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Elder DE

Yanira Aranda Rubio, María de la Puente Martín, Alberto Socorro García
No abstract text is available yet for this article.
February 13, 2019: Revista Española de Geriatría y Gerontología
M P J Hermans, D C Eindhoven, L A M van Winden, G J de Grooth, G J Blauw, M Muller, M J Schalij
OBJECTIVE: Consistent with the aging population in the Western world, there is a growing number of elderly patients with ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI) is the recommended reperfusion strategy in elderly patients; risk models to determine which of these patients are prone to have poor clinical outcomes are, however, essential. The purpose of this study was to assess the association between frailty and short-term mortality and PCI-related serious adverse events (SAE) in elderly patients...
February 15, 2019: Netherlands Heart Journal
M L Ridderikhof, E De Kruif, M F Stevens, H M Baumann, P B Lirk, J C Goslings, M W Hollmann
INTRODUCTION: In the Emergency Department, regional anesthesia is increasingly used in elderly patients with hip fractures. An example is a Fascia Iliaca Compartment Block (FICB). Traditionally, this block is administered below the inguinal ligament. There is no Emergency Department data regarding effectivity of an alternative, more cranial approach above the inguinal ligament. The objective was to determine analgesic effects of an ultrasound-guided supra-inguinal FICB in hip fracture patients in the Emergency Department...
February 11, 2019: American Journal of Emergency Medicine
Sebastian Candía, Priscila Candia, Rafael Pizarro Mena, Samuel Durán Agüero
INTRODUCTION: With the increase in the elderly population of Chile, it is very important to evaluate the quality of food of this age group using simple and quick tools. OBJECTIVE: To compare the food quality of the elderly, according to gender and age. MATERIAL AND METHODS: A cross sectional study was conducted on 458 elderly subjects ≥60 years-old of Santiago de Chile. Each one of them were interviewed in their home using the Food Quality Survey for Elderly (FQSE)...
February 12, 2019: Revista Española de Geriatría y Gerontología
Véronique Bourcy, Emmanuelle Boubouloux, Virginie Moiteaux, Fabienne Empereur, David Guillet, Martine Jouin-Bernier, Laure de Decker
Anticancer medicines evolve in terms of their mode of action as well as their galenics. The advent of oral therapies has multiple benefits such as the possibility of taking the treatments at home. However, what are the implications with regard to compliance, the management of side effects and the community-hospital relationship? Elderly patients, often isolated, taking several medicines and frail, are disorientated faced with all these medications and their side effects. A study was undertaken to evaluate the benefit of visits by private practice nurses to support patients taking oral cancer drugs...
January 2019: Soins. Gérontologie
Guillaume Chapelet, Anne Sophie Boureau, Emmanuel Montassier, Quentin Le Bastard, Eric Batard, Didier Lepelletier, Gilles Berrut, Laure de Decker
Aging is a major risk factor of cancers. In recent years, several studies highlighted a change in the diversity and the abundance of the intestinal microbiota associated with aging. Moreover, epidemiological studies, experimental and clinical studies have suggested that the microbiota is implicated in cancer physiopathology and could modulate the efficacy and the tolerance of oncological treatments, for example the incidence of gastrointestinal toxicity and infectious disease. In this review, our objective was first to described the main studies that have focused on the composition of the microbiota associated with aging, cancer and during cancer therapies...
February 12, 2019: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
Gabriele Bellio, Marina Troian, Arianna Pasquali, Nicolò De Manzini
BACKGROUND: Laparoscopy for locally advanced colorectal cancer is not standardized yet and its potential risks and benefits in elderly patients are still under debate. The aim of this study was to evaluate clinical and oncologic results of laparoscopic surgery for pT3/pT4 lesions in both old and young people. METHODS: Between 2006 and 2015, 115 patients aged <70 years and 112 patients aged ≥70 years underwent elective laparoscopic surgery for pT3/pT4 colorectal cancer presenting without distant metastasis at the Department of General Surgery, Trieste...
February 13, 2019: Minerva Chirurgica
Samuele Vaccari, Augusto Lauro, Maurizio Cervellera, Giorgio Palazzini, Giovanni Casella, Alberto Santoro, Domenico Mascagni, Pietro Ursi, Eliana Gulotta, Umberto D'errico, Alessandro Ussia, Nicolò De Siena, Stefania Bianchini, Vito D'andrea, Valeria Tonini
BACKGROUND: The number of surgical operations in elderly patients is increasing due to the aging demographics of western populations. The aim of the present study was to investigate the peri- operative outcome of octogenarian patients undergoing cholecystectomy for acute cholecystitis. METHODS: We performed a retrospective analysis including all patients who underwent cholecystectomy for acute cholecystitis from January 2013 to December 2017. Records were collected prospectively from two centers: "St Orsola Hospital - Emergency Surgery Unit - University of Bologna" and "Umberto I" Hospital - Department of Surgical Sciences - La Sapienza University of Rome...
February 13, 2019: Minerva Chirurgica
Camilla Vieira Esteves, Wellington H Yanaguizawa, Celso A Lemos, Fábio A Alves, Oslei Paes de Almeida, Norberto Nobuo Sugaya
Oral manifestations of tuberculosis (TB) are not so frequent, and the lesions may emerge in immunosuppressed patients as a secondary expression of pulmonary TB. The following two case reports focus on the clinical challenge of early diagnosis of painful ulcerative lesions in oral mucosa that occurred in two senior females, both human immunodeficiency virus negative patients, however receiving immunosuppressing medication. The patients did not present classic symptoms of TB. Nevertheless, based on different studies, extrapulmonary TB should still be considered as differential diagnosis for the oral mucosa lesions developed by these patients...
February 14, 2019: Special Care in Dentistry
Fernando Vieira Pericole, Mariana Lazarini, Luciana Bueno de Paiva, Adriana da Silva Santos Duarte, Karla Priscila Vieira Ferro, Fernanda Soares Niemann, Fernanda Marconi Roversi, Sara Teresinha Olalla Saad
Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell-based disorders characterized by ineffective hematopoiesis, increased genomic instability and a tendency to progress toward acute myeloid leukemia (AML). MDS and AML cells present genetic and epigenetic abnormalities and, due to the heterogeneity of these molecular alterations, the current treatment options remain unsatisfactory. Hypomethylating agents (HMA), especially azacitidine, are the mainstay of treatment for high-risk MDS patients and HMA are used in treating elderly AML...
2019: Frontiers in Oncology
Carmen Vida, Hikaru Kobayashi, Antonio Garrido, Irene Martínez de Toda, Eva Carro, José Antonio Molina, Mónica De la Fuente
In Parkinson's Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of the immune system, based on a chronic-oxidative stress situation, is involved in the rate of aging. We analyzed several functions in isolated peripheral blood neutrophils and mononuclear cells from PD stage 2 patients, and compared the results to those in healthy elderly and adult controls...
February 12, 2019: International Journal of Molecular Sciences
Cristina Franco Gontijo, Josélia Oliveira Araújo Firmo, Maria Fernanda Lima-Costa, Antônio Ignácio de Loyola Filho
The aim of this study was to verify whether social capital is a predictor of all-cause mortality in community-dwelling elderly Brazilians. Participation included 935 surviving elderly from the elderly cohort of the Bambui Project in 2004, who were followed until 2011. The outcome was all-cause mortality and the exposure of interest was social capital, measured in its two components, cognitive (social cohesion and social support) and structural (social participation and neighborhood satisfaction). Sociodemographic variables, health conditions, and smoking were included in the analysis for adjustment purposes...
February 11, 2019: Cadernos de Saúde Pública
Tatiana Albuquerque Gonçalves de Lima, Evandro Cabral de Brito, Robson Martins, Sandro Gonçalves de Lima, Rodrigo Pinto Pedrosa
OBJECTIVE: To evaluate quality of life in elderly patients with obstructive sleep apnea (OSA) who have a pacemaker. METHODS: This was a cross-sectional study involving elderly patients (≥ 60 years of age) with a pacemaker. The dependent variable was quality of life, as evaluated with the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36). Sociodemographic and clinical parameters, including anxiety and depression (Hospital Anxiety and Depression Scale score), as well as the presence of OSA (defined as an apnea-hypopnea index ≥ 15 events/h), were analyzed as independent variables...
February 11, 2019: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Riobaldo Cintra, Filipe A Moura, Luis Sergio F de Carvalho, Joaquim Barreto, Marcos Tambascia, Roberto Pecoits-Filho, Andrei C Sposito
The prevalence of type 2 diabetes mellitus (T2DM) in the elderly grew sharply over the last decade. Reduced insulin sensitivity and secretory capacity, weight gain, sarcopenia, and elevated adiposity are all common metabolic and body changes in the aging population that favor an increased risk of hypoglycemia, frailty syndrome, falls, and cognitive dysfunction. First line antidiabetic therapy is frequently not safe in older individuals because of its high risk of hypoglycemia and prevalent co-morbid diseases, such as chronic kidney disease, osteoporosis, cardiovascular disease, and obesity...
January 2019: Revista da Associação Médica Brasileira
Paul M Graham, Naeha Gupta, David A Altman
En coup de sabre (ECDS) is a rare form of localized scleroderma that typically manifests in children and women. It presents as a fibrous pansclerotic plaque extending in a bandlike distribution on the frontoparietal scalp with surrounding scarring alopecia. Many patients have comorbid central nervous system involvement in addition to the cutaneous findings. En coup de sabre is a rare entity that should be delineated from Parry-Romberg syndrome, as both entities share some common features and may coexist. Corticosteroids remain the treatment of choice, but other modalities such as methotrexate, excimer laser, and grafting have been used with varying success...
January 2019: Cutis; Cutaneous Medicine for the Practitioner
Marie-Louise El Bartelink, Yvette Baggen, Diede E Stevens, Martin Smalbrugge, Nynke Scherpbier, Roger Amj Damoiseaux, Esther de Groot
BACKGROUND: Clinician-scientists (CSs) are physicians who work in daily care and have an academic role in research or education. They may act as knowledge brokers and help to connect research and clinical practice. There is no data available on CSs' brokering activities and the perceived barriers and facilitators to optimising their role in general practice (GP) and elderly care medicine (EM). AIM: To identify the brokering activities of CSs in these fields and the barriers and facilitators they come across whilst sharing knowledge and connecting people in research and frontline health care...
February 12, 2019: Education for Primary Care
Irene Martínez de Toda, Carmen Vida, Antonio Garrido, Mónica De la Fuente
Oxidative stress has been reported to increase with aging and although several age-related changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and lifespan. Therefore, antioxidant (catalase, glutathione peroxidase and reductase activities and reduced glutathione) and oxidant (oxidized glutathione, basal superoxide anion and malondialdehyde concentrations) parameters were studied in whole blood cells from humans divided into different age groups (adult, mature, elderly, nonagenarian and centenarian) in a cross-sectional study...
February 11, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Ana Luisa Quintella do Couto Aleixo, Raquel Vasconcelos C de Oliveira, Maíra Cavalcanti Albuquerque, Ana Luiza Biancardi, André Luiz Land Curi, Eliezer Israel Benchimol, Maria Regina Reis Amendoeira
PURPOSE: To analyze risk factors for recurrent toxoplasmic retinochoroiditis. DESIGN: Single center prospective case series. POPULATION AND METHODS: A total of 230 patients with toxoplasmic retinochoroiditis were prospectively followed to assess recurrences. All patients were treated with a specific drug regime for toxoplasmosis in each episode of active retinochoroiditis. Individuals with chronic diseases and pregnant women were excluded...
2019: PloS One
Sandra Nora Gonzalez-Diaz, Rosalaura Virginia Villarreal-Gonzalez, Cindy Elizabeth De Lira-Quezada, Rosa Ivett Guzman-Avilan
PURPOSE OF REVIEW: Asthma is a chronic heterogeneous respiratory disease which is characterized by airflow limitation and variable respiratory symptoms. Asthma in patients more than 65 years of age has an important negative impact on quality of life. The pathophysiology and treatment of asthma in older patients are not as well identified as in younger groups of ages. In this review we intend to outline characteristics found in elderly adults which distinguish them from other age groups of patients with asthma...
February 8, 2019: Current Opinion in Allergy and Clinical Immunology
Ana Verdelho, Sofia Madureira, Manuel Correia, José Manuel Ferro, Mário Rodrigues, Manuel Gonçalves-Pereira, Mafalda Gonçalves, Ana Catarina Santos, Pedro Vilela, Helena Bárrios, Mariana Borges, Helena Santa-Clara
BACKGROUND: Cognitive impairment and cerebrovascular pathology are both frequent with ageing. Cognitive impairment due to vascular pathology of the brain, termed vascular cognitive impairment (VCI), is one of the most frequent causes of cognitive impairment in elderly subjects. Thus far, VCI has no specific pharmacological treatment. Recent observational studies have suggested a protective effect of physical activity in cognition, but adequate randomised controlled trials (RCT) are lacking...
February 11, 2019: Trials
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