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spontaneous recovery

Fabio Timeus, Nicoletta Crescenzio, Luiselda Foglia, Alessandra Doria, Maria Giuseppina Stillitano, Emanuela Garelli, Raffaela Mazzone, Laura Vivalda, Stefano Vallero, Ugo Ramenghi, Paola Saracco
Myelopoiesis was evaluated in 66 pediatric patients with chronic neutropenia who were positive for anti-neutrophil antibodies (median age at diagnosis: 11 months, median neutrophil count at diagnosis: 419/μl). Other causes of neutropenia were excluded. Bone marrow morphology, clonogenic tests and/or the peripheral blood CD 34+ cell count, and apoptotic rate were evaluated in 61 patients with neutropenia lasting > 12 months or severe infections. The peripheral blood CD 34+ cell count and apoptotic rate were evaluated in five patients with shorter neutropenia...
2019: PloS One
Akash Wasil, Katherine Venturo-Conerly, Rebecca Shingleton, John Weisz
Patients with eating disorders (EDs) often lack motivation to recover, and interventions designed to increase recovery motivation have not demonstrated to be effective. In fact, few studies have identified factors that increase recovery motivation in patients with EDs. We performed interviews with 13 women who recovered from EDs to identify factors that influenced their motivation to recover. Here, we present exploratory findings about a central theme from these interviews: the importance of hearing from others who had recovered from EDs (i...
March 14, 2019: Psychotherapy
Wenxuan Liu, Ning Ma, Xia Gao, Wencong Liu, Jinhai Jia, Longmei Tang, Man Li, Lei Yang, Tao Li, Lina Yan, Xiaolin Zhang, Fengxue Yu
Purpose. ERF3 , having been found expressing differently in liver tissues in our previous work, including eRF3a and eRF3b , which are structural homologues and named GSPT1 and GSPT2 Recent studies have indicated that eRF3b involved in the development and proliferation of HepG2 cell, and eRF3a may be associated with tumor susceptibility. Based on this, We tested the effects of GSPT1 and GSPT2 single-nucleotide polymorphisms for all major HBV outcomes and lamivudine treatment in Han Chinese. Method. A total of 1649 samples were enrolled, and peripheral blood samples were collected in this study...
March 13, 2019: Bioscience Reports
Ali Rezaei Haddad, Vanessa Lythe, Alexander L Green
OBJECTIVES: Minimally conscious state (MCS) is a disorder of consciousness in which minimal but definite behavioral evidence of self-awareness or environmental awareness is demonstrated. Deep brain stimulation (DBS) of various targets has been used to promote recovery in patients with disorders of consciousness with varying results. The aim of this systematic review was to assess the effects of DBS in MCS following traumatic brain injury (TBI). MATERIALS AND METHODS: A systematic literature review was carried out using a number of electronic bibliographic data bases to identify relevant studies...
March 13, 2019: Neuromodulation: Journal of the International Neuromodulation Society
Nathan Evaniew, Nader Fallah, Carly S Rivers, Vanessa K Noonan, Charles G Fisher, Marcel F Dvorak, Jefferson R Wilson, Brian K Kwon
BACKGROUND: Clinical trials of novel therapies for acute SCI are challenging because variability in spontaneous neurologic recovery can make discerning actual treatment effects difficult. Unbiased Recursive Partitioning regression with Conditional Inference Trees (URP-CTREE) is a novel approach developed through analyses of a large European SCI database (EMSCI). URP-CTREE uses early neurologic impairment to predict achieved motor recovery, with potential to optimize clinical trial design, optimizing stratifying patients and decreasing sample sizes...
March 13, 2019: Journal of Neurotrauma
Jovana Bradic, Vladimir Zivkovic, Ivan Srejovic, Vladimir Jakovljevic, Anica Petkovic, Tamara Nikolic Turnic, Jovana Jeremic, Nevena Jeremic, Slobodanka Mitrovic, Tanja Sobot, Nenad Ponorac, Marko Ravic, Marina Tomovic
Galium verum L. ( G . verum , lady's bedstraw ) is a perennial herbaceous plant, belonging to the Rubiaceae family. It has been widely used throughout history due to multiple therapeutic properties. However, the effects of this plant species on functional recovery of the heart after ischemia have still not been fully clarified. Therefore, the aim of our study was to examine the effects of methanol extract of G. verum on myocardial ischemia/reperfusion (I/R) injury in spontaneously hypertensive rats (SHR), with a special emphasis on the role of oxidative stress...
2019: Oxidative Medicine and Cellular Longevity
Jeong Ho Park, Yu Jin Kim, Young Sun Ro, Sola Kim, Won Chul Cha, Sang Do Shin
Background: Longer transport adversely affects outcomes in out-of-hospital cardiac arrest (OHCA) patients who do not return to spontaneous circulation (ROSC). The aim of this study was to determine the association between the transport time interval (TTI) and neurological outcomes in OHCA patients without ROSC. Methods: We analyzed adult OHCA patients with presumed cardiac etiology and without prehospital ROSC from 2012 to 2015. The study population was divided into 2 groups according to STI (short STI [1-5 minutes] and long STI [≥ 6 minutes])...
March 11, 2019: Journal of Korean Medical Science
Yui Sasaki, Zhoujie Zhang, Tsuyoshi Minami
Herein, a very simple colorimetric chemosensor array is reported for saccharides (D -glucose, D -fructose, D -xylose, D -galactose, D -mannose, L -rhamnose, and N -acetyl-D -gluosamine). While various types of chemosensors for saccharides have been investigated extensively to-this-date, tremendous additional efforts are still required on a regular basis for the syntheses of new chemosensors. Complicated syntheses would be a bottleneck, given that artificial receptor-based chemosensing systems are not so popular in comparison to biomaterial-based (e...
2019: Frontiers in Chemistry
Tie-Quan Sui, Fa-Yue Zhang, Ai-Ling Jiang, Xiu-Qiang Zhang, Zhi-Wei Zhang, Yang Yang, Li-Ping Sun
This study aims to explore the effect of sequential acupoint stimulation on the postoperative pulmonary function of patients with spontaneous pneumothorax who underwent video-assisted thoracoscopic surgery (VATS).Using a random number table, the patients were randomly divided into 2 groups: routine nursing group and sequential acupoint stimulation group. Patients in the routine nursing group received standard nursing care of thoracic surgery, while patients in the acupoint group received sequential acupoint stimulation on Shenshu (BL23), Gaohuang (BL43), Feishu (BL13), and Tiantu (CV22)...
March 2019: Medicine (Baltimore)
Tamil S Anthonymuthu, Elizabeth M Kenny, Andrew M Lamade, Hitesh Gidwani, Nicholas M Krehel, Amalea Misse, Xiaotian Gao, Andrew A Amoscato, Adam C Straub, Valerian E Kagan, Cameron Dezfulian, Hülya Bayır
OBJECTIVES: Brain mitochondrial dysfunction limits neurologic recovery after cardiac arrest. Brain polyunsaturated cardiolipins, mitochondria-unique and functionally essential phospholipids, have unprecedented diversification. Since brain cardiolipins are not present in plasma normally, we hypothesized their appearance would correlate with brain injury severity early after cardiac arrest and return of spontaneous circulation. DESIGN: Observational case-control study...
January 11, 2019: Critical Care Medicine
Johan Ormel, Ronald C Kessler, Robert Schoevers
PURPOSE OF REVIEW: Since the 70s, treatment of depression, especially pharmacologically, has expanded enormously. However, epidemiological studies show that 12-month population prevalence rates have not dropped. This observation raises multiple questions. How good are treatments of depression actually? Do they improve long-term outcomes? Have the treatment gaps narrowed? And how can we make mental healthcare more effective at the population level? RECENT FINDINGS: Recent publications suggest some answers...
March 6, 2019: Current Opinion in Psychiatry
Yasaman Nemati, Payam Zahedi, Majid Baghdadi, Sahar Ramezani
This work aimed at producing nanoparticles (NPs) based on thiol-functionalized chitosan (CS) using capillary microfluidic (MF) device combined with ionic gelation method to adsorb mercury ion [Hg (II)] from aqueous solutions. In this line, CS was functionalized with epichlorohydrin/cysteaminium chloride (2.73 M ratio) followed by fabricating NPs via MF and bulk mixing (BM) methods. To characterize the morphology, zeta potential, functionality, structure, and magnetic property of the samples, a series of tests such as SEM, TEM, DLS, FTIR, XRD, and VSM were carried out, respectively...
March 6, 2019: Journal of Environmental Management
Cora Blázquez-Bermejo, Lidia Carreño-Gago, David Molina-Granada, Josu Aguirre, Javier Ramón, Javier Torres-Torronteras, Raquel Cabrera-Pérez, Miguel Ángel Martín, Cristina Domínguez-González, Xavier de la Cruz, Anne Lombès, Elena García-Arumí, Ramon Martí, Yolanda Cámara
Polymerase γ catalytic subunit ( POLG) gene encodes the enzyme responsible for mitochondrial DNA (mtDNA) synthesis. Mutations affecting POLG are the most prevalent cause of mitochondrial disease because of defective mtDNA replication and lead to a wide spectrum of clinical phenotypes characterized by mtDNA deletions or depletion. Enhancing mitochondrial deoxyribonucleoside triphosphate (dNTP) synthesis effectively rescues mtDNA depletion in different models of defective mtDNA maintenance due to dNTP insufficiency...
March 8, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Georg M Schmölzer
Newborn infants receiving chest compressions in the delivery room have a high incidence of mortality (41%) and short-term neurological morbidity (e.g., 57% hypoxic-ischemic encephalopathy and seizures). Furthermore, infants who have no signs of life at 10 min despite chest compressions have 83% mortality, with 93% of survivors experiencing moderate-to-severe disability. The poor prognosis associated with receiving chest compressions in the delivery room raises questions as to whether improved cardiopulmonary resuscitation methods specifically tailored to the newborn could improve outcomes...
February 2019: JACC. Basic to Translational Science
Yukihiro Yamanaka, Kenko Uchida, Momoka Akashi, Yuta Watanabe, Arino Yaguchi, Shuji Shimamoto, Shingo Shimoda, Hitoshi Yamada, Masashi Yamashita, Hidenori Kimura
BACKGROUND: Mathematical models of diseases may provide a unified approach for establishing effective treatment strategies based on fundamental pathophysiology. However, models that are useful for clinical practice must overcome the massive complexity of human physiology and the diversity of patients' environmental conditions. With the aim of modeling a complex disease, we choose sepsis, which is highly complex, life-threatening systemic disease with high mortality. In particular, we focused on septic shock, a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities are profound enough to substantially increase mortality...
March 6, 2019: Theoretical Biology & Medical Modelling
Nicholas Bayfield, Nikki Stamp, Andrew Laycock, Chris Merry
A 38-year-old woman developed a spontaneous right-sided tension pneumothorax during light aircraft travel. The aircraft was diverted to a regional centre, where emergent needle thoracostomy and chest tube insertion were performed. History suggested that this was the second episode of pneumothorax, with an untreated event with similar symptomatology during air travel 1 year ago. She was taken for surgical intervention. Intraoperative findings were of a large right middle lobe cyst of uncertain origin; the procedure was subsequently aborted...
March 4, 2019: BMJ Case Reports
Sepehr Mohammadi, Hossein Faghihian
For elimination of cesium from aqueous solutions, mesoporous SBA-15 was synthesized and employed as the support for immobilization of potassium copper hexacyanoferrate. The synthesized adsorbent was characterized by various techniques and was used for adsorption of cesium. The results indicated that its adsorption capacity was 174.80 mg/g and superior to many studied adsorbents. The adsorbent represented good selectivity in the presence of some studied co-existing. The Temkin, Redlich-Peterson, Sips, Langmuir, and Freundlich isotherm models were used to evaluate the experimental data...
March 2, 2019: Environmental Science and Pollution Research International
Olivia A Galea, Shaun P O'Leary, Julia M Treleaven
AIM: To further explore symptoms in patients beyond the expected recovery period post mild Traumatic Brain Injury (mTBI) that are potentially indicative of impairment. METHODS: Ninety-four individuals (62 diagnosed with mTBI within the previous 4-24 weeks and 32 healthy controls) participated in the study. Participants in the mTBI group were further grouped as symptomatic (n = 33) or asymptomatic (n = 29) based on their spontaneous report of symptoms at the time of screening...
February 20, 2019: Musculoskeletal Science & Practice
Fabio Bianchi, Valerio Pereno, Julian H George, Mark S Thompson, Hua Ye
Peripheral nerves contain neuron fibers vital for movement and sensation and are subject to continuous elongation and compression during everyday movement. At supraphysiological strains conduction blocks occur, resulting in permanent or temporary loss of function. The mechanisms underpinning these alterations in electrophysiological activity remain unclear; however, there is evidence that both ion channels and network synapses may be affected through cell membrane transmitted strain. The aim of this work was to quantify the changes in spontaneous activity resulting from application of uniaxial strain in a human iPS-derived motor neuron culture model, and to investigate the role of cell membrane mechanical properties during cell straining...
February 26, 2019: Neuroscience
Alonso Martínez-Canabal, Grecia López-Oropeza, Abril Gaona-Gamboa, Paola Ballesteros-Zebadua, Olinca Galvan de la Cruz, Sergio Moreno-Jimenez, Francisco Sotres-Bayon
Safe exposure to a context that was previously associated with threat leads to extinction of defensive responses. Such contextual fear extinction involves the formation of a new memory that inhibits a previously acquired contextual fear memory. However, fear-related responses often return with the simple passage of time (spontaneous fear recovery). Given that contextual fear and extinction memories are hippocampus-dependent and hippocampal neurogenesis has been reported to modify preexisting memories, we hypothesized that neurogenesis-mediated modification of preexisting extinction memory would modify spontaneous fear recovery...
February 27, 2019: Scientific Reports
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