Jung Woo Han, Hun Soo Chang, Jin Young Yang, Han Sol Choi, Hyo Song Park, Hyoung Oh Jun, Ji Hye Choi, Sun-Sook Paik, Kyung Hwun Chung, Hee Jeong Shin, Seungyeon Nam, Ji-Hye Son, Si Hyung Lee, Eun Jung Lee, Kyoung Yul Seo, Jungmook Lyu, Jin Woo Kim, In-Beom Kim, Tae Kwann Park
Increasing evidence suggests that exosomes are involved in retinal cell degeneration, including their insufficient release; hence, they have become important indicators of retinopathies. The exosomal microRNA (miRNA), in particular, play important roles in regulating ocular and retinal cell functions, including photoreceptor maturation, maintenance, and visual function. Here, we generated retinal organoids (ROs) from human induced pluripotent stem cells that differentiated in a conditioned medium for 60 days, after which exosomes were extracted from ROs (Exo-ROs)...
July 27, 2023: International Journal of Molecular Sciences