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BACKGROUND: Although post-tuberculosis lung disease (PTLD) is a known consequence of pulmonary tuberculosis (pTB), few studies have reported the prevalence and spectrum of PTLD in children and adolescents. METHODS: Children and adolescent (≤19 years) survivors of pTB in the Western Regions of The Gambia underwent a respiratory symptom screening, chest X-ray (CXR) and spirometry at TB treatment completion. Variables associated with lung function impairment were identified through logistic regression models...

Herein, a strategy to stamp laser-produced reduced graphene oxide (rGO) onto flexible polymers using only office-grade tools, namely, roll-to-roll thermal stamping, is proposed, proving for the first time its effectiveness for direct bioelectrocatalysis. This straightforward, scalable, and low-cost approach allows us to overcome the limits of the integration of laser-induced rGO-films in bioanalytical devices. Laser-produced rGO has been thermally stamped (TS) onto different polymeric substrates (PET, PVC, and EVA) using a simple roll-laminator; the obtained TS-rGO films have been compared with the native rGO (untransferred) via morphochemical and electrochemical characterization...

In this paper, we consider the structural change in a class of discrete valued time series, where the true conditional distribution of the observations is assumed to be unknown. The conditional mean of the process depends on a parameter <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mi>θ</mml:mi><mml:mo>∗</mml:mo></mml:msup></mml:math> which may change over time. We provide sufficient conditions for the consistency and the asymptotic normality of the Poisson quasi-maximum likelihood estimator (QMLE) of the model...

Efficient techniques for separating target cells from undiluted blood are necessary for various diagnostic and research applications. This paper presents acoustic focusing in dense media containing iodixanol to purify peripheral blood mononuclear cells (PBMCs) from whole blood in a label-free and flow-through format. If the blood is laminated or mixed with iodixanol solutions while passing through the resonant microchannel, all the components (fluids and cells) rearrange according to their acoustic impedances...

Achieving mastery over light using thermochromic materials is crucial for energy-saving glazing. However, challenges such as high production costs, limited durability, and recyclability issues have hindered their widespread application in buildings. Herein, we develop a glass interlayer made of a polyvinyl butyral-based hydrogel swollen with LiCl solution. In addition to a fast, isochoric, and reversible transparency-to-opacity transition occurring as ambient temperatures exceed thermally comfortable levels, this hydrogel uniquely encompasses multiple features such as frost resistance, recyclability, scalability, and toughness...

The Mode I, Mode II, and mixed-mode interlaminar failure behavior of a thin-ply (54 gsm) carbon fiber-epoxy laminated composite reinforced by 20 μm tall z -direction-aligned carbon nanotubes (CNTs), comprising ∼50 billion CNT fibers per cm2 , is analyzed following J-integral-based data reduction methods. The inclusion of aligned CNTs in the ply interfaces provides enhanced crack resistance, resulting in sustained crack deflection from the reinforced interlaminar region to the intralaminar region of the adjacent plies, i...

Understanding the fundamental physical characteristics of extremely toxic compounds and their behavior across different environments plays a crucial role in assessing their danger. Additionally, this knowledge informs the development of protocols for gathering forensic evidence related to harmful chemicals misuse. In 2018, former Russian spy Sergei Skripal and his daughter were poisoned in Salisbury, England, with a substance later identified as the unconventional nerve agent A-234. Contamination with the compound was found on items inside Skripal's home...

Small-molecule positive allosteric modulator 1 (SPAM1), which targets pituitary adenylate cyclase-activating polypeptide receptor 1 (PAC1-R), has been found to have a neuroprotective effect, and the underlying mechanism was explored in this study. First, using a D-galactose (D-gal)-induced aging mouse model, we confirmed that SPAM1 improves the structure of the hippocampal dentate gyrus and restores the number of neurons. Compared with D-gal model mice, SPAM1-treated mice showed up-regulated expression of Sirtuin 6 (SIRT6) and Lamin B1 and down-regulated expression of YinYang 1 (YY1) and p16...

This study examines the behavior of hybrid bolted/bonded (HBB) joints loaded in tensile shear comprising plain weave carbon/epoxy laminates in quasi-isotropic (QI) and cross-ply (CP) layups. It proposes a combined approach of 3D digital image correlation and finite element analysis (FEA) to assess their behavior. To apply the FEA simulation accurately, a single layer of plain fabric was replaced with [0/90]s lamination. Experimental standard open-hole tension test results, as well as only bolted (OB) and HBB, along with FEA predictions, confirmed the accuracy of the substitution method...

Cracking in fibrous composites is inevitable, and the fracture pattern is influenced by its fiber distribution. Bamboo fibrous composites have a distinct fiber distribution, which makes them an excellent material for studng the relationship between fiber distribution and fracture mode. Glued laminated bamboo is a bi-directional bamboo fibrous composite, which is called glubam for short. Its vertical thickness is about 28 mm, and the ratio of the number of longitudinal fiber layers to the number of transverse fiber layers is 4:1...

Low fiber-direction compressive strength is a well-recognized weakness of carbon fiber-reinforced polymer (CFRP) composites. When a CFRP is produced using 3D printing, the compressive strength is further degraded. To solve this issue, in this paper, a novel magnetic compaction force-assisted additive manufacturing (MCFA-AM) method is used to print CFRP laminates reinforced with carbon nanofiber (CNF) z-threads (i.e., ZT-CFRP). MCFA-AM utilizes a magnetic force to simultaneously levitate, deposit, and compact fast-curing CFRP prepregs in free space and quickly solidifies the CFRP laminate part without any mold nor supporting substrate plate; it effectively reduces the voids...

Semi-aromatic poly (hexamethylene terephthalamide) (PA6T) oligomer (prePA6T) ultrafine powder, with a diameter of <5 μm, was prepared as an emulsion sizing agent to improve the impregnation performance of CF/PA6T composites. The prePA6T hyperfine powder was acquired via the dissolution and precipitation "phase conversion" method, and the prePA6T emulsion sizing agent was acquired to continuously coat the CF bundle. The sized CF unidirectional tape was knitted into a fabric using the plain weave method, while the CF/PA6T laminated composites were obtained by laminating the plain weave fabrics with PA6T films...

"Interleaving" is widely used for interlaminar toughening of fiber-reinforced composites, and the structure of interleaving is one of the important factors affecting the toughening efficiency of laminates. Several experiments have demonstrated that compared to continuous and dense structures, toughening layers with structural heterogeneity can trigger multiple toughening mechanisms and have better toughening effects. On this basis, this work further investigates the application of heterogeneous toughening phases in interlaminar toughening of bidirectional GFRP...

The noticeable difference in the coefficient of thermal expansion (CTE) for polytetrafluoroethylene (PTFE) coatings and copper substrates is a major challenge for thermal debonding of the copper-clad laminate (CCL) in high-frequency communications. Theoretically, ceramic fillers with low CTEs in the coating can effectively reduce the gap, and there remains a trade-off between the dispersibility of fillers and the interfacial interactions with the polymeric matrix. Here, we propose a novel approach to prepare a pentafluorobenzoyl chloride (PFBC)-modified polydopamine (PDA) shell on silica particles by using amidation...

In the process of paper recycling, certain amounts of metals can be found in the cellulose suspension, the source of which is mainly printing inks. The paper industry often uses different technologies to reduce heavy metal emissions. The recycling of laminated packaging contributes to the formation of sticky particles, which affects the concentration of heavy metals. This study aimed to determine the mass fraction of metals in the different phases of the deinking process to optimize the cellulose pulp's quality and design healthy correct packaging products...

Carbon-fiber-reinforced polymer (CFRP) composites are widely used in lightweight structures because of their high specific strength, specific modulus, and low coefficient of thermal expansion. Additionally, the unidirectionally arrayed chopped strand (UACS) laminates have excellent mechanical properties and flowability, making them suitable for fabricating structures with complex geometry. In this paper, the damage process of UACS quasi-isotropic laminates under tensile load was tested using acoustic emission detection technology...

BACKGROUND: The nuclear lamina links the nuclear membrane to chromosomes and plays a crucial role in regulating chromatin states and gene expression. However, current knowledge of nuclear lamina in plants is limited compared to animals and humans. RESULTS: This study mainly focused on elucidating the mechanism through which the putative nuclear lamina component protein KAKU4 regulates chromatin states and gene expression in Arabidopsis leaves. Thus, we constructed a network using the association proteins of lamin-like proteins, revealing that KAKU4 is strongly associated with chromatin or epigenetic modifiers...

PURPOSE OF REVIEW: The studies on chromatin-modifying enzymes and how they respond to different stimuli within the cell have revolutionized our understanding of epigenetics. In this review, we provide an overview of the recent studies on epigenetic mechanisms implicated in heart failure. RECENT FINDINGS: We focus on the major mechanisms and the conceptual advances in epigenetics as evidenced by studies in humans and mouse models of heart failure. The significance of epigenetic modifications and the enzymes that catalyze them is also discussed...

Porous composite battery electrode performance is influenced by a large number of manufacturing decisions. While it is common to evaluate only finished electrodes when making process adjustments, one must then make inferences about the fabrication process dynamics from static results, which makes process optimization very costly and time-consuming. To get information about the dynamics of the manufacturing processes of these composites, we have built a miniature coating and drying apparatus capable of fabricating lab-scale electrode laminates while operating within an X-ray beamline hutch...