keyword
https://read.qxmd.com/read/38498126/somatostatin-receptor-imaging-of-thyroid-tissue-and-differentiated-thyroid-cancer-using-gallium-68-labeled-radiotracers-a-review-of-clinical-studies
#1
REVIEW
Reza Pishdad, Giorgio Treglia, Ami Mehta, Prasanna Santhanam
INTRODUCTION: The rise in thyroid cancer incidence, especially papillary thyroid cancer (PTC), has underscored the need for improved diagnostic methods and management strategies. Herein, we aim to comprehensively review the evolving landscape in thyroid cancer diagnosis and the potential utility of Gallium-68 (Ga-68) based somatostatin receptor imaging. METHODS: We reviewed the clinical studies involving Ga-68 based radiotracers by looking at the following literature databases -PUBMED, EMBASE, WEB OF SCIENCE and COCHRANE...
March 18, 2024: Endocrine
https://read.qxmd.com/read/38488989/reduction-of-68-ga-ga-dota-tate-injected-activity-for-digital-pet-mr-in-comparison-with-analogue-pet-ct
#2
JOURNAL ARTICLE
Christina P W Cox, Tessa Brabander, Erik Vegt, Quido G de Lussanet de la Sablonière, Laura H Graven, Frederik A Verburg, Marcel Segbers
BACKGROUND: New digital detectors and block-sequential regularized expectation maximization (BSREM) reconstruction algorithm improve positron emission tomography (PET)/magnetic resonance (MR) image quality. The impact on image quality may differ from analogue PET/computed tomography (CT) protocol. The aim of this study is to determine the potential reduction of injected [68 Ga]Ga-DOTA-TATE activity for digital PET/MR with BSREM reconstruction while maintaining at least equal image quality compared to the current analogue PET/CT protocol...
March 15, 2024: EJNMMI Physics
https://read.qxmd.com/read/38454762/challenging-axillary-lymph-nodes-on-pet-ct-in-cancer-patients-throughout-covid-19-vaccination-era
#3
Alessia Giordano, Rosj Gallicchio, Mariarita Milella, Rebecca Storto, Anna Nardelli, Teresa Pellegrino, Antonio Nappi, Michele Di Cosola, Giovanni Storto
BACKGROUND: The unexpected detection of axillary lymphadenopathy (AxL) in cancer patients (pts) represents a real concern during the COVID-19 vaccination era. Benign reactions may take place after vaccine inoculation, which can mislead image interpretation in patients undergoing F-18-FDG, F-18-Choline, and Ga-68-DOTATOC PET/CT. They may also mimic loco-regional metastases or disease. We assessed PET/CT findings after COVID-19 first dose vaccination in cancer patients and the impact on their disease course management...
March 6, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38447298/improved-purification-of-cyclotron-68-ga-gacl-3-for-the-production-of-68-ga-radiopharmaceuticals
#4
JOURNAL ARTICLE
Ivan E Wang, Allen F Brooks, Mara Clark, Luke J Morrissette, Peter J H Scott
INTRODUCTION: Increased demand for NetSpot and Illuccix as requirement to receive the respective Lutathera and Pluvicto radiotherapies, and monitor subsequent response to treatment, have reinforced the need to develop alternative ways of producing gallium-68 (68 Ga). Building on our efforts to produce 68 Ga in a liquid target on a GE PETtrace, the goal of this work is to modify the current GE Gallium Chloride cassette using the FASTLab 2 synthesis module to produce [68 Ga]GaCl3 equivalent to a 1...
February 24, 2024: Nuclear Medicine and Biology
https://read.qxmd.com/read/38442920/patient-derived-tumor-xenograft-study-with-cdk4-6-inhibitor-plus-akt-inhibitor-for-the-management-of-metastatic-castration-resistant-prostate-cancer
#5
JOURNAL ARTICLE
Adam M Kase, Justyna Gleba, James L Miller, Erin Miller, Joachim Petit, Michael T Barrett, Yumei Zhou, Ephraim E Parent, Hancheng Cai, Joshua A Knight, Jacob Orme, Jordan Reynolds, William F Durham, Thomas M Metz, Nathalie Meurice, Brandy Edenfield, Aylin Alasonyalilar Demirer, Ahmet Bilgili, Peyton G Hickman, Matthew L Pawlush, Laura Marlow, Daniel P Wickland, Winston Tan, John A Copland
Metastatic castration-resistant prostate cancer (mCRPC) is an aggressive malignancy with poor outcomes. To investigate novel therapeutic strategies, we characterized three new metastatic prostate cancer PDTX models and developed 3D spheroids from each to investigate molecular targeted therapy combinations including CDK4/6 inhibitors (CDK4/6i) with AKT inhibitors (ATKi). Metastatic prostate cancer tissue was collected and three PDTX models were established and characterized using WES. PDTX 3-D spheroids were developed from these three PDTXs to show resistance patterns and test novel molecular targeted therapies...
March 6, 2024: Molecular Cancer Therapeutics
https://read.qxmd.com/read/38352266/a-case-of-metastatic-lymphoepithelial-carcinoma-of-parotid-gland-identified-on-68-gallium-dota-tyr3-octreotate-pet-ct
#6
Han Chung Low, Kelvin Siu Hoong Loke, Fu Qiang Wang, Shuting Han, Amit Jain, Joe Yeong, Wen Long Nei
The authors present the case of a 59-year-old lady diagnosed with lymphoepithelial carcinoma (LEC) of the left parotid gland. The primary tumour was identified using contrast-enhanced CT, and diagnosis was confirmed via fine needle aspiration cytology and immunohistochemistry. Staging using fluorine-18 fluorodeoxyglucose PET CT revealed regional nodal metastases, while no distant metastasis was evident. Following radical radiotherapy, a favourable locoregional response was observed on MRI, yet the patient's plasma Epstein-Barr virus load continued to rise...
January 2024: BJR Case Reports
https://read.qxmd.com/read/38313450/delayed-68-ga-fapi-46-pet-mr-imaging-confirms-ongoing-fibroblast-activation-in-patients-after-acute-myocardial-infarction
#7
JOURNAL ARTICLE
Jana Kupusovic, Lukas Kessler, Sandra Kazek, Michal Kamil Chodyla, Lale Umutlu, Fadi Zarrad, Michael Nader, Wolfgang P Fendler, Zohreh Varasteh, Ken Hermann, Dobromir Dobrev, Reza Wakili, Tienush Rassaf, Johannes Siebermair, Christoph Rischpler
PURPOSE OF THE REPORT: Combined cardiac 68 Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and cardiac magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of myocardial damage after an acute myocardial infarction (AMI). Purpose of this pilot study was to evaluate simultaneous Ga-68-FAPI-46-PET/MR imaging in the delayed phase after AMI. MATERIAL AND METHODS: Eleven patients underwent hybrid 68 Ga-FAPI-46 PET/MRI post AMI...
February 2024: IJC Heart & Vasculature
https://read.qxmd.com/read/38304011/noninsulinoma-pancreatogenous-hypoglycemia-syndrome-in-a-patient-with-1p36-deletion-syndrome
#8
Elizabeth Diane Auckley, Marilyn Arosemena, Louis H Philipson
The 1p36 deletion syndrome involves a phenotypic presentation that includes central nervous system, cardiac, and craniofacial anomalies. We report the case of a 21-year-old female patient with 1p36 deletion syndrome who was found to have noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS) after hospitalization for persistent falls. On admission, vital signs were normal and physical examination revealed a thin, nonverbal patient. During hospitalization and prolonged fasting (14-18 hours), she persistently developed hypoglycemia (serum glucose nadir 57 mg/dL [3...
February 2024: JCEM Case Rep
https://read.qxmd.com/read/38291706/sensitive-positron-emission-tomography-imaging-of-pd-l1-expression-in-human-breast-and-lung-carcinoma-xenografts-using-the-radiometalated-peptide-ga-68-trap-wl12
#9
JOURNAL ARTICLE
Neil Gerard Quigley, Katja Steiger, Stefanie Felicitas Färber, Frauke Richter, Wilko Weichert, Johannes Notni
Noninvasive imaging of the immune checkpoint protein programmed death ligand 1 (PD-L1; synonyms: CD274, B7-H1) holds great promise to improve patient selection and, thus, response rates for immune checkpoint therapy (ICT) with monoclonal antibodies targeting the PD1/PD-L1 axis. The PD-L1 specific peptide WL12 (cyclo(AcY-( N Me)A-N-P-H-L-Hyp-W-S-W(Me)-( N Me)Nle-( N Me)Nle-O-C)-G-NH2 ) was functionalized with the Gallium-68 chelator TRAP by means of click chemistry (CuAAC). The resulting conjugate TRAP-WL12 was labeled with Gallium-68 within 16 min, with approximately 90% radiochemical yield and 99% radiochemical purity, affording Ga-68-TRAP-WL12 with molar activities typically exceeding 100 MBq/nmol...
January 30, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38288815/an-expedition-on-synthetic-methodology-of-fda-approved-anticancer-drugs-2018-2021
#10
JOURNAL ARTICLE
Vishakha S, Navneesh N, Balak Das Kurmi, Ghanshyam Das Gupta, Sant Kumar Verma, Ankit Jain, Preeti Patel
New drugs being established in the market every year produce specified structures for selective biological targeting. With medicinal insights into molecular recognition, these begot molecules open new rooms for designing potential new drug molecules. In this review, we report the compilation and analysis of a total of 56 drugs including 33 organic small molecules (Mobocertinib, Infigratinib, Sotorasib, Trilaciclib, Umbralisib, Tepotinib, Relugolix, Pralsetinib, Decitabine, Ripretinib, Selpercatinib, Capmatinib, Pemigatinib, Tucatinib, Selumetinib, Tazemetostat, Avapritinib, Zanubrutinib, Entrectinib, Pexidartinib, Darolutamide, Selinexor, Alpelisib, Erdafitinib, Gilteritinib, Larotrectinib, Glasdegib, Lorlatinib, Talazoparib, Dacomitinib, Duvelisib, Ivosidenib, Apalutamide), 6 metal complexes (Edotreotide Gallium Ga-68, fluoroestradiol F-18, Cu 64 dotatate, Gallium 68 PSMA-11, Piflufolastat F-18, 177Lu (lutetium)), 16 macromolecules as monoclonal antibody conjugates (Brentuximabvedotin, Amivantamab-vmjw, Loncastuximabtesirine, Dostarlimab, Margetuximab, Naxitamab, Belantamabmafodotin, Tafasitamab, Inebilizumab, SacituzumabGovitecan, Isatuximab, Trastuzumab, Enfortumabvedotin, Polatuzumab, Cemiplimab, Mogamulizumab) and 1 peptide enzyme (Erwiniachrysanthemi-derived asparaginase) approved by the U...
January 29, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38262470/incidental-papillary-thyroid-carcinoma-detected-by-ga-68-dotatate-pet-ct-a-rare-case-study-and-clinical-considerations
#11
JOURNAL ARTICLE
Adem Maman
No abstract text is available yet for this article.
January 23, 2024: Nuklearmedizin. Nuclear Medicine
https://read.qxmd.com/read/38196815/insulinoma-metastatic-recurrence-38-years-following-initial-diagnosis-in-pregnancy
#12
Christopher A Preston, Nirupa Sachithanandan, Ie-Wen Sim, Jon van Heerden, Stephen Farrell
A case of recurrent insulinoma spanning 4 decades is described. Following a delayed diagnosis, hyperinsulinemic hypoglycemia was confirmed in a 24-year-old woman during early pregnancy. Initial surgery, culminating in subtotal pancreatectomy, was noncurative. A 1-cm insulinoma was subsequently resected from the head of the pancreas postpartum, with postoperative resolution of hypoglycemia. However, 32 years later, the patient experienced a recurrence of hypoglycemic symptoms. Eventually, a subcentimeter extrapancreatic lesion was identified anterior to the pancreatic head on gallium-68 DOTA-Exendin-4 positron emission tomography/computed tomography...
February 2024: JCEM Case Rep
https://read.qxmd.com/read/38177615/evaluating-the-patterns-of-fapi-uptake-in-the-shoulder-joint-a-preliminary-study-comparing-with-fdg-uptake-in-oncological-studies
#13
JOURNAL ARTICLE
Yohji Matsusaka, Rudolf A Werner, Sebastian E Serfling, Andreas K Buck, Aleksander Kosmala, Takanori Sasaki, Alexander Weich, Takahiro Higuchi
BACKGROUND: Fibroblast activation protein inhibitor (FAPI) targeting PET has been introduced as a novel molecular imaging modality for visualizing cancer-associated fibroblasts. There have also been reports suggesting incidental findings of localized accumulation in the shoulder joints. However, further characterization in a larger patient cohort is still lacking. METHODS: 77 consecutive patients (28 females; mean age, 63.1 ± 11.6) who underwent Ga-68 FAPI-04 PET/CT for diagnosis of solid tumors were included...
January 4, 2024: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/38164239/formulating-a-national-position-statement-and-guide-on-modern-theranostics-in-the-philippines
#14
JOURNAL ARTICLE
Patricia A Bautista-Peñalosa, Francis Gerard M Estrada, Emerita A Barrenechea, Teofilo O L San Luis
Barriers to the establishment of advanced technologies in developing countries were overcome when modern theranostics pertaining to the use of Ga-68 and Lu-177 PSMA and DOTATATE were first offered to patients in the Philippines in early 2018. However, significant growth was not experienced at St. Luke's Medical Center for five years and lutetium was not yet distributed to other institutions by a radiopharmaceutical supplier. Due to the relative novelty and rapid expansion of theranostics worldwide, position statements were released by the Australasian Association of Nuclear Medicine Specialists, European Association of Nuclear Medicine, Society of Nuclear Medicine and Molecular Imaging, and International Atomic Energy Agency primarily to uphold patient safety and ensure a level of standard among its practitioners...
2024: Asia Oceania Journal of Nuclear Medicine & Biology
https://read.qxmd.com/read/38115121/hotspots-and-frontiers-in-psma-research-for-prostate-cancer-a-bibliometric-and-visualization-analysis-over-the-past-20%C3%A2-years
#15
JOURNAL ARTICLE
Hanfei Zhang, Liu Xiao, Hangyu Xie, Lin Li
BACKGROUND: Prostate-specific membrane antigen (PSMA)-targeted imaging and therapy have significantly changed the management of patients with prostate cancer (PCa) at different disease stages. This advancement has attracted the attention of scholars, leading to a prolific output of scholarly publications. This study comprehensively outlines the knowledge framework associated with PSMA-based diagnosis and treatment of PCa through the application of bibliometric analysis, and discusses the potential research trends and foci...
December 19, 2023: European Journal of Medical Research
https://read.qxmd.com/read/38114351/rational-use-of-ga-68-psma-pet-ct-according-to-nomograms-and-risk-groups-for-the-detection-of-lymph-node-metastasis-in-prostate-cancer
#16
JOURNAL ARTICLE
Serdar Madendere, Mert Kılıç, Ersin Köseoğlu, İbrahim Can Aykanat, Arzu Baygül Eden, Bilgen Coşkun, Fadimana Bozkurt Tekkalan, Mevlana Derya Balbay
OBJECTIVES: The aim was to ensure efficient utilization of PSMA PET-CT by examining the correlation of pathological lymph node metastasis with nomogram scores and risk classifications. METHODS AND MATERIALS: Robot-assisted radical prostatectomy and bilateral pelvic lymph node dissections for pelvic lymph nodes were performed using the same template. Bilaterally pelvic lymph nodes were removed within the boundaries of genitofemoral nerves, psoas muscle and lateral pelvic wall laterally, ureteric crossing of the iliac vessels superiorly, lateral bladder wall medially, Cooper ligaments distally, and endopelvic fascia, neurovascular bundles and internal iliac arteries posteriorly...
December 18, 2023: Urologic Oncology
https://read.qxmd.com/read/38089587/3bp-3940-a-highly-potent-fap-targeting-peptide-for-theranostics-production-validation-and-first-in-human-experience-with-ga-68-and-lu-177
#17
JOURNAL ARTICLE
Lukas Greifenstein, Annika Gunkel, Aileen Hoehne, Frank Osterkamp, Christiane Smerling, Christian Landvogt, Corinna Mueller, Richard P Baum
Hardly any new tracers attracted more attention in nuclear medicine in the last couple of years than radiolabeled fibroblast activation protein inhibitors (FAPi' s ). Molecules targeting cancer-associated fibroblasts (CAFs) or disease-associated fibroblasts in benign disorders (DAFs) gave rise to a new class of radiopharmaceuticals widely applicable for imaging and with the desired use as therapeutic compounds. Despite displaying benefits in diagnostic sensitivity over FDG, most FAP-targeting compounds in today's clinical routine continue to lack therapeutic utility due to short tumor retention...
December 15, 2023: IScience
https://read.qxmd.com/read/38036687/signet-cell-rectal-carcinoma-with-prostatic-involvement-detected-by-fapi-04-pet-mri-fusion
#18
JOURNAL ARTICLE
K Arun Prashanth, Deepti Jain, R Manikandan, Suman Kalyan, Vimalraj Velayutham, R Surendran
A 60-year-old male patient diagnosed with mucinous adenocarcinoma of lower third of rectum underwent abdominoperineal resection and permanent colostomy followed by adjuvant chemotherapy. Response evaluation with F-18 FDG PET-CT showed a complete metabolic response. After 6 months, CEA levels started increasing and clinically a recurrence was suspected. A restaging FDG PET-CT showed no obvious malignant disease. Patient presented again within a month with complaints of urinary retention and haematuria. CEA levels were further elevated, and Ga-68 FAPI-04 (FAPI) PET-CT was performed...
December 1, 2023: European Journal of Hybrid Imaging
https://read.qxmd.com/read/37945775/accuracy-of-combined-multi-parametric-mri-and-psma-pet-ct-in-diagnosing-localized-prostate-cancer-newer-horizons-for-a-biopsy-free-pathway
#19
JOURNAL ARTICLE
Aditya Prakash Sharma, Rajender Kumar, Rohit Chauhan, Shiraz Akif Ziauddin, Shanky Singh, Harmandeep Singh, Sudheer Kumar Devana, Ujjwal Gorsi, Girdhar Singh Bora, Ravimohan S Mavuduru, Santosh Kumar, Uttam K Mete, Bhagwant Rai Mittal
INTRODUCTION: Prostate-specific antigen (PSA) is a reliable biomarker for identification of prostate cancer, although a biopsy is still the gold standard for detecting prostate cancer. Similar to higher PIRADS lesions on MRI, the maximal standard uptake value (SUV max) on PSMA PET is linked to a higher likelihood of prostate cancer. Can an mpMRI in conjunction with PSMA PET Scan accurately predict prostate cancer and further trigger omission of biopsy similar to other solid organ urological malignancies? METHODS: Ga-68 PSMA PET and mpMRI were performed for each patient who was a part of this retrospective study...
November 10, 2023: European Journal of Hybrid Imaging
https://read.qxmd.com/read/37908983/a-sdhb-variant-of-unknown-significance-in-a-patient-with-a-cardiac-functional-paraganglioma
#20
Lindsay Carafone, Adrienne Victor, Inga Harbuz-Miller
Cardiac paragangliomas are extremely rare tumors derived from chromaffin cells of the neural crest. Succinate dehydrogenase B ( SDHB ) mutations are associated with metastatic potential and potentially worse prognosis. Here we describe the case of a 64-year-old man who presented with chest pain, fatigue, and weight loss. Cardiac workup revealed a nearly 7-cm cardiac mass in the right lateral wall. Incisional biopsy demonstrated paraganglioma. Plasma free normetanephrine and chromogranin A were elevated. A DOTATATE positron emission tomography/computed tomography (PET/CT) revealed avidity of the mass with no evidence of distant metastases...
July 2023: JCEM Case Rep
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