keyword
https://read.qxmd.com/read/38507087/-outcome-of-abo-incompatible-living-donor-kidney-transplants-a%C3%A2-plea-for-crossover-living-donor-kidney-transplantation
#1
REVIEW
L Liefeldt, P Glander, F Friedersdorff
BACKGROUND: The lack of postmortem donated organs is the background to varyingly high rates of living-donor kidney transplants worldwide. ABO blood group-incompatible living-donor kidney transplants have also been established for at least 20 years. The equivalence of the results of ABO-incompatible and ABO-compatible transplants has recently been questioned. OBJECTIVE: In the sense of a critical reflection of our own kidney transplant program, we were interested in comparing ABO-incompatible with ABO-compatible living-donor kidney transplants...
March 20, 2024: Urologie
https://read.qxmd.com/read/38504664/imlifidase-in-kidney-transplantation
#2
JOURNAL ARTICLE
Mehmet Kanbay, Sidar Copur, Mustafa Guldan, Ahmet U Topcu, Lasin Ozbek, Baris Hasbal, Caner Süsal, Burak Kocak, Jasper Callemeyn, Mårten Segelmark
Kidney transplantation, the gold-standard therapeutic approach for patients with end-stage kidney disease, offers improvement in patient survival and quality of life. However, broad sensitization against human leukocyte antigens often resulting in a positive crossmatch against the patient's living donor or the majority of potential deceased donors in the allocation system represents a major obstacle due to a high risk for antibody-mediated rejection, delayed graft function and allograft loss. Kidney-paired donation and desensitization protocols have been established to overcome this obstacle, with limited success...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38435064/national-attitudes-toward-living-kidney-donation-in-the-united-states-results-of-a-public-opinion-survey
#3
JOURNAL ARTICLE
Katya Kaplow, Jessica M Ruck, Macey L Levan, Alvin G Thomas, Darren Stewart, Allan B Massie, Hannah C Sung, Sarah F Pisano, Carolyn Sidoti, Dorry L Segev, Joseph Sinacore, Amy D Waterman
RATIONALE & OBJECTIVE: Understanding national attitudes about living kidney donation will enable us to identify and address existing disincentives to living kidney donation. We performed a national survey to describe living kidney donation perceptions, perceived factors that affect the willingness to donate, and analyzed differences by demographic subgroups. STUDY DESIGN: The survey items captured living kidney donation awareness, living kidney donation knowledge, willingness to donate, and barriers and facilitators to living kidney donation...
March 2024: Kidney medicine
https://read.qxmd.com/read/38317337/unrecognized-opportunities-the-landscape-of-pediatric-kidney-paired-donation-in-the-united-states
#4
JOURNAL ARTICLE
Jennifer Verbesey, Alvin G Thomas, Amy D Waterman, Sunil Karhadkar, Victoria R Cassell, Dorry L Segev, Julien Hogan, Matt Cooper
BACKGROUND: Pediatric (age < 18 years) kidney transplant (KT) candidates face increasingly complex choices. The 2014 kidney allocation system nearly doubled wait times for pediatric recipients. Given longer wait times and new ways to optimize compatibility, more pediatric candidates may consider kidney-paired donation (KPD). Motivated by this shift and the potential impact of innovations in KPD practice, we studied pediatric KPD procedures in the US from 2008 to 2021...
February 2024: Pediatric Transplantation
https://read.qxmd.com/read/38216782/predicting-wait-time-for-pediatric-kidney-transplant-a-novel-index
#5
JOURNAL ARTICLE
Alexandra Alvarez, Ashley Montgomery, Nhu Thao Nguyen Galván, Eileen D Brewer, Abbas Rana
BACKGROUND: Over one thousand pediatric kidney transplant candidates are added to the waitlist annually, yet the prospective time spent waiting is unknown for many. Our study fills this gap by identifying variables that impact waitlist time and by creating an index to predict the likelihood of a pediatric candidate receiving a transplant within 1 year of listing. This index could be used to guide patient management by giving clinicians a potential timeline for each candidate's listing based on a unique combination of risk factors...
January 12, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38094131/relationship-of-social-deprivation-among-living-kidney-donor-recipient-pairs
#6
JOURNAL ARTICLE
Yara Bilen, Jesse D Schold, Susana Arrigain, R Blake Buchalter, Anne M Huml
BACKGROUND: Living kidney transplant is the most effective renal replacement therapy for patients with end-stage kidney disease. Community-level factors contribute to pervasive socioeconomic and racial disparities in access to living donor kidney transplantation. Little is known about social and environmental conditions between living donors and recipients. Further understanding of these relationships may enhance opportunities for transplantation. METHODS: From 2010 to 2020, 59 575 living kidney donor-recipient pairs (≥18 y old) were identified using the Scientific Registry of Transplant Recipients...
January 2024: Transplantation Direct
https://read.qxmd.com/read/38054539/kidney-paired-donation
#7
EDITORIAL
Jill R Krissberg, Priya S Verghese
No abstract text is available yet for this article.
December 6, 2023: Pediatric Transplantation
https://read.qxmd.com/read/37946545/the-determinants-and-consequences-of-living-donor-discussion-direction
#8
JOURNAL ARTICLE
Mary K Roberts, Jonathan Daw
Introduction: Living donor discussions in which kidney transplant candidates discuss living kidney donation with their social network are an important step in the living donor kidney transplant process. No prior research has investigated whether who initiates discussion or influences evaluation agreement rates or how these processes may contribute to disparities. Research Questions: This study aimed to determine how common candidate- and potential-donor-initiated discussions were, at what rate each discussion type resulted in agreement to be evaluated for living donation, and what sociodemographic characteristics predicted living donor discussion and agreements...
November 9, 2023: Progress in Transplantation
https://read.qxmd.com/read/37885074/safety-of-patients-with-renal-artery-aneurysm-to-proceed-with-living-donation
#9
JOURNAL ARTICLE
Dana Meshkin, Rachel J Kann, Andrew C Crane, Martin Wijkstrom, Vik Gunabushanam, Michele Molinari, Armando Ganoza, Amit D Tevar
BACKGROUND: Renal artery aneurysm (RAA) is a rare condition that involves dilation of all layers of the arterial wall of the renal artery. The risk of rupture is rare, but intervention is recommended for larger aneurysms. Surgical decision-making regarding live donor renal transplantation (LDRT) centers around safety for the living donor, and laterality of the donated kidney is based on providing the donor with the best longevity pertaining to the remaining kidney. We looked to review our long-term outcomes surrounding live donor transplants from donors with RAA with ex vivo resection and reconstruction prior to implantation...
October 26, 2023: American Surgeon
https://read.qxmd.com/read/37739347/temporal-trends-in-kidney-paired-donation-in-the-united-states-2006-2021-unos-optn-database-analysis
#10
JOURNAL ARTICLE
Neetika Garg, Carrie Thiessen, Peter P Reese, Matthew Cooper, Ruthanne Leishman, John Friedewald, Asif A Sharfuddin, Angie G Nishio Lucar, Darshana M Dadhania, Vineeta Kumar, Amy D Waterman, Didier A Mandelbrot
Kidney paired donation (KPD) is a major innovation that is changing the landscape of kidney transplantation in the United States. We used the 2006-2021 United Network for Organ Sharing data to examine trends over time. KPD is increasing, with 1 in 5 living donor kidney transplants (LDKTs) in 2021 facilitated by KPD. The proportion of LDKT performed via KPD was comparable for non-Whites and Whites. An increasing proportion of KPD transplants are going to non-Whites. End-chain recipients are not identified in the database...
September 20, 2023: American Journal of Transplantation
https://read.qxmd.com/read/37720696/kidney-paired-donation-in-developing-countries-a-global-perspective
#11
JOURNAL ARTICLE
Vivek B Kute, Vidya A Fleetwood, Sanshriti Chauhan, Hari Shankar Meshram, Yasar Caliskan, Chintalapati Varma, Halil Yazıcı, Özgür Akın Oto, Krista L Lentine
PURPOSE OF REVIEW: We review the key principles of kidney paired donation (KPD) and discuss the status and unique considerations for KPD in developing countries. RECENT FINDINGS: Despite the advantages of KPD programs, they remain rare among developing nations, and the programs that exist have many differences with those of in developed countries. There is a paucity of literature and lack of published data on KPD from most of the developing nations. Expanding KPD programs may require the adoption of features and innovations of successful KPD programs...
September 2023: Current Transplantation Reports
https://read.qxmd.com/read/37636486/sex-and-gender-disparities-in-living-kidney-donation-a-scoping-review
#12
JOURNAL ARTICLE
Eswari Vilayur, Anita van Zwieten, Mingxing Chen, Anna Francis, Melanie Wyld, Siah Kim, Tess Cooper, Germaine Wong
BACKGROUND: Women are more likely than men to be living kidney donors. We summarized the evidence concerning the reasons behind sex and gender disparities in living kidney donation (LKD). METHODS: A scoping review of quantitative and qualitative evidence on reasons for sex and gender disparities in LKD was conducted from inception to March 2023. RESULTS: Of 1123 studies screened, 45 were eligible for inclusion. Most studies were from North America, Europe, and Central Asia (n = 33, 73%)...
September 2023: Transplantation Direct
https://read.qxmd.com/read/37547516/sociodemographic-drivers-of-donor-and-recipient-gender-disparities-in-living-kidney-donation-in-australia
#13
JOURNAL ARTICLE
Siah Kim, Anita van Zwieten, Melanie Wyld, Maleeka Ladhani, Chandana Guha, Amanda Dominello, Kylie-Ann Mallitt, Anna Francis, Roslyn B Mannon, Germaine Wong
BACKGROUND: Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation. METHODS: Data from the ANZDATA (Australian and New Zealand Dialysis and Transplantation) and ANZOD (Australian and New Zealand Organ Donor) registries (2002-2019) were used to identify the sociodemographic characteristics and their interactions associated with living donation from female donors...
August 2023: KI Reports
https://read.qxmd.com/read/37343659/a-paired-kidney-allocation-study-found-superior-survival-with-hla-dr-compatible-kidney-transplants-in-the-eurotransplant-senior-program
#14
JOURNAL ARTICLE
Johan de Fijter, Geertje Dreyer, Marko Mallat, Klemens Budde, Johann Pratschke, Jürgen Klempnauer, Martin Zeier, Wolfgang Arns, Christian Hugo, Lars-Christian Rump, Ingeborg Hauser, Peter Schenker, Mario Schiffer, Marc-Oliver Grimm, Volker Kliem, Christoph J Olbricht, Przemyslaw Pisarski, Bernhard Banas, Barbara Suwelack, Oliver Hakenberg, Gabriela Berlakovich, Stefan Schneeberger, Jacqueline van de Wetering, Stefan Berger, Frederike Bemelman, Dirk Kuypers, Sebastiaan Heidt, Axel Rahmel, Frans Claas, Patrick Peeters, Rainer Oberbauer, Uwe Heemann, Bernhard Krämer
The Eurotransplant Senior Program (ESP) has expedited the chance for elderly patients with kidney failure to receive a timely transplant. This current study evaluated survival parameters of kidneys donated after brain death with or without matching for HLA-DR antigens. This cohort study evaluated the period within ESP with paired allocation of 675 kidneys from donors 65 years and older to transplant candidates 65 years and older, the first kidney to 341 patients within the Eurotransplant Senior DR-compatible Program and 334 contralateral kidneys without (ESP) HLA-DR antigen matching...
June 19, 2023: Kidney International
https://read.qxmd.com/read/37064665/effectiveness-of-education-and-attitudes-toward-different-types-of-deceased-donor-kidneys-survey-analysis-of-single-center-experience
#15
JOURNAL ARTICLE
Sumi S Nair, Andrea N Thorp, Wael Hanna, Bradley K Johnson, Byron Smith, Savitha Iyengar, Elizabeth A Howe, Girish K Mour
BACKGROUND: We lack data on the effectiveness of education and the patient's attitude toward different deceased donor kidney types. A prospective study was performed to evaluate patient attitudes, baseline knowledge, and effectiveness of our kidney transplant education process. We also analyzed the knowledge retention of our waitlist patients. DESIGN: We prospectively surveyed a patient cohort using a paired analysis pre and post education with initial evaluation visit...
2023: Frontiers in Public Health
https://read.qxmd.com/read/36958131/factors-associated-with-health-inequities-in-access-to-kidney-transplantation-in-the-usa-a-scoping-review
#16
REVIEW
Zachary Ernst, Andrew Wilson, Andriana Peña, Mitchell Love, Ty Moore, Matt Vassar
BACKGROUND: The kidney is the most needed organ for transplantation in the United States. However, demand and scarcity of this organ has caused significant inequities for historically marginalized groups. In this review, we report on the frequency of inequities in all steps of kidney transplantation from 2016 to 2022. Search criteria was based on the National Institute of Health's (NIH) 2022 list of populations who experience health inequities, which includes: race and ethnicity; sex or gender; Lesbian, Gay, Bisexual, Transgender, Queer + (LGBTQ+); underserved rural communities; education level; income; and occupation status...
April 2023: Transplantation Reviews
https://read.qxmd.com/read/36908308/changing-landscape-in-living-kidney-donation-in-greece
#17
REVIEW
Nikolaos Karydis, Ioannis Maroulis
Patients with end-stage renal disease in Greece are facing long waiting times to receive a kidney transplant from a deceased donor. Living kidney donation offers a valuable alternative that provides optimal outcomes and significantly expands the donor pool but still remains relatively underutilised. Developments around the world in the field of kidney transplantation mandate a change in current practice to include additional options for living donation through paired exchange, antibody-incompatible transplantation and other strategies, following careful consideration of the cultural and ethical factors involved in these complex clinical decisions...
February 18, 2023: World Journal of Transplantation
https://read.qxmd.com/read/36890053/long-term-outcomes-of-kidney-paired-donation-transplantation-a-single-center-retrospective-cohort-study
#18
JOURNAL ARTICLE
Eda Altun, Melike Yavuz
BACKGROUND: This study aimed to compare the kidney paired donation (KPD) program recipients with the traditional living donor kidney transplantation (LDKT) recipients regarding patient and graft survival. METHODS: We retrospectively analyzed 141 recipients of the KPD program and 141 classic LDKT recipients that we matched for age and sex as controls between July 2005 and June 2019. We compared the 2 transplant groups for patient and kidney survival using the Kaplan-Maier test...
March 6, 2023: Transplantation Proceedings
https://read.qxmd.com/read/36868325/real-world-data-on-renal-transplantations-from-a-tertiary-care-hospital-in-north-india-in-context-of-indian-regulatory-act-transplantation-of-human-organs-and-tissues-act-thota-a-retrospective-analysis
#19
JOURNAL ARTICLE
Riya Bhargava, Rajni Chauhan, Aseem Kumar Tiwari, Simmi Mehra, Swati Pabbi, Geet Aggarwal, Vishal Sharma, Vaishali Bhardwaj
INTRODUCTION: Renal transplantation is the treatment of choice for patients suffering from end stage renal disease (ESRD). Indian regulations defined under Transplantation of Human Organs and Tissues Act (THOTA), 2014 restricts organ donations to near-related living donors to curb any malpractices like 'paid donors' in living-donor kidney transplantation (LDKT). The aim of our study was to look at real-world data of donor-recipient pairs and to identify relationship of donors (with their respective patients) and the common (or uncommon) DNA profiling methods used for supporting "claimed relationship" in accordance with the regulations...
March 1, 2023: Transplant Immunology
https://read.qxmd.com/read/36825030/a-parallel-evaluation-of-short-and-mid-term-changes-of-ambulatory-blood-pressure-in-kidney-transplant-recipients-and-kidney-donors
#20
JOURNAL ARTICLE
Efstathios Xagas, Pantelis A Sarafidis, Marieta P Theodorakopoulou, Maria Eleni Alexandrou, Maria Korogiannou, Antonis Argyris, Athanase Protogerou, Ioannis N Boletis, Smaragdi Marinaki
INTRODUCTION: Kidney transplantation (KTx) is associated with improved blood pressure (BP) levels for kidney transplant recipients (KTRs) without evoking significant changes in donors. However, there is a paucity of studies offering simultaneous detailed evaluation of BP profiles over time in transplant donor-recipient pairs. The aim of the present study was the parallel evaluation of ambulatory BP levels and trajectories in KTRs and their respective living kidney donors in the short and mid-term following KTx...
November 2022: Clinical Kidney Journal
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