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https://read.qxmd.com/read/30777406/therapeutic-potential-of-phosphodiesterase-type-5-inhibitors-in-heart-failure-with-preserved-ejection-fraction-and-combined-post-and-pre-capillary-pulmonary-hypertension
#1
Tilmann Kramer, Daniel Dumitrescu, Felix Gerhardt, Kristina Orlova, Henrik Ten Freyhaus, Martin Hellmich, Stephan Baldus, Stephan Rosenkranz
OBJECTIVE: Heart failure with preserved ejection fraction (HFpEF) is frequently associated with pulmonary hypertension (PH), which substantially impacts survival. Based on pulmonary vascular resistance (PVR) and the diastolic pressure gradient (DPG), current guidelines distinguish between isolated post-capillary PH (IpcPH) and combined post- and pre-capillary PH (CpcPH). However, the therapeutic consequences of this sub-classification remain entirely unclear. We specifically investigated the efficacy and safety of PDE5i in patients with HFpEF and CpcPH...
January 4, 2019: International Journal of Cardiology
https://read.qxmd.com/read/30776981/evaluation-of-a-human-glycated-hemoglobin-test-in-canine-diabetes-mellitus
#2
Na-Yon Kim, Jaehoon An, Jae-Kyung Jeong, Sumin Ji, Sung-Hyun Hwang, Hong-Seok Lee, Myung-Chul Kim, Hyun-Wook Kim, Sungho Won, Yongbaek Kim
Glycated hemoglobin A1c (HbA1c) is widely used for monitoring and diagnosing human diabetes mellitus, but is rarely used in veterinary clinics. The goal of our study was to validate the commercial HbA1c testing system SD A1cCare analyzer (Bionote, Gyeoggi-do, South Korea) for use in dogs. Dogs were recruited with owner's consent. Diabetic status was determined based on clinical signs, fasting hyperglycemia, and glycosuria. Intra-assay precision and linearity were evaluated with EDTA, heparin, or citrate as anticoagulants, and had excellent precision with mean coefficients of variation (CVs) of 2...
February 18, 2019: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/30776767/the-cost-of-hypoglycemia-associated-with-type-2-diabetes-mellitus-in-taiwan
#3
Alena Strizek, Chee-Jen Chang, Wesley Furnback, Bruce Wang, Jérémie Lebrec, Thomas Lew
OBJECTIVES: To quantify the incremental burden of patients with type 2 diabetes mellitus (T2DM) and a hypoglycemic event in Taiwan using the National Health Insurance Research Database. METHODS: Data from 2000 through 2013 with an index period of 2001 through 2012 from the National Health Insurance Research Database's 2-million-patient sample were used. Using a nested case-control study design, patients were indexed if they reported a diagnosis of T2DM during the index period...
February 15, 2019: Value in Health Regional Issues
https://read.qxmd.com/read/30774274/zinc-deficiency-in-patients-with-chronic-pancreatitis
#4
Miroslav Vujasinovic, Aleksandra Hedström, Patrick Maisonneuve, Roberto Valente, Henrik von Horn, J-Matthias Löhr, Stephan L Haas
BACKGROUND: Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis (CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency (PEI), which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results. AIM: To investigate serum zinc levels in patients with CP of various etiologies...
February 7, 2019: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/30772075/a-novel-diagnostic-information-based-framework-for-super-resolution-of-retinal-fundus-images
#5
Vineeta Das, Samarendra Dandapat, Prabin Kumar Bora
Advancements in tele-medicine have led to the development of portable and cheap hand-held retinal imaging devices. However, the images obtained from these devices have low resolution (LR) and poor quality that may not be suitable for retinal disease diagnosis. Therefore, this paper proposes a novel framework for the super-resolution (SR) of the LR fundus images. The method takes into consideration the diagnostic information in the fundus images during the SR process. In this work, SR is performed on the zone of interest of the fundus images...
February 1, 2019: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://read.qxmd.com/read/30771796/use-of-the-ksvm-based-system-for-the-definition-validation-and-identification-of-the-incisional-hernia-recurrence-risk-factors
#6
L Licari, G Salamone, S Campanella, F Carfì, T Fontana, N Falco, R Tutino, P De Marco, A Comelli, D Cerniglia, G Petrucci, S Vitabile, G Gulotta
BACKGROUND: Incisional hernia is one of the most common complications after abdominal surgery with an incidence rate of 11 to 20% post laparotomy. Many different factors can be considered as risk factors of incisional hernia recurrence. The aim of this study is to confirm and to validate the incisional hernia recurrence risk factors and to identify and to validate new ones. METHODS: In the period from July 2007 to July 2017, 154 patients were selected and subjected to incisional hernia repair...
January 2019: Il Giornale di Chirurgia
https://read.qxmd.com/read/30771759/adverse-events-and-their-risk-factors-90-days-after-cervical-spine-surgery-analysis-from-the-michigan-spine-surgery-improvement-collaborative
#7
Hesham Mostafa Zakaria, Michael Bazydlo, Lonni Schultz, Markian A Pahuta, Jason M Schwalb, Paul Park, Ilyas Aleem, David R Nerenz, Victor Chang
OBJECTIVEThe Michigan Spine Surgery Improvement Collaborative (MSSIC) is a statewide, multicenter quality improvement initiative. Using MSSIC data, the authors sought to identify 90-day adverse events and their associated risk factors (RFs) after cervical spine surgery.METHODSA total of 8236 cervical spine surgery cases were analyzed. Multivariable generalized estimating equation regression models were constructed to identify RFs for adverse events; variables tested included age, sex, diabetes mellitus, disc herniation, foraminal stenosis, central stenosis, American Society of Anesthesiologists Physical Classification System (ASA) class > II, myelopathy, private insurance, anterior versus posterior approach, revision procedures, number of surgical levels, length of procedure, blood loss, preoperative ambulation, ambulation day of surgery, length of hospital stay, and discharge disposition...
February 15, 2019: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/30770743/performance-of-hba1c-versus-oral-glucose-tolerance-test-ogtt-as-a-screening-tool-to-diagnose-dysglycemic-status-in-high-risk-thai-patients
#8
Yotsapon Thewjitcharoen, Amia Jones Elizabeth, Siriwan Butadej, Soontaree Nakasatien, Phawinpon Chotwanvirat, Ekgaluck Wanothayaroj, Sirinate Krittiyawong, Tinapa Himathongkam, Thep Himathongkam
BACKGROUND: Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of glycated hemoglobin (HbA1c) when compared with oral glucose tolerance test (OGTT) as a reference test in identifying dysglycemic status among high-risk Thai patients receiving care in an out-patient setting. METHODS: An 11-year retrospective cross-sectional study of high-risk Thai patients who underwent OGTT during 2007-2017 was analysed...
February 15, 2019: BMC Endocrine Disorders
https://read.qxmd.com/read/30767386/pentraxin-3-a-new-parameter-in-predicting-the-severity-of-diabetic-foot-infection
#9
Safak Ozer Balin, Ayse Sagmak Tartar, Kader Uğur, Faruk Kilinç, Selda Telo, Ali Bal, Mehmet Balin, Ayhan Akbulut
This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin-3 (PTX-3) in patients with infected diabetic foot ulcers (IDFU) as well as to assess the association between PTX-3 levels and IDFU severity. This study included 60 IDFU patients (Group 1), 45 diabetic patients without DFU (Group 2), and 45 healthy controls. Patients with IDFU were divided into mild, moderate, and severe subgroups based on classification of clinical severity. Patients who underwent amputation were also documented...
February 15, 2019: International Wound Journal
https://read.qxmd.com/read/30765436/diagnostic-accuracy-of-a-device-for-the-automated-detection-of-diabetic-retinopathy-in-a-primary-care-setting
#10
Frank D Verbraak, Michael D Abramoff, Gonny C F Bausch, Caroline Klaver, Giel Nijpels, Reinier O Schlingemann, Amber A van der Heijden
OBJECTIVE: To determine the diagnostic accuracy in a real-world primary care setting of a deep learning-enhanced device for automated detection of diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS: Retinal images of people with type 2 diabetes visiting a primary care screening program were graded by a hybrid deep learning-enhanced device (IDx-DR-EU-2.1; IDx, Amsterdam, the Netherlands), and its classification of retinopathy (vision-threatening [vt]DR, more than mild [mtm]DR, and mild or more [mom]DR) was compared with a reference standard...
February 14, 2019: Diabetes Care
https://read.qxmd.com/read/30763043/performance-of-the-adapted-diabetes-complications-severity-index-translated-to-icd-10
#11
Felix Sebastian Wicke, Anastasiya Glushan, Ingrid Schubert, Ingrid Köster, Robert Lübeck, Marc Hammer, Martin Beyer, Kateryna Karimova
OBJECTIVES: To assess the performance of the adapted Diabetes Complications Severity Index (aDCSI) translated to International Classification of Diseases, Tenth Revision (ICD-10) in predicting hospitalizations, mortality, and healthcare-associated costs. STUDY DESIGN: Retrospective closed cohort study based on secondary data analysis. METHODS: We translated the aDCSI to ICD-10 and calculated aDCSI scores based on health insurance claims data...
February 1, 2019: American Journal of Managed Care
https://read.qxmd.com/read/30762763/increased-risk-of-neurodegenerative-dementia-in-women-with-migraines-a-nested-case-control-study-using-a-national-sample-cohort
#12
Sang-Yeon Lee, Jae-Sung Lim, Dong Jun Oh, Il Gyu Kong, Hyo Geun Choi
The present study aimed to evaluate the association between migraines and dementia.Data were collected from 11,438 dementia participants who were 1:4 matched by age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 45,752 controls from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Dementia was diagnosed using the International Classification of Disease-10 (ICD-10) codes (G30 or F00). For the integrity of diagnoses, we included only participants ≥60 years old who had been diagnosed with an ICD-10 code twice or more during ambulatory visits for the same episode...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762737/the-triad-of-diabetes-ketoacidosis-hypertriglyceridemia-and-acute-pancreatitis-how-does-it-affect-mortality-and-morbidity-a-10-year-analysis-of-the-national-inpatient-sample
#13
C Roberto Simons-Linares, Sunguk Jang, Madhusudan Sanaka, Amit Bhatt, Rocio Lopez, John Vargo, Tyler Stevens, Prabhleen Chahal
The triad of acute pancreatitis (AP) coexisting with diabetes ketoacidosis (DKA) and hypertriglyceridemia (HTG) has been reported, but no impact on mortality has been found to date. We aim to assess if patients with this triad are at a higher inpatient mortality compared to patients with acute pancreatitis only.Retrospective cohort. The National Inpatient Sample (NIS) database from 2003 to 2013 was queried for patients with a discharge diagnosis of AP and presence of DKA and HTG was ascertained based on International Classification of Diseases, 9th revision (ICD9) codes...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762470/evolution-of-transluminal-necrosectomy-for-acute-pancreatitis-to-stent-in-stent-therapy-step-up-approach-leads-to-low-mortality-and-morbidity-rates-in-302-consecutive-cases-of-acute-pancreatitis
#14
Helwig V Wundsam, Georg O Spaun, Franziska Bräuer, Christoph Schwaiger, Ines Fischer, Reinhold Függer
BACKGROUND: The step-up approach, using either flexible endoscopy or a minimal invasive retroperitoneal access, has reduced mortality and morbidity in patients with acute pancreatitis. The use of fully covered self-expanding metal stents (FCSEMS) or lumen apposing metal stents (LAMS) facilitates endoscopic necrosectomy and drainage of walled-off necrosis (WON). The aim of our analysis was to investigate the 30/90/365-day mortality and morbidity rates of the subtypes of the revised Atlanta classification for acute pancreatitis...
February 14, 2019: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/30761687/reduced-mortality-from-lower-respiratory-tract-disease-in-adult-diabetic-patients-treated-with-metformin
#15
Angelico Mendy, Radha Gopal, John F Alcorn, Erick Forno
BACKGROUND AND OBJECTIVE: Chronic lower respiratory diseases (CLRD) increase the risk of type 2 diabetes, which in turn may worsen lung function. Metformin, a common antidiabetic with anti-inflammatory and antioxidant properties, may improve respiratory outcomes. Therefore, we examined the association of metformin use with the risk of mortality from CLRD. METHODS: We analysed data from the National Health and Nutrition Examination Survey during 1988-1994 and 1999-2010 for participants aged 40 years or older who had diabetes and were followed up for mortality through 2011...
February 13, 2019: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/30760636/lumbosacral-radiculoplexus-neuropathy-incidence-and-the-association-with-diabetes-mellitus
#16
Peng Soon Ng, Peter J Dyck, Ruple S Laughlin, Prabin Thapa, Marcus V Pinto, P James B Dyck
OBJECTIVE: To determine the previously unknown incidence of lumbosacral-radiculoplexus neuropathy (LRPN) and its association with diabetes mellitus (DM). METHODS: LRPN defined by clinical and electrophysiologic criteria was identified among Olmsted County, Minnesota, residents during a 16-year period (2000-2015) using the unique facilities of the Rochester Epidemiology Project. DM was ascertained using American Diabetes Association criteria. RESULTS: Of 1,892 medical records reviewed, 59 patients (33 men, 26 women) were identified as having LRPN...
February 13, 2019: Neurology
https://read.qxmd.com/read/30760148/current-smoking-is-associated-with-delayed-wound-healing-but-not-with-improvement-of-contracture-after-the-open-palm-technique-for-dupuytren-s-disease
#17
Akinori Sakai, Yukichi Zenke, Kunitaka Menuki, Yoshiaki Yamanaka, Takafumi Tajima, Soshi Uchida
BACKGROUND: Some cases treated with open palm technique need relatively long wound healing time. This study aims to clarify whether the preoperative lifestyle-related diseases or factors are associated with surgical results after the open palm technique for Dupuytren's contracture. METHODS: The study included 122 fingers of 84 hands of 84 consecutive male patients with Dupuytren's contracture who were treated with McCash's open palm technique at our hospital from 1980 to 2016...
March 2019: Journal of Hand Surgery Asian-Pacific Volume
https://read.qxmd.com/read/30758833/association-of-the-serum-total-cholesterol-to-triglyceride-ratio-with-diabetic-retinopathy-in-chinese-patients-with-type-2-diabetes-a-community-based-study
#18
Yifan Zhong, Song Yue, Jingyang Wu, Peng Guan, Guisen Zhang, Lei Liu, Lei Chen
INTRODUCTION: The relationship of total cholesterol (TC) or triglyceride (TG) to diabetic retinopathy (DR) has proven difficult to determine. In addition, there is no report of any study of the correlation between the TC/TG ratio and DR. This study was therefore undertaken to investigate the relationship between the TC/TG ratio and DR in Chinese adults with type 2 diabetes mellitus. METHODS: A community-based study was conducted from August to October 2014 in Fengyutan, Shenyang, China...
February 13, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30747825/association-of-pancreatic-steatosis-with-chronic-pancreatitis-obesity-and-type-2-diabetes-mellitus
#19
Temel Tirkes, Christie Y Jeon, Liang Li, Aron Y Joon, Ted A Seltman, Meghana Sankar, Scott A Persohn, Paul R Territo
OBJECTIVE: The aim of this study was to determine the association of the pancreatic steatosis with obesity, chronic pancreatitis (CP), and type 2 diabetes mellitus. METHODS: Patients (n = 118) were retrospectively identified and categorized into no CP (n = 60), mild (n = 21), moderate (n = 27), and severe CP (n = 10) groups based on clinical history and magnetic resonance cholangiopancreatography using the Cambridge classification as the diagnostic standard. Visceral and subcutaneous compartments were manually segmented, and fat tissue was quantitatively measured on axial magnetic resonance imaging...
February 8, 2019: Pancreas
https://read.qxmd.com/read/30745267/avulsion-fractures-of-posterior-calcaneal-tuberosity-identification-of-prognostic-factors-and-classification
#20
Pablo Carnero-Martín de Soto, David Bautista-Enrique, Abel Gómez-Cáceres, Alfredo Rodríguez-León, María José Bravo-Zurita, María Teresa Santos-Maraver
Avulsion fractures of the posterior calcaneal tuberosity are rare injuries, and little is known about the underlying factors, outcomes, and prognosis. Furthermore, classifications described previously focus on fracture morphology, with uncertain clinical utility. We present the results of a retrospective study of 21 patients treated for this pathology from January 2002 to December 2015. Features analyzed were age; sex; mechanism of injury; medical comorbidities; type of fracture, as proposed by Beavis; fracture displacement; fragment size; type of treatment; complications; need for secondary surgery; and the American Orthopaedic Foot and Ankle Society score after treatment and follow-up care...
February 8, 2019: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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