Zaker Rana, Sophia C Kamran, Amol C Shetty, Philip Sutera, Yang Song, Soha Bazyar, Abhishek A Solanki, Jeffry P Simko, Alan Pollack, David McConkey, Max Kates, M Minhaj Siddiqui, Jeffrey Hiken, Jon Earls, David Messina, Kent W Mouw, David Miyamoto, William U Shipley, M Dror Michaelson, Anthony Zietman, John J Coen, Douglas M Dahl, Ashesh B Jani, Luis Souhami, Brian K Chang, R Jeffrey Lee, Huong Pham, David T Marshall, Xinglei Shen, Stephanie L Pugh, Felix Y Feng, Jason A Efstathiou, Phuoc T Tran, Matthew P Deek
Chemoradiation therapy (CRT) is a treatment for muscle-invasive bladder cancer (MIBC). Using a novel transcriptomic profiling panel, we validated prognostic immune biomarkers to CRT using 70 pretreatment tumor samples from prospective trials of MIBC (NRG/RTOG 0524 and 0712). Disease-free survival (DFS) and overall survival (OS) were estimated via the Kaplan-Meier method and stratified by genes correlated with immune cell activation. Cox proportional-hazards models were used to assess group differences. Clustering of gene expression profiles revealed that the cluster with high immune cell content was associated with longer DFS (hazard ratio [HR] 0...
April 18, 2024: European Urology Oncology