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Jari Tiihonen, Heidi Taipale, Juha Mehtälä, Pia Vattulainen, Christoph U Correll, Antti Tanskanen
Importance: The effectiveness of antipsychotic polypharmacy in schizophrenia relapse prevention is controversial, and use of multiple agents is generally believed to impair physical well-being. Objective: To study the association of specific antipsychotic combinations with psychiatric rehospitalization. Design, Setting, and Participants: In this nationwide cohort study, the risk of psychiatric rehospitalization was used as a marker for relapse among 62 250 patients with schizophrenia during the use of 29 different antipsychotic monotherapy and polypharmacy types between January 1, 1996, and December 31, 2015, in a comprehensive, nationwide cohort in Finland...
February 20, 2019: JAMA Psychiatry
Kiki Metsäranta, Marjo Kurki, Maritta Valimaki, Minna Anttila
BACKGROUND: Depression in adolescence is common. Less than half of the adolescents with depression receive mental health care; furthermore, treatment tends to be suspended, and its success rates are low. There is a need for these adolescents to have a safe place to share their thoughts. Studies have shown that writing may be a useful treatment method for people with mental health problems. OBJECTIVE: This study aims to describe the use of an electronic diary (e-diary) among adolescents with depressive symptoms...
February 20, 2019: Journal of Medical Internet Research
Henrik Hintz, Agathe Vanas, Daniel Klose, Gunnar Jeschke, Adelheid Godt
Finland trityl radical (FTR) shows very attractive EPR spectroscopical properties for a manifold of applications. For most of its applications only one chemically reactive functional group is needed. The presence of three equally reactive carboxyl groups leads to FTR modifications through reactions which give statistical mixtures of onefold, twofold and threefold modified, and unmodified FTR. To avoid the side effects of such a statistical reaction - limited yields and sepa-ration challenges - we took a route to FTR-type trityl radicals with scaffold assembly by addition of an aryllithium with one type of substituent to a diarylketone with another type of substituent...
February 20, 2019: Journal of Organic Chemistry
Tiia T M Reho, Salla A Atkins, Nina Talola, Markku P T Sumanen, Mervi Viljamaa, Jukka Uitti
OBJECTIVES: Frequent attenders (FAs) create a substantial portion of primary care workload but little is known about FAs' sickness absences. The aim of the study is to investigate how occasional and persistent frequent attendance is associated with sickness absences among the working population in occupational health (OH) primary care. SETTING AND PARTICIPANTS: This is a longitudinal study using medical record data (2014-2016) from an OH care provider in Finland...
February 19, 2019: BMJ Open
Sarianna Ilmaniemi, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen
BACKGROUND: Injuries caused by falling are a major health concern among older population. For older people, falls are the leading cause of head injuries; especially, persons with cognitive disorders have an increased risk of falling. OBJECTIVE: To compare the incidence of head injury and traumatic brain injury (TBI) among persons with Alzheimer's disease (AD) with persons without AD. METHODS: This register-based study was conducted on a nationwide cohort, which includes all community-dwelling persons diagnosed with AD in Finland in 2005-2011...
February 19, 2019: Journal of Epidemiology and Community Health
Zahra Roustaei, Sari Räisänen, Mika Gissler, Seppo Heinonen
OBJECTIVES: We described the trend of fertility rates, age-specific fertility rates and associated factors in Finland over a 30-year period. DESIGN: A descriptive population-based register study. SETTING: Fertility data, including age at first birth, childlessness and educational levels were gathered from the Finnish Medical Birth Register and Statistics Finland. PARTICIPANTS: All 1 792 792 live births from 1987 to 2016 in Finland...
January 15, 2019: BMJ Open
Joonas H Kauppila, Pasi Ohtonen, Tuomo J Karttunen, Arto Kokkola, Simo Laine, Tuomo Rantanen, Ari Ristimäki, Jari V Räsänen, Juha Saarnio, Eero Sihvo, Vesa Toikkanen, Tuula Tyrväinen
INTRODUCTION: Surgery for oesophageal and gastric cancers is associated with high morbidity, mortality and poor quality of life postoperatively. The Finnish National Esophago-Gastric Cancer Cohort has been established with the aim of identifying factors that could contribute to improved outcomes in oesophago-gastric cancer. METHODS AND ANALYSIS: All patients with oesophageal and gastric cancer diagnosed in Finland between 1987 and 2015 will be identified from the Finnish national registries...
January 15, 2019: BMJ Open
Minna K Salonen, Mikaela B von Bonsdorff, Hannu Kautiainen, Monika E von Bonsdorff, Eero Kajantie, Niko S Wasenius, Anukatriina Pesonen, Katri Räikkönen, Johan G Eriksson
INTRODUCTION: Traumatic experiences, such as separation from parents in childhood causing early life stress (ELS) may increase the risk of adverse long-term health outcomes and biological age-related changes. This may have an impact on work career. Our aim was to examine long term consequences of ELS due to temporary separation from parents during World War II (WWII) in relation to work career. MATERIAL AND METHODS: The Helsinki Birth Cohort Study comprises 13,345 individuals born in Helsinki, Finland, between the years 1934-1944...
March 2019: Journal of Psychosomatic Research
Jonathan T Evans, Jonathan P Evans, Robert W Walker, Ashley W Blom, Michael R Whitehouse, Adrian Sayers
BACKGROUND: Total hip replacement is a common and highly effective operation. All hip replacements would eventually fail if in situ long enough and it is important that patients understand when this might happen. We aimed to answer the question: how long does a hip replacement last? METHODS: We did a systematic review and meta-analysis with a search of MEDLINE and Embase from the start of records to Sept 12, 2017. We included articles reporting 15-year survival of primary, conventional total hip replacement constructs in patients with osteoarthritis...
February 16, 2019: Lancet
Alex-Mikael Barkoff, Jussi Mertsola, Denis Pierard, Tine Dalby, Silje Vermedal Hoegh, Sophie Guillot, Paola Stefanelli, Marjolein van Gent, Guy Berbers, Didrik Vestrheim, Margrethe Greve-Isdahl, Lena Wehlin, Margaretha Ljungman, Norman K Fry, Kevin Markey, Qiushui He
IntroductionPertussis outbreaks have occurred in several industrialised countries using acellular pertussis vaccines (ACVs) since the 1990s. High prevalence of pertactin (PRN)-deficient Bordetella pertussis isolates has been found in these countries.AimsTo evaluate in Europe: (i) whether proportions of PRN-deficient strains increased in consecutive collections of B. pertussis clinical isolates; (ii) if the frequency of PRN-deficient strains in countries correlated with the time since ACV introduction; (iii) the presence of pertussis toxin (PT)-, filamentous haemagglutinin (FHA)- or fimbriae (Fim)-deficient isolates...
February 2019: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Reetta Lehto, Carola Ray, Henna Vepsäläinen, Liisa Korkalo, Kaija Nissinen, Essi Skaffari, Suvi Määttä, Eva Roos, Maijaliisa Erkkola
OBJECTIVE: We aimed to examine associations between early educators' feeding practices and opinions and children's dietary intake at pre-school, in a context where uniform meals are served and pre-schools are highly regulated. DESIGN: Cross-sectional study. Food consumption data of the children consisted of two-day food records from pre-school kept by early educators. Early educators also reported their feeding practices and opinions on pre-school food. Serving style was observed...
February 20, 2019: Public Health Nutrition
M Anette E Haukilahti, Lauri Holmström, Juha Vähätalo, Tuomas Kenttä, Jani Tikkanen, Lasse Pakanen, Marja-Leena Kortelainen, Juha Perkiömäki, Heikki Huikuri, Robert J Myerburg, M Juhani Junttila
BACKGROUND: Despite recent progress in profiling of risk for sudden cardiac death (SCD) and prevention and intervention of cardiac diseases, SCD remains a major cause of death. Among women, the incidence of SCD is significant, but lower than in men, particularly in the premenopausal and early postmenopausal years. Possibly, as a consequence of the difference in population burden, the mechanisms and risk markers of SCD are not as well defined for women. The aim of this study was to determine the autopsy findings and causes of death among women in a large SCD population...
February 19, 2019: Circulation
Zdravko Z Taralov, Peter K Dimov, Kiril V Terziyski, Blagoi I Marinov, Mariyan K Topolov, Stefan S Kostianev
AIM: The aim of this study was to compare the activity of the autonomic nervous system (ANS) using heart rate variability (HRV) in 'healthy' young smokers and non-smokers before, during and after exogenous hypoxic provocation. METHODS: Twenty-one healthy non-smoking males aged 28.0 ± 7.4 years (mean ± SD) and 14 'healthy' smoking males aged 28.1 ± 4.3 years with 9.2 ± 5.6 pack-years were subjected to one-hour hypoxic exposure (Fi O2 = 12.3 ± 1.5%) via a hypoxicator...
February 14, 2019: Cardiovascular Journal of Africa
Tommi Härkänen, Päivi Sainio, Sari Stenholm, Annamari Lundqvist, Heli Valkeinen, Arpo Aromaa, Seppo Koskinen
BACKGROUND: Policy makers need disability projections for planning adequate services and measures for health promotion. The aim of this study is to provide projections on severe mobility limitations up to year 2044 and illustrate how the projected prevalence and the number of persons with severe mobility limitations are affected by potential changes in the modifiable risk factors, namely excess weight, physical inactivity and smoking. METHODS: We analysed the nationally representative, repeated measures Health 2000 and 2011 Surveys (BRIF8901) with 8615 and 6740 participants, respectively, aged 18 years and older...
February 18, 2019: Journal of Epidemiology and Community Health
Brenda Happell, Chris Platania-Phung, Brett Scholz, Julia Bocking, Aine Horgan, Fionnuala Manning, Rory Doody, Elisabeth Hals, Arild Granerud, Mari Lahti, Jarmo Pullo, Annaliina Vatula, Heikki Ellilä, Kornelis Jan van der Vaart, Jerry Allon, Martha Griffin, Siobhan Russell, Liam MacGabhann, Einar Bjornsson, Pall Biering
BACKGROUND: Understanding student attitudes towards people diagnosed with mental illness is central to realising evidence-based nursing education and policy at an international level. Redressing stigmatised views can assist in preparing nursing students to work in mental health settings and support the active involvement of consumers in all aspects of mental health service delivery (known as: consumer participation) at individual and systemic levels. Accurate research on nursing student attitudes is dependent on the availability of valid and reliable measures...
February 12, 2019: Nurse Education Today
Heidi Taipale, Pasi Lampela, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen
BACKGROUND: Antiepileptic drugs (AEDs) have sedative properties which may lead to an increased risk of pneumonia. OBJECTIVES: To investigate whether incident AED use is associated with an increased risk of pneumonia among community-dwelling persons with Alzheimer's disease (AD). In addition, we determined the risk according to duration of AED use and specific AEDs. METHODS: Persons with AD were identified from the MEDALZ dataset which includes all community-dwelling persons who received a clinically verified diagnosis of AD during 2005-2011 in Finland (N=70,718)...
February 11, 2019: Journal of Alzheimer's Disease: JAD
Pertti Jääskeläinen, Jagadish Vangipurapu, Joose Raivo, Teemu Kuulasmaa, Tiina Heliö, Katriina Aalto-Setälä, Maija Kaartinen, Erkki Ilveskoski, Sari Vanninen, Liisa Hämäläinen, John Melin, Jorma Kokkonen, Markku S Nieminen, Markku Laakso, Johanna Kuusisto
AIMS: Nationwide large-scale genetic and outcome studies in cohorts with hypertrophic cardiomyopathy (HCM) have not been previously published. METHODS AND RESULTS: We sequenced 59 cardiomyopathy-associated genes in 382 unrelated Finnish patients with HCM and found 24 pathogenic or likely pathogenic mutations in six genes in 38.2% of patients. Most mutations were located in sarcomere genes (MYBPC3, MYH7, TPM1, and MYL2). Previously reported mutations by our study group (MYBPC3-Gln1061Ter, MYH7-Arg1053Gln, and TPM1-Asp175Asn) and a fourth major mutation MYH7-Val606Met accounted for 28...
February 18, 2019: ESC Heart Failure
Sofie Hellsten, Tommy Dalgaard, Katri Rankinen, Kjetil Tørseth, Lars Bakken, Marianne Bechmann, Airi Kulmala, Filip Moldan, Stina Olofsson, Kristoffer Piil, Kajsa Pira, Eila Turtola
During the past twenty years, the Nordic countries (Denmark, Sweden, Finland and Norway) have introduced a range of measures to reduce losses of nitrogen (N) to air and to aquatic environment by leaching and runoff. However, the agricultural sector is still an important N source to the environment, and projections indicate relatively small emission reductions in the coming years. The four Nordic countries have different priorities and strategies regarding agricultural N flows and mitigation measures, and therefore they are facing different challenges and barriers...
February 14, 2019: Journal of Environmental Management
Heini Postila, Elisangela Heiderscheidt, Tiina Leiviskä
Discharge of metal-containing wastewater streams into the environment is an environmental concern because these pollutants do not degrade and tend to bioaccumulate. A number of laboratory-based investigations on the effectiveness of a wide range of filter materials for metal removal from diluted wastewater streams have been reported. However, only a few pilot or full-scale investigations have been conducted. Therefore, this study investigated the metal retention capabilities of mineral-based filter materials (commercially available mineral product (5-15 mm), recycled mineral material (2-4 mm) and slag by-product (2-4 and 4-16 mm)) when used in pilot-scale filter systems under continuous operation in a closed mining area in North Ostrobothnia, Finland, between June and October 2017...
February 14, 2019: Journal of Environmental Management
Riku Airaksinen, Ilkka Mattila, Eero Jokinen, Jukka Salminen, Juha Puntila, Miia L Lehtinen, Tiina Ojala, Paula Rautiainen, Otto Rahkonen, Pertti Suominen, Tommi Pätilä
BACKGROUND: Operative mortality after complete atrioventricular septal defect (cAVSD) repair has improved vastly. Less improvement has been demonstrated regarding late mortality and reoperation rates. There is evident lack of comprehensive population-based studies analyzing the history and progress of the ever-changing operative results. METHODS: This is a 5-million population-based retrospective study of consecutive 388 cAVSD patients operated in Finland between 1962 and 2014...
February 13, 2019: Annals of Thoracic Surgery
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