keyword
https://read.qxmd.com/read/37021413/predictors-of-adherence-to-continuous-positive-airway-pressure-in-older-adults-with-apnea-and-amnestic-mild-cognitive-impairment
#21
JOURNAL ARTICLE
Kathy C Richards, Alicia J Lozano, Jennifer Morris, Stephen T Moelter, Wenyan Ji, Vani Vallabhaneni, Yanyan Wang, Luqi Chi, Eric M Davis, Cindy Cheng, Vanessa Aguilar, Sneha Khan, Mira Sankhavaram, Alexandra L Hanlon, David A Wolk, Nalaka Gooneratne
BACKGROUND: Almost 60% of adults with amnestic mild cognitive impairment (aMCI) have obstructive sleep apnea (OSA). Treatment with continuous positive airway pressure (CPAP) may delay cognitive decline, but CPAP adherence is often suboptimal. In this study we report predictors of CPAP adherence in older adults with aMCI who have increased odds of progressing to dementia, particularly due to Alzheimer's disease. METHODS: The data are from Memories 2, "Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep Apnea"...
April 6, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/36894020/neuronal-glutamate-transporters-are-associated-with-cognitive-impairment-in-obstructive-sleep-apnea-patients-without-dementia
#22
JOURNAL ARTICLE
Song Xue, Tengqun Shen, Mengfan Li, Bing Leng, Ran Yao, Yanling Gao, Hairong Sun, Zhenguang Li, Jinbiao Zhang
Increasing evidence supports a link between obstructive sleep apnea (OSA) and cognition, and the mechanism is complex and still not well understood. We analyzed the relationship between the glutamate transporters and cognitive impairment in OSA. For this study 317 subjects without dementia, including 64 healthy controls (HCs), 140 OSA patients with mild cognitive impairment (MCI) and 113 OSA patients without cognitive impairment were assessed. All participants who completed polysomnography, cognition and white matter hyperintensity (WMH) volume were used...
April 1, 2023: Neuroscience Letters
https://read.qxmd.com/read/36859634/adherence-to-continuous-positive-airway-pressure-treatment-in-a-cohort-of-elderly-adults-with-newly-diagnosed-obstructive-sleep-apnea
#23
JOURNAL ARTICLE
Fannie Onen, Saban-Hakki Onen, Marc Le Vaillant, Frédéric Gagnadoux, Francis Martin
PURPOSE: To evaluate adherence to continuous positive airway pressure (CPAP) treatment in elderly patients newly diagnosed with obstructive sleep apnea syndrome (OSAS). METHODS: Consecutive patients ≥ 70 years attending one of the participating centers, requiring CPAP treatment and agreeing to participate, were included. Mean hours of CPAP during the first 5 months of treatment defined adherence as CPAP ≥ 4 h/day on 70% of nights over a 30-day period...
March 2, 2023: Sleep & Breathing
https://read.qxmd.com/read/36805589/obstructive-sleep-apnea-is-associated-with-markers-of-cerebral-small-vessel-disease-in-a-dose-response-manner-a-systematic-review-and-meta-analysis
#24
REVIEW
Grace Lee, Laavanya Dharmakulaseelan, Ryan T Muir, Carol Iskander, Tetyana Kendzerska, Mark I Boulos
Cerebral small vessel disease manifests on neuroimaging as white matter hyperintensities, lacunes, cerebral microbleeds, perivascular spaces or subcortical infarcts and is a major contributor to dementia, stroke and incident death. We aimed to determine whether obstructive sleep apnea severity is associated cerebral small vessel disease. A systematic search was conducted for studies examining the association between obstructive sleep apnea and cerebral small vessel disease markers. A random-effects model was used to meta-analyze unadjusted odds ratios derived from event rates...
April 2023: Sleep Medicine Reviews
https://read.qxmd.com/read/36796834/obstructive-sleep-apnoea-and-5-year-cognitive-decline-in-the-elderly
#25
JOURNAL ARTICLE
Nicola Andrea Marchi, Geoffroy Solelhac, Mathieu Berger, José Haba-Rubio, Nadia Gosselin, Peter Vollenweider, Pedro Marques-Vidal, Julius Popp, Armin von Gunten, Martin Preisig, Bogdan Draganski, Raphael Heinzer
BACKGROUND: The relationship between obstructive sleep apnoea (OSA) and cognitive decline remains controversial, especially in the elderly population. We used data from the HypnoLaus study to assess associations between OSA and longitudinal cognitive changes in a sample of community-dwelling elderly individuals. METHODS: We studied associations between polysomnographic OSA parameters (of breathing/hypoxaemia and sleep fragmentation) and cognitive changes over a 5-year period, after adjustment for potential confounders...
April 2023: European Respiratory Journal
https://read.qxmd.com/read/36758347/prevalence-of-sleep-related-breathing-disorders-and-associated-risk-factors-among-people-with-dementia-a-meta-analysis
#26
JOURNAL ARTICLE
Nur Aini, Hsin Chu, Kondwani Joseph Banda, Ruey Chen, Tso-Ying Lee, Li-Chung Pien, Doresses Liu, Yueh-Jung Lai, Xiao Linda Kang, Kuei-Ru Chou
OBJECTIVE: Sleep-related breathing disorders (SRBD) have shown to cause worsened cognitive impairment among people with dementia. Therefore, we conducted the first meta-analysis to estimate the prevalence of SRBD among people with dementia. METHODS: Comprehensive searches were conducted in Embase, Ovid-MEDLINE, PubMed, PsycINFO, Scopus, Web of Science, and CINAHL. The generalized linear mixed model (GLMM) was used for the pooled prevalence analysis and heterogeneity using I2 test and Cochran's Q-statistic in R-software...
March 2023: Sleep Medicine
https://read.qxmd.com/read/36692174/complement-proteins-levels-in-serum-astrocyte-derived-exosomes-are-associated-with-cognitive-impairment-in-obstructive-sleep-apnea
#27
JOURNAL ARTICLE
Mengfan Li, Chao Sun, Song Xue, Bing Leng, Hairong Sun, Tengqun Shen, Xiaoxiao Liu, Zhenguang Li, Xiuli Shang, Jinbiao Zhang
STUDY OBJECTIVES: An association between neuroinflammation and cognitive decline has been established. The complement system regulates neuroinflammation. Dysregulation, impairment or inadvertent activation of complement components contribute to preclinical Alzheimer's disease. The astrocyte-derived exosome (ADE) complement proteins, including C3b and C5b-9, may be predictive biomarkers of mild cognitive impairment conversion to Alzheimer's disease dementia. We hypothesized that complement proteins might be involved in cognitive impairment during obstructive sleep apnea (OSA)...
January 24, 2023: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/36627155/effect-of-cpap-on-cognitive-function-in-stroke-patients-with-obstructive-sleep-apnoea-a-meta-analysis-of-randomised-controlled-trials
#28
JOURNAL ARTICLE
Yingxia Yang, Weiqi Wu, Honghong Huang, Haining Wu, Junying Huang, Liya Li, Lingxing Wang
OBJECTIVE: To investigate the effect of continuous positive airway pressure (CPAP) treatment on cognitive function in stroke patients with obstructive sleep apnoea (OSA) by exploring randomised controlled trials (RCTs). METHODS: Published RCTs that assessed the therapeutic effects of CPAP on cognition in stroke patients with OSA, compared with controls or sham CPAP, were included. Electronic databases, including MEDLINE, Embase and Cochrane library, were searched in October 2020 and October 2021...
January 10, 2023: BMJ Open
https://read.qxmd.com/read/36585689/paroxysmal-slow-wave-events-are-associated-with-cognitive-impairment-in-patients-with-obstructive-sleep-apnea
#29
JOURNAL ARTICLE
Mengfan Li, Zhuoran Sun, Hairong Sun, Guochen Zhao, Bing Leng, Tengqun Shen, Song Xue, Huimin Hou, Zhenguang Li, Jinbiao Zhang
BACKGROUND: Increasing evidence has supported a link between obstructive sleep apnea (OSA) and cognition, and blood-brain barrier (BBB) dysfunction which can be reflected by paroxysmal slow wave events (PSWEs) may be a potential mechanism. The purpose of our study was to investigate the correlation between the PSWEs and cognitive impairment in patients with OSA, with a focus on the possible mechanism. METHODS: In total, 339 subjects with subjective snoring complaints from the Sleep Medicine Center underwent magnetic resonance imaging and whole-night polysomnography...
December 30, 2022: Alzheimer's Research & Therapy
https://read.qxmd.com/read/36516600/investigating-changes-in-cognition-associated-with-the-use-of-cpap-in-cognitive-impairment-and-dementia-a-retrospective-study
#30
JOURNAL ARTICLE
Yakdehikandage S Costa, Andrew S P Lim, Kevin E Thorpe, David R Colelli, Sara Mitchell, Mario Masellis, Benjamin Lam, Sandra E Black, Mark I Boulos
STUDY OBJECTIVES: To characterize the impact of CPAP use on cognition in a clinical cohort with obstructive sleep apnea (OSA) and cognitive impairment due to neurodegenerative or vascular etiologies after controlling for baseline sleepiness. METHODS: We retrospectively analyzed data from 171 patients with cognitive impairment and an OSA diagnosis confirmed with in-laboratory polysomnography or home sleep apnea testing (mean age 69.8 ± 10.6; 66% male) who were eligible to use CPAP...
December 5, 2022: Sleep Medicine
https://read.qxmd.com/read/36509166/elevated-complement-component-8-gamma-levels-in-astrocyte-derived-exosomes-are-associated-with-cognitive-impairment-in-obstructive-sleep-apnea-patients-without-dementia
#31
JOURNAL ARTICLE
Yanyan Yang, Tengqun Shen, Mengfan Li, Bing Leng, Ran Yao, Yanling Gao, Hairong Sun, Zhenguang Li, Jinbiao Zhang
The complement system plays a crucial role in cognitive impairment in obstructive sleep apnea (OSA). The present study aimed to investigate the connections between complement component 8 gamma (C8G) levels in astrocyte-derived exosomes (ADEs) and cognitive impairment in OSA patients without dementia. This cross-sectional cohort study recruited 274 participants without dementia, including 124 OSA patients with mild cognitive impairment (MCI), 100 OSA patients without MCI, and 50 healthy control subjects. Enrolled participants underwent polysomnography (PSG) evaluation, neuropsychological scale assessment, magnetic resonance imaging scanning, and collection of peripheral blood samples for quantification of complement proteins in ADEs...
January 18, 2023: Neuroscience Letters
https://read.qxmd.com/read/36370516/the-treatment-of-sleep-dysfunction-to-improve-cognitive-function-a-meta-analysis-of-randomized-controlled-trials
#32
REVIEW
Katherine H Franks, Ella Rowsthorn, Jessica Nicolazzo, Alexandra Boland, Alexandra Lavale, Jenalle Baker, Shantha M W Rajaratnam, Marina G Cavuoto, Stephanie R Yiallourou, Matthew T Naughton, Garun S Hamilton, Leonid Churilov, Yen Ying Lim, Matthew P Pase
OBJECTIVE: This meta-analysis of randomized controlled trials (RCTs) evaluates if treating sleep disturbances improves cognitive function over at least 12 weeks. METHODS: Multiple data sources were searched until November 1, 2021. RCTs were included if they examined the effect of an intervention (behavioral or medical) on sleep and cognition in an adult sample with sleep disturbances and had an intervention duration and follow-up of at least 12 weeks. Two independent reviewers located 3784 studies; 16 satisfied the inclusion criteria...
October 28, 2022: Sleep Medicine
https://read.qxmd.com/read/36327964/association-of-a-history-of-sleep-disorder-with-risk-of-mild-cognitive-impairment-and-alzheimer-s-disease-dementia
#33
JOURNAL ARTICLE
Young Min Choe, Guk-Hee Suh, Jee Wook Kim
OBJECTIVE: We explored whether a history of sleep disorder affected a current diagnosis of cognitive impairment and clinical conversion in a non-demented elderly population. METHODS: Comprehensive clinical data collected as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI) was analyzed. A history of sleep disorder was recorded in the recent ADNI medical database. Standard clinical and neuropsychological tests were performed both at baseline and follow-up visit...
October 2022: Psychiatry Investigation
https://read.qxmd.com/read/36068685/international-consensus-statement-on-obstructive-sleep-apnea
#34
REVIEW
Jolie L Chang, Andrew N Goldberg, Jeremiah A Alt, Alzoubaidi Mohammed, Liza Ashbrook, Dennis Auckley, Indu Ayappa, Hira Bakhtiar, José E Barrera, Bethany L Bartley, Martha E Billings, Maurits S Boon, Pien Bosschieter, Itzhak Braverman, Kara Brodie, Cristina Cabrera-Muffly, Ray Caesar, Michel B Cahali, Yi Cai, Michelle Cao, Robson Capasso, Sean M Caples, Lana M Chahine, Corissa P Chang, Katherine W Chang, Nilika Chaudhary, Crystal S J Cheong, Susmita Chowdhuri, Peter A Cistulli, David Claman, Jacob Collen, Kevin C Coughlin, Jennifer Creamer, Eric M Davis, Kara L Dupuy-McCauley, Megan L Durr, Mohan Dutt, Mazen El Ali, Nabil M Elkassabany, Lawrence J Epstein, Justin A Fiala, Neil Freedman, Kirat Gill, M Boyd Gillespie, Lea Golisch, Nalaka Gooneratne, Daniel J Gottlieb, Katherine K Green, Arushi Gulati, Indira Gurubhagavatula, Nathan Hayward, Paul T Hoff, Oliver M G Hoffmann, Steven J Holfinger, Jennifer Hsia, Colin Huntley, Kevin C Huoh, Phillip Huyett, Sanjana Inala, Stacey L Ishman, Tarun K Jella, Aesha M Jobanputra, Andrew P Johnson, Mithri R Junna, Jenna T Kado, Thomas M Kaffenberger, Vishesh K Kapur, Eric J Kezirian, Meena Khan, Douglas B Kirsch, Alan Kominsky, Meir Kryger, Andrew D Krystal, Clete A Kushida, Thomas J Kuzniar, Derek J Lam, Christopher J Lettieri, Diane C Lim, Hsin-Ching Lin, Stanley Y C Liu, Stuart G MacKay, Ulysses J Magalang, Atul Malhotra, Meghna P Mansukhani, Joachim T Maurer, Anna M May, Ron B Mitchell, Babak Mokhlesi, Anna E Mullins, Eman M Nada, Sreelatha Naik, Brandon Nokes, Michael D Olson, Allan I Pack, Edward B Pang, Kenny P Pang, Susheel P Patil, Eli Van de Perck, Jay F Piccirillo, Grace W Pien, Amanda J Piper, Andrea Plawecki, Mark Quigg, Madeline J L Ravesloot, Susan Redline, Brian W Rotenberg, Armand Ryden, Kathleen F Sarmiento, Firas Sbeih, Amy E Schell, Christopher N Schmickl, Helena M Schotland, Richard J Schwab, Jiyeon Seo, Neomi Shah, Anita Valanju Shelgikar, Isaac Shochat, Ryan J Soose, Toby O Steele, Erika Stephens, Carl Stepnowsky, Kingman P Strohl, Kate Sutherland, Maria V Suurna, Erica Thaler, Sritika Thapa, Olivier M Vanderveken, Nico de Vries, Edward M Weaver, Ian D Weir, Lisa F Wolfe, B Tucker Woodson, Christine H J Won, Josie Xu, Pratyusha Yalamanchi, Kathleen Yaremchuk, Yerem Yeghiazarians, Jason L Yu, Michelle Zeidler, Ilene M Rosen
BACKGROUND: Evaluation and interpretation of the literature on obstructive sleep apnea (OSA) allows for consolidation and determination of the key factors important for clinical management of the adult OSA patient. Toward this goal, an international collaborative of multidisciplinary experts in sleep apnea evaluation and treatment have produced the International Consensus statement on Obstructive Sleep Apnea (ICS:OSA). METHODS: Using previously defined methodology, focal topics in OSA were assigned as literature review (LR), evidence-based review (EBR), or evidence-based review with recommendations (EBR-R) formats...
July 2023: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/35933417/rationale-and-study-protocol-for-we-pap-a-randomized-pilot-feasibility-trial-of-a-couples-based-intervention-to-promote-pap-adherence-and-sleep-health-compared-to-an-educational-control
#35
JOURNAL ARTICLE
Kelly Glazer Baron, Allyson Gilles, Krishna M Sundar, Brian R W Baucom, Kevin Duff, Wendy Troxel
BACKGROUND: Obstructive sleep apnea (OSA) is a serious health condition that affects approximately 30-50% of older adults and contributes to risk for cardiometabolic disorders and dementia. Despite the well-documented role of partners in treatment seeking and adherence to positive airway pressure (PAP), treatments for OSA have nearly exclusively focused on the patient and current treatments for OSA do not address co-existing sleep problems such as insomnia that are prevalent in both patients with OSA and their partners...
August 6, 2022: Pilot and Feasibility Studies
https://read.qxmd.com/read/35922660/obstructive-sleep-apnea-chronic-obstructive-pulmonary-disease-and-hypertensive-microvascular-disease-a-cross-sectional-observational-cohort-study
#36
JOURNAL ARTICLE
Sky Chew, Deb Colville, Anastasia Hutchinson, Piers Canty, Lauren Hodgson, Judy Savige
Hypertensive microvascular disease is associated with an increased risk of diastolic heart failure, vascular dementia and progressive renal impairment. This study examined whether individuals with obstructive sleep apnoea (OSA) had more retinal hypertensive microvascular disease than those with chronic obstructive pulmonary disease (COPD) and hospital controls. This was a single-centre, cross-sectional, observational study of participants recruited consecutively from a general respiratory clinic and a general medical clinic...
August 3, 2022: Scientific Reports
https://read.qxmd.com/read/35913462/the-link-between-obstructive-sleep-apnea-and-neurocognitive-impairment-an-official-american-thoracic-society-workshop-report
#37
JOURNAL ARTICLE
Chitra Lal, Indu Ayappa, Najib Ayas, Andrew E Beaudin, Camilla Hoyos, Clete A Kushida, Marta Kaminska, Anna Mullins, Sharon L Naismith, Ricardo S Osorio, Craig L Phillips, Ankit Parekh, Katie L Stone, Arlener D Turner, Andrew W Varga
There is emerging evidence that obstructive sleep apnea (OSA) is a risk factor for preclinical Alzheimer's disease (AD). An American Thoracic Society workshop was convened that included clinicians, basic scientists, and epidemiologists with expertise in OSA, cognition, and dementia, with the overall objectives of summarizing the state of knowledge in the field, identifying important research gaps, and identifying potential directions for future research. Although currently available cognitive screening tests may allow for identification of cognitive impairment in patients with OSA, they should be interpreted with caution...
August 2022: Annals of the American Thoracic Society
https://read.qxmd.com/read/35880410/the-prevalence-of-obstructive-sleep-apnoea-risk-factors-in-individuals-with-cognitive-impairment-south-london-cross-sectional-study
#38
JOURNAL ARTICLE
Leiah Kirsh, Rebecca Cox, Heloise Mongue-Din, Robert Lawrence
AIMS AND METHOD: We aimed to determine the prevalence of risk factors for obstructive sleep apnoea (OSA) in patients with mild cognitive impairment (MCI) or dementia. Using patient records across a 5 year period, we identified 16 855 patients with dementia or MCI. We gave scores for keywords relating to each modified STOP BANG parameter in patient progress notes. Based on individual scores, we stratified the population into groups with low, intermediate and high risk of OSA. RESULTS: Our population had a high prevalence of risk factors and consequently high risk scores for OSA (18...
July 26, 2022: BJPsych Bulletin
https://read.qxmd.com/read/35766800/complement-activation-mainly-mediates-the-association-of-heart-rate-variability-and-cognitive-impairment-in-adults-with-obstructive-sleep-apnea-without-dementia
#39
JOURNAL ARTICLE
Song Xue, Meng-Fan Li, Bing Leng, Ran Yao, Zhuoran Sun, Yanyan Yang, Yan-Ling Gao, Xiaoxiao Liu, Hai-Rong Sun, Zhenguang Li, Jinbiao Zhang
STUDY OBJECTIVES: The relationship between autonomic nervous system (ANS) dysfunction measured by heart rate variability (HRV) and cognitive impairment in obstructive sleep apnea (OSA) patients is complex and still not well understood. We aimed to analyze the role of complement activation, Alzheimer's disease (AD) biomarkers and white matter hyperintensity (WMH) in modulating the association of HRV with cognitive performance. METHODS: There were 199 subjects without dementia, including 42 healthy controls, 80 OSA patients with mild cognitive impairment (MCI) and 77 OSA patients without cognitive impairment...
June 29, 2022: Sleep
https://read.qxmd.com/read/35669316/obstructive-sleep-apnea-cerebrovascular-disease-and-amyloid-in-older-adults-with-down-syndrome-across-the-alzheimer-s-continuum
#40
JOURNAL ARTICLE
Patrick Lao, Molly E Zimmerman, Sigan L Hartley, José Gutierrez, David Keator, Kay C Igwe, Krystal K Laing, Dejania Cotton-Samuel, Mithra Sathishkumar, Fahmida Moni, Howard Andrews, Sharon Krinsky-McHale, Elizabeth Head, Joseph H Lee, Florence Lai, Michael A Yassa, H Diana Rosas, Wayne Silverman, Ira T Lott, Nicole Schupf, Adam M Brickman
We determined the extent to which obstructive sleep apnea (OSA) is associated with increased cerebrovascular disease and amyloid burden, and the relation of the two processes across clinical Alzheimer's disease (AD) diagnostic groups in adults with Down syndrome (DS). Adults with DS from the Biomarkers of Alzheimer's Disease in Down Syndrome (ADDS) study were included given available research MRI ( n = 116; 50 ± 8 years; 42% women) and amyloid PET scans ( n = 71; 50 ± 7 years; 39% women) at the time of analysis...
2022: Sleep advances: a journal of the Sleep Research Society
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