Cindy Shin-Yi Lin, James Howells, Seward Rutkove, Sanjeev Nandedkar, Christoph Neuwirth, Yu-Ichi Noto, Nortina Shahrizaila, Roger G Whittaker, Hugh Bostock, David Burke, Hatice Tankisi
This chapter discusses comprehensive neurophysiological biomarkers utilised in motor neuron disease (MND) and, in particular, its commonest form, amyotrophic lateral sclerosis (ALS). These encompass the conventional techniques including nerve conduction studies (NCS), needle and high-density surface electromyography (EMG) and H-reflex studies as well as novel techniques. In the last two decades, new methods of assessing the loss of motor units in a muscle have been developed, that are more convenient than earlier methods of motor unit number estimation (MUNE),and may use either electrical stimulation (e...
March 20, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology