Sara Kassel, Alison J Hanson, Hassina Benchabane, Kenyi Saito-Diaz, Carly R Cabel, Lily Goldsmith, Muhammad Taha, Aksheta Kanuganti, Victoria H Ng, George Xu, Fei Ye, Julia Picker, Fillip Port, Michael Boutros, Vivian L Weiss, David J Robbins, Curtis A Thorne, Yashi Ahmed, Ethan Lee
The Wnt-β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt signaling converts TCF from a transcriptional repressor to an activator in a process facilitated by the E3 ligase XIAP. XIAP-mediated monoubiquitylation of the transcriptional corepressor Groucho (also known as TLE) decreases its affinity for TCF, thereby allowing the transcriptional coactivator β-catenin to displace it on TCF. Through a genome-scale screen in cultured Drosophila melanogaster cells, we identified the deubiquitylase USP47 as a positive regulator of Wnt signaling...
February 7, 2023: Science Signaling