keyword
https://read.qxmd.com/read/38468313/plasma-oligomer-beta-amyloid-is-associated-with-disease-severity-and-cerebral-amyloid-deposition-in-alzheimer-s-disease-spectrum
#1
JOURNAL ARTICLE
Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Philip Scheltens, Hyun Kook Lim
BACKGROUND: Multimer detection system-oligomeric amyloid-β (MDS-OAβ) is a measure of plasma OAβ, which is associated with Alzheimer's disease (AD) pathology. However, the relationship between MDS-OAβ and disease severity of AD is not clear. We aimed to investigate MDS-OAβ levels in different stages of AD and analyze the association between MDS-OAβ and cerebral Aβ deposition, cognitive function, and cortical thickness in subjects within the AD continuum...
March 11, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38427194/amyloid-pet-imaging-standard-procedures-and-semiquantification
#2
JOURNAL ARTICLE
Francesca D'Amico, Luca Sofia, Matteo Bauckneht, Silvia Morbelli
Amyloid plaques are a neuropathologic hallmark of Alzheimer's disease (AD), which can be imaged through positron emission tomography (PET) technology using radiopharmaceuticals that selectively bind to the fibrillar aggregates of amyloid-β plaques (Amy-PET). Several radiotracers for amyloid PET have been validated (11 C-Pittsburgh compound B and the 18 F-labeled compounds such as 18 F-florbetaben, 18 F-florbetapir, and 18 F-flutemetamol). Images can be interpreted by means of visual/qualitative, semiquantitative, and quantitative criteria...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38377442/association-between-years-of-education-and-amyloid-burden-in-patients-with-subjective-cognitive-decline-mci-and-alzheimer-disease
#3
JOURNAL ARTICLE
Merle Hönig, Daniele Altomare, Camilla Caprioglio, Lyduine Collij, Frederik Barkhof, Bart Van Berckel, Philip Scheltens, Gill Farrar, Mark R Battle, Hendrik Theis, Kathrin Giehl, Gerard N Bischof, Valentina Garibotto, José Luis L Molinuevo, Oriol Grau-Rivera, Julien Delrieu, Pierre Payoux, Jean Francois Demonet, Agneta K Nordberg, Irina Savitcheva, Zuzana Walker, Paul Edison, Andrew W Stephens, Rossella Gismondi, Frank Jessen, Christopher J Buckley, Juan Domingo Gispert, Giovanni B Frisoni, Alexander Drzezga
OBJECTIVES: Higher-educated patients with Alzheimer disease (AD) can harbor greater neuropathologic burden than those with less education despite similar symptom severity. In this study, we assessed whether this observation is also present in potential preclinical AD stages, namely in individuals with subjective cognitive decline and clinical features increasing AD likelihood (SCD+). METHODS: Amyloid-PET information ([18 F]Flutemetamol or [18 F]Florbetaben) of individuals with SCD+, mild cognitive impairment (MCI), and AD were retrieved from the AMYPAD-DPMS cohort, a multicenter randomized controlled study...
March 26, 2024: Neurology
https://read.qxmd.com/read/38263017/associations-between-sex-body-mass-index-and-the-individual-microglial-response-in-alzheimer-s-disease
#4
JOURNAL ARTICLE
Gloria Biechele, Boris-Stephan Rauchmann, Daniel Janowitz, Katharina Buerger, Nicolai Franzmeier, Endy Weidinger, Selim Guersel, Sebastian Schuster, Anika Finze, Stefanie Harris, Simon Lindner, Nathalie L Albert, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Carla Palleis, Sabrina Katzdobler, Lena Burow, Carolin Kurz, Mirlind Zaganjori, Lena-Katharina Trappmann, Oliver Goldhardt, Timo Grimmer, Jan Haeckert, Daniel Keeser, Sophia Stoecklein, Estrella Morenas-Rodriguez, Peter Bartenstein, Johannes Levin, Günter U Höglinger, Mikael Simons, Robert Perneczky, Matthias Brendel
BACKGROUND AND OBJECTIVES: 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer's disease (AD) research. Sex and obesity effects on TSPO-PET binding have been reported for cognitively normal humans (CN), but such effects have not yet been systematically evaluated in patients with AD. Thus, we aimed to investigate the impact of sex and obesity on the relationship between β-amyloid-accumulation and microglial activation in AD...
January 23, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38247423/associations-between-education-years-and-resting-state-functional-connectivity-modulated-by-apoe-%C3%AE%C2%B54-carrier-status-in-cognitively-normal-older-adults
#5
JOURNAL ARTICLE
Jiwon Kim, Sunghwan Kim, Yoo Hyun Um, Sheng-Min Wang, Regina Ey Kim, Yeong Sim Choe, Jiyeon Lee, Donghyeon Kim, Hyun Kook Lim, Chang Uk Lee, Dong Woo Kang
OBJECTIVE: : Cognitive reserve has emerged as a concept to explain the variable expression of clinical symptoms in the pathology of Alzheimer's disease (AD). The association between years of education, a proxy of cognitive reserve, and resting-state functional connectivity (rFC), a representative intermediate phenotype, has not been explored in the preclinical phase, considering risk factors for AD. We aimed to evaluate whether the relationship between years of education and rFC in cognitively preserved older adults differs depending on amyloid-beta deposition and APOE ε4 carrier status as effect modifiers...
February 29, 2024: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://read.qxmd.com/read/38169114/cognitive-reserve-in-parkinson-s-disease-without-dementia-%C3%AE-amyloid-and-metabolic-assessment
#6
JOURNAL ARTICLE
Beatriz Fernández-Rodríguez, Rafael Rodríguez-Rojas, Pasqualina Guida, Santiago Angulo-Díaz-Parreño, Clara Trompeta, David Mata-Marín, Ignacio Obeso, Lydia Vela, Isabel Plaza de Las Heras, José A Obeso, Carmen Gasca-Salas
BACKGROUND: Cognitive reserve (CR) is the mismatch between preserved cognition and neuropathological damage. Amyloidopathy in Parkinson's disease (PD) could be associated with faster progression to dementia, but the putative protective effect of CR is unknown. OBJECTIVES: To evaluate the effect of CR on β-amyloid burden and brain metabolism in non-demented PD subjects. METHODS: Participants with PD (n = 53) underwent a clinical evaluation, [18 F]-fluorodeoxyglucose and [18 F]-flutemetamol positron emission tomography magnetic resonances, and were classified according to CR...
January 3, 2024: Movement Disorders Clinical Practice
https://read.qxmd.com/read/38163657/higher-fat-related-body-composition-measurement-and-lower-resting-state-inter-network-functional-connectivity-of-apoe-%C3%AE%C2%B54-carrier-in-mild-cognitive-impairment-patients-with-a%C3%AE-deposition
#7
JOURNAL ARTICLE
In Hyeok Choi, Sheng-Min Wang, Yoo Hyun Um, Hyun Kook Lim, Chang Uk Lee, Dong Woo Kang
OBJECTIVE: We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition. METHODS: MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [18F]flutemetamol, and bioelectrical impedance analysis for measuring body composition...
December 2023: Psychiatry Investigation
https://read.qxmd.com/read/38050727/hybrid-pet-mri-with-flutemetamol-and-fdg-in-alzheimer-s-disease-clinical-continuum
#8
JOURNAL ARTICLE
Lutfiye Ozlem Atay, Esen Saka, Umit Ozgur Akdemir, Ezgi Yetim, Erdem Balcı, Ethem Murat Arsava, Mehmet Akif Topcuoglu
AIMS: We aimed to investigate the interaction between β -amyloid (Aβ) accumulation and cerebral glucose metabolism, cerebral perfusion, and cerebral structural changes in the Alzheimer's disease (AD) clinical continuum. BACKGROUND: Utility of positron emission tomography (PET) / magnetic resonance imaging (MRI) hybrid imaging for diagnostic categorization of the AD clinical continuum including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI) and Alzheimer's disease dementia (ADD) has not been fully crystallized...
2023: Current Alzheimer Research
https://read.qxmd.com/read/38012799/clinical-outcomes-up-to-9%C3%A2-years-after-18-f-flutemetamol-amyloid-pet-in-a-symptomatic-memory-clinic-population
#9
JOURNAL ARTICLE
Lyduine E Collij, Gill Farrar, Marissa Zwan, Elsmarieke van de Giessen, Rik Ossenkoppele, Frederik Barkhof, Annemieke J M Rozemuller, Yolande A L Pijnenburg, Wiesje M van der Flier, Femke Bouwman
BACKGROUND: Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. However, studies investigating longitudinal outcomes over an extended period of time are limited. Therefore, we aimed to investigate clinical outcomes up to 9 years after amyloid-PET to support the clinical validity of the imaging technique. METHODS: We analyzed longitudinal data from 200 patients (Mage  = 61.8, 45.5% female, MMMSE  = 23...
November 27, 2023: Alzheimer's Research & Therapy
https://read.qxmd.com/read/37901794/clinical-effects-of-novel-susceptibility-genes-for-beta-amyloid-a-gene-based-association-study-in-the-korean-population
#10
JOURNAL ARTICLE
Bo-Hyun Kim, HyunWoo Lee, Hongki Ham, Hee Jin Kim, Hyemin Jang, Jun Pyo Kim, Yu Hyun Park, Mansu Kim, Sang Won Seo
Amyloid-beta (Aβ) is a pathological hallmark of Alzheimer's disease (AD). We aimed to identify genes related to Aβ uptake in the Korean population and investigate the effects of these novel genes on clinical outcomes, including neurodegeneration and cognitive impairments. We recruited a total of 759 Korean participants who underwent neuropsychological tests, brain magnetic resonance imaging, 18 F-flutemetamol positron emission tomography, and microarray genotyping data. We performed gene-based association analysis, and also performed expression quantitative trait loci and network analysis...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37897616/impact-of-simulated-reduced-injected-dose-on-the-assessment-of-amyloid-pet-scans
#11
JOURNAL ARTICLE
Peter Young, Fiona Heeman, Jan Axelsson, Lyduine E Collij, Anne Hitzel, Amirhossein Sanaat, Aida Niñerola-Baizan, Andrés Perissinotti, Mark Lubberink, Giovanni B Frisoni, Habib Zaidi, Frederik Barkhof, Gill Farrar, Suzanne Baker, Juan Domingo Gispert, Valentina Garibotto, Anna Rieckmann, Michael Schöll
PURPOSE: To investigate the impact of reduced injected doses on the quantitative and qualitative assessment of the amyloid PET tracers [18 F]flutemetamol and [18 F]florbetaben. METHODS: Cognitively impaired and unimpaired individuals (N = 250, 36% Aβ-positive) were included and injected with [18 F]flutemetamol (N = 175) or [18 F]florbetaben (N = 75). PET scans were acquired in list-mode (90-110 min post-injection) and reduced-dose images were simulated to generate images of 75, 50, 25, 12...
October 28, 2023: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/37894772/sex-related-disparities-in-the-resting-state-functional-connectivity-of-the-locus-coeruelus-and-salience-network-in-preclinical-alzheimer-s-disease
#12
JOURNAL ARTICLE
Yoo Hyun Um, Sheng-Min Wang, Dong Woo Kang, Sunghwan Kim, Chang Uk Lee, Donghyeon Kim, Yeong Sim Choe, Regina E Y Kim, Soyoung Lee, Hyun Kook Lim
Recent studies have demonstrated the pivotal role of locus coeruleus (LC) and salience network (SN) resting state functional connectivity (rsFC) changes in the early stage of Alzheimer's disease (AD). Moreover, sex has been a crucial point of discussion in understanding AD pathology. We aimed to demonstrate the sex-related disparities in the functional connectivity (FC) of the SN and LC in preclinical AD. A total of 89 cognitively normal patients with evidence of amyloid beta (Aβ) accumulation ([18F] flutemetamol +) were recruited in the study...
October 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37829142/modulation-of-associations-between-education-years-and-cortical-volume-in-alzheimer-s-disease-vulnerable-brain-regions-by-a%C3%AE-deposition-and-apoe-%C3%AE%C2%B54-carrier-status-in-cognitively-normal-older-adults
#13
JOURNAL ARTICLE
Hak-Bin Kim, Sung-Hwan Kim, Yoo Hyun Um, Sheng-Min Wang, Regina E Y Kim, Yeong Sim Choe, Jiyeon Lee, Donghyeon Kim, Hyun Kook Lim, Chang Uk Lee, Dong Woo Kang
BACKGROUND: Education years, as a measure of cognitive reserve, have been shown to affect the progression of Alzheimer's disease (AD), both pathologically and clinically. However, inconsistent results have been reported regarding the association between years of education and intermediate structural changes in AD-vulnerable brain regions, particularly when AD risk factors were not considered during the preclinical phase. OBJECTIVE: This study aimed to examine how Aβ deposition and APOE ε4 carrier status moderate the relationship between years of education and cortical volume in AD-vulnerable regions among cognitively normal older adults...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37759734/olfactory-dysfunction-is-associated-with-cerebral-amyloid-deposition-and-cognitive-function-in-the-trajectory-of-alzheimer-s-disease
#14
JOURNAL ARTICLE
Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Hyun Kook Lim
Olfactory dysfunction is consistently observed in individuals with Alzheimer's disease (AD), but its association with beta-amyloid (Aβ) deposition remains unclear. This study aimed to investigate the relationship among olfactory function, cerebral Aβ deposition, and neuropsychological profiles in individuals with no cognitive impairment (NCI), mild cognitive impairment (MCI), and AD dementia. A total of 164 participants were included, and olfactory function was assessed using the brief smell identification test (B-SIT)...
August 31, 2023: Biomolecules
https://read.qxmd.com/read/37595816/evaluation-of-novel-data-driven-metrics-of-amyloid-%C3%AE-deposition-for-longitudinal-pet-studies
#15
JOURNAL ARTICLE
Ariane Bollack, Pawel J Markiewicz, Alle Meije Wink, Lloyd Prosser, Johan Lilja, Pierrick Bourgeat, Jonathan M Schott, William Coath, Lyduine E Collij, Hugh G Pemberton, Gill Farrar, Frederik Barkhof, David M Cash
PURPOSE: Positron emission tomography (PET) provides in vivo quantification of amyloid-β (Aβ) pathology. Established methods for assessing Aβ burden can be affected by physiological and technical factors. Novel, data-driven metrics have been developed to account for these sources of variability. We aimed to evaluate the performance of four of these amyloid PET metrics against conventional techniques, using a common set of criteria. METHODS: Three cohorts were used for evaluation: Insight 46 (N=464, [18 F]florbetapir), AIBL (N=277, [18 F]flutemetamol), and an independent test-retest data (N=10, [18 F]flutemetamol)...
October 15, 2023: NeuroImage
https://read.qxmd.com/read/37574523/age-sex-and-pathology-related-variability-in-brain-structure-and-cognition
#16
JOURNAL ARTICLE
Dario Bachmann, Andreas Buchmann, Sandro Studer, Antje Saake, Katrin Rauen, Isabelle Zuber, Esmeralda Gruber, Roger M Nitsch, Christoph Hock, Anton Gietl, Valerie Treyer
This work aimed to investigate potential pathways linking age and imaging measures to early age- and pathology-related changes in cognition. We used [18F]-Flutemetamol (amyloid) and [18F]-Flortaucipir (tau) positron emission tomography (PET), structural MRI, and neuropsychological assessment from 232 elderly individuals aged 50-89 years (46.1% women, 23% APOE-ε4 carrier, 23.3% MCI). Tau-PET was available for a subsample of 93 individuals. Structural equation models were used to evaluate cross-sectional pathways between age, amyloid and tau burden, grey matter thickness and volumes, white matter hyperintensity volume, lateral ventricle volume, and cognition...
August 14, 2023: Translational Psychiatry
https://read.qxmd.com/read/37561144/positron-emission-tomography-in-the-diagnosis-and-follow-up-of-transthyretin-amyloid-cardiomyopathy-patients-a-systematic-review
#17
REVIEW
H S A Tingen, A Tubben, J H A van 't Oever, E M Pastoor, P P A van Zon, H L A Nienhuis, P van der Meer, R H J A Slart
PURPOSE: Transthyretin (ATTR) amyloidosis is a progressive protein misfolding disease with frequent cardiac involvement. This review aims to determine the value of PET in diagnosis, assessment of disease progression or treatment response and its relation to clinical outcome in follow-up of ATTR amyloid cardiomyopathy (ATTR-CM) patients. METHODS: Medline, Cochrane Library, Embase and Web of Science databases were searched, from the earliest date available until December 2022, for studies investigating the use of PET in ATTR-CM patients...
August 10, 2023: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/37558171/prediction-of-amyloid-positron-emission-tomography-positivity-using-multiple-regression-analysis-of-quantitative-susceptibility-mapping
#18
JOURNAL ARTICLE
Yohei Ikebe, Ryota Sato, Tomoki Amemiya, Niki Udo, Masaaki Matsushima, Ichiro Yabe, Akinori Yamaguchi, Makoto Sasaki, Masafumi Harada, Noriyuki Matsukawa, Yasuo Kawata, Yoshitaka Bito, Toru Shirai, Hisaaki Ochi, Kohsuke Kudo
PURPOSE: To develop a method for predicting amyloid positron emission tomography (PET) positivity based on multiple regression analysis of quantitative susceptibility mapping (QSM). MATERIALS AND METHODS: This prospective study included 39 patients with suspected dementia from four centers. QSM images were obtained through a 3-T, three-dimensional radiofrequency-spoiled gradient-echo sequence with multiple echoes. The cortical standard uptake value ratio (SUVR) was obtained using amyloid PET with 18 F-flutemetamol, and susceptibility in the brain regions was obtained using QSM...
August 7, 2023: Magnetic Resonance Imaging
https://read.qxmd.com/read/37492802/a-universal-neocortical-mask-for-centiloid-quantification
#19
JOURNAL ARTICLE
Pierrick Bourgeat, Vincent Doré, Christopher C Rowe, Tammie Benzinger, Duygu Tosun, Manu S Goyal, Pamela LaMontagne, Liang Jin, Michael W Weiner, Colin L Masters, Jurgen Fripp, Victor L Villemagne
INTRODUCTION: The Centiloid (CL) project was developed to harmonize the quantification of amyloid beta (Aβ) positron emission tomography (PET) scans to a unified scale. The CL neocortical mask was defined using 11 C Pittsburgh compound B (PiB), overlooking potential differences in regional distribution among Aβ tracers. We created a universal mask using an independent dataset of five Aβ tracers, and investigated its impact on inter-tracer agreement, tracer variability, and group separation...
2023: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/37491358/profiling-of-plasma-biomarkers-in-the-context-of-memory-assessment-in-a-tertiary-memory-clinic
#20
JOURNAL ARTICLE
Marco Bucci, Marina Bluma, Irina Savitcheva, Nicholas J Ashton, Konstantinos Chiotis, Anna Matton, Miia Kivipelto, Guglielmo Di Molfetta, Kaj Blennow, Henrik Zetterberg, Agneta Nordberg
Plasma biomarkers have shown promising performance in research cohorts in discriminating between different stages of Alzheimer's disease (AD). Studies in clinical populations are necessary to provide insights on the clinical utility of plasma biomarkers before their implementation in real-world settings. Here we investigated plasma biomarkers (glial fibrillary acidic protein (GFAP), tau phosphorylated at 181 and 231 (pTau181, pTau231), amyloid β (Aβ) 42/40 ratio, neurofilament light) in 126 patients (age = 65 ± 8) who were admitted to the Clinic for Cognitive Disorders, at Karolinska University Hospital...
July 25, 2023: Translational Psychiatry
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