Friederike Völter, Leonie Beyer, Florian Eckenweber, Maximilian Scheifele, Ngoc Bui, Marianne Patt, Henryk Barthel, Sabrina Katzdobler, Carla Palleis, Nicolai Franzmeier, Johannes Levin, Robert Perneczky, Boris-Stephan Rauchmann, Osama Sabri, Jimin Hong, Paul Cumming, Axel Rominger, Kuangyu Shi, Peter Bartenstein, Matthias Brendel
PURPOSE: Characteristic features of amyloid-PET (A), tau-PET (T), and FDG-PET (N) can serve for the A/T/N classification of neurodegenerative diseases. Recent studies showed that the early, perfusion-weighted phases of amyloid- or tau-PET recordings serve to detect cerebrometabolic deficits equally to FDG-PET, therefore providing a surrogate of neuronal injury. As such, two channels of diagnostic information can be obtained in the setting of a single PET scan. However, there has hitherto been no comparison of early-phase amyloid- and tau-PET as surrogates for deficits in perfusion/metabolism...
December 27, 2022: European Journal of Nuclear Medicine and Molecular Imaging