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Marlon Perera, Nathan Papa, Matthew Roberts, Michael Williams, Cristian Udovicich, Ian Vela, Daniel Christidis, Damien Bolton, Michael S Hofman, Nathan Lawrentschuk, Declan G Murphy
CONTEXT: Accurate staging of high-risk localised, advanced, and metastatic prostate cancer is becoming increasingly more important in guiding local and systemic treatment. Gallium-68 prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has increasingly been utilised globally to assess the local and metastatic burden of prostate cancer, typically in biochemically recurrent or advanced disease. Following our previous meta-analysis, a high-volume series has been reported highlighting the utility of 68 Ga-PSMA PET in this setting...
February 14, 2019: European Urology
Frederik A Verburg, Martin Wiessmann, Georg Neuloh, Felix M Mottaghy, Marc-Alexander Brockmann
AIM: Here we describe the results of superselective intraarterial application of diagnostic Ga-68-DOTA0,Tyr3-octreotate (Ga-68-DOTATATE) in a series of patients with inoperable WHO grade II meningiomas which were no longer amenable to radiotherapy. METHODS: Four patients with inoperable WHO grade II meningioma underwent systemic venous infusion of Ga-68-DOTATATE followed by PET/CT. Ga-68-DOTATATE application was repeated intraarterially via transfemoral catheterization of vessels supplying the meningioma and another PET/CT was performed...
February 2019: Nuklearmedizin. Nuclear Medicine
Lebriz Uslu-Beşli, Sait Sağer, Elife Akgün, Sertaç Asa, Onur Erdem Şahin, Çetin Demirdağ, Ekrem Güner, Baresh Razavi Khosroshahi, Emre Karayel, Hüseyin Pehlivanoğlu, Aslan Aygün, İlhami Uslu, Zübeyr Talat, Kerim Sönmezoğlu
Background/aim: The aim of our study was to compare Tc-99m MDP bone scan and Ga-68 PSMA PET/CT in terms of detection of bone metastasis in prostate cancer patients. Materials and methods: A total of 28 prostate cancer patients with bone scan and PSMA PET/CT performed within 90 days were retrospectively included in our analysis. All bone lesions were scored as negative (score-0), positive (score-1), or suspicious (score-2) for metastasis by two experienced nuclear medicine physicians...
February 11, 2019: Turkish Journal of Medical Sciences
Límbano Iván López-Coello, Eugenio Torres-García, Luis Enrique Díaz-Sánchez, Rigoberto Oros-Pantoja, Liliana Aranda-Lara
The aim of this work was to calculate S values for 99 mTc, 67 Ga, 68 Ga, 18 F, 223 Ra, 166 Ho, 90 Y, 161 Tb 131 I and 177 Lu, using a mouse phantom (MOBY) standard and considering the anatomic sizes from males and females, the simulation of radiation transport was performed with GATE/Geant4 platform. This indicates that in the internal dosimetry the use of a customized geometry is relevant for each gender and a standard model is not a good choice.
January 28, 2019: Applied Radiation and Isotopes
Vijay Alexander, Maria Koshy, Riddhi Dasgupta, Ronald Albert Carey
Cushing's syndrome is known to present with a characteristic set of clinical manifestations and complications, well described in literature. However, hypercoagulability remains an under recognised entity in Cushing's syndrome. A 31-year-old woman from Southern India presented with history of fever, left upper quadrant pain and progressive breathing difficulty for 3 weeks. Clinical examination revealed discriminatory features of Cushing's syndrome. Laboratory investigations showed biochemical features of endogenous ACTH-dependent Cushing's syndrome...
February 6, 2019: BMJ Case Reports
Congcong Wang, Hao Liu, Sheng Yu, Houbin Chen, Fuchu Hu, Huiling Zhan, Xifen Pan, Yuhua Lao, Silin Zhong, Biyan Zhou
Warm winters and hot springs may promote panicle leaf growing and repress floral development. To identify genes potentially involved in litchi panicle leaf senescence, eight RNA-sequencing (RNA-Seq) libraries of the senescing panicle leaves under low temperature (LT) conditions and the developing panicle leaves under high temperature (HT) conditions were constructed. For each library, 4.78⁻8.99 × 10⁶ clean reads were generated. Digital expression of the genes was compared between the senescing and developing panicle leaves...
February 1, 2019: Genes
U N Pallavi, Vindhya Malasani, Ishita Sen, Parul Thakral, Sugandha Dureja, Vineet Pant, Vinay Samuel Gaikwad, Arvind Sabharwal
Background: Insulinoma is an islet-cell neoplasm that secretes insulin. It is usually localized to the pancreas and is often the most common cause of endogenous hyperinsulinemic hypoglycaemia in non-diabetic adult patients. Surgical excision with a curative intent is the standard modality of treatment, and it requires precise localization of tumor tissue. Ga-68 DOTA-exendin-4 PET/CT scan is a clinically reasonable and sensitive scan for the identification of insulinoma. The aim of this prospective cohort study was to determine the overall accuracy of Ga-68 DOTA-exendin-4 PET/CT scan in the detection of insulinoma...
January 2019: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Tatiana Segard, Laurence Mja Morandeau, Marina L Dunne, James O Robinson, Ronan J Murray, Elizabeth A Geelhoed, Roslyn J Francis
BACKGROUND: Preliminary studies have reported promising results for the utility of Ga-68 citrate PET-CT for infection imaging. This technique offers reduced radiation dose to patients, shorter time between injection and imaging and reduced time for image acquisition compared to the 'gold standard' nuclear imaging technique: Ga-67 citrate scintigraphy. AIMS: To compare the two imaging modalities to ascertain whether Ga-68 citrate PET-CT is of equivalent diagnostic efficacy for bone and joint infection or pyrexia of unknown origin (PUO) and to assess image quality and reporter confidence...
January 22, 2019: Internal Medicine Journal
Usman Bashir, Alison Tree, Erik Mayer, Daniel Levine, Chris Parker, David Dearnaley, Wim J G Oyen
PURPOSE: With the availability of ultra-sensitive PSA assays, early biochemical relapse (eBCR) of prostate cancer is increasingly being detected at values much lower than the conventional threshold of 0.2 ng/ml. Accurate localisation of disease in this setting may allow treatment modification and improved outcomes, especially in patients with pelvis-confined or extra-pelvic oligometastasis (defined as up to three pelvic nodal or distant sites). We aimed to measure the detection rate of [68]Ga-PSMA-HBNED-CC (PSMA)-PET/CT and its influence on patient management in eBCR of prostate cancer following radical prostatectomy (RP)...
January 8, 2019: European Journal of Nuclear Medicine and Molecular Imaging
Christian H Pfob, Ilham Karimov, Moritz Jesinghaus, Alexander Novotny, Wolfgang A Weber, Matthias Eiber, Benedikt Feuerecker
No abstract text is available yet for this article.
December 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Stefano Riga, Gianfranco Cicoria, Davide Pancaldi, Federico Zagni, Sara Vichi, Michele Dassenno, Luca Mora, Filippo Lodi, Maria Pia Morigi, Mario Marengo
PURPOSE: In recent years the use of 68 Ga (t1/2  = 67.84 min, β+ : 88.88%) for the labelling of different PET radiopharmaceuticals has significantly increased. This work aims to evaluate the feasibility of the production of 68 Ga via the 68 Zn(p,n)68 Ga reaction by proton irradiation of an enriched zinc solution, using a biomedical cyclotron, in order to satisfy its increasing demand. METHODS: Irradiations of 1.7 Msolution of 68 Zn(NO3 )2 in 0.2 N HNO3 were conducted with a GE PETtrace cyclotron using a slightly modified version of the liquid target used for the production of fluorine-18...
November 2018: Physica Medica: PM
Louise Emmett, Ur Metser, Glenn Bauman, Rodney J Hicks, Andrew Weickhardt, Ian D Davis, Shonit Punwani, Gregory R Pond, Sue Siew-Chen Chua, Bao Ho, Edward Johnston, Frederic Pouliot, Andrew Scott
Background: A significant proportion of men with rising PSA following radical prostatectomy (RP) fail prostate fossa salvage radiotherapy (SRT). This study assessed the ability of F18 fluoro-methyl-choline PET/CT(FCH), Ga-68 HBED-CC PSMA-11 PET/CT (PSMA) and pelvic multi-parametric magnetic resonance imaging (pelvic MRI) to identify men who will best benefit from SRT. Methods: Prospective, multisite, imaging study in men with rising PSA post RP, high-risk features (PSA > 0.2ng/mL and either Gleason Score (GS) > 7 or PSA doubling time <10 months, or PSA >1...
November 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Francesco Collamati, Valerio Bocci, Paolo Castellucci, Micol De Simoni, Stefano Fanti, Riccardo Faccini, Alessandro Giordano, Daria Maccora, Carlo Mancini-Terracciano, Michela Marafini, Riccardo Mirabelli, Silvio Morganti, Riccardo Schiavina, Teresa Scotognella, Giacomo Traini, Elena Solfaroli Camillocci
Radio Guided Surgery is a technique helping the surgeon in the resection of tumors: a radiolabeled tracer is administered to the patient before surgery and then the surgeon evaluates the completeness of the resection with a handheld detector sensitive to emitted radiation. Established methods rely on γ emitting tracers coupled with γ detecting probes. The efficacy of this technique is however hindered by the high penetration of γ radiation, limiting its applicability to low background conditions. To overtake such limitations, a novel approach to RGS has been proposed, relying on β- emitting isotopes together with a dedicated β probe...
November 1, 2018: Scientific Reports
Milos Petrik, Eva Umlaufova, Vladislav Raclavsky, Andrea Palyzova, Vladimir Havlicek, Hubertus Haas, Zbynek Novy, Dalibor Dolezal, Marian Hajduch, Clemens Decristoforo
Pseudomonas aeruginosa is an increasingly prevalent opportunistic pathogen that causes a variety of life-threatening nosocomial infections. Novel strategies for the development of new antibacterial treatments as well as diagnostic tools are needed. One of the novel diagnostic strategies for the detection of infection could be the utilization of siderophores. Siderophores are low-molecular-weight chelators produced by microbes to scavenge essential iron. Replacing iron in siderophores by suitable radiometals, such as Ga-68 for positron emission tomography (PET) imaging, opens approaches for targeted imaging of infection...
October 24, 2018: Scientific Reports
Siroos Mirzaei, Peter Knoll, Shahin Zandieh
Prostate cancer is the most frequent cancer type in men in industrialized countries. In case of biochemical recurrent disease of prostate cancer is molecular imaging with PET-CT or PET-MRI a very promising modality for the detection of local recurrence, lymph node involvement or distant metastasis. Of the so far implemented radiopharmaceuticals the radioactive labeled PSMA ligands (i. e. Ga-68 PSMA) have prevailed. There are also in the meanwhile treatment approaches with PSMA ligands (i. e. Lu-177 PSMA) in case of metastatic disease...
October 22, 2018: Wiener Medizinische Wochenschrift
Stephen Thompson, Melissa E Rodnick, Jenelle Stauff, Janna Arteaga, Timothy J Desmond, Peter J H Scott, Benjamin L Viglianti
Radiolabeled erythrocytes have multiple applications in nuclear medicine, including blood pool imaging. Historically they have been labeled with SPECT radionuclides. A PET blood pool imaging agent is highly desirable as it would improve clinical applications with better image quality and resolution, higher sensitivity, and dynamic scanning capabilities. With the coming of age of modern 68 Ge/68 Ga generator systems, gallium-68 is now widely accessible. In this paper we describe an updated method for the preparation of 68 Ga-labeled erythrocytes and their preliminary use in rodent blood pool imaging...
March 1, 2018: MedChemComm
Parul Thakral, Ishita Sen, Vineet Pant, Santosh Kumar Gupta, Sugandha Dureja, Jyotsna Kumari, Sunil Kumar, Pallavi Un, Vindhya Malasani
OBJECTIVE: Two radiosensitizing chemotherapeutic drugs, capecitabine (CAP) and temozolomide (TEM), are administered concurrently to enhance the therapeutic efficacy of peptide receptor radionuclide therapy (PRRT). This study aims to assess the biodistribution and normal-organ and tumor radiation dosimetry for Lu-177 DOTATATE administered concurrently with CAP/TEM. METHODS: 20 patients with non-resectable histologically confirmed gastroenteropancreatic neuroendocrine tumors with normal kidney function, a normal haematological profile and somatostatin receptor expression of the tumor lesions, as scintigraphically assessed by a Ga-68 DOTANOC scan, were included in two groups-case group (n = 10) and control group (n = 10)...
November 2018: British Journal of Radiology
Stefanie Felicitas Färber, Alexander Wurzer, Florian Reichart, Roswitha Beck, Horst Kessler, Hans-Jürgen Wester, Johannes Notni
The epithelial integrin αvβ6 is expressed by many malignant carcinoma cell types, including pancreatic cancer, and thus represents a promising target for radionuclide therapy. The peptide cyclo(FRGDLAFp( N Me)K) was decorated with different chelators (DOTPI, DOTAGA, and DOTA). The Lu(III) complexes of these conjugates exhibited comparable αvβ6 integrin affinities (IC50 ranging from 0.3 to 0.8 nM) and good selectivities against other integrins (IC50 for αvβ8 >43 nM; for α5β1 >238 nM; and for αvβ3, αvβ5, and αIIbβ3 >1000 nM)...
February 28, 2018: ACS Omega
Alexander Wurzer, Julia Pollmann, Alexander Schmidt, Dominik Reich, Hans-Jürgen Wester, Johannes Notni
Radiopharmaceuticals targeting the enzyme prostate-specific membrane antigen (PSMA; synonyms: glutamate carboxypeptidase II, NAALADase; EC have recently emerged as powerful agents for diagnosis and therapy (theranostics) of prostate carcinoma (PCa). The radiation doses for therapeutic application of such compounds are limited by substantial uptakes in kidneys and salivary glands, with excess doses reportedly leading to radiotoxicity-related adverse effects, such as kidney insufficiency or xenostomia...
September 4, 2018: Molecular Pharmaceutics
Julian M Rogasch, Hannes Cash, Sebastian Zschaeck, Sefer Elezkurtaj, Winfried Brenner, Bernd Hamm, Marcus Makowski, Holger Amthauer, Christian Furth, Alexander D J Baur
PURPOSE: To evaluate the accuracy of clinical parameters and established pre-treatment risk stratification systems for prostate cancer (PCa) in predicting PSMA-positive metastases in men undergoing Ga-68-PSMA PET/CT as initial staging examination. MATERIALS AND METHODS: A retrospective analysis in 108 consecutive treatment-naïve patients with biopsy-proven PCa undergoing Ga-68-PSMA PET/CT (median age, 72 years [range, 49-82 years]) was performed. Prediction of PSMA-positive metastases by serum PSA, clinical T stage (cT), ISUP group, percentage of positive biopsy cores, and derived risk scores (D'Amico risk classification system, Roach [RF], Yale formula [YF], and Briganti nomogram [BN]) was examined with ROC analysis...
July 5, 2018: Prostate
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