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JOURNAL ARTICLE
Efstathios Xagas, Pantelis A Sarafidis, Marieta P Theodorakopoulou, Maria Eleni Alexandrou, Maria Korogiannou, Antonis Argyris, Athanase Protogerou, Ioannis N Boletis, Smaragdi Marinaki
INTRODUCTION: Kidney transplantation (KTx) is associated with improved blood pressure (BP) levels for kidney transplant recipients (KTRs) without evoking significant changes in donors. However, there is a paucity of studies offering simultaneous detailed evaluation of BP profiles over time in transplant donor-recipient pairs. The aim of the present study was the parallel evaluation of ambulatory BP levels and trajectories in KTRs and their respective living kidney donors in the short and mid-term following KTx...
November 2022: Clinical Kidney Journal
#22
REVIEW
Kailing Marcus, Delphine Berner, Karine Hadaya, Samia Hurst
The objective of this study was to investigate reasons for or against anonymity that are pertinent to kidney paired donations (KPD). We conducted a systematic review of reasons using PubMed and Google Scholar until May 2022 and through snowballing. Inclusion criteria were publications that: 1) discussed organ donation anonymity; 2) was peer-reviewed; 3) presented at least one reason on anonymity. Exclusion criteria: 1) not published in a scientific journal; 2) grey literature and dissertations. Four researchers independently reviewed and selected papers based on the criteria, extracted text passages and coded them into narrow and broad reason types, selected reasons that were valid for kidney paired donations...
2023: Transplant International
#23
JOURNAL ARTICLE
Georgina L Irish, Lachlan C McMichael, Matthew Kadatz, Neil Boudville, Scott Campbell, Steven Chadban, Doris Chang, John Kanellis, Edward Sharples, John S Gill, Philip A Clayton
The inclusion of blood group- and human leukocyte antigen-compatible donor and recipient pairs (CPs) in kidney paired donation (KPD) programs is a novel strategy to increase living donor (LD) transplantation. Transplantation from a donor with a better Living Donor Kidney Profile Index (LKDPI) may encourage CP participation in KPD programs. We undertook parallel analyses using data from the Scientific Registry of Transplant Recipients and the Australia and New Zealand Dialysis and Transplant Registry to determine whether the LKDPI discriminates death-censored graft survival (DCGS) between LDs...
February 2023: American Journal of Transplantation
#24
JOURNAL ARTICLE
Lucino Bahena-Carrera, Héctor F Noyola-Villalobos, Edgar E Ramos-Díaz, Marco A Loera-Torres, Ricardo Mendiola-Fernández, Mónica L Razo-Padilla
OBJECTIVE: To demonstrate the experience since the transplant program under paired kidney donation implementation; program that increases the donation rate by 25-30% in hospitals with no inferior graft survival compared to directed living donor kidney transplantation. METHOD: Observational, analytical, longitudinal and prospective study from December 2018 to July 2021. All G5 KDIGO chronic kidney patients who were HLA or ABO incompatible with their original donors in the pretransplant protocol and who were transplanted under the paired kidney donation program, were included...
2023: Cirugia y Cirujanos
#25
JOURNAL ARTICLE
Nikolas H Zaphiros, Jing Nie, Michael W Alchaer, Liise K Kayler
Donation after circulatory death (DCD) kidneys are exposed to warm ischemia, which, coupled with cold ischemia time (CIT) exacerbates delayed graft function (DGF) and is possibly associated with worse graft survival. To analyze the risk of CIT-induced DGF on DCD kidney outcomes, we evaluated national data between 2008 and 2018 of adult kidney-only recipients of paired DCD kidneys where one kidney recipient experienced DGF and the other did not. Of 5602 paired DCD kidney recipients, multivariate analysis between recipients with higher CIT relative to lower CIT showed that increasing CIT differences had a significant dose-dependent effect on overall graft survival...
April 2023: Clinical Transplantation
#26
JOURNAL ARTICLE
Thunyatorn Wuttiputhanun, Suwasin Udomkarnjananun, Nitt Hanprathet, Wiroj Jiamjarasrangsi, Nattavudh Townamchai, Yingyos Avihingsanon, Pisut Katavetin
The kidney is a notable site of glycolysis, gluconeogenesis, and fatty acid oxidation. Loss of a kidney after kidney donation might, therefore, affect the glucose and lipid metabolism of the donors. This matched cohort study investigated the effect of nephrectomy on glucose and lipid metabolisms using Bayesian hypothesis testing. There were 77 pairs of matched donor-control pairs in the present study. Clinical and laboratory data of the participants, at baseline and 1-year, were extracted from electronic medical records...
February 2023: Nephrology
#27
JOURNAL ARTICLE
Miguel Ángel Frutos, Marta Crespo, María de la Oliva Valentín, Ángel Alonso-Melgar, Juana Alonso, Constantino Fernández, Gorka García-Erauzkin, Esther González, Ana M González-Rinne, Lluis Guirado, Alex Gutiérrez-Dalmau, Jorge Huguet, José Luis López Del Moral, Mireia Musquera, David Paredes, Dolores Redondo, Ignacio Revuelta, Carlos J Van-der Hofstadt, Antonio Alcaraz, Ángel Alonso-Hernández, Manuel Alonso, Purificación Bernabeu, Gabriel Bernal, Alberto Breda, Mercedes Cabello, José Luis Caro-Oleas, Joan Cid, Fritz Diekmann, Laura Espinosa, Carme Facundo, Marta García, Salvador Gil-Vernet, Miquel Lozano, Beatriz Mahillo, María José Martínez, Blanca Miranda, Federico Oppenheimer, Eduard Palou, María José Pérez-Saez, Lluis Peri, Oscar Rodríguez, Carlos Santiago, Guadalupe Tabernero, Domingo Hernández, Beatriz Domínguez-Gil, Julio Pascual
This Guide for Living Donor Kidney Transplantation (LDKT) has been prepared with the sponsorship of the Spanish Society of Nephrology (SEN), the Spanish Transplant Society (SET), and the Spanish National Transplant Organization (ONT). It updates evidence to offer the best chronic renal failure treatment when a potential living donor is available. The core aim of this Guide is to supply clinicians who evaluate living donors and transplant recipients with the best decision-making tools, to optimise their outcomes...
December 2022: Nefrología
#28
JOURNAL ARTICLE
Afshin A Khan, Koji Hashimoto, Choon H David Kwon, Masato Fujiki, Mahwish Ahmad, Jamak Modaresi Esfeh
The dearth of deceased liver donors has created a supply demand gap, necessitating creation of living donor liver transplantation. However, living donor liver transplantation has relied on directed donation, whereby many potential directed donors are rejected based on ABO blood group incompatibility, hepatic size incompatibility, or the need for biliary or arterial reconstruction during transplant surgery. Much like kidney paired exchange, liver paired exchange (LPE) circumvents these incompatibility issues by relying on anonymous, nondirected, or bridge donors that are better anatomical or histological matches for recipients...
November 29, 2022: Transplantation
#29
JOURNAL ARTICLE
Md Sanwar Siraj
The stipulation of living organ transplantation policy and practice in Bangladesh is family-oriented, with relatives being the only people legally eligible to donate organs. There have been very few transplantations of bone marrows, liver lobes, and kidneys from related-living donors in Bangladesh. The major question addressed in this study is why Bangladesh is not getting adequate organs for transplantation. In this study, I examin the stipulations of the policy and practice of living organ donation through the lens of 32 key stakeholders including physicians and nurses, a health administrator, organ donors and recipients, and their family members, as they can shed light on the realities and problems of organ donation for transplantation in Bangladesh...
November 10, 2022: HEC Forum
#30
JOURNAL ARTICLE
Shivani S Bisen, Samantha N Getsin, Po-Yu Chiang, Kayleigh Herrick-Reynolds, Laura B Zeiser, Sile Yu, Niraj M Desai, Fawaz Al Ammary, Kyle R Jackson, Dorry L Segev, Allan B Massie
UNLABELLED: ABO type B and O kidney transplant candidates have increased difficulty identifying a compatible donor for living donor kidney transplantation (LDKT) and are harder to match in kidney paired donation registries. A2-incompatible (A2i) LDKT increases access to LDKT for these patients. To better inform living donor selection, we evaluated the association between A2i LDKT and patient and graft survival. METHODS: We used weighted Cox regression to compare mortality, death-censored graft failure, and all-cause graft loss in A2i versus ABO-compatible (ABOc) recipients...
November 2022: Transplantation Direct
#31
JOURNAL ARTICLE
Fang-Cheng Kuo, Tsai-Hun Wu, Che-Chuan Loong, Niang-Cheng Lin, Shuo-Ming Ou, Cheng-Yen Chen
BACKGROUND: The disparity between kidney donation and the number of uremic patients on the waiting list has increased the demand for older live-donor kidneys (OLK). However, the donor-recipient age gap may have an impact on the recipient's outcome. METHODS: Patients who underwent living donor kidney transplantation at our institute between 2005 and 2019 were enrolled and categorized into four donor-recipient groups according to age (≥50 years and <50 years)...
January 1, 2023: Journal of the Chinese Medical Association: JCMA
#32
JOURNAL ARTICLE
Ahmed Khaled Alanzi, Fatma Reda Elsaid Gomaa, Omar Reda Gomaa, Abdulrahman Ismail Mohamed Janahi, Mohamed Yosri Ezzat, Shahid Adeel, Sundus Mahdi Jaafar Ali Ali Almukhodher, Mai Helmy, Feten Fekih-Romdhane, Haitham Jahrami
OBJECTIVES: Awareness regarding organ donation has been steadily growing in the Arab world yet is still far from the current demand. A thorough analysis of population behavior toward organ donation can improve organ transplant education. Therefore, we designed this study to assess the knowledge, attitude, donation desires, and views on organ donation among adults in Arab countries. MATERIALS AND METHODS: An observational cross- sectional study approach was used by assessing 1004 adult survey respondents from 22 Arab countries through the snowball sampling technique via social media platforms and emails...
September 2022: Experimental and Clinical Transplantation
#33
JOURNAL ARTICLE
Uyenlinh L Mirshahi, Ahana Bhan, Lotte E Tholen, Brian Fang, Guoli Chen, Bryn Moore, Adam Cook, Prince Mohan Anand, Kashyap Patel, Mary E Haas, Luca A Lotta, Peter Igarashi, Jeroen H F de Baaij, Silvia Ferrè, Joost G J Hoenderop, David J Carey, Alexander R Chang
Introduction: Monogenic causes in over 300 kidney-associated genes account for approximately 12% of end stage kidney disease (ESKD) cases. Advances in sequencing and large customized panels enable the noninvasive diagnosis of monogenic kidney disease at relatively low cost, thereby allowing for more precise management for patients and their families. A major challenge is interpreting rare variants, many of which are classified as variants of unknown significance (VUS). We present a framework in which we thoroughly evaluated and provided evidence of pathogenicity for HNF1B -p...
September 2022: KI Reports
#34
JOURNAL ARTICLE
May A Hassaballa
The idea for a kidney exchange program was expressed by Dr. Felix Rapaport in 1986; since then, it has been increasing all over the world. This article discusses the indications of kidney paired donation and how it proved to be the best option for living donation, the innovations done for its expansion over the years, and how to adopt it in countries deprived of this service, highlighting the measures it takes for its implementation and the drawbacks of its nonexistence.
August 2022: Experimental and Clinical Transplantation
#35
JOURNAL ARTICLE
Aksel Braanen Sterri, Sadie Regmi, John Harris
Organ shortage is a major survival issue for millions of people worldwide. Globally 1.2 million people die each year from kidney failure. In this paper, we critically examine and find lacking extant proposals for increasing organ supply, such as opting in and opt out for deceased donor organs, and parochial altruism and paired kidney exchange for live organs. We defend two ethical solutions to the problem of organ shortage. One is to make deceased donor organs automatically available for transplant without requiring consent from the donor or their relatives...
July 2022: Cambridge Quarterly of Healthcare Ethics: CQ
#36
JOURNAL ARTICLE
Md Sanwar Siraj
BACKGROUND: Advocates for a regulated system to facilitate kidney donation between unrelated donor-recipient pairs argue that monetary compensation encourages people to donate vital organs that save the lives of patients with end-stage organ failure. Scholars support compensating donors as a form of reciprocity. This study aims to assess the compensation system for the unrelated kidney donation program in the Islamic Republic of Iran, with a particular focus on the implications of Islam on organ donation and organ sales...
July 28, 2022: Philosophy, Ethics, and Humanities in Medicine: PEHM
#37
Yolanda Calzada, Ignacio Revuelta, Elena Codina, Antonio Alcaraz, Víctor López-Báez, David Paredes, Pedro Arango, Eduard Palou, Adriana Garcia-Herrera, Federico Oppenheimer, Fritz Diekmann, Álvaro Madrid
INTRODUCTION: HLA sensitization is a growing problem in children awaiting kidney transplantation. In some cases, finding an immunologically compatible donor entails contemplating the option of an ABO incompatible transplant or paired transplant. METHODS: Patient with genetic nephrotic syndrome and progressive chronic kidney disease, with a previous thrombosis of a first kidney transplant, resulting hypersensitized and remaining for a long-time on hemodialysis. Despite a desensitization strategy, family members were incompatible and deceased donation options must be ruled out due to the presentation of donor-specific antibodies (DSA)...
December 2022: Pediatric Transplantation
#38
JOURNAL ARTICLE
Rita Veríssimo, Manuela Almeida, João Pedro Oliveira, Pedro R Pereira, Bárbara O Ribeiro, Sofia Pedroso, Jorge Malheiro, Sandra Tafulo, La Salete Martins, Leonidio Dias
BACKGROUND: A living donor (LD) kidney transplant is the best therapeutic option for end-stage kidney disease. Potential donors must undergo multiple analyses and the rates of live donation can be as low as 8% to 18%. Here, we report on the live kidney donor program in our unit with emphasis on the reasons why potential donors do not proceed to donation. METHODS: We performed a single-center retrospective study of all potential kidney donors with a first LD appointment at Centro Hospitalar Universitário do Porto between January 2016 and December 2020...
June 2022: Transplantation Proceedings
#39
JOURNAL ARTICLE
S L Li, X Y Sun, K Qin, N Wen, J X Liao, L G Lan, Y Huang, Z Y Lei, Q D Su, J H Wu
Objective: To examine the technique and effect of combined thoracic and abdominal organ clusters resection. Methods: From February 2019 to August 2021, totally 50 cases of combined thoracoabdominal organ cluster resection were completed at Transplant Medical Center, the Second Affiliated Hospital of Guangxi Medical University from donation after brain death donors. There were 47 males and 3 females, aging (34.8±12.3) years (range: 5 to 55 years). The length of hospital stay( M (IQR)) was 4(4) days (range: 2 to 43 days), the length of tube time was 4(2) days (range: 1 to 43 days)...
June 28, 2022: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
#40
JOURNAL ARTICLE
Julien Combe, Victor Hiller, Olivier Tercieux, Benoît Audry, Jules Baudet, Géraldine Malaquin, François Kerbaul, Corinne Antoine, Marie-Alice Macher, Christian Jacquelinet, Olivier Bastien, Myriam Pastural
Almost one third of kidney donation candidates are incompatible (HLA and/or ABO) with their directed recipient. Kidney paired donation allows potential donors to be exchanged and gives access to a compatible kidney transplant. The Bioethics Law of 2011 authorised kidney paired donation in France with reciprocity between 2 incompatible "donor-recipient" pairs. A limited number of transplants have been performed due to a too restricted authorization compared to other European practices. This study presents the perspectives of the new Bioethics Law, enacted in 2021, which increases the authorised practices for kidney paired donation in France...
July 2022: Néphrologie & Thérapeutique
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