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vascular remodeling and hypertension

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https://read.qxmd.com/read/30878387/tanshinone-i-inhibits-vascular-smooth-muscle-cell-proliferation-by-targeting-insulin-like-growth-factor-1-receptor-phosphatidylinositol-3-kinase-signaling-pathway
#1
Yu-Ting Wu, Yi-Ming Bi, Zhang-Bin Tan, Ling-Peng Xie, Hong-Lin Xu, Hui-Jie Fan, Hong-Mei Chen, Jun Li, Bin Liu, Ying-Chun Zhou
Vascular smooth muscle cell (VSMC) proliferation plays a critical role in arterial remodeling during various vascular diseases including atherosclerosis and hypertension. Tanshinone I, a major component of Salvia miltiorrhiza, exerts protective effects against cardiovascular diseases. In this study, we investigated the effects of tanshinone I on VSMC proliferation, as well as the underlying mechanisms. We found that this compound inhibited the proliferation of VSMCs in a dose-dependent manner, based on 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) and 5-ethynyl-2'-deoxyuridine (EdU) assays...
March 13, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/30865840/platelet-derived-growth-factor-up-regulates-ca-2-sensing-receptors-in-idiopathic-pulmonary-arterial-hypertension
#2
Aya Yamamura, Md Junayed Nayeem, Abdullah Al Mamun, Rie Takahashi, Hisaki Hayashi, Motohiko Sato
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease associated with remodeling of the pulmonary artery. We previously reported that the Ca2+ -sensing receptor (CaSR) is up-regulated in pulmonary arterial smooth muscle cells (PASMCs) from patients with idiopathic PAH (IPAH) and contributes to enhanced Ca2+ responses and excessive cell proliferation. However, the mechanisms underlying the up-regulation of CaSR have not yet been elucidated. We herein examined involvement of platelet-derived growth factor (PDGF) on CaSR expression, Ca2+ responses, and proliferation in PASMCs...
March 13, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/30864566/nobiletin-alleviates-vascular-alterations-through-modulation-of-nrf-2-ho-1-and-mmp-pathways-in-l-name-induced-hypertensive-rats
#3
Prapassorn Potue, Chutamas Wunpathe, Putcharawipa Maneesai, Upa Kukongviriyapan, Parichat Prachaney, Poungrat Pakdeechote
Nobiletin, a citrus flavonoid, exhibits a wide range of biological activities. This study investigated the effect of nobiletin on vascular dysfunction and remodeling in l-NAME-induced hypertensive rats. Male Sprague-Dawley rats were given l-NAME (40 mg kg-1) for five weeks to induce hypertension and treated with nobiletin (20 or 40 mg kg-1) or captopril (5 mg kg-1) for the last two weeks. Nobiletin or captopril significantly reduced blood pressure and the enhancement of the contractile response to sympathetic nerve stimulation in the mesenteric vascular beds of l-NAME rats (p < 0...
March 13, 2019: Food & Function
https://read.qxmd.com/read/30864507/an-update-on-the-association-of-protein-kinases-with-cardiovascular-diseases
#4
Fakhra Amin, Aijaz Ahmad, Anna Feroz, Shariq Shaheen Khaqi, Mohd Shahnwaz Khan, Shams Tabrez, Syed Kashif Zaidi, Wasem H Abulaal, Anas Shamsi, Wajihullah Khan, Bilqees Bano
BACKGROUND: Protein kinases are the enzymes involved in phosphorylation of different proteins and leads to functional changes in those proteins. They are classified into the AGC (Protein kinase A/ Protein kinase G/ Protein kinase C) families of protein and Rho-associated kinase protein (ROCK) and belong to serine-threonine kinases family. The AGC family of kinases are involved in G-protein stimuli, muscle contraction, platelet biology and lipid signaling. On the other hand, ROCK regulates actin cytoskeleton which is involved in the development of stress fibres...
March 11, 2019: Current Pharmaceutical Design
https://read.qxmd.com/read/30857524/long-non-coding-rna-casc2-suppresses-pulmonary-artery-smooth-muscle-cell-proliferation-and-phenotypic-switch-in-hypoxia-induced-pulmonary-hypertension
#5
Junsong Gong, Zujun Chen, Yu Chen, Huanran Lv, Haisong Lu, Fuxia Yan, Lihuan Li, Weili Zhang, Jia Shi
BACKGROUND: In this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling. METHODS: The expression of lncRNAs or mRNAs was detected by qRT-PCR, and western blot analysis or immunochemistry was employed for detecting the protein expression. Cell number assay and EdU (5-ethynyl-2'-deoxyuridine) staining were performed to assess cell proliferation. Besides, flow cytometry and wound healing assay were employed for assessments of cell apoptosis and cell migration, respectively...
March 11, 2019: Respiratory Research
https://read.qxmd.com/read/30857304/anti-remodeling-effects-of-xanthohumol-fortified-beer-in-pulmonary-arterial-hypertension-mediated-by-erk-and-akt-inhibition
#6
Ana Filipa Silva, Gabriel Faria-Costa, Fábio Sousa-Nunes, Manuel Filipe Santos, Manuel João Ferreira-Pinto, Delfim Duarte, Ilda Rodrigues, João Tiago Guimarães, Adelino Leite-Moreira, Daniel Moreira-Gonçalves, Tiago Henriques-Coelho, Rita Negrão
Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Male Wistar rats with monocrotaline (MCT)-induced PAH (60 mg/kg) were allowed to drink either xanthohumol-fortified beer (MCT + FB) or 5...
March 9, 2019: Nutrients
https://read.qxmd.com/read/30856466/grape-seed-proanthocyanidin-inhibits-monocrotaline-induced-pulmonary-arterial-hypertension-via-attenuating-inflammation-in-vivo-and-in-vitro-studies
#7
Fangzheng Chen, Heng Wang, Jie Zhao, Junjie Yan, Hanyan Meng, Huilu Zhan, Luowei Chen, Linbo Yuan
Inflammation in pulmonary arterioles initiates and maintains pathological processes in pulmonary arterial hypertension (PAH), and inhibition of it attenuates PAH development. Grape seed proanthocyanidin (GSP) is believed to be effective in protecting vascular system via inhibiting inflammation, while its effect on pulmonary circulation remains inconclusive. In this study, we made observations in monocrotaline (MCT)-induced PAH rats and found decreases in mean pulmonary arterial pressure, pulmonary vessel resistance, right ventricular hypertrophy index, percentage of medial wall thickness, percentage of medial wall area, and lung weight of wet and dry tissue ratio after GSP administration in vivo...
February 10, 2019: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/30851272/death-associated-protein-kinase-3-deficiency-alleviates-vascular-calcification-via-ampk-mediated-inhibition-of-endoplasmic-reticulum-stress
#8
Ke-Xue Li, Qiong Du, Hui-Ping Wang, Hai-Jian Sun
Vascular calcification (VC) is a critical feature of chronic kidney disease (CKD), diabetes, hypertension, and atherosclerosis. Death-associated protein kinase 3 (DAPK3) is involved in vascular remodeling in hypertension. However, it remains to be clarified whether DAPK3 controls vascular smooth muscle cell (VSMC) phenotypic transition into an osteogenic cell phenotype, which is an important process for VC. In vivo VC was induced in rats by vitamin D3 and nicotine. VSMCs were incubated with calcifying media containing β-glycerophosphate and Ca2+ to induce VC in vitro...
March 6, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/30847510/key-inflammatory-pathways-underlying-vascular-remodeling-in-pulmonary-hypertension
#9
E M Berghausen, L Feik, M Zierden, M Vantler, S Rosenkranz
Independent of the underlying cause, pulmonary hypertension (PH) remains a devastating condition that is characterized by limited survival. Cumulating evidence indicates that in addition to a dysbalance of mediators regulating vascular tone and growth factors promoting vascular remodeling, failure to resolve inflammation and altered immune processes play a pivotal role in the development and progression of PH. Here, we highlight the role of key inflammatory pathways in the pathobiology of vascular remodeling and PH, and discuss potential therapeutic interventions that may halt disease progression or even reverse pulmonary vascular remodeling...
March 7, 2019: Herz
https://read.qxmd.com/read/30846225/preliminary-evidence-of-a-paternal-maternal-genetic-conflict-on-the-placenta-link-between-imprinting-disorder-and-multi-generational-hypertensive-disorders
#10
REVIEW
Katsuhiko Naruse, Taihei Tsunemi, Naoki Kawahara, Hiroshi Kobayashi
There has been great research progress on hypertensive disorders in pregnancy (HDP) in the last few decades. Failure of placentation, especially a lack of uterine spiral artery remodeling, is the main pathological finding of HDP. Currently, members of the vascular endothelial growth factor family are used as markers for the early prediction of onset of HDP. Epidemiologic research has also shown that HDP can have effects on the next generation infants, representing a Development Origins of Health and Disease-related disease...
February 23, 2019: Placenta
https://read.qxmd.com/read/30841544/regulation-of-smooth-muscle-cell-proliferation-by-nadph-oxidases-in-pulmonary-hypertension
#11
REVIEW
John C Huetsch, Karthik Suresh, Larissa A Shimoda
Hyperproliferation of pulmonary arterial smooth muscle cells is a key component of vascular remodeling in the setting of pulmonary hypertension (PH). Numerous studies have explored factors governing the changes in smooth muscle cell phenotype that lead to the increased wall thickness, and have identified various potential candidates. A role for reactive oxygen species (ROS) has been well documented in PH. ROS can be generated from a variety of sources, including mitochondria, uncoupled nitric oxide synthase, xanthine oxidase, and reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase...
March 5, 2019: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/30840486/time-course-of-decompensation-after-angiotensin-ii-and-high-salt-diet-in-balb-cj-mice-suggests-pulmonary-hypertension-induced-cardiorenal-syndrome
#12
Mediha Becirovic-Agic, Sofia Jönsson, Maria K Tveitarås, Trude Skogstrand, Tine Veronica Karlsen, Åsa Lidén, Sabine Leh, Madelene Ericsson, Stefan K Nilsson, Rolf K Reed, Michael Hultström
Genetic background of a mouse strain determines its susceptibility to disease. C57BL/6J and Balb/CJ are two widely used inbred mouse strains that we found react dramatically differently to angiotensin II and high-salt diet (AngII+Salt). Balb/CJ show increased mortality associated with anuria and edema formation while C57BL/6J develop arterial hypertension but do not decompensate and die. Clinical symptoms of heart failure in Balb/CJ mice gave the hypothesis that AngII+Salt impairs cardiac function and induces cardiac remodelling in male Balb/CJ, but not in male C57BL/6J mice...
March 6, 2019: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/30839510/2-methoxyestradiol-attenuates-angiotensin-ii-induced-hypertension-cardiovascular-remodeling-and-renal-injury
#13
Eman Salah, Sheldon I Bastacky, Edwin K Jackson, Stevan P Tofovic
Estradiol may antagonize the adverse cardiovascular effects of angiotensin II (Ang II). We investigated the effects of 2-methoxyestradiol (2-ME), a nonestrogenic estradiol metabolite, on Ang II-induced cardiovascular and renal injury in male rats. First, we determined the effects of 2-ME on Ang II-induced acute changes in blood pressure, renal hemodynamics, and excretory function. Next, we investigated the effects of 2-ME and 2-hydroxyestardiol (2-HE) on hypertension and cardiovascular and renal injury induced by chronic infusion of Ang II...
March 2019: Journal of Cardiovascular Pharmacology
https://read.qxmd.com/read/30826898/eplerenone-versus-spironolactone-in-resistant-hypertension-an-efficacy-and-or-cost-or-just-a-men-s-issue
#14
REVIEW
Antonis A Manolis, Theodora A Manolis, Helen Melita, Antonis S Manolis
PURPOSE OF REVIEW: To review comparative efficacy and tolerability data between the two main mineralocorticoid receptor antagonists (MRAs), spironolactone and eplerenone, in patients with resistant hypertension (HTN). The focus was whether spironolactone, being the classical non-selective agent that has been used for years, albeit with several anti-androgenic side effects, can be rivaled by eplerenone, an apparently weaker, but better tolerated, more selective MRA. RECENT FINDINGS: Evidence has accumulated that resistant HTN is generally volume-dependent, attributable to varying degrees of aldosterone excess with its attendant renal effects of sodium and fluid retention...
March 2, 2019: Current Hypertension Reports
https://read.qxmd.com/read/30825543/impact-of-moderate-and-high-intensity-exercise-on-the-endothelial-ultrastructure-and-function-in-mesenteric-arteries-from-hypertensive-rats
#15
Fang Ye, Ying Wu, Yu Chen, Daliao Xiao, Lijun Shi
Oxidative stress (OS) influences vascular function and structure in spontaneously hypertensive rats (SHRs). It is also responsible for the decreased nitric oxide (NO) bioavailability that influences endothelial vasodilation. The effects of high-intensity exercise on endothelial function and ultrastructure in hypertension remain unknown. Thus, this study investigated the effects of moderate- and high-intensity exercise on hypertension-associated endothelial dysfunction and ultrastructural remodeling. Moderate-intensity (SHR-M) and high-intensity (SHRH) aerobic exercise training groups were compared in age-matched sedentary SHRs (SHRC) and normotensive Wistar-Kyoto rats (WKY-C)...
February 27, 2019: Life Sciences
https://read.qxmd.com/read/30822814/magnesium-lithospermate-b-derived-from-salvia-miltiorrhiza-ameliorates-right-ventricle-remodeling-in-pulmonary-hypertensive-rats-via-inhibition-of-nox-vpo1-pathway
#16
Tao Li, Jing-Jie Peng, E-Li Wang, Nian-Sheng Li, Feng-Lin Song, Jin-Fu Yang, Xiu-Ju Luo, Bin Liu, Jun Peng
Right ventricle (RV) remodeling is a major pathological feature in pulmonary arterial hypertension (PAH). Magnesium lithospermate B (MLB) is a compound isolated from the roots of Salvia miltiorrhiza and it possesses multiple pharmacological activities such as anti-inflammation and antioxidation. This study aims to investigate whether MLB is able to prevent RV remodeling in PAH and the underlying mechanisms. In vivo , SD rats were exposed to 10% O2 for 21 d to induce RV remodeling, which showed hypertrophic features (increases in the ratio of RV weight to tibia length, cellular size, and hypertrophic marker expression), accompanied by upregulation in expression of NADPH oxidases (NOX2 and NOX4) and vascular peroxidase 1 (VPO1), increases in hydrogen peroxide (H2 O2 ) and hypochlorous acid (HOCl) production and elevation in phosphorylation levels of ERK; these changes were attenuated by treating rats with MLB...
March 1, 2019: Planta Medica
https://read.qxmd.com/read/30822118/differences-in-pulmonary-arterial-flow-hemodynamics-between-children-and-adults-with-pulmonary-arterial-hypertension-as-assessed-by-4d-flow-cmr-studies
#17
Michal Schäfer, D Dunbar Ivy, Steven H Abman, Kurt R Stenmark, Lorna Browne, Alex J Barker, Max B Mitchell, Gareth J Morgan, Neil Wilson, Anar Shah, Madhukar Kollengode, Nivedita Naresh, Brian Fonseca, Michael DiMaria, J Kern Buckner, Kendall S Hunter, Vitaly Oleg Kheyfets, Brett E Fenster, Uyen Truong
Despite different developmental and pathologic processes affecting lung vascular remodeling in both patient populations, differences in 4D-MRI findings between children and adults with PAH have not been studied. The purpose of this study was to compare flow hemodynamic state, including flow-mediated shear forces, between pediatric and adult patients with PAH matched by severity of pulmonary vascular resistance index (PVRi). Adults (n=10) and children (n=10) with PAH matched by pulmonary vascular resistance index (PVRi), and healthy adult (n=10) and pediatric (n=10) subjects underwent comprehensive 4D-Flow MRI to assess peak systolic wall shear stress (WSSmax ) measured in the main, right, and left pulmonary arteries (MPA, RPA, and LPA), viscous energy loss ( EL ) along the MPA-RPA and MPA-LPA tract, and qualitative analysis of secondary flow hemodynamics...
March 1, 2019: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/30817168/pfkfb3-in-smooth-muscle-promotes-vascular-remodeling-in-pulmonary-arterial-hypertension
#18
Laszlo Kovacs, Yapeng Cao, Weihong Han, Louise Meadows, Anita Kovacs-Kasa, Dmitry Kondrikov, Alexander D Verin, Scott A Barman, Zheng Dong, Yuqing Huo, Yunchao Su
RATIONALE: Glycolytic shift is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). It remains unknown how glycolysis is increased and how increased glycolysis contributes to pulmonary vascular remodeling in PAH. OBJECTIVES: To determine whether increased glycolysis is caused by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) and how PFKFB3-driven glycolysis induces vascular remodeling in PAH. METHODS: PFKFB3 levels were measured in pulmonary arteries of PAH patients and animals...
February 28, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30816802/transthoracic-pulmonary-artery-denervation-for-pulmonary-arterial-hypertension
#19
Yuan Huang, Yi-Wei Liu, Hai-Zhou Pan, Xiao-Ling Zhang, Jun Li, Li Xiang, Jian Meng, Pei-He Wang, Jun Yang, Zhi-Cheng Jing, Hao Zhang
Objective- Pulmonary arterial hypertension is characterized by progressive pulmonary vascular remodeling and persistently elevated mean pulmonary artery pressures and pulmonary vascular resistance. We aimed to investigate whether transthoracic pulmonary artery denervation (TPADN) attenuated pulmonary artery (PA) remodeling, improved right ventricular (RV) function, and affected underlying mechanisms. We also explored the distributions of sympathetic nerves (SNs) around human PAs for clinical translation. Approach and Results- We identified numerous SNs in adipose and connective tissues around the main PA trunks and bifurcations in male Sprague Dawley rats, which were verified in samples from human heart transplant patients...
February 28, 2019: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/30813929/pulmonary-arterial-remodelling-by-deficiency-of-peroxisome-proliferator-activated-receptor-%C3%AE-in-murine-vascular-smooth-muscle-cells-occurs-independently-of-obesity-related-pulmonary-hypertension
#20
Evren Caglayan, Manuela Trappiel, Arnica Behringer, Eva Maria Berghausen, Margarete Odenthal, Ernst Wellnhofer, Kai Kappert
BACKGROUND: Obesity is associated with cardiovascular complications, including pulmonary hypertension (PH). Reports suggest that peroxisome proliferator-activated receptor-γ (PPARγ) has direct action in preventing vascular remodelling in PH. Here we dissected the specific role of high-fat-diet (HFD)-induced obesity and vascular smooth muscle cell (VSMC)-PPARγ for remodelling of small pulmonary arteries. METHODS: Wild-type (WT) and VSMC-specific PPARγ-knockout (SmPparγ-/- ) mice were fed a low-fat-diet (LFD, 10% kcal from fat) or HFD (60% kcal from fat) for 24 weeks...
February 27, 2019: Respiratory Research
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