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https://read.qxmd.com/read/30767712/population-pharmacokinetic-and-pharmacogenetics-of-imatinib-in-chinese-patients-with-chronic-myeloid-leukemia
#1
Qing Wang, Zhi-Ping Jiang, Er-Qian Yu, Jing Zeng, Yan Zhu, Hua-Lin Cai, Miao Yan, Da-Xiong Xiang, Xie-Lan Zhao, Ping Xu, Zheng Jiao, Hoan Linh Banh
AIM: This study aimed to establish a population pharmacokinetic (PPK) model in Chinese patients with chronic myeloid leukemia, and to quantify the effects of pharmacogenetics on pharmacokinetic parameters of imatinib. METHODS: A total of 229 plasma concentrations from 170 patients were analyzed. Nonlinear mixed effect model was used to establish the PPK model. RESULTS: A one-compartment model with first-order absorption and first-order elimination adequately describes imatinib pharmacokinetics...
February 15, 2019: Pharmacogenomics
https://read.qxmd.com/read/30765842/inhibition-of-g9a-by-a-small-molecule-inhibitor-unc0642-induces-apoptosis-of-human-bladder-cancer-cells
#2
Yue-Peng Cao, Jing-Ya Sun, Mei-Qian Li, Yu Dong, Yuan-Heng Zhang, Jun Yan, Rui-Min Huang, Xiang Yan
Urinary bladder cancer (UBC) is characterized by frequent recurrence and metastasis despite the standard chemotherapy with gemcitabine and cisplatin combination. Histone modifiers are often dysregulated in cancer development, thus they can serve as an excellent drug targets for cancer therapy. Here, we investigated whether G9a, one of the histone H3 methyltransferases, was associated with UBC development. We first analyzed clinical data from public databases and found that G9a was significantly overexpressed in UBC patients...
February 14, 2019: Acta Pharmacologica Sinica
https://read.qxmd.com/read/30764946/preparation-of-a-pt-active-carbon-fiber-catalyst-and-its-application-in-the-synthesis-of-p-chloroaniline-with-catalytic-hydrogenation
#3
Baoliang Liu, Bing Yang, Meiyu Sun, Xiangli Qian, Qikun Zhang
In this study, a Pt loaded active carbon fiber (Pt/ACF) catalyst was prepared by immobilizing Pt nanoparticles on ACF. The catalyst accelerated hydrogenation of p -chloronitrobenzene ( p -CNB) to p -chloroaniline ( p -CA) at lower temperature and atmospheric pressure, resulting in approximately 100% yield and selectivity. Several factors that affect p -CA yield were investigated. The nitro reduction rate reached 100% under the optimal reaction conditions, indicating excellent selectivity of the prepared catalyst...
July 1, 2019: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/30762540/deep-learning-for-fast-and-spatially-constrained-tissue-quantification-from-highly-accelerated-data-in-magnetic-resonance-fingerprinting
#4
Zhenghan Fang, Yong Chen, Mingxia Liu, Lei Xiang, Qian Zhang, Qian Wang, Weili Lin, Dinggang Shen
Magnetic resonance fingerprinting (MRF) is a quantitative imaging technique that can simultaneously measure multiple important tissue properties of human body. Although MRF has demonstrated improved scan efficiency as compared to conventional techniques, further acceleration is still desired for translation into routine clinical practice. The purpose of this work is to accelerate MRF acquisition by developing a new tissue quantification method for MRF that allows accurate quantification with fewer sampling data...
February 13, 2019: IEEE Transactions on Medical Imaging
https://read.qxmd.com/read/30762286/ssrp1-promotes-colorectal-cancer-progression-and-is-negatively-regulated-by-mir-28-5p
#5
Wei Wu, Ke He, Qian Guo, Jingdi Chen, Mengjiao Zhang, Kai Huang, Dongmei Yang, Lu Wu, Yunchao Deng, Xu Luo, Honggang Yu, Qianshan Ding, Guoan Xiang
In this study, microarray data analysis, real-time quantitative PCR and immunohistochemistry were used to detect the expression levels of SSRP1 in colorectal cancer (CRC) tissue and in corresponding normal tissue. The association between structure-specific recognition protein 1 (SSRP1) expression and patient prognosis was examined by Kaplan-Meier analysis. SSRP1 was knocked down and overexpressed in CRC cell lines, and its effects on proliferation, cell cycling, migration, invasion, cellular energy metabolism, apoptosis, chemotherapeutic drug sensitivity and cell phenotype-related molecules were assessed...
February 14, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30758674/mutation-in-a-putative-glycosyltransferase-like-gene-causes-programmed-cell-death-and-early-leaf-senescence-in-rice
#6
Shanwen Ke, Shuchun Liu, Xin Luan, Xin-Ming Xie, Tzung-Fu Hsieh, Xiang-Qian Zhang
Leaf senescence is a genetically regulated, highly complex and ordered process. Although it has been extensively studied, the mechanism of leaf senescence is not well understood. In this study, we isolated a rice mutant, designated as premature senescence leaf (psl), which exhibits early senescence and spontaneous lesion mimic phenotype after flowering. The psl mutant displays programmed cell death with elevated accumulation of reactive oxygen species (ROS). Molecular and genetic analyses revealed that the phenotypes were caused by a phenylalanine deletion in the OsPSL (LOC_Os12g42420) that encode a putative core 2/I branching beta-1,6-N-acetylglucosaminyl transferase predicted to be involved in protein glycosylation modification...
February 13, 2019: Rice
https://read.qxmd.com/read/30754020/simultaneous-removal-of-aniline-antimony-and-chromium-by-zvi-coupled-with-h-2-o-2-implication-for-textile-wastewater-treatment
#7
Xue Gang, Qi Wang, Yajie Qian, Pin Gao, Yiming Su, Zhenhong Liu, Hong Chen, Xiang Li, Jiabin Chen
Aniline, antimony (Sb) and chromium (Cr) are typical and regulated co-contaminants in textile wastewater, but their removal was often investigated individually. In this work, simultaneous removal of aniline, Sb and Cr by ZVI coupled with H2 O2 was studied. With the dosage of 0.5 g L-1 ZVI and 2 mM H2 O2 , aniline, Sb and Cr can be removed completely at pH 3. Experiment with iso-propanol as the radical scavenger confirmed that OH derived from Fenton reaction accounts for aniline degradation, but not for Sb and Cr removal...
February 5, 2019: Journal of Hazardous Materials
https://read.qxmd.com/read/30744477/the-effect-of-smoking-on-residual-platelet-reactivity-to-clopidogrel-a-systematic-review-and-meta-analysis
#8
Zhiyan Liu, Qian Xiang, Guangyan Mu, Qiufen Xie, Shuang Zhou, Zining Wang, Shuqing Chen, Kun Hu, Yanjun Gong, Jie Jiang, Yimin Cui
Cigarette smoking is an important cardiovascular risk factor, causing morbidity and mortality. There are many original studies on the impact of smoking, but its influence on platelet ADP-P2Y12 receptor inhibitors lack consistency. Thus, we conducted a systematic review and meta-analysis of already existing data/studies to further explore this issue. PubMed, Web of science, EMBASE, Clinical Trials, and the Cochrane Library were searched from inception to March 2018. Studies investigating the residual platelet reactivity categorized by smoking status and patients treated with platelet ADP-P2Y12 receptor inhibitors qualified the inclusion criteria...
February 11, 2019: Platelets
https://read.qxmd.com/read/30744329/selection-signature-reveals-genes-associated-with-susceptibility-loci-affecting-respiratory-disease-due-to-pleiotropic-and-hitchhiking-effect-in-chinese-indigenous-pigs
#9
Zhong Xu, Hao Sun, Zhe Zhang, Cheng-Yue Zhang, Qing-Bo Zhao, Qian Xiao, Babatunde Shittu Olasege, Pei-Pei Ma, Xiang-Zhe Zhang, Qi-Shan Wang, Yu-Chun Pan
Background: Porcine respiratory disease is one of the most important health problems which causes significant economic losses. Objective: To understand the genetic basis for susceptibility to swine enzootic pneumonia (EP) in pigs, we detected 102,809 SNPs in a total of 249 individuals based on genome-wide sequencing data. Methods: Genome comparison of three susceptibility to swine EP pig breeds (Jinhua, Erhualian and Meishan) with two western lines that are considered more resistant (Duroc and Landrace) using XP-EHH and FST statistical approaches identified 691 positively selected genes...
February 7, 2019: Asian-Australasian Journal of Animal Sciences
https://read.qxmd.com/read/30742060/a-new-model-for-predicting-intravenous-immunoglobin-resistant-kawasaki-disease-in-chongqing-a-retrospective-study-on-5277-patients
#10
Xu-Hai Tan, Xiao-Wei Zhang, Xiao-Yun Wang, Xiang-Qian He, Chu Fan, Tie-Wei Lyu, Jie Tian
Accurate evaluation of individual risk of intravenous immunoglobin (IVIG)-resistance is critical for adopting regimens for the first treatment and prevention of coronary artery lesions (CALs) in patients with Kawasaki disease (KD). METHODS: The KD patients hospitalized in Chongqing Children's Hospital, in west China, from October 2007 to December 2017 were retrospectively reviewed. Data were collected and compared between IVIG-resistant group and IVIG-responsive group. The independent risk factors were determined using multivariate regression analysis...
February 11, 2019: Scientific Reports
https://read.qxmd.com/read/30739419/-application-of-self-made-chronic-wound-closure-device-in-the-repair-of-scarred-lower-extremity-wounds
#11
Shaoquan Pu, Qian Lü, Zeyu Zhao, Dan Hu, Xiang Chen, Hanfen Chen, Yueliang Zhu, Yongqing Xu
Objective: To investigate the effectiveness of self-made limb chronic wound closure device in the treatment of scarred lower limbs and complex skin and soft tissue defects. Methods: Between January 2014 and January 2017, 29 patients with complex fractures of the lower extremities and skin and soft tissue defects were treated. There were 19 males and 10 females with an average age of 31.1 years (range, 21-66 years). The causes of injury included 14 cases of traffic accidents, 5 cases of falling from height, 4 cases of heavy object crushing injury, 4 cases of mechanical crushing injury, and 2 cases of exposed steel plate after fracture...
February 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/30738465/-prevalence-and-genetic-analysis-of-%C3%AE-thalassemia-in-neonates-in-wuhan-area-of-china
#12
Qian Xiong, Xi-Jiang Hu, Xiang Dai, Bin Zhou, Wen-Qian Cai
OBJECTIVE: To investigate the β-thalassemia genotypes in neonates in Wuhan area of China and their characteristics of molecular epidemiology. METHODS: A total of 2721 neonates in Wuhan who were positive in primary screening for β-thalassemia were included in this study. Genotypes of β-thalassemia gene were determined with PCR-flow cytometry and fluorescence hybridization assay. RESULTS: There were 537 cases of β-thalassemia with over 15 kinds of genotypes, and 19 cases of α-composite β-thalassemia with 8 genotypes...
February 2019: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/30735603/hetero-oligomeric-cpn60-resembles-highly-symmetric-group-i-chaperonin-structure-revealed-by-cryo-em
#13
Qian Zhao, Xiang Zhang, Frederik Sommer, Na Ta, Ning Wang, Michael Schroda, Yao Cong, Cuimin Liu
The chloroplast chaperonin system is indispensable for the biogenesis of Rubisco, the key enzyme in photosynthesis. Using Chlamydomonas reinhardtii as a model system, we found that in vivo the chloroplast chaperonin consists of CPN60α, CPN60β1, and CPN60β2, and the co-chaperonin of the three subunits CPN20, CPN11 and CPN23. In E. coli, CPN20 homo-oligomers and all possible other chloroplast co-chaperonin hetero-oligomers are functional, but only that consisting of CPN11/20/23-CPN60αβ1β2 can fully replace GroES/GroEL under stringent stress conditions...
February 8, 2019: Plant Journal: for Cell and Molecular Biology
https://read.qxmd.com/read/30734512/comparative-analysis-of-main-active-components-and-hypoglycemic-effects-after-the-compatibility-of-scutellariae-radix-and-coptidis-rhizoma
#14
Xiang Cui, Yu-Meng Shen, Shu Jiang, Da-Wei Qian, Er-Xin Shang, Zhen-Hua Zhu, Jin-Ao Duan
In this study, a rapid and highly sensitive ultra performance liquid chromatography-triple quadrupole mass spectrometer method with the mobile phases of acetonitrile and 0.1% aqueous formic acid was established and successfully applied to comparatively analyze main active components after their compatibility. Besides, the effects of Scutellariae Radix, Coptidis Rhizoma and combined extracts on type 2 diabetic rats induced by high-fat diet along with low dose of streptozocin were investigated. Under the optimized chromatographic conditions, good separation of seven target components was achieved within 12 min...
February 7, 2019: Journal of Separation Science
https://read.qxmd.com/read/30732199/the-efficacy-of-the-traditional-chinese-medicine-jia-wei-niu-bang-zi-granule-combined-with-methotrexate-in-treating-active-rheumatoid-arthritis-a-multicenter-randomized-double-blinded-controlled-clinical-trial
#15
Yi-Ru Wang, Li Liu, Xiao-Yun Wang, Qiong Wang, Min Yao, Xue-Jun Cui, Jian-Chun Mao, Jian Liu, Xiao-Hua Gu, Yong-Li Chen, Xiang Yu, Qi Shi, Qian-Qian Liang, Yong-Jun Wang
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic and autoimmune inflammatory disease ending with the destruction of joints. Current therapies can relieve RA symptoms, but some also bring severe adverse events. Therefore, an effective and safe therapeutic strategy remains to be created to benefit patients with RA by large. Jia Wei Niu Bang Zi granule (NBZG) consisting of RA-fighting Chinese herbals has been used in Longhua Hospital in the last several decades. NBZG has potential therapeutic effect on RA, which should be evaluated by larger sample clinical trial...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30717712/intrahepatic-bile-duct-exploration-lithotomy-is-a-useful-adjunctive-hepatectomy-method-for-bilateral-primary-hepatolithiasis-an-eight-year-experience-at-a-single-centre
#16
En-Liang Li, Rong-Fa Yuan, Wen-Jun Liao, Qian Feng, Jun Lei, Xiang-Bao Yin, Lin-Quan Wu, Jiang-Hua Shao
BACKGROUND: To evaluate the perioperative and long-term results of intrahepatic bile duct exploration lithotomy (IHBDIL) combined with hepatectomy for patients with complicated bilateral primary hepatolithiasis. METHODS: A study was conducted involving 56 patients with complicated bilateral primary hepatolithiasis who underwent IHBDIL combined with hepatectomy at our hospital from January 2006 to December 2014. The perioperative and long-term outcomes that were retrospectively analysed included the stone clearance rate, operative morbidity and mortality, and stone recurrence rate...
February 4, 2019: BMC Surgery
https://read.qxmd.com/read/30716440/long-non-coding-rna-dilc-promotes-the-progression-of-gallbladder-carcinoma
#17
Chi Liang, Pinghua Yang, Tao Han, Ruo-Yu Wang, Xiang-Lei Xing, An-Feng Si, Qian-Yun Ma, Zhong Chen, Heng-Yu Li, Baohua Zhang
Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) contribute to tumorigenesis, progression and recurrence of various malignancies including Gallbladder carcinoma (GBC). Lnc-DILC is reported to be the tumor suppressor gene to play an important role in liver cancer stem cells (CSCs). However, the role of lnc-DILC in GBC remains to be elucidated. Herein, we show that lnc-DILC is upregulated in gallbladder CSCs and GBC patients' tissues. Knockdown of lnc-DILC attenuates the self-renewal, tumorigenicity, proliferation and metastasis of gallbladder CSCs...
February 1, 2019: Gene
https://read.qxmd.com/read/30714606/imaging-dynamic-changes-of-an-intracellular-cysteine-pool-that-responds-to-the-stimulation-of-external-oxidative-stress
#18
Kun Chen, Meng Zhang, Yalin Qi, Jing Fan, Xiang Ma, Hailiang Zhu, Yong Qian
Understanding the dynamic status of intracellular cysteine that responds to the stimulation of external oxidative stress is of great importance to mechanistic studies of cysteine related biology and medicine. However, due to the interference of structural similarity and comparable reactivity of other bio-thiols under physiological conditions, it is exceedingly challenging to develop fluorescent probes with excellent selectivity and sensitivity for the visualization of cysteine activities in an intricate biological context...
February 4, 2019: Analyst
https://read.qxmd.com/read/30712327/the-role-of-intestinal-microbiota-in-cardiovascular-disease
#19
REVIEW
Mengchao Jin, Zhiyuan Qian, Jiayu Yin, Weiting Xu, Xiang Zhou
Accumulating evidence has indicated that intestinal microbiota is involved in the development of various human diseases, including cardiovascular diseases (CVDs). In the recent years, both human and animal experiments have revealed that alterations in the composition and function of intestinal flora, recognized as gut microflora dysbiosis, can accelerate the progression of CVDs. Moreover, intestinal flora metabolizes the diet ingested by the host into a series of metabolites, including trimethylamine N-oxide, short chain fatty acids, secondary bile acid and indoxyl sulfate, which affects the host physiological processes by activation of numerous signalling pathways...
February 3, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30711839/hydrothermal-liquefaction-of-cellulose-in-ammonia-water
#20
Zhi-Xiang Xu, Jin-Hong Cheng, Zhi-Xia He, Qian Wang, Yue-Wen Shao, Xun Hu
In order to obtain the N-containing organics from cellulose under mild conditions, hydrothermal liquefaction of cellulose in the presence of ammonia was conducted in this study. The results showed that the increasing reaction temperature and prolonging time facilitated the conversion of cellulose in hydrothermal liquefaction (HTL) with NH3 ·H2 O and decreased the amount of solid residue. Reaction temperature showed more influence than reaction time on solid residue formation. The components of bio-oil were significantly affected by reaction temperature and reaction time...
January 15, 2019: Bioresource Technology
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