Zizhong Hu, Jingfan Wang, Ting Pan, Xinsheng Li, Chao Tao, Yan Wu, Xingxing Wang, Zhengyu Zhang, Yu Liu, Weiwei Zhang, Changlin Xu, Xinjing Wu, Qinyuan Gu, Yuanyuan Fan, Huiming Qian, Aime Mugisha, Songtao Yuan, Qinghuai Liu, Ping Xie
Diabetic retinopathy (DR), one of the most common microangiopathic complications in diabetes mellitus, causes severe visual damage among working-age populations. Retinal vascular endothelial cells, the key cell type in DR pathogenesis, are responsible for abnormal retinal angiogenesis in advanced stages of DR. The roles of exosomes in DR have been largely unknown. In this study, we report the first evidence that exosomes derived from the vitreous humor of patients with proliferative diabetic retinopathy (PDR-exo) promote proliferation, migration and tube formation of human retinal vascular endothelial cells (HRVECs)...
June 22, 2023: Diabetes