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Mehdi Siddiqui, Joshua Iltis, Petar Yanev, John Sladic, Charles Huynh, Daniel Nolan, Michael Singer
Purpose: There is a limited understanding of factors that influence the efficacy of topical glaucoma medication. Our study is a long-term, case-control analysis of how systemic antihypertensive (anti-HTN) medications influence the change in IOP after initiating prostaglandin (PG) drop therapy. Materials and methods: A retrospective chart review of 3,781 patients was performed on patients with a diagnosis of glaucoma suspect that progressed to primary open-angle glaucoma (POAG) by ICD-9 codes over a 10-year period...
2019: Clinical Ophthalmology
Herbert Reitsamer, Chelvin Sng, Vanessa Vera, Markus Lenzhofer, Keith Barton, Ingeborg Stalmans
PURPOSE: To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG). METHODS: In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification...
February 13, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Barbara Terelak-Borys, Iwona Grabska-Liberek, Andreas Schoetzau, Katarzyna Konieczka
BACKGROUND: It is still debatable whether visual field defects in glaucoma have a reversible component and to what extent a temporary loss can be provoked. OBJECTIVE: To investigate the response of the visual function to a cold provocation in glaucoma patients, particularly to test whether subjects with Flammer syndrome (FS) behaved differently from subjects without FS. METHODS: Ten (10) primary open-angle glaucoma (POAG) patients with FS, 7 POAG patients without FS, and 11 healthy controls were tested with program G2 on the Octopus 101 perimeter before and after putting one hand in cold water (4°C) for 2 min...
February 5, 2019: Restorative Neurology and Neuroscience
Markus Avar, Jens F Jordan, Matthias Neuburger, Diana Engesser, Jan Lübke, Alexandra Anton, Thomas Wecker
BACKGROUND: The minimally invasive ab-interno trabeculectomy (AIT) via electro-ablation with the Trabectome has been on the European market since 2009. Many studies have proven the safety and efficacy of the procedure. Up until now, studies investigating the long-term effect of AIT have been sparse. In this study, we present long-term results of AIT in patients with primary and secondary open-angle glaucoma. METHODS: In a retrospective monocentric study, the data of all the patients having undergone the procedure in 2010 at our institution were recorded...
February 9, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Homa Hassankarimi, Seyed Mohammad Reza Noori, Ebrahim Jafarzadehpour, Shahin Yazdani, Fatemeh Radinmehr
PURPOSE: To evaluate discrete wavelet transform coefficients and identify descriptors of pattern electroretinogram (PERG) waveforms in order to determine PERG characteristics for optimizing the diagnosis of early primary open-angle glaucoma (POAG). METHODS: Pattern electroretinogram was performed in 30 normal eyes and 30 eyes with primary open-angle glaucoma according to the ISCEV protocol. The check size was 0.8° and 16°, and the color was black/white in both groups...
February 6, 2019: International Ophthalmology
Przemysław Zabel, Jakub J Kałużny, Monika Wiłkość-Dębczyńska, Martyna Gębska-Tołoczko, Karolina Suwała, Robert Kucharski, Aleksander Araszkiewicz
BACKGROUND The aim of this study was to assess and compare peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer's disease (AD), primary open-angle glaucoma (POAG), preperimetric glaucoma (PPG), and healthy controls with the use of Spectral Domain Optical Coherence Tomography (SD-OCT). MATERIAL AND METHODS Thirty patients with AD, 30 patients with POAG, 30 patients with PPG, and 30 healthy controls were enrolled in this cross-sectional study. Only 1 randomly selected eye of each patient was analyzed...
February 5, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Penpe Gül Firat, Ersan Ersin Demirel, Soner Demirel, Seyhan Dikci, Yusuf Turkoz, Fatma Ozyalın
PURPOSE: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls. PATIENTS AND METHODS: 25 primary open angle glaucoma paients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry...
February 1, 2019: Current Eye Research
Adrien Buisset, Philippe Gohier, Stéphanie Leruez, Jeanne Muller, Patrizia Amati-Bonneau, Guy Lenaers, Dominique Bonneau, Gilles Simard, Vincent Procaccio, Cedric Annweiler, Dan Milea, Pascal Reynie, Juan Manuel Chao de la Barca
We compared the metabolomic profile of aqueous humor from patients with primary open-angle glaucoma (POAG; n = 26) with that of a group of age- and sex-matched non-POAG controls (n = 26), all participants undergoing cataract surgery. Supervised paired partial least squares discriminant analysis showed good predictive performance for test sets with a median area under the receiver operating characteristic of 0.89 and a p-value of 0.0087. Twenty-three metabolites allowed discrimination between the two groups...
January 31, 2019: Journal of Proteome Research
Catherine M Marando, Kaweh Mansouri, Malik Y Kahook, Leonard K Seibold
PURPOSE: The purpose of the study was to evaluate the tolerability and functionality of a wireless ocular telemetry sensor in African American patients with glaucoma. MATERIALS AND METHODS: In this prospective, observational cohort study, 20 African American patients with primary open angle glaucoma (POAG) were evaluated at the University of Colorado Eye Center. Before lens placement, patients recorded ocular comfort and underwent a baseline eye exam. Following the exam, patients were fitted with a SENSIMED Triggerfish contact lens sensor and data recording device...
February 2019: Journal of Glaucoma
J Buffault, C Baudouin, A Labbé
PURPOSE: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN® Gel Stent as a solo procedure or in association with phacoemulsification in patients with chronic open angle glaucoma (OAG). METHODS: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN® gel stent...
February 2019: Journal Français D'ophtalmologie
Hsin-Yi Chen, Cheng-Li Lin, Chia-Hung Kao
To determine whether cataract or glaucoma and combined cataract and glaucoma surgery (CGS) affect glaucoma medication usage.We recruited patients who received new diagnoses of glaucoma, either primary open-angle glaucoma (POAG) (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] code 365.1) or primary angle-closure glaucoma (PACG) (ICD-9-CM code 365.2), between 1998 and 2011 and had undergone cataract surgery alone (CS), glaucoma surgery alone (GS), or CGS under the National Health Insurance program in Taiwan...
January 2019: Medicine (Baltimore)
Lili Xie, Mao Mao, Cong Wang, Lusi Zhang, Zheng Pan, Jingming Shi, Xuanchu Duan, Songbo Jia, Bing Jiang
This study aimed to identify potential biomarkers for primary open-angle glaucoma (POAG) diagnosis. First, lncRNA and message RNA (mRNA) expression profiles in the aqueous humor (AH) from 10 POAG and 10 control patients were accessed by microarray analyses. Moreover, coding-non-coding gene co-expression networks were drawn to predict potential lncRNA functions. LncRNAs-T267384, ENST00000607393, and T342877 expression were further tested by quantitative real-time PCR in AH from 29 POAG and 30 cataract patients, in iris tissues from 16 POAG patients and 10 controls, and in plasma from 49 POAG patients and 55 healthy controls...
January 21, 2019: American Journal of Pathology
Steven R Sarkisian, Basil Mathews, Kai Ding, Aashka Patel, Zachary Nicek
Purpose: The purpose of this study was to evaluate the safety and efficacy of microinvasive glaucoma surgery (MIGS) with 360° ab-interno trabeculotomy using the TRAB360 device as a stand-alone procedure in patients with refractory primary open-angle glaucoma (POAG) and preoperative IOP ≥18 mmHg. Setting: This study evaluated patients treated in a tertiary-referral clinical practice setting. Design: This study is a retrospective analysis of 81 eyes...
2019: Clinical Ophthalmology
D G Gubin, Т N Malishevskaya, Y S Astakhov, S Y Astakhov, G Cornelissen, V A Kuznetsov, D Weinert
Advanced primary open-angle glaucoma (POAG) is characterized by progressive retinal ganglion cell complex (RGCC) damage that may cause subsequent disruption of the circadian rhythms. Therefore, we evaluated circadian body temperature (BT) rhythm and sleep characteristics of 115 individuals (38 men and 77 women) diagnosed with POAG. GLV (global loss volume; %), a measure of RGCC damage, was estimated by high-definition optical coherence tomography, and RGC functional ability was assessed by pattern electroretinogram amplitude (PERGA)...
January 21, 2019: Chronobiology International
Yeoun Sook Chun, Kyung Rim Sung, Chan Kee Park, Hwang Ki Kim, Chungkwon Yoo, Yong Yeon Kim, Ki Ho Park, Chan Yun Kim, Kyu-Ryong Choi, Kyoo Won Lee, Seungbong Han, Chang-Sik Kim
PURPOSE: To assess influence of the location of visual field (VF) loss on vision-related quality of life (VRQOL) in patients with glaucoma. METHODS: We included 826 patients with primary open-angle glaucoma (POAG) enrolled in the prospectively designed Life Quality of Glaucoma Patients Who Underwent Treatment (LIGHT) study organized by the Korean Glaucoma Society. We divided the integrated binocular visual field (IVF) into four regions and evaluated the associations between Rasch-analysed 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) and location of the IVF using univariate and hierarchical multivariable linear regression...
January 17, 2019: Acta Ophthalmologica
Harini V Gudiseva, Maxwell Pistilli, Rebecca Salowe, Larry N Singh, David W Collins, Brian Cole, Jie He, Sayaka Merriam, Naira Khachataryan, Jeffrey Henderer, Victoria Addis, Qi Cui, Prithvi S Sankar, Eydie Miller-Ellis, Venkata R M Chavali, Gui-Shuang Ying, Douglas Wallace, Joan M O'Brien
Mitochondrial dysfunction has been implicated in the pathogenesis of primary open-angle glaucoma (POAG). However, the potential significance of mitochondrial DNA (mtDNA) haplogroups to POAG has not been evaluated in the overaffected African American population. To investigate the association of mtDNA haplogroups with POAG and its phenotypic characteristics, genotyping data from 4081 African American subjects (1919 cases and 2162 controls) was analyzed using 1293 positions on mtDNA. The overall frequency of mtDNA haplogroups in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study cohort was 37% L3, 29% L2, 21% L1, 4% L0, and 10% non-African haplogroups (non-L)...
January 14, 2019: Experimental Eye Research
Kerem Can Yilmaz, Sirel Sur Gungor, Orcun Ciftci, Ahmet Akman, Haldun Muderrisoglu
BACKGROUND: Glaucoma is commonly defined as high intra ocular pressure (≥21 mmHg) with optic neuropathy characterised by progressive loss of retinal ganglion cells which is associated with characteristic structural damage to the optic nerve and visual field loss. There are several studies investigating relation between primary open angle glaucoma (POAG) and both systemic hypertension and especially night hypotension. Our aim was to compare 24-h ambulatory blood pressure variability of patients with glaucoma followed-up in the eye outpatient clinic with that of patients free of glaucoma...
January 16, 2019: Acta Cardiologica
Andrew J Anderson, Abadh K Chaurasia, Ajay Sharma, Amisha Gupta, Shikha Gupta, Anurag Khanna, Viney Gupta
Purpose: To compare the distribution of visual field progression rates in three subgroups of glaucoma, being primary angle-closure glaucoma (PACG), POAG, and juvenile open-angle glaucoma (JOAG). Methods: We assessed glaucoma patients treated in an Indian tertiary care setting with at least four visual field assessments. We determined rates from a single eye of each of 525 patients using linear regression of the summary index mean deviation (MD) over time. The main outcome measures were the proportions of fast (<-1...
January 2, 2019: Investigative Ophthalmology & Visual Science
Aniruddha Banerjee, Mona Khurana, Ramya Sachidanandam, Parveen Sen
PURPOSE: A prospective, cross-sectional, case-control study was conducted to investigate the role of broadband and monochromatic photopic negative response (PhNR) of the full-field flash electroretinogram (ERG) in the evaluation of ganglion cell damage in primary open-angle glaucoma (POAG) subjects. METHODS: Subjects with POAG and age-matched normal subjects were recruited from the outpatient department of a tertiary eye care center in South India. A total of 25 patients with POAG and 50 age-matched normal subjects were recruited...
January 12, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Siddarth Rathi, Chris Andrews, David S Greenfield, Joshua D Stein
PURPOSE: To characterize differences in resource utilization and cost of managing enrollees with exfoliation glaucoma (XFG) compared to primary open-angle glaucoma (POAG). DESIGN: Retrospective utilization and cost comparison using Medicare claims data. METHODS: We identified Medicare beneficiaries with XFG or POAG and ≥5 years of continuous enrollment from January 2008 to December 2014. We distinguished newly-diagnosed cases from those with pre-existing disease...
January 8, 2019: American Journal of Ophthalmology
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