Liangping Su, Yitian Chen, Cheng Huang, Sangqing Wu, XiaoJuan Wang, Xinbao Zhao, Qiuping Xu, Ruipu Sun, Xiangzhan Kong, Xue Jiang, Xiaoyi Qiu, Xiaoming Huang, Minghui Wang, Ping-Pui Wong
Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways, such as pyroptosis, can be an alternative cancer treatment strategy. Pyroptosis is a gasdermin-driven lytic programmed cell death triggered by inflammatory caspases when initiated by canonical or noncanonical pathways that has been recently seen as a potential therapeutic target in cancer treatment. However, overcoming chemoresistance in cancers by modulating pyroptosis has not been explored...
January 11, 2023: Science Translational Medicine