Patrick Wagner, Edward A Levine, Alex C Kim, Perry Shen, Nicole D Fleming, Shannon N Westin, Laurel K Berry, Giorgos C Karakousis, Janos L Tanyi, Madeline T Olson, Brian Madajewski, Brian Ostrander, Kartik Krishnan, Charles M Balch, David L Bartlett
BACKGROUND: For patients with peritoneal carcinomatosis, extent of disease and completeness of cytoreductive surgery (CRS) are major prognostic factors for long-term survival. Assessment of these factors could be improved using imaging agents. Pegsitacianine is a pH-sensitive polymeric micelle conjugated to the fluorophore indocyanine green. The micelle disassembles in acidic microenvironments, such as tumors, resulting in localized fluorescence unmasking. We assessed the utility of pegsitacianine in detecting residual disease following CRS...
April 15, 2024: Annals of Surgical Oncology