keyword
https://read.qxmd.com/read/38442672/phytochemicals-targeting-alzheimer-s-disease-via-the-amp-activated-protein-kinase-pathway-effects-and-mechanisms-of-action
#21
REVIEW
Zheng Zhao, Jun Yan, Lei Huang, Xue Yang
Alzheimer's disease (AD), characterized by cognitive dysfunction and other behavioral abnormalities, is a progressive neurodegenerative disease that occurs due to aging. Currently, effective drugs to mitigate or treat AD remain unavailable. AD is associated with several abnormalities in neuronal energy metabolism, such as decreased glucose uptake, mitochondrial dysfunction, and defects in cholesterol metabolism. Amp-activated protein kinase (AMPK) is an important serine/threonine protein kinase that regulates the energy status of cells...
March 4, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38441836/a-comprehensive-model-for-the-biochemistry-of-ageing-senescence-and-longevity
#22
REVIEW
Hiskias Gerrit Keizer, R Brands, Ronald Sake Oosting, Willem Seinen
Various models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and non-coherent portrayal of ageing. Here, we describe a concise and comprehensive model for the biochemistry of ageing consisting of three interacting signalling hubs. These are the nuclear factor kappa B complex (NFκB), controlling the innate immune system, the mammalian target for rapamycin complex, controlling cell growth, and the integrated stress responses, controlling homeostasis...
March 5, 2024: Biogerontology
https://read.qxmd.com/read/38441777/long-term-intake-of-sulforaphene-alleviates-d-galactose-induced-skin-senescence-by-activating-ampk-sirt-1-pathway
#23
JOURNAL ARTICLE
Bo Zhang, Pengtao Liu, Huakang Sheng, Yongzhi Han, Qipeng Yuan
D-Galactose (D-gal) accumulation triggers the generation of oxygen free radicals, resulting in skin aging. Sulforaphene (SFE), an isothiocyanate compound derived from radish seeds, possesses diverse biological activities, including protective effects against inflammation and oxidative damage. This investigation delves into the antioxidant impact of SFE on age-related skin injury. In vivo experiments demonstrate that SFE treatment significantly improves the macro- and micro-morphology of dorsal skin. It effectively diminishes the elevation of oxidative stress biomarkers in mice skin tissue treated with D-gal, concurrently enhancing the activity of antioxidant enzymes...
March 5, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38439187/dihydroartemisinin-eliminates-senescent-cells-by-promoting-autophagy-dependent-ferroptosis-via-ampk-mtor-signaling-pathway
#24
JOURNAL ARTICLE
Xing Wan, Can Li, Yue Hao Tan, Shi Qi Zuo, Feng Mei Deng, Jing Sun, Yi Lun Liu
Cellular senescence is an irreversible cell-cycle arrest in response to a variety of cellular stresses, which contribute to the pathogenesis of a variety of age-related degenerative diseases. However, effective antisenescence strategies are still lacking. Drugs that selectively target senescent cells represent an intriguing therapeutic strategy to delay aging and age-related diseases. Thus, we thought to investigate the effects of dihydroartemisinin (DHA) on senescent cells and elucidated its mechanisms underlying aging...
March 4, 2024: Cell Biology International
https://read.qxmd.com/read/38435399/enriched-oxygen-improves-age-related-cognitive-impairment-through-enhancing-autophagy
#25
JOURNAL ARTICLE
Shengyuan Wang, Bengang Chen, Minghao Yuan, Shu Liu, Haixia Fan, Xu Yang, Qian Zou, Yinshuang Pu, Zhiyou Cai
Age-related cognitive impairment represents a significant health concern, with the understanding of its underlying mechanisms and potential interventions being of paramount importance. This study aimed to investigate the effects of hyperbaric oxygen therapy (HBOT) on cognitive function and neuronal integrity in aged (22-month-old) C57BL/6 mice. Male mice were exposed to HBOT for 2 weeks, and spatial learning and memory abilities were assessed using the Morris water maze. We employed transcriptome sequencing and Gene Ontology (GO) term enrichment analysis to examine the effects of HBOT on gene expression profiles, with particular attention given to synapse-related genes...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38409646/longevity-and-anti-aging-effects-of-curcumin-supplementation
#26
REVIEW
Mehran Izadi, Nariman Sadri, Amirhossein Abdi, Mohammad Mahdi Raeis Zadeh, Dorsa Jalaei, Mohammad Mahdi Ghazimoradi, Sara Shouri, Safa Tahmasebi
Aging is a gradual and irreversible process that is accompanied by an overall decline in cellular function and a significant increase in the risk of age-associated disorders. Generally, delaying aging is a more effective method than treating diseases associated with aging. Currently, researchers are focused on natural compounds and their therapeutic and health benefits. Curcumin is the main active substance that is present in turmeric, a spice that is made up of the roots and rhizomes of the Curcuma longa plant...
February 27, 2024: GeroScience
https://read.qxmd.com/read/38403802/the-sglt2-inhibitor-empagliflozin-inhibits-skeletal-muscle-fibrosis-in-naturally-aging-male%C3%A2-mice-through-the-ampk%C3%AE-mmp9-tgf-%C3%AE-1-smad-pathway
#27
JOURNAL ARTICLE
Qixuan Huang, Jie Chen, Siqi Liao, Jiangchuan Long, Ronghua Fang, Yusen He, Peiyun Chen, Dongfang Liu
With advancing age, the incidence of sarcopenia increases, eventually leading to a cascade of adverse events. However, there is currently a lack of effective pharmacological treatment for sarcopenia. Sodium-glucose co-transporter 2 inhibitor (SGLT2i) empagliflozin demonstrates anti-fibrotic capabilities in various organs. This study aims to determine whether empagliflozin can improve skeletal muscle fibrosis induced by sarcopenia in naturally aging mice. A natural aging model was established by feeding male mice from 13 months of age to 19 months of age...
February 26, 2024: Biogerontology
https://read.qxmd.com/read/38397781/bone-marrow-mesenchymal-stem-cell-derived-exosomes-ameliorate-aging-induced-btb-impairment-in-porcine-testes-by-activating-autophagy-and-inhibiting-ros-nlrp3-inflammasomes-via-the-ampk-mtor-signaling-pathway
#28
JOURNAL ARTICLE
Yi Zhou, Jiale Yan, Limin Qiao, Jiaqin Zeng, Fuyu Cao, Xihui Sheng, Xiaolong Qi, Cheng Long, Bingying Liu, Xiangguo Wang, Hua Yao, Longfei Xiao
As a pivotal player in spermatogenesis, the blood-testis barrier (BTB) made from junction apparatus coexisting in Sertoli cells (SCs) is impaired with an increase in age and ultimately induces spermatogenic dysfunction or even infertility. It has been corroborated that bone marrow mesenchymal stem cell (BMSC) transplantation can efficiently repair and regenerate the testicular function. As vital mediators of cell-to-cell communication, MSC-derived exosomes (Exos) can directly serve as therapeutic agents for tissue repair and regeneration...
January 31, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38396729/mitochondrial-quantity-and-quality-in-age-related-sarcopenia
#29
REVIEW
Emanuele Marzetti, Riccardo Calvani, Hélio José Coelho-Júnior, Francesco Landi, Anna Picca
Sarcopenia, the age-associated decline in skeletal muscle mass and strength, is a condition with a complex pathophysiology. Among the factors underlying the development of sarcopenia are the progressive demise of motor neurons, the transition from fast to slow myosin isoform (type II to type I fiber switch), and the decrease in satellite cell number and function. Mitochondrial dysfunction has been indicated as a key contributor to skeletal myocyte decline and loss of physical performance with aging. Several systems have been implicated in the regulation of muscle plasticity and trophism such as the fine-tuned and complex regulation between the stimulator of protein synthesis, mechanistic target of rapamycin (mTOR), and the inhibitor of mTOR, AMP-activated protein kinase (AMPK), that promotes muscle catabolism...
February 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38394540/time-series-analysis-of-hematopoietic-stem-cells
#30
JOURNAL ARTICLE
Jingjing Han, Shuangshuang Duan, Ya Li, Chunlei Xin
This study aimed to investigate the molecular mechanisms underlying the aging of hematopoietic stem cells (HSCs). Gene expression profile GSE32719 was downloaded from the Gene Expression Omnibus database, including 14 young, 5 middle, and 8 old HSCs. Differential expression analysis, short time-series expression miner analysis, and weighted co-expression network analysis were conducted to screen for hub genes whose expression changed over time during HSC aging. Subsequently, functional enrichment and multiple regulatory network analyses of the hub genes were performed...
February 23, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38385186/postabsorptive-and-postprandial-myofibrillar-protein-synthesis-rates-at-rest-and-after-resistance-exercise-in-women-with-post-menopause
#31
JOURNAL ARTICLE
Colleen F McKenna, Andrew T Askow, Kevin J M Paulussen, Amadeo F Salvador, Hsin-Yu Fang, Alexander V Ulanov, Zhong Li, Scott A Paluska, Joseph W Beals, Ralf Jäger, Martin Purpura, Nicholas A Burd
Feeding and resistance exercise stimulate myofibrillar protein synthesis rates (MPS) in healthy adults. This anabolic characterization of 'healthy adults' has been namely focused on males. Therefore, the purpose of this study was to examine the temporal responses of MPS and anabolic signaling to resistance exercise alone or combined with the ingestion of protein in post-menopausal females and compare postabsorptive rates with young females. Sixteen females (60 ± 7 y; BMI = 26 ± 12 kg·m-2 ) completed an acute bout of unilateral resistance exercise before consuming either: a fortified whey protein supplement (WHEY) or water...
February 22, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38377006/acute-resistance-exercise-modifies-extracellular-vesicle-mirnas-targeting-anabolic-gene-pathways-a-prospective-cohort-study
#32
JOURNAL ARTICLE
William R Conkright, Chris K Kargl, Monica J Hubal, Dakota R Tiede, Meaghan E Beckner, Adam J Sterczala, Kellen T Krajewski, Brian J Martin, Shawn D Flanagan, Julie P Greeves, Thomas J O'Leary, Sophie L Wardle, Amrita Sahu, Fabrisia Ambrosio, Bradley C Nindl
BACKGROUND: Resistance training confers numerous health benefits that are mediated in part by circulating factors. Towards an enhanced molecular understanding, there is growing interest in a class of signaling biomarkers called extracellular vesicles (EVs). Extracellular vesicles support physiological adaptations to exercise by transporting their cargo (e.g., microRNA [miRNA]) to target cells. Previous studies of changes in EV cargo have focused on aerobic exercise, with limited data examining the effects of resistance exercise...
February 12, 2024: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/38376276/integrated-bioinformatics-approach-to-unwind-key-genes-and-pathways-involved-in-colorectal-cancer
#33
JOURNAL ARTICLE
Syeda Anjum Mobeen, Pallavi Saxena, Arun Kumar Jain, Ravi Deval, Khateef Riazunnisa, Dibyabhaba Pradhan
BACKGROUND: Colorectal cancer (CRC) is the fifth leading cause of death in India. Until now, the exact pathogenesis concerning CRC signaling pathways is largely unknown; however, the diseased condition is believed to deteriorate with lifestyle, aging, and inherited genetic disorders. Hence, the identification of hub genes and therapeutic targets is of great importance for disease monitoring. OBJECTIVE: Identification of hub genes and targets for identification of candidate hub genes for CRC diagnosis and monitoring...
October 1, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38365048/progranulin-promotes-regulatory-t-cells-plasticity-by-mitochondrial-metabolism-through-ampk-pgc-1%C3%AE-pathway-in-ards
#34
JOURNAL ARTICLE
Yanqing Chen, Minkang Guo, Ke Xie, Ming Lei, Yusen Chai, Zhengtao Zhang, Zhenhua Deng, Qiaozhi Peng, Ju Cao, Shihui Lin, Fang Xu
As the aging population increases, the focus on elderly patients with acute respiratory distress syndrome (ARDS) is also increasing. In this article, we found progranulin (PGRN) differential expression in ARDS patients and healthy controls, even in young and old ARDS patients. Its expression strongly correlates with several cytokines in both young and elderly ARDS patients. PGRN has comparable therapeutic effects in young and elderly mice with lipopolysaccharide-induced acute lung injury, manifesting as lung injury, apoptosis, inflammation, and regulatory T cells (Tregs) differentiation...
February 14, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38364258/liraglutide-improves-sevoflurane-induced-postoperative-cognitive-dysfunction-via-activating-autophagy-and-inhibiting-apoptosis
#35
JOURNAL ARTICLE
Ying Hu, Haijin Huang, Yao Jiang, Jingling Zhang, Yang Zhang, Ying Tian, Qin Zhang
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly patients. Liraglutide (LRG) has high homology (97%) with natural glucagon like peptide-1, and it has been proved to be effective in some nervous system diseases. Whether LRG could regulate POCD has not been reported. METHODS: Sevoflurane (Sev) was used to simulate postoperative cognitive dysfunction (POCD) model. Morris water maze test was performed to evaluate the memory ability and neurological function of rats...
February 15, 2024: Aging
https://read.qxmd.com/read/38360276/sorafenib-extends-the-lifespan-of-c-elegans-through-mitochondrial-uncoupling-mechanism
#36
JOURNAL ARTICLE
Lu-Yao Zheng, Yan-Xin Da, Xiu Luo, Xiao Zhang, Zhi-Jie Sun, De-Li Dong
Sorafenib is a targeted anticancer drug in clinic. Low-dose sorafenib has been reported to activate AMPK through inducing mitochondrial uncoupling without detectable toxicities. AMPK activation has been the approach for extending lifespan, therefore, we investigated the effect of sorafenib on lifespan and physical activity of C. elegans and the underlying mechanisms. In the present study, we found that the effect of sorafenib on C. elegans lifespan was typically hermetic. Sorafenib treatment at higher concentrations (100 μM) was toxic but at lower concentrations (1, 2...
February 13, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38359339/evaluation-and-normalization-of-a-set-of-reliable-reference-genes-for-quantitative-sgk-1-gene-expression-analysis-in-caenorhabditis-elegans-focused-cancer-research
#37
JOURNAL ARTICLE
Özgür Ülkü Özdemir, Kübra Yurt, Ayşe Nur Pektaş, Şeyda Berk
Multiple signaling pathways have been discovered to play a role in aging and longevity, including the insulin/IGF-1 signaling system, AMPK pathway, TOR signaling, JNK pathway, and germline signaling. Mammalian serum and glucocorticoid-inducible kinase 1 ( sgk-1 ), which has been associated with various disorders including hypertension, obesity, and tumor growth, limits survival in C. elegans by reducing DAF-16/FoxO activity while suppressing FoxO3 activity in human cell culture. C. elegans provides significant protection for a number of genes associated with human cancer...
February 15, 2024: Nucleosides, Nucleotides & Nucleic Acids
https://read.qxmd.com/read/38348888/metformin-rejuvenates-nap1l2-impaired-immunomodulation-of-bone-marrow-mesenchymal-stem-cells-via-metabolic-reprogramming
#38
JOURNAL ARTICLE
Fan Liu, Ruohui Han, Shaochen Nie, Yuxin Cao, Xinming Zhang, Feng Gao, Zhengyang Wang, Liangyu Xing, Zhaoguang Ouyang, Lei Sui, Wenyi Mi, Xudong Wu, Lu Sun, Meilin Hu, Dayong Liu
Ageing and cell senescence of mesenchymal stem cells (MSCs) limited their immunomodulation properties and therapeutic application. We previously reported that nucleosome assembly protein 1-like 2 (Nap1l2) contributes to MSCs senescence and osteogenic differentiation. Here, we sought to evaluate whether Nap1l2 impairs the immunomodulatory properties of MSCs and find a way to rescue the deficient properties. We demonstrated that metformin could rescue the impaired migration properties and T cell regulation properties of OE-Nap1l2 BMSCs...
February 13, 2024: Cell Proliferation
https://read.qxmd.com/read/38346909/ampk-alchemy-therapeutic-potentials-in-allergy-aging-and-cancer
#39
JOURNAL ARTICLE
Ram Hari Pokhrel, Suman Acharya, Sunil Mishra, Ye Gu, Umar Manzoor, Jeon-Kyung Kim, Youngjun Park, Jae-Hoon Chang
All cells are equipped with intricate signaling networks to meet the energy demands and respond to the nutrient availability in the body. AMP-activated protein kinase (AMPK) is among the most potent regulators of cellular energy balance. Under ATP -deprived conditions, AMPK phosphorylates substrates, affect various biological processes, such as lipid/glucose metabolism and protein synthesis. These actions further affect the cell growth, death, and functions, altering the cellular outcomes in energy-restricted environments...
February 13, 2024: Biomolecules & Therapeutics
https://read.qxmd.com/read/38324260/effect-of-resveratrol-on-insulin-action-in-primary-myotubes-from-lean-and-individuals-with-severe-obesity
#40
JOURNAL ARTICLE
Sanghee Park, Filip Jevtovic, Polina M Krassovskaia, Alec B Chaves, Donghai Zheng, Jonas T Treebak, Joseph A Houmard
Background. Resveratrol (RSV), a natural polyphenol compound contained in numerous plants, has been proposed as a treatment for obesity-related disease processes such as insulin resistance. However, in humans there are conflicting results concerning the efficacy of RSV in improving insulin action; the purpose of the present study was to determine if obesity status (lean, severely obese) affects the response to RSV in human skeletal muscle. Methods. Primary skeletal muscle cells were derived from biopsies obtained from age-matched lean and insulin-resistant women with severe obesity and incubated with RSV (1µM) for 24-hours...
February 7, 2024: American Journal of Physiology. Endocrinology and Metabolism
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