature and bioavailability across biological barriers. In the present work, effects of nano-sizing of emulsion-based delivery vehicle on the bioavailability of polyunsaturated fatty acids rich fish oil have been investigated via three-step experimental design; ex vivo rat everted intestinal sac model, cellular lipid uptake and the bioactivity in rat PBMCs. Nanoemulsion in comparison to the conventional emulsion has shown significant higher rate of uptake of polyunsaturated fatty acids in three segments of small intestine...
March 1, 2019: Food Chemistry
Sameh A Korma, Wei Wei, Abdelmoneim H Ali, Sherif M Abed, Liyou Zheng, Qingzhe Jin, Xingguo Wang
Novel structured lipids (SLs) enriched with medium-and long-chain triacylglycerols (MLCTs) were synthesized to combine the benefits of both arachidonic acid and medium-chain fatty acids; however, they are susceptible to oxidative degradation. In this work, the influences of the partial replacement of whey protein isolate (WPI) as the primary wall material by prebiotic carbohydrates, such as maltodextrin (MD) and inulin (IN) as the secondary wall materials on the physicochemical characteristics and oxidative stability of the spray-dried MLCTs-rich SLs microcapsules were investigated...
February 2019: Food Research International
Karin Luize Mazur, Paulo Emílio Feuser, Alexsandra Valério, Arthur Poester Cordeiro, Camila Indiani de Oliveira, João Paulo Assolini, Wander Rogério Pavanelli, Claudia Sayer, Pedro H H Araújo
Leishmaniasis is considered a neglected tropical disease that represents a Public Health problem due to its high incidence. In the search of new alternatives for Leishmaniasis treatment diethyldithiocarbamate (DETC) has shown an excellent leishmanicidal activity and the incorporation into drug carrier systems, such as solid lipid nanoparticles (SLNs), is very promising. In the present work DETC loaded in beeswax nanoparticles containing copaiba oil were obtained by the double emulsion/melt technique. The nanoparticles were characterized and leishmanicidal activity against L...
December 18, 2018: Colloids and Surfaces. B, Biointerfaces
Wenshuai Wang, Xinling Song, Zheng Gao, Huajie Zhao, Xiuxiu Wang, Min Liu, Le Jia
In the present work, we investigated the anti-hyperlipidemic, antioxidant and organic protection effects of acidic-extractable Dictyophora indusiata polysaccharides (Ac-DPS) on hyperlipidemic mice induced by high-fat emulsion. The results demonstrated that Ac-DPS had impressive abilities to mitigate oxidative stress by increasing the activities of antioxidant enzyme and reducing the contents of lipid peroxide. Moreover, lipid levels in serum were returned to normal status. Besides, Ac-DPS exhibited potential hepatic and renal protection effects reflected by decreasing serum enzyme activities, lowering TBIL, UREA and CREA levels and increasing ALB content...
January 29, 2019: International Journal of Biological Macromolecules
Alan Mackie, Simon Gourcy, Neil Rigby, Jonathan Moffat, Isabel Capron, Balazs Bajka
It is well recognised that the average UK diet does not contain sufficient fibre. However, the introduction of fibre is often at the detriment of the organoleptic properties of a food. In this study on the gastrointestinal fate of nanoparticles, we have used cellulose nano-crystals (CNCs) as Pickering stabilising agents in oil in water emulsions. These emulsions were found to be highly stable against coalescence. The CNC and control emulsions were then exposed to simulated upper gastrointestinal tract digestion and the results compared to those obtained from a conventional protein stabilised emulsion...
January 30, 2019: Nanoscale
Mafalda Meireles, Sonia Losada-Barreiro, Marlene Costa, Fátima Paiva-Martins, Carlos Bravo-Díaz, Luís S Monteiro
BACKGROUND: Controlling the interfacial concentrations of antioxidants (AOs) in O/W emulsions can be regarded as an unique approach for increasing the efficiency of AOs in inhibiting the oxidation of lipids. Classical methods to determine the AO distribution in binary systems cannot be employed and their distribution needs to be assessed in the intact emulsion. RESULTS: We have employed a well-established kinetic method to determine the distribution of a homologous series of AOs derived of chlorogenic acid in olive oil-in-water emulsions and analyse the effects of AO hydrophobicity on their distributions and their efficiencies...
January 29, 2019: Journal of the Science of Food and Agriculture
Takashi Miida, Satoshi Hirayama
PURPOSE OF REVIEW: Lipoprotein-X (Lp-X) is an abnormal lipoprotein containing abundant free cholesterol and phospholipids, as well as some apolipoprotein E (apoE). Serum Lp-X increases in patients with cholestasis and lecithin-cholesterol acyltransferase deficiency, as well as in those receiving intravenous lipid emulsion. Lp-X is often associated with skin xanthomas in cholestatic patients. However, earlier studies showed that Lp-X is not taken up by murine macrophages, but exerts antiatherogenic actions...
January 28, 2019: Current Opinion in Endocrinology, Diabetes, and Obesity
Israel Rubinstein, Richard van Breemen, Daniel G Nosal, Guy Weinberg, Ronald C Hershow, Douglas L Feinstein
A recent multi-state outbreak of life-threatening bleeding following inhalation of synthetic cannabinoids has been attributed to contamination with the long-acting anticoagulant rodenticide (LAAR) brodifacoum, a second-generation, highly potent, long-acting derivative of the commonly used blood thinner warfarin. While long-term treatment with high-dose vitamin K1 restores coagulation, it does not affect brodifacoum metabolism or clearance, and, consequently, brodifacoum remains in the human body for several months, thereby predisposing to risk of bleeding recurrence and development of coagulation-independent injury in extrahepatic tissues and fetuses...
January 28, 2019: Drugs in R&D
Melike Ersoz, Aysegul Erdemir, Dilek Duranoglu, Deniz Uzunoglu, Tulin Arasoglu, Serap Derman, Banu Mansuroglu
The aim of this study was to evaluate anti-cancer properties of hesperetin (Hsp) and hesperetin-loaded poly(lactic-co-glycolic acid) nanoparticles (HspNPs) for glioblastoma treatment. Nanoparticles prepared by single emulsion method had a size of less than 300 nm with 70.7 ± 3.9% reaction yield and 26.4 ± 1.1% Hsp loading capacity. Treatment of C6 glioma cells with HspNPs for 24 and 48 h resulted in dose- and time-dependent decrease in cell viability, with approximate IC50 of 28 and 21 μg/mL, respectively (p = ...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Hanna M Gottschalk, Thomas Wecker, Mohammed H Khattab, Charlotte V Fischer, Josep Callizo, Florian Rehfeldt, Roswitha Lubjuhn, Christoph Russmann, Hans Hoerauf, Christian van Oterendorp
Purpose: Contrast agents applicable for optical coherence tomography (OCT) imaging are rare. The intrascleral aqueous drainage system would be a potential application for a contrast agent, because the aqueous veins are of small diameter and located deep inside the highly scattering sclera. We tested lipid emulsions (LEs) as candidate OCT contrast agents in vitro and ex vivo, including milk and the anesthetic substance Propofol. Methods: Commercial OCT and OCT angiography (OCTA) devices were used...
January 2, 2019: Investigative Ophthalmology & Visual Science
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