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Lymphedema cancer

M Simon, S Vignes
INTRODUCTION: In France, breast cancer is the most frequent cancer in women. Lymphedema, the main complication, is poorly known. The objective of this study was to assess the state of knowledge of upper limb lymphedema (risk factors, complications, treatment) after treatment of breast cancer among general practitioners from the Haute-Normandie and Île-de-France regions. MATERIALS AND METHODS: A cross-sectional study with 23 closed questions was sent by email to 490 practicing doctors...
February 2019: Journal de Médecine Vasculaire
(no author information available yet)
New England Journal of Medicine, Volume 380, Issue 7, Page 694-694, February 2019.
February 14, 2019: New England Journal of Medicine
Yinan Yuan, Valeria Arcucci, Sidney M Levy, Marc G Achen
The debilitating condition known as secondary lymphedema frequently occurs after lymphadenectomy and/or radiotherapy for the treatment of cancer. These therapies can damage lymphatic vessels leading to edema, fibrosis, inflammation and dysregulated adipogenesis, which result in profound swelling of an affected limb. Importantly, lymphedema patients often exhibit impaired immune function which predisposes them to a variety of infections. It is known that lymphadenectomy can compromise the acquisition of adaptive immune responses and antibody production; however the cellular mechanisms involved are poorly understood...
2019: Frontiers in Immunology
Tessa De Vrieze, Lore Vos, Nick Gebruers, An De Groef, Lore Dams, Elien Van der Gucht, Ines Nevelsteen, Nele Devoogdt
BACKGROUND: Lymphedema is associated with significant physical and psychosocial problems. The Lymphedema Functioning, Disability and Health questionnaire for upper limb lymphedema is a valid and reliable tool quantifying the amount of problems in functioning in patients with breast cancer-related lymphedema. Patients suggested a revision of the scoring system to facilitate completion of the questionnaire. Therefore, adjustment of the questionnaire was carried out by implementing a numeric rating scale instead of the existing visual analog scale...
February 13, 2019: Lymphatic Research and Biology
Onur Engin, Elif Akalın, Efe Sarıbay, Ceren Aslan, Ebru Şahin, Serap Alper
Aim and Hypothesis: The standard volumeter is heavy and fragile, and using the same volumeter for different patients can result in hygiene problems. These disadvantages point to the need for the development of a new model of volumeter. The new volumeter put forward in this study is lighter, smaller, sturdier, and easier to clean, while also having its own scale. In this study, the validity of this newly designed volumeter is investigated. MATERIALS AND METHODS: In the first step, the volume of standard cylinders was measured thrice using a standard volumeter and an easy-measurement volumeter, after which a total of 30 arm volumes of 15 volunteers were measured...
February 8, 2019: Lymphatic Research and Biology
Lavinia Volpi, Giulio Sozzi, Vito Andrea Capozzi, Matteo Ricco', Carla Merisio, Maurizio Di Serio, Vito Chiantera, Roberto Berretta
OBJECTIVE: To determine the incidence of long term lymphadenectomy complications in primary surgery for endometrial cancer and to elucidate risk factors for these complications. METHODS: A retrospective chart review was carried out for all patients with endometrial cancer managed at Parma University Hospital Unit of Gynecology and Obstetrics between 2010 and 2016. Inclusion criteria were surgical procedure including hysterectomy and lymphadenectomy (pelvic or pelvic and aortic)...
February 2019: International Journal of Gynecological Cancer
M B Ligabue, I Campanini, P Veroni, A Cepelli, M Lusuardi, A Merlo
PURPOSE: After surgery, breast cancer-related lymphedema (BCRL) is a frequent chronic condition. The complex decongestive therapy (CDT) delivered by physiotherapists at hospitals is the state-of-the-art treatment choice. As lymphedema requires continuous management, we designed a 1-month-long course to train women to professionally carry out a self-administered CDT (saCDT) and tested its efficacy while keeping the benefits of CDT. METHODS: Consecutive patients treated with CDT over a 1-year period at an Italian facility were randomly assigned to either experimental (EXP, saCDT course) or control (CTRL, usual care) group...
February 2, 2019: Breast Cancer Research and Treatment
Gunn Ammitzbøll, Trille Kristina Kjær, Christoffer Johansen, Charlotte Lanng, Elisabeth Wreford Andersen, Niels Kroman, Bo Zerahn, Ole Hyldegaard, Pernille Envold Bidstrup, Susanne Oksbjerg Dalton
AIMS: To examine the effect of progressive resistance training (PRT) on health related quality of life and a predefined symptom cluster of pain-sleep-fatigue. METHODS: This study was a planned secondary analysis of a randomized controlled trial examining the effect of PRT on prevention of arm lymphedema in a population of women between 18 and 75 years undergoing breast cancer surgery with axillary lymph node dissection. Participants were allocated by computer randomization to usual care control or a PRT intervention in a 1:1 ratio...
January 31, 2019: Acta Oncologica
Iris M Lu, J Brandon Dixon
BACKGROUND: There are various methods of detecting and monitoring arm lymphedema after breast cancer (BC) treatment. Using volumetric measurements is the most common method performed clinically in the United States, and several techniques exist. Recently, the use of infrared cameras has been explored by several groups. This study shows the use of this technology and its ability to assess arm volume measurements comparable to the Perometer while being more inexpensive, having a smaller footprint in clinics, and being easy to use...
January 29, 2019: Lymphatic Research and Biology
Carolina Gutierrez, Ron J Karni, Syed Naqvi, Melissa B Aldrich, Banghe Zhu, J Rodney Morrow, Eva M Sevick-Muraca, John C Rasmussen
Ten head and neck cancer survivors diagnosed with head and neck lymphedema (HNL) were imaged using near-infrared fluorescence lymphatic imaging (NIRFLI) prior to and immediately after an initial advance pneumatic compression device treatment and again after 2 weeks of daily at-home use. Images assessed the impact of pneumatic compression therapy on lymphatic drainage. Facial composite measurement scores assessed reduction/increase in external swelling, and survey results were obtained. After a single pneumatic compression treatment, NIRFLI showed enhanced lymphatic uptake and drainage in all subjects...
January 29, 2019: Otolaryngology—Head and Neck Surgery
Hin-Lun Liu, Joseph Chun-Kit Chung
INTRODUCTION: Vascularized lymph node transfer (VLNT) has become the established treatment for secondary lymphedema. The proposed mechanisms of VLNT include lymphangiogenesis and absorptive action of transplanted lymphatic tissue. Therefore, in theory, the lymph node content of lymph node flap is crucial to clinical response. The supraclavicular lymph node flap (SCLNF) has been described as one of the flap options for VLNT. However, its lymph node content has not been fully studied. The aim of this study is to find out the lymph node content of SCLNF with histological examination...
January 29, 2019: Lymphatic Research and Biology
Elizabeth Lokich
Survivorship care includes surveillance and prevention of cancer recurrence, addressing side effects of cancer and cancer treatment and coordination of follow-up care. This article reviews guidelines for surveillance of women with ovarian, endometrial, cervical, and vulvar cancer. It also reviews many of the long-term physical side effects of gynecologic cancer treatment including fatigue, neuropathy, lymphedema, cognitive dysfunction, sexual health concerns, menopausal symptoms, infertility, and economic stressors...
March 2019: Obstetrics and Gynecology Clinics of North America
Marco Invernizzi, Anna Michelotti, Marianna Noale, Gianluca Lopez, Letterio Runza, Massimo Giroda, Luca Despini, Concetta Blundo, Stefania Maggi, Donatella Gambini, Nicola Fusco
Breast cancer related lymphedema (BCRL) is frequent but strategies for an individualized risk assessment are lacking. We aimed to define whether tumor-specific pathological features, coupled with clinical and therapeutic data, could help identify patients at risk. Data from 368 patients with node-positive breast cancers were retrospectively collected, including 75 patients with BCRL (0.4⁻25.6 years follow-up). BCRL was assessed during the standard follow-up oncology visits using the circumferential measurement...
January 24, 2019: Journal of Clinical Medicine
Kwan Sik Seo, Minseok Suh, Sunmok Hong, Gi Jeong Cheon, Shi-Uk Lee, Gwang Pyo Jung
OBJECTIVES: Lymphedema is a chronic disease that occurs frequently after breast cancer treatment. For the treatment of lymphedema, surgical approach such as vascularized lymph node transfer and super-microscopic lymphovenous anastomosis surgery is well established. Complex decongestive therapy (CDT) and sympathetic ganglion block (SGB) are two non-surgical therapeutic options. This study aimed to evaluate the effectiveness of lymphoscintigraphy in guiding the selection of the optimal non-surgical treatment in lymphedema...
January 18, 2019: Clinical Nuclear Medicine
Lavinia Volpi, Giulio Sozzi, Vito Andrea Capozzi, Matteo Ricco', Carla Merisio, Maurizio Di Serio, Vito Chiantera, Roberto Berretta
OBJECTIVE: To determine the incidence of long term lymphadenectomy complications in primary surgery for endometrial cancer and to elucidate risk factors for these complications. METHODS: A retrospective chart review was carried out for all patients with endometrial cancer managed at Parma University Hospital Unit of Gynecology and Obstetrics between 2010 and 2016. Inclusion criteria were surgical procedure including hysterectomy and lymphadenectomy (pelvic or pelvic and aortic)...
January 18, 2019: International Journal of Gynecological Cancer
Olivia A Ho, Chia-Yu Lin, Marco Pappalardo, Ming-Huei Cheng
Background: The vascularized groin and submental lymph node (VGLN and VSLN) flaps are valuable options in the treatment of lymphedema. This study was to compare outcomes between VGLN and VSLN transfers for breast cancer-related lymphedema. Methods: Between January 2008 and December 2016, VGLN and VSLN transfers for upper limb lymphedema were compared including flap characteristics, flap elevation time, complications, and limb circumference changes. Results: All flaps survived...
December 2018: Plastic and Reconstructive Surgery. Global Open
Takumi Yamamoto
Supermicrosurgery is sophisticated microsurgical technique, which allows dissection and anastomosis of blood/lymphatic vessels and nerves with external diameter of 0.5 mm or smaller. With increasing attention to quality of life of cancer survivors, less invasive and functionally-better oncological reconstruction using supermicrosurgical techniques is warranted. Unlike conventional free flap reconstruction, supermicrosurgical free flaps can be elevated from anywhere using innominate vessels with diameter of 0...
January 9, 2019: European Journal of Surgical Oncology
David Cibula, J Dusek, J Jarkovsky, P Dundr, D Querleu, A van der Zee, A Kucukmetin, R Kocian
OBJECTIVE: Sentinel lymph node (SLN) biopsy has been increasingly used in the management of early-stage cervical cancer. It appears in guidelines as an alternative option to systematic pelvic lymphadenectomy. The evidence about safety is, however, based mostly on retrospective studies, in which SLN was combined with systematic lymphadenectomy. MATERIALS AND METHODS: SENTIX is a prospective multicenter trial aiming to prove that less-radical surgery with SLN is non-inferior to treatment with systematic pelvic lymphadenectomy...
January 2019: International Journal of Gynecological Cancer
Sahar Salehi, Elisabeth Åvall-Lundqvist, Yvonne Brandberg, Hemming Johansson, Chikako Suzuki, Henrik Falconer
BACKGROUND AND OBJECTIVES: In the Robot Assisted Surgery for High Risk Endometrial Cancer (RASHEC) trial, patients with high-risk endometrial cancer were randomly assigned to robot-assisted laparoscopic surgery (RALS) or laparotomy for pelvic and infrarenal para-aortic lymph node dissection. We here report on self-reported lower limb lymphedema (LLL), lymphocyst formation, ascites, and long-term serious adverse events 12 months after surgery. PATIENTS AND METHODS: Patients were enrolled between 2013 and 2016, and 96 patients were included in the per protocol analysis, evenly distributed between RALS and laparotomy...
January 2019: International Journal of Gynecological Cancer
Bayu Brahma, Takumi Yamamoto
Breast cancer is the most common cancer in Dharmais hospital. The treatment can give rise to breast cancer treatment-related lymphedema (BCRL) that will cause significant morbidities. Based on author's (BB) patient series in Dharmais hospital, BCRL occurred in 27.7% after axillary lymph nodes dissection (ALND). The development of diagnostic modalities as well as lymphatic microsurgery have become promising instruments for lymphedema treatment. To date, modern approach of lymphedema care and surgical intervention have not been recognized and established in Indonesia...
January 4, 2019: European Journal of Surgical Oncology
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