Zhi-Hua Zheng, Jiao-Jiao Wang, Jiu-Guo Lin, Wei-le Ye, Jia-Mi Zou, Li-Yin Liang, Ping-Lian Yang, Wan-Lu Qiu, Yuan-Yuan Li, Si-Jia Yang, Man Zhao, Qing Zhou, Cheng-Zhi Li, Min Li, Zhuo-Ming Li, Dong-Mei Zhang, Pei-Qing Liu, Zhi-Ping Liu
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating evidence indicates that DNA damage occurs in aging vascular cells, especially in endothelial cells (ECs). However, the mechanism of EC senescence has not been completely elucidated, and so far, there is no specific drug in the clinic to treat EC senescence and vascular aging. Here we show that various aging stimuli induce nuclear DNA and mitochondrial damage in ECs, thus facilitating the release of cytoplasmic free DNA (cfDNA), which activates the DNA-sensing adapter protein STING...
April 30, 2024: Acta Pharmacologica Sinica