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Vidya Chelerkar, Puja Parekh, V K S Kalyani, Madan Deshpande, Rajiv Khandekar
PURPOSE: Comparative clinical study of medically controlled non-severe chronic Primary Angle Closure Glaucoma (PACG) with co-existing cataract surgically managed by phacoemulsification as against combined phacotrabeculectomy. METHODS: This randomized clinical trial was conducted between December 2011 and December 2013. Patients were randomly assigned to Phacoemulsification (PE) and Phacotrabeculectomy (PT) groups for surgery. Intraocular pressure, anti-glaucoma medications, Best Corrected Visual Acuity, anterior chamber angle widening and post-operative complications in both groups were compared after 12 months...
July 2018: Middle East African Journal of Ophthalmology
Fei Jiang, Chen Yu, Min-Jing Zuo, Chun Zhang, Ying Wang, Fu-Qing Zhou, Xian-Jun Zeng
Objective: In this study, we aimed to investigate the frequency-dependent spontaneous neural activity in primary angle-closure glaucoma (PACG) using the amplitude of low-frequency fluctuations (ALFF) method. Patients and methods: In total, 52 PACG individuals (24 males and 28 females) and 52 normal-sighted controls (NS; 24 males and 28 females) who were closely matched in age, sex, and education underwent resting-state magnetic resonance imaging scans. A repeated-measures ANOVA and post hoc two-sample t -tests were conducted to analyze the different ALFF values in two different frequency bands (slow-4, 0...
2019: Neuropsychiatric Disease and Treatment
Hsin-Yi Chen, Cheng-Li Lin, Chia-Hung Kao
To determine whether cataract or glaucoma and combined cataract and glaucoma surgery (CGS) affect glaucoma medication usage.We recruited patients who received new diagnoses of glaucoma, either primary open-angle glaucoma (POAG) (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] code 365.1) or primary angle-closure glaucoma (PACG) (ICD-9-CM code 365.2), between 1998 and 2011 and had undergone cataract surgery alone (CS), glaucoma surgery alone (GS), or CGS under the National Health Insurance program in Taiwan...
January 2019: Medicine (Baltimore)
Jun-Dong Zhu, Li-Lian Xie, Zhi-Yuan Li, Xiao-He Lu
AIM: To evaluate whether the level of thrombospondin-1 (TSP-1) in aqueous humor can predict the prognosis of trabeculectomy in patients with primary angle-closure glaucoma (PACG). METHODS: This case-control study involved 26 patients with PACG who experienced a failed trabeculectomy (case group) and 78 age- and sex-matched patients with PACG who underwent successful trabeculectomy (control group). Aqueous humor was collected at the time of trabeculectomy and tested for TSP-1 and TGF-β2 levels with an enzyme-linked immunosorbent assay method...
2019: International Journal of Ophthalmology
Andrew J Anderson, Abadh K Chaurasia, Ajay Sharma, Amisha Gupta, Shikha Gupta, Anurag Khanna, Viney Gupta
Purpose: To compare the distribution of visual field progression rates in three subgroups of glaucoma, being primary angle-closure glaucoma (PACG), POAG, and juvenile open-angle glaucoma (JOAG). Methods: We assessed glaucoma patients treated in an Indian tertiary care setting with at least four visual field assessments. We determined rates from a single eye of each of 525 patients using linear regression of the summary index mean deviation (MD) over time. The main outcome measures were the proportions of fast (<-1...
January 2, 2019: Investigative Ophthalmology & Visual Science
Eleftherios I Paschalis, Elise V Taniguchi, James Chodosh, Louis R Pasquale, Kathryn Colby, Claes H Dohlman, Lucy Q Shen
PURPOSE: Boston keratoprosthesis (KPro) patients are prone to glaucoma even with well-controlled intraocular pressure (IOP). Recent experimental data have shown that soluble tumor necrosis factor alpha (TNF-α) after ocular injury may contribute to progressive retinal damage and subsequent glaucoma. This study evaluates the blood plasma levels of soluble TNF-α, TNF receptors 1 (TNFR1) and 2 (TNFR2), and leptin in patients with Boston type I KPro. METHODS: Venous blood samples were collected from KPro patients with glaucoma (KPro G, n = 19), KPro patients without glaucoma (KPro NoG, n = 12), primary angle closure glaucoma without KPro (PACG n = 13), and narrow angles without glaucoma or KPro (NA, n = 21)...
January 11, 2019: Current Eye Research
Harsha L Rao, Shruthi Sreenivasaiah, Mohammed Riyazuddin, Srilakshmi Dasari, Shivani Dixit, Jayasree P Venugopal, Zia S Pradhan, Narendra K Puttaiah, Sathi Devi, Robert N Weinreb, Kaweh Mansouri, Carroll Ab Webers
PURPOSE: To determine the prevalence and factors associated with the presence of choroidal microvascular dropout (CMvD) in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes. DESIGN: Cross-sectional study METHODS: Thirty-six POAG eyes (36 patients) and 28 PACG eyes (28 patients) underwent optical coherence tomography angiography (OCTA). Presence of CMvD was evaluated on choroidal OCTA slabs. VF defects in the glaucoma eyes were classified into initial nasal defect (IND), initial parafoveal scotoma (IPFS) and combined nasal and parafoveal defect, and the association between type of VF defect and CMvD was evaluated...
December 12, 2018: American Journal of Ophthalmology
Youn Hye Jo, Kyung Rim Sung, Sung-Cheol Yun
Purpose: To investigate whether the relationship between circumpapillary vascular density (cpVD) and visual field (VF) mean sensitivity (MS) differs between primary open-angle (POAG) and angle-closure glaucoma (PACG). Methods: The cpVD and retinal nerve fiber layer thickness (RNFLT) were obtained using optical coherence tomography angiography (OCTA, AngioVue/RTVue-XR) in 146 eyes from 146 subjects (age- and VF mean deviation-matched 86 POAG and 60 PACG). Global and regional relationships (superotemporal [ST], superonasal [SN], nasoupper [NU], nasolower [NL], inferonasal [IN], inferotemoporal [IT], temporolower [TL], and temporoupper [TU] sectors) were estimated between cpVD and VF MS using multiple linear regression models controlling for the confounding variables in two disease categories...
December 3, 2018: Investigative Ophthalmology & Visual Science
Siamak Yousefi, Hiroshi Sakai, Hiroshi Murata, Yuri Fujino, Masato Matsuura, David Garway-Heath, Robert Weinreb, Ryo Asaoka
Purpose: The purpose of this study was to evaluate the rate of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Methods: Four hundred forty eyes of 282 patients with POAG (aged 53.4 ± 12.0: mean ± standard deviation, years) and 79 eyes of 49 patients with PACG (aged 62.7 ± 9.0 years) with at least six or more reliable VF tests were studied. Point-wise, region-wise, and global rates of VF change were assessed for POAG and PACG eyes...
December 3, 2018: Investigative Ophthalmology & Visual Science
Uday Kumar Addepalli, Ganesh B Jonnadula, Chandra Sekhar Garudadri, Rohit C Khanna, Eric B Papas
PURPOSE: To report the prevalence of primary glaucoma as identified by study optometrists of the L. V. Prasad Eye Institute - Glaucoma Epidemiology and Molecular Genetics Study (LVPEI-GLEAMS). METHODS: Two study optometrists and a total number of 3833 individuals participated in the LVPEI-GLEAMS. All subjects underwent a complete medical history and comprehensive eye examination including slit lamp photography, imaging of anterior and posterior segment, frequency doubling technology and standard automated perimetry including gonioscopy with a Sussman 4 mirror goniolens, post dilated evaluation of the optic disc and fundus was done with a 90 D lens by the study optometrist...
November 29, 2018: Ophthalmic Epidemiology
Teh Chong Seong Niven, Yaakub Azhany, Abdul J Rohana, Tirmandas V N Karunakar, Sandragasu Thayanithi, Mohd N Jelinar Noor, Husain Norhalwani, Mustari Zuraidah, Ab H Siti Azrin, Mt S Ahmad, Tin Aung, Ahmad T Liza-Sharmini
PURPOSE: The purpose of this study was to determine the association between cigarette smoking and the severity of primary angle closure glaucoma (PACG) in Malay patients residing in Malaysia. METHODS: A cross-sectional study was conducted involving 150 Malay PACG patients between April 2014 and August 2016. Ocular examination was performed including Humphrey visual field (HVF) 24-2 analysis assessment. On the basis of the 2 consecutive reliable HVFs, the severity of glaucoma was scored according to modified Advanced Glaucoma Intervention Study (AGIS) by 2 masked investigators and classified as mild, moderate, and severe...
November 19, 2018: Journal of Glaucoma
X H Yang, C Y Qiao
Glaucoma is the leading cause of irreversible blindness throughout the world. Primary angle closure glaucoma (PACG) is one of the common types of this disease. Research indicates that its prevalence is always associated with many factors, including ocular anatomical characteristics and the genetic susceptibility. According to many studies, phenotypes related to PACG, such as anterior chamber depth, relative lens position and thickness, chamber angle state, and axial length, are heritable. Heritability is an important indicator to quantify this genetic tendency...
November 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Yayi Wang, Shida Chen, Yaoming Liu, Wenbin Huang, Xinyi Li, Xiulan Zhang
Acute primary angle-closure (APAC) eyes show an early "acute inflammatory" condition, while the inflammation condition has not been fully elucidated in the development of primary angle-closure glaucoma (PACG). To evaluate the roles of inflammatory cytokines in the pathogenesis of PACG, this cross-sectional study involved 40 eyes of 32 PACG patients who required trabeculectomy and 24 eyes of 24 patients who required cataract surgery. The aqueous humor samples were collected at the time of surgery. Fifteen inflammatory cytokines were detected using the multiplex bead immunoassay technique, and the clinical information was recorded for the correlation analysis...
November 14, 2018: Bioscience Reports
Nilgün Özkan Aksoy, Burçin Çakır, Emine Doğan, Gürsoy Alagöz
Objectives: To evaluate anterior segment parameters measured by dual Scheimpflug corneal topography in pseudoexfoliative glaucoma (PEXG), primary angle-closure glaucoma (PACG), and healthy eyes. Materials and Methods: One hundred forty-three eyes of 86 patients were included in this study. Forty-seven eyes of 38 patients with PEXG, 30 eyes of 15 patients with PACG, and 66 eyes of 33 healthy subjects were evaluated. Patients who underwent previous ophthalmic surgery and contact lens wearers were excluded...
October 2018: Turkish Journal of Ophthalmology
Wenjuan Zhuang, Shaolin Wang, Juan Hao, Manyun Xu, Hao Chi, Shunyu Piao, Jianqing Ma, Xiaolong Zhang, Shaoping Ha
PURPOSE: Recent genome-wide association studies (GWAS) have verified eight genetic loci that were significantly associated with primary angle-closure glaucoma (PACG). The present study investigated whether these variants are associated with the ocular biometric parameters of anterior chamber depth (ACD) and axial length (AL) in a northern Chinese population, as well as whether there were differences in the association of genetic markers in our cohort based on ethnicity. METHODS: A case-control association study of 500 patients and 720 controls was undertaken...
2018: PloS One
Sana' Muhsen, Feras Alkhalaileh, Mohammad Hamdan, Saif Aldeen AlRyalat
BACKGROUND: Central corneal thickness (CCT) has long been implicated to affect glaucoma predisposition. Several reports have identified that thinner CCT is a risk factor for open-angle glaucoma, and that CCT can be very variable between different ethnic groups. In this study, we aim to identify the relation between CCT and different glaucoma parameters in different types of glaucoma in an Arabian ethnicity. METHODS: We classified our participants into four main groups: primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), pseudoexfoliative glaucoma (PXFG), and a control group...
October 29, 2018: BMC Ophthalmology
Shaolin Wang, Wenjuan Zhuang, Jianqing Ma, Manyun Xu, Shunyu Piao, Juan Hao, Wen Zhang, Hao Chi, Zhongqi Xue, Shaoping Ha
BACKGROUND: The membrane frizzled-related protein (MFRP) gene is involved in axial length (AL) regulation and MFRP mutations cause nanophthalmos; also, the hepatocyte growth factor (HGF) gene is reported to result in morphologic changes of the anterior segment and abnormal aqueous regulation that increases the risk of primary angle-closure glaucoma (PACG), while the zinc ring finger 3 (ZNRF3) gene is associated with AL. The present study investigated the association of single nucleotide polymorphisms (SNPs) in ZNRF3, HGF and MFRP with PACG in a northern Chinese population, as well as the association of these SNPs with the ocular biometric parameters of anterior chamber depth (ACD) and AL...
October 22, 2018: BMC Ophthalmology
Won Hyuk Oh, Bum Gi Kim, Haksu Kyung, Joo Hwa Lee
PURPOSE: To investigate the prevalence of normal intraocular pressure (IOP) at first visit among patients with primary angle-closure glaucoma (PACG) and their ocular characteristics. PATIENTS AND METHODS: We retrospectively reviewed patients with PACG in a referral center. According to untreated IOP, we divided PACG eyes into 2 groups: those with normal IOP and those with high IOP (>21 mm Hg) at the first visit. RESULTS: One hundred sixty eyes of 160 Korean PACG patients were included...
January 2019: Journal of Glaucoma
Dongpeng Hu, Shu Tu, Chengguo Zuo, Jian Ge
Purpose: To assess the efficacy and safety of HIFU-based ultrasonic cyclocoagulation in Chinese patients with end-stage refractory glaucoma. Method: Patients were recruited consecutively from May 2016 to May 2017 in the Zhongshan Ophthalmic Center. Ultrasonic cyclocoagulation was performed on every patient, using the EyeOP1 ultrasound emitting device. Return visits were set at 1 day, 7 days, 1 month, and 3 months after the treatment. An intraocular pressure (IOP) reduction of ≥20% while IOP ≥ 5 mmHg was deemed as success...
2018: Journal of Ophthalmology
Ke Xu, Lingling Wu, Zhizhong Ma, Yuling Liu, Fang Qian
PURPOSE: To investigate the frequency of primary angle closure (PAC) and primary angle closure glaucoma (PACG) in patients with retinal vein occlusion (RVO) based on a hospital population. METHODS: A total of 375 consecutive cases newly diagnosed with RVO by fluorescein fundus angiography at a single eye centre in Peking were reviewed. Gonioscopy was performed in all patients. Glaucoma was diagnosed according to the criteria of the International Society of Geographical and Epidemiological Ophthalmology...
September 21, 2018: Acta Ophthalmologica
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