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Medical marijuana cannabis

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https://read.qxmd.com/read/30767424/the-relationship-between-cannabis-and-male-infertility-sexual-health-and-neoplasm-a-systematic-review
#1
REVIEW
S Rajanahally, O Raheem, M Rogers, W Brisbane, K Ostrowski, T Lendvay, T Walsh
BACKGROUND: In the United States of America (USA), cannabis is legal in 28 states for medical purposes and 8 states for recreational use. In 2016, the legal marijuana industry reached nearly $7 billion in sales in the USA alone. Although consumption continues to increase, the medical effects of marijuana remain understudied. Young males comprise the demographic most likely to consume cannabis, and these individuals will be most vulnerable to its short- and long-term consequences. OBJECTIVE: The purpose of this manuscript is to systematically review the available literature describing the effects of marijuana on male infertility, sexual health, and urologic neoplasms...
February 15, 2019: Andrology
https://read.qxmd.com/read/30747733/patient-preferences-for-rheumatoid-arthritis-treatment
#2
Betty Hsiao, Liana Fraenkel
PURPOSE OF REVIEW: To provide an overview of recent articles discussing patient preferences for rheumatoid arthritis (RA) treatment. RECENT FINDINGS: Recent studies examined patient preferences for RA treatment in several populations, finding that most participants were willing to accept certain risks of adverse effects to gain potential benefits. Perspectives regarding cannabis were studied, with patients describing medical marijuana as an alternative therapy to be used with prescription medications or as means of tapering off these medications...
February 11, 2019: Current Opinion in Rheumatology
https://read.qxmd.com/read/30671616/new-trends-in-cannabis-potency-in-usa-and-europe-during-the-last-decade-2008-2017
#3
Suman Chandra, Mohamed M Radwan, Chandrani G Majumdar, James C Church, Tom P Freeman, Mahmoud A ElSohly
Through the potency monitoring program at the University of Mississippi supported by National Institute on Drug Abuse (NIDA), a total of 18108 samples of cannabis preparations have been analyzed over the last decade, using a validated GC/FID method. The samples are classified as sinsemilla, marijuana, ditchweed, hashish, and hash oil (now referred to as cannabis concentrate). The number of samples received over the last 5 years has decreased dramatically due to the legalization of marijuana either for medical or for recreational purposes in many US states...
January 22, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30638971/recurrent-cardiogenic-shock-associated-with-cannabis-use-report-of-a-case-and-review-of-the-literature
#4
Christopher E Grigoriadis, David P Cork, Walter Dembitsky, Brian E Jaski
BACKGROUND: The United States has recently undergone increases in the legalization and use of marijuana. There have been previous reports on the association of cannabis use and myocardial dysfunction, however, few on the association with acute stress cardiomyopathy and cardiogenic shock. CASE REPORT: This is a case of a 58-year-old female with a history of inhaled cannabis use, no history of diabetes, and no known history of cardiac disease, that illustrates an association between cannabis use and the recurrent development of stress cardiomyopathy and cardiogenic shock...
January 10, 2019: Journal of Emergency Medicine
https://read.qxmd.com/read/30620324/why-marijuana-is-headed-for-the-mainstream
#5
Thomas Reinke
The credibility of cannabis as a source of a legitimate pharmaceutical ingredient in prescription medications took a major step forward in 2018 when the FDA approved Epidiolex (cannabidiol) for two types of severe seizures. Epidiolex was a stellar candidate for approval. It reduced convulsive seizures by about 40% and has a good safety profile.
December 2018: Managed Care
https://read.qxmd.com/read/30595363/clinical-use-of-marijuana-the-thin-line-between-good-and-evil
#6
Juan Salazar, Milagros Rojas, Cristobal Espinoza
From centuries ago cannabis has been known as a botanic product with several properties, with medical use in the ancient world. Nowadays, it is recognized as the active component of marijuana, the drug with the highest rates of illicit use and abuse worldwide according to data provided by the World Health Organization. A huge debate has emerged in these past years with the growing interest to employ cannabis-based products with therapeutic purposes, a strategy that has increased in various European countries, Canada and more than half of the states that conform the United States, simultaneously with an important increase of flexibility in laws and regulations regarding the recreational use of this substance, especially in North America...
December 27, 2018: Archives of Medical Research
https://read.qxmd.com/read/30593477/the-misclassification-of-medical-marijuana
#7
Hannah Krystal
Marijuana has a complicated legal, social, and economic history in the United States, as well as an uncertain future. Marijuana has been consistently tied to racial minority groups since its arrival in the United States in the 1900s, and former Attorney General Jeff Sessions further propagated that notion. AG Sessions even recently wrote a memo that directly contradicted Obama-era policy, demonstrating that the current legal status of marijuana in both state and federal government is currently up for debate...
December 2018: Journal of the American Academy of Psychiatry and the Law
https://read.qxmd.com/read/30567245/marijuana-associated-st-elevation-myocardial-infarction-is-this-a-benign-drug
#8
Sundeep Kumar, Ruthvik Srinivasamurthy, Olga Karasik, Aamir Javaid
Marijuana is the most commonly used psychoactive drug in the USA. A 35-year-old man with a medical history of marijuana abuse is admitted to the hospital due to crushing substernal chest pain. ECG shows evolving ST-segment elevation with a rise in cardiac enzymes, consistent with ST-elevation myocardial infarction. A urine toxicology screen is positive for cannabis and negative for cocaine and other stimulant drugs. An emergent cardiac catheterisation reveals no evidence of coronary artery disease or thrombosis...
December 13, 2018: BMJ Case Reports
https://read.qxmd.com/read/30557813/use-of-marijuana-exclusively-for-medical-purposes
#9
Melanie M Wall, Jun Liu, Deborah S Hasin, Carlos Blanco, Mark Olfson
OBJECTIVES: To characterize the socio-demographic characteristics, medical conditions, and psychiatric comorbidities of users of marijuana for medical and non-medical purposes. METHODS: Data were from the National Epidemiological Survey on Alcohol and Related Conditions III, a US nationally representative in-person interview of 36,309 adults age ≥18 years in 2012-2013. RESULTS: In relation to non-medical only users (n = 3339), combined (n = 362) and medical only (n = 82) users had higher prevalence of every medical condition examined...
February 1, 2019: Drug and Alcohol Dependence
https://read.qxmd.com/read/30545431/increased-use-of-medical-marijuana-skepticism-vs-evidence
#10
Jeannette Y Wick
The use of medical marijuana-both the psychoactive tetrahydrocannabinol and its nonpsychoactive relative cannabidiol-is a growing practice in facilities served by senior care pharmacists. Currently, 30 states have approved its use under a variety of different regulations and for a number of conditions. Its use is bolstered by a growing number of Americans who support legalization of cannabis. Though oral synthetic cannabinoid compounds are approved by the Food and Drug Administration for chemotherapy-induced nausea and vomiting and appetite stimulation associated with AIDS, synthetic products differ from plant-derived products in several ways...
December 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://read.qxmd.com/read/30522595/medical-cannabis
#11
REVIEW
Jon O Ebbert, Eugene L Scharf, Ryan T Hurt
Medicolegal realities surrounding "medical marijuana" or "medical cannabis" are rapidly evolving in the United States. Clinicians are increasingly being asked by patients to share information about or certify them for medical cannabis. In order to engage in informed discussions with patients or be comfortable certifying them in states with medical cannabis laws, clinicians may benefit from an understanding of the current state of medical knowledge about medical cannabis. Intended for the generalist and subspecialist, this review provides an overview of the legal status, pharmacology, benefits, risks, and abuse liability of medical cannabis along with a general framework for counseling patients...
December 2018: Mayo Clinic Proceedings
https://read.qxmd.com/read/30506888/marijuana-use-in-transplantation-a-call-for-clarity
#12
REVIEW
Marilyn E Levi, Brian T Montague, Christian Thurstone, Deepali Kumar, Shirish S Huprikar, Camille N Kotton
Transplant centers have varying policies for marijuana (MJ) use in donors, transplant candidates, and recipients. Rationales for these differences range from concerns for fungal complications, impaired adherence, and drug interactions. This paper reviews the current status of MJ policies and practices in transplant centers and results of a survey sent to the American Society of Transplantation (AST) membership by the Executive Committee of the AST Infectious Diseases Community of Practice.The purpose of the survey was to compare policies and concerns of MJ use to actual observed complications...
December 2, 2018: Clinical Transplantation
https://read.qxmd.com/read/30489198/the-role-of-cb-sub-2-sub-receptor-in-the-recovery-of-mice-after-traumatic-brain-injury
#13
Lital Magid, Sami Heymann, Merav Elgali, Liat Avram, Yoram Cohen, Sigal Liraz-Zaltsman, Raphael Mechoulam, Esther Shohami
Cannabis is one of the most widely used plant drugs in the world today. In spite of the large number of scientific reports on medical marijuana there still exists much controversy surrounding its use and the potential for abuse due to the undesirable psychotropic effects. However, recent developments in medicinal chemistry of novel non-psychoactive synthetic cannabinoids have indicated that it is possible to separate some of the therapeutic effects from the psychoactivity. We have previously shown that treatment with the endocannabinoid 2-AG that binds to both CB1 and CB2 receptors 1 hr after traumatic brain injury in mice attenuates neurological deficits, edema formation, infarct volume, blood-brain barrier permeability, neuronal cell loss at the CA3 hippocampal region and neuroinflammation...
November 29, 2018: Journal of Neurotrauma
https://read.qxmd.com/read/30471810/impact-of-recreational-and-medicinal-marijuana-on-surgical-patients-a-review
#14
REVIEW
Chetna Bakshi, Allison M Barrett
BACKGROUND: As medicinal and recreational marijuana use broadens across the United States, knowledge of its effects on the body will become increasingly important to all health care providers, including surgeons. DATA SOURCES: We performed a literature review of Pubmed for articles discussing the basic science related to cannabinoids, as well as articles regarding cannabinoid medications, and cannabis use in surgical patients. CONCLUSIONS: The primary components in the cannabis plant, tetrahydrocannabinol (THC) and cannabidiol (CBD), have been made available in numerous forms and formulations to treat multiple medical conditions, and recreational access to marijuana is increasing...
November 14, 2018: American Journal of Surgery
https://read.qxmd.com/read/30464676/butane-hash-oil-and-dabbing-insights-into-use-amateur-production-techniques-and-potential-harm-mitigation
#15
REVIEW
Ihsan Al-Zouabi, John M Stogner, Bryan Lee Miller, Elizabeth S Lane
The use of marijuana concentrates has escalated in recent years with butane extracts appearing particularly popular. The administration of butane hash oil, colloquially referred to as "dabbing," is distinct from traditional flower cannabis usage due to the THC content of samples and the presence of impurities such as unpurged butane. While this may confer heightened risk to the user, additional significant concerns are tied to fires and explosions. Using butane as a solvent in amateur "blasting" methods may result in a flammable vapor pooling in enclosed spaces and igniting when exposed to a spark...
2018: Substance Abuse and Rehabilitation
https://read.qxmd.com/read/30426899/cannabis-associated-high-cardiovascular-morbidity-and-mortality-marijuana-smoke-like-tobacco-smoke-a-d%C3%A3-j%C3%A3-vu-d%C3%A3-j%C3%A3-v%C3%A3-cu-story
#16
Theodora A Manolis, Antonis A Manolis, Antonis S Manolis
BACKGROUND: Cannabis use has increased over the past several years as some countries have legalized its use for treatment of certain medical conditions and/or for recreational use. Thus, concerns have risen about potential adverse health effects. Increasing number of reports have associated cannabis use with serious cardiovascular (CV) complications. Furthermore, there appears to be a likeness in the harmful health effects, especially on the CV and respiratory systems, of cannabis smoking to those of tobacco smoking...
November 13, 2018: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/30415756/medical-cannabis-use-in-older-patients-update-on-medical-knowledge
#17
REVIEW
Olivier Beauchet
BACKGROUND: There is increasing scientific data suggesting that cannabis is beneficial for a large range of medical conditions. Physicians need up-to-date medical knowledge (i.e., indications, dose and safety properties) before prescribing cannabis for older patients, who are, a priori, more prone to its adverse effects than younger patients. A mini-review was conducted to examine the evidence on medical cannabis use in older patients. METHODS: An English and French systematic Medline (PubMed) search, from January 1, 2001 to October 15, 2018, was conducted using the MeSH terms "Cannabis"[Mesh] OR "Marijuana Abuse"[Mesh] OR "Medical Marijuana"[Mesh] OR "Marijuana Smoking"[Mesh] combined with the MeSH terms ("Aged"[Mesh]) OR "Aged, 80 and over"[Mesh]...
December 2018: Maturitas
https://read.qxmd.com/read/30385981/marijuana-use-in-the-era-of-changing-cannabis-laws-what-are-the-risks-who-is-most-at-risk
#18
William V Stoecker, Emily E Rapp, Joseph M Malters
We review recent findings on medical aspects of marijuana use in order to identify those who are at greatest risk of marijuana-related medical problems. We analyze the impact of medical marijuana laws on health, in particular the disproportionate effects on adolescents and children. Chronic marijuana use predominantly affects certain areas of the brain that overlap the default mode network, linked hubs in the brain that play a supervisory role in critical thought processes such as attention, memory, and social interactions...
September 2018: Missouri Medicine
https://read.qxmd.com/read/30380925/dermatology-related-uses-of-medical-cannabis-promoted-by-dispensaries-in-canada-europe-and-the-united-states
#19
Megan Lim, Mark G Kirchhof
There is a growing interest in the use of medical cannabis for a variety of dermatologic conditions. Despite the lack of evidence to validate the effectiveness and safety of marijuana, it is approved to treat a variety of dermatologic conditions in the United States. Furthermore, medical cannabis dispensaries have been making unsubstantiated claims about medical cannabis. It is important for dermatologists to know about the purported use of medical cannabis to help patients navigate this new treatment option, particularly as cannabis becomes legal in Canada in October 2018...
October 31, 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30361897/a-systematic-review-of-the-efficacy-of-cannabinoid-agonist-replacement-therapy-for-cannabis-withdrawal-symptoms
#20
REVIEW
Maira Aguiar Werneck, Guilherme Trevizan Kortas, Arthur Guerra de Andrade, João Mauricio Castaldelli-Maia
BACKGROUND: About 30% of regular cannabis users report withdrawal symptoms on cessation of prolonged use, such as irritability, insomnia, decreased appetite, depressed mood, anxiety, and restlessness. However, among highly dependent and/or in-treatment users, the incidence of withdrawal can be even higher, reaching up to 50-95% of individuals. This syndrome was only recognized by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) as a diagnosis with specific criteria in 2013...
December 2018: CNS Drugs
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