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JOURNAL ARTICLE
Giovanni Santacroce, Marco Vincenzo Lenti, Giulia Maria Abruzzese, Giacomo Alunno, Francesco Di Terlizzi, Carmine Frenna, Antonella Gentile, Mario Andrea Latorre, Clarissa Petrucci, Damiano Ruggeri, Simone Soriano, Nicola Aronico, Annalisa De Silvestri, Gino Roberto Corazza, Marietta Iacucci, Antonio Di Sabatino
INTRODUCTION: Diverticular disease (DD), commonly associated with the elderly, is becoming more prevalent among younger individuals. This retrospective study aimed to evaluate the differences in the natural history and outcomes between young and old patients with DD. METHODS: Adult patients with DD diagnosed between 2010 and 2022 at an Italian tertiary referral center were enrolled, and their demographic and clinical data were retrieved. The patients were categorized as young or old based on the 25th percentile of the population's age at diagnosis...
2024: Frontiers in Medicine
#2
Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Roberto Novizio, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Giovanni Iannetti, Stefano Laureti, Celestino Pio Lombardi, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Laura Tonzar, Franco Grimaldi, Renato Cozzi, Roberto Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. METHODS: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) and Società Italiana dell'Osteoporosi, del Metabolismo Minerale e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices...
December 23, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
#3
JOURNAL ARTICLE
Ana Isabel Hormigo-Sánchez, Marta Neira-Álvarez, Teresa Pareja-Sierra
Osteoporosis is a metabolic and systemic disease characterized by alterations at the level of bone tissue with loss of bone mineral density, changes in microarchitecture, mineralization and remodeling that determine greater bone fragility and risk of fracture. Falls in the elderly are a risk factor closely related to fragility fractures and numerous studies demonstrate this relationship. Vertebral fractures are a major cause of morbidity and mortality. The epidemiology differs from osteoporotic fractures at other skeletal sites, as only one-third are clinically recognized...
April 18, 2024: Revista Española de Cirugía Ortopédica y Traumatología
#4
JOURNAL ARTICLE
Colin Simon, David A E Bolton, James F Meaney, Rose Anne Kenny, Vivienne A Simon, Céline De Looze, Silvin Knight, Kathy L Ruddy
Recent research has indicated that the relationship between age-related cognitive decline and falling may be mediated by the individual's capacity to quickly cancel or inhibit a motor response. This longitudinal investigation demonstrates that higher white matter fibre density in the motor inhibition network paired with low physical activity was associated with falling in elderly participants. We measured the density of white matter fibre tracts connecting key nodes in the inhibitory control network in a large sample (n = 414) of older adults...
April 18, 2024: European Journal of Neuroscience
#5
JOURNAL ARTICLE
Alexandra G Zonnefeld, Chang-Yi Cui, Dimitrios Tsitsipatis, Yulan Piao, Jinshui Fan, Krystyna Mazan-Mamczarz, Yutong Xue, Fred E Indig, Supriyo De, Myriam Gorospe
Evaporation of sweat on the skin surface is the major mechanism for dissipating heat in humans. The secretory capacity of sweat glands (SWGs) declines during aging, leading to heat intolerance in the elderly, but the mechanisms responsible for this decline are poorly understood. We investigated the molecular changes accompanying SWG aging in mice, where sweat tests confirmed a significant reduction of active SWGs in old mice relative to young mice. We first identified SWG-enriched mRNAs by comparing the skin transcriptome of Eda mutant Tabby male mice, which lack SWGs, with that of wild-type control mice by RNA-sequencing analysis...
April 17, 2024: Aging
#6
JOURNAL ARTICLE
Danyllo do Nascimento Silva Junior, Ádala Nayana de Sousa Mata, Gidyenne Christine Bandeira Silva de Medeiros, Marilane Vilela Marques, Thais Teixeira Dos Santos, Maria Eduarda de Sousa Monteiro, Gabriela Góis Costa, Eleonora D Orsi, Eva Vegue Parra, Grasiela Piuvezam
INTRODUCTION: The COVID-19 pandemic has become a significant health crisis, marked by high mortality rates on a global scale, with mortality from the disease being notably concentrated among the elderly due to various factors. OBJECTIVE: This study aims to investigate the biological and non-biological factors associated with COVID-19 mortality rates among the elderly worldwide. METHODS: The following databases will be consulted: PubMed, Scopus, EMBASE, Web of Science and ScienceDirect...
2024: PloS One
#7
JOURNAL ARTICLE
Silvia Carpenè, Barbara Silvestri, Martina Bertinazzi, Enrico Armato, Maurizio Amadori, Roberto Spinato, Francesca de Terlizzi, Giuseppe Azzarello
BACKGROUND: Sinonasal Mucosal Melanoma (SNMM) is a rare but aggressive disease. Surgery with free margins, when feasible, is the treatment of choice. In the last three decades, electrochemotherapy (ECT) has emerged as a local ablative procedure, performed with the Cliniporator, for cutaneous and mucosal tumours of different histology. We present a case report of an ECT treatment performed by means of a new endoscopic electrode, on an elderly patient affected by primary SNMM. METHODS: An 88-year-old man with a diagnosis of SNMM (cT4aN0M0)-Stage IV, of the left nasal fossa presented at our institution...
April 18, 2024: European Archives of Oto-rhino-laryngology
#8
JOURNAL ARTICLE
Lucy Gately, C Mesía, J M Sepúlveda, S Del Barco, E Pineda, R Gironés, J Fuster, M Dumas, S Gill, L M Navarro, A Herrero, A Dowling, R de Las Peñas, M A Vaz, M Alonso, Z Lwin, R Harrup, S Peralta, A Long, P Perez-Segura, E Ahern, C O Garate, M Wong, R Campbell, K Cuff, R Jennens, O Gallego, C Underhill, M Martinez-Garcia, M Covela, A Cooper, S Brown, M Rosenthal, J Torres, I M Collins, P Gibbs, C Balana
PURPOSE: The impact of age on optimal management of glioblastoma remains unclear. A recent combined analysis of two randomised trials, GEINO14-01 and EX-TEM, found no benefit from extending post-radiation temozolomide in newly diagnosed glioblastoma. Here, we explore the impact of age. METHODS: Relevant intergroup statistics were used to identify differences in tumour, treatment and outcome characteristics based on age with elderly patients (EP) defined as age 65 years and over...
April 17, 2024: Journal of Neuro-oncology
#9
JOURNAL ARTICLE
Rubia Pereira Barra, Edgar Nunes de Moraes, Maria Margaret de Vasconcellos Lemos, Poliana Castro de Resende Bonati, José Flávio Morais Castro, André Augusto Jardim
OBJECTIVE: To describe the functional clinical profile of elderly people linked to primary health care, using the Functional Clinical Vulnerability Index (IVCF-20) and to spatialize those with the greatest functional decline by primary health care units in the municipality of Uberlândia, in the state of Minas Gerais (MG), in the year 2022. METHODS: A cross-sectional study with secondary data from the Municipal Health Department of Uberlândia-MG. The variables were compared using Student's t-test, Mann Whitney test, Pearson's chi-square, and multinomial logistic regression to obtain the independent effect of each variable...
2024: Revista de Saúde Pública
#10
JOURNAL ARTICLE
Melquesedeque Dos Santos, Eurico Cleto Ribeiro de Campos, Rivair Gonçalves Junior, Adriana Yuriko Koga, Pedro Afonso Kono, Matheus Von Jelita Salina, Elder Dalazoana Filho, Alceu de Oliveira Toledo Junior, Leandro Cavalcante Lipinski
PURPOSE: To evaluate the effects of curcumin supplementation on abdominal surgical wound healing in rats using clinical, histological, and hematological parameters. METHODS: Forty Wistar rats were randomly divided into two groups: the curcumin group, and the control group. The curcumin group received, in addition to water and standard feed, curcumin via gavage at the dose of 200 mg/kg for seven days preceding and seven days following surgery. The control group received only water and standard feed...
2024: Acta Cirúrgica Brasileira
#11
JOURNAL ARTICLE
Dana Jafarpour, Nesma El-Amier, Jocelyne Feine, Christophe Bedos, Samer Abi-Nader, Shahrokh Esfandiari, Tibor Shuster, Elizabeth Zimmermann, Raphael de Souza
BACKGROUND: Complete tooth loss is a significant global oral health issue, particularly impacting older individuals with lower socioeconomic status. Computer-assisted technologies enhance oral healthcare access by the elderly. Despite promising in vitro reports on digital denture materials, evidence from randomized clinical trials (RCTs) is lacking to verify their performance. This cross-over RCT will investigate whether 3D-printed implant-retained mandibular overdentures (IMO) are more satisfactory for edentulous seniors than those made through traditional methods...
April 16, 2024: Trials
#12
JOURNAL ARTICLE
Marina M Norde, Sabri Bromage, Dirce M L Marchioni, Ana Carolina Vasques, Megan Deitchler, Joanne Arsenaut, Aline M de Carvalho, Lício Velloso, Walter Willett, Edward Giovannucci, Bruno Geloneze
BACKGROUND: The Global Diet Quality Score (GDQS) was developed to be a simple, timely and cost-effective tool to track, simultaneously, nutritional deficiency and non-communicable disease risks from diet in diverse settings. The objective was to investigate the performance of GDQS as an indicator of adequate nutrient intake and dietary quality in a national-representative sample of the Brazilian population. METHODS: Nationally-representative data from 44,744 men and non-pregnant and non-lactating women aging ≥ 10 years, from the Brazilian National Dietary Survey were used...
April 17, 2024: Nutrition Journal
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REVIEW
Betsy S Thomas, Danielle Perry, Samantha S Moe, Ricky D Turgeon, Jen Potter, Émélie Braschi, Nicholas Dugré, Jessica E M Kirkwood, G Michael Allan
OBJECTIVE: To provide a summary of the noteworthy medical articles published in 2023 that are relevant to family physicians. SELECTING THE EVIDENCE: Articles were chosen and ranked by the PEER (Patients, Experience, Evidence, Research) team, a group of primary care health professionals focused on evidence-based medicine. The selection process involved routine surveillance of tables of contents in high-impact medical journals and continuous monitoring of EvidenceAlerts...
April 2024: Canadian Family Physician Médecin de Famille Canadien
#14
JOURNAL ARTICLE
Xiang Zhou, Tao Chen, Yu-Lin Jiang, De-Bin Chen, Zhi-Yong Tian
BACKGROUND: The proximal femoral nail anti-rotation (PFNA) with cement enhancement enhances the anchorage ability of internal fixation in elderly with osteoporotic intertrochanteric fracture. However, whether it is superior to hemiarthroplasty is still controversial. The present study aimed to determine which treatment has better clinical outcomes among older patients. METHODS: We retrospectively analyzed 102 elderly patients with osteoporosis who developed intertrochanteric fractures and underwent PFNA combined with cement-enhanced internal fixation (n = 52, CE group), and hemiarthroplasty (n = 50, HA group) from September 2012 to October 2018...
April 15, 2024: BMC Musculoskeletal Disorders
#15
JOURNAL ARTICLE
Wenrong Duan, Jian Huang, Qiuling Huang, Birong Dong
BACKGROUND: Chronic pain poses a significant problem for older adults and may potentially impact cognitive function. This study aimed to examine the cross-sectional relationship between pain severity and cognitive function in elderly individuals residing in the community. Additionally, this study sought to examine the mediating effect of depression on the relationship between pain and dementia. METHODS: The study sample was derived from the 2018 China Health and Aging Longitudinal Study (CHARLS), comprising cross-sectional data from 4559 community residents aged 65 years or older...
April 2024: Actas Españolas de Psiquiatría
#16
JOURNAL ARTICLE
Cecilio Álamo, Jerónimo Sáiz Ruiz, Cristina Zaragozá Arnáez
Insomnia disorder is a common condition that is considered a risk factor for multiple physical and mental disorders, contributing to reduced quality of life and increased healthcare expenditures. Although cognitive behavioral therapy (CBT) is typically recommended as the primary intervention, its accessibility is hindered by limited resources, prompting the prevalent use of pharmacological interventions as the primary treatment in clinical settings. This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment...
April 2024: Actas Españolas de Psiquiatría
#17
JOURNAL ARTICLE
Jhonny Acevedo Ayala, Andrea Solari Del Sol, Magdalena Arroyo Concha, Dominique Tirreau Román
Chile is facing an increasingly aging population and, with it, changes in its demographic, epidemiological, and healthcare structure. As a result, the sexual health of the elderly is an emerging area at the social level and in healthcare systems. This research aims to identify general aspects of sexuality in the elderly and learn about educational content delivered to this group using digital technologies. To do this, we proposed a review of scientific literature on the subject between January 1st, 2018, and December 31st, 2022, in the databases Web of Science, MEDLINE/PubMed, LILACS, Cochrane, Scopus, and Google Scholar...
April 15, 2024: Medwave
#18
JOURNAL ARTICLE
Andressa Crystine da Silva Sobrinho, Grace Angelica de Oliveira Gomes, Carlos Roberto Bueno Júnior
BACKGROUND: Although comprehensive lifestyle habits are crucial for healthy aging, their adherence tends to decline as individuals grow older. Sustaining a healthy life over time poses a motivational challenge. Some digital tools, such as smartphone apps aimed at promoting healthy habits, have been used to counteract this decline. However, a more profound investigation is necessary into the diverse experiences of users, particularly when it concerns older adults or those who are unfamiliar with information and communications technologies...
April 15, 2024: JMIR Formative Research
#19
Ozioma Akahara, Robert Hennis, Jared J Bies, Aymara Y Chang
Streptococcus agalactiae infection is typically seen in specific populations, including neonates, pregnant women, and the elderly. These patients have immature, lower, and waning immune systems, which makes them more susceptible to infections. Typical S. agalactiae infections manifest as cellulitis, bacteremia, endocarditis, meningitis, ventriculitis (a rare complication of meningitis), and osteomyelitis. In rare cases, a patient can present with two or more of these typical infection manifestations. The authors present a case of a 48-year-old female with a past medical history of hypothyroidism and chronic back pain who presented to the emergency department with altered mental status...
March 2024: Curēus
#20
JOURNAL ARTICLE
C Pollak, J Verghese, A S Buchman, Y Jin, H M Blumen
BACKGROUND: Loneliness is highly prevalent among older adults and is associated with frailty. Most studies consider loneliness in isolation without consideration for structural and functional measures of social relationships - and longitudinal studies are scarce. OBJECTIVES: This study examined longitudinal associations between loneliness and frailty and analyzed how structural and functional social measures influence these associations. DESIGN: Linear mixed effects models examined longitudinal associations between loneliness and frailty assessed with the frailty index (scale 0-100)...
2024: Journal of Frailty & Aging
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