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Andrey Shatskiy, Andrey Bardin, Michael Oschmann, Roc Matheu, Jordi Benet-Bucholz, Lars Eriksson, Markus Kärkäs, Eric Johnston, Carolina Gimbert-Suriñach, Antoni Llobet, Björn Åkermark
Herein is described a highly active ruthenium-based water oxidation catalyst [RuX(mcbp)(OHn)(py)2] (5, mcbp2- = 2,6-bis(1-methyl-4-(carboxylate)benzimidazol-2-yl)pyridine; n = 2, 1, and 0 for X = II, III, and IV, respectively), which can be generated in a mixture of RuIII/RuIV states from either [RuII(mcbp)(py)2] (4II) or [RuIII(Hmcbp)(py)2]2+ (4III). Complexes 4II and 4III were isolated and characterized by single crystal X-ray analysis, NMR, UV-vis, FT-IR, ESI-HRMS, EPR, and elemental analysis, and their redox properties were studied in detail by electrochemical and spectroscopic methods...
February 13, 2019: ChemSusChem
Antonio de Iure, Francesco Napolitano, Goichi Beck, Ana Quiroga Varela, Valentina Durante, Miriam Sciaccaluga, Petra Mazzocchetti, Alfredo Megaro, Michela Tantucci, Antonella Cardinale, Daniela Punzo, Andrea Mancini, Cinzia Costa, Veronica Ghiglieri, Alessandro Tozzi, Barbara Picconi, Stella M Papa, Alessandro Usiello, Paolo Calabresi
OBJECTIVE: Spreading depolarization (SD) is a transient self-propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Parkinson's disease (PD) pathophysiology, has been poorly investigated. METHODS: We characterized the participation of glutamatergic and dopaminergic transmission in the induction of striatal spreading depolarization by using a novel approach combining optical imaging, measurements of endogenous DA levels, and pharmacological and molecular analyses...
February 13, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
Patricia Nance, Niklas Thompson, Paul Oyala, Jonas Peters
Species with 2-center, 3-electron (2c/3e-) σ-bonds are of interest owing to their fascinating electronic structures and potential for interesting reactivity patterns. Herein we report the synthesis and characterization of a pair of zerovalent (d9) trigonal pyramidal Rh and Ir complexes that feature 2c/3e- σ-bonds to the Si atom of a tripodal tris(phosphine)silatrane ligand. X-ray diffraction, continuous wave and pulse electron paramagnetic resonance, density functional theory calculations, and reactivity studies have been used to characterize these electronically distinctive compounds...
February 13, 2019: Angewandte Chemie
Tania L King, Allison Milner, Zoe Aitken, Amalia Karahalios, Eric Emerson, Anne M Kavanagh
Adolescence is a period of elevated stress for many young people, and it is possible that the challenges of adolescence are different for vulnerable groups. We aimed to document the depressive and anxiety symptoms, emotional-behavioural difficulties and suicidal/self-harming behaviours among adolescents with borderline intellectual functioning (BIF) or a disability, compared to those with neither disability nor BIF. Data were drawn from the nationally representative Longitudinal Study of Australian Children...
February 13, 2019: European Child & Adolescent Psychiatry
David A White, Gautam M Anand, Omar Qayum, Chizitam F Ibezim, Ashley K Sherman, Geetha Raghuveer
Atherosclerosis promoting cardiovascular disease risk factors (CVDrf) are highly prevalent among youth in the U.S. Determining which standard modifiable clinical measures (SMCMs) has the greatest impact on vascular structure and function is valuable for the health care provider to help identify children at highest risk. The aim of this study was to determine modifiable outpatient clinical predictors of vascular health in youth with CVDrf. Children and adolescents with CVDrf (n = 120, 13.1 ± 1.9 years, 49% female) were recruited from a pediatric preventive cardiology clinic...
February 13, 2019: Pediatric Cardiology
Shuly Lim, Michelina Kierzek, Anne E O'Connor, Christoph Brenker, D Jo Merriner, Hidenobu Okuda, Marianna Volpert, Avinash Gaikwad, Deborah Bianco, David Potter, Ranganathan Prabhakar, Timo Strünker, Moira K O'Bryan
The Cysteine-RIch Secretory Proteins (CRISPs) are a group of proteins which show a pronounced expression biased to the male reproductive tract. While sperm encounter CRISPs at virtually all phases of sperm development and maturation, CRISP2 is the sole CRISP produced during spermatogenesis, wherein it is incorporated into the developing sperm head and tail. Within this study we test the necessity for CRISP2 in male fertility using Crisp2 loss-of-function mouse models. In doing so, we reveal a role for CRISP2 in establishing the ability of sperm to undergo the acrosome reaction, and in establishing a normal flagellum wave form...
February 13, 2019: Endocrinology
David Aparício, Pedro Ribeiro, Tijana Milenkovic, Fernando Silva
Motivation: Network alignment (NA) finds conserved regions between two networks. NA methods optimize node conservation (NC) and edge conservation (EC). Dynamic graphlet degree vectors (DGDVs) are a state-of-the-art dynamic NC measure, used within the fastest and most accurante NA method for temporal networks: DynaWAVE. Here, we use graphlet-orbit transitions (GoTs), a different graphlet-based measure of temporal node similarity, as a new dynamic NC measure within DynaWAVE, resulting in GoT-WAVE...
February 13, 2019: Bioinformatics
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No abstract text is available yet for this article.
March 2019: Hypertension
Xueting Gao, Siyun Gao, Yi Guan, Lin Huang, Jiale Huang, Li Lin, Yuan Liu, Hong Zhao, Bijun Huang, Tianyou Yuan, Yi Liu, Dandan Liang, Yangyang Zhang, Xiue Ma, Li Li, Jun Li, Daizhan Zhou, Dan Shi, Liang Xu, Yi-Han Chen
TLRs have been proven to be essential mediators for the early innate immune response. Overactivation of TLR-mediated immune signaling promotes deterioration of cardiovascular diseases; however, the role of TLRs in the heart under physiologic conditions remains neglected. Here, we show that Tlr3 deficiency induced the endoplasmic reticulum (ER) retention of Kv4.2/4.3 proteins and consequent degradation via the ubiquitin-proteasome pathway. Knockout of Tlr3 resulted in a prolonged QT interval (the space between the start of the Q wave and the end of the T wave) in mice with no significant signs of inflammation and tissue abnormality in cardiac muscles...
February 13, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Kelly E Moore, Lindsay M S Oberleitner, Howard V Zonana, Alec W Buchanan, Brian P Pittman, Terril L Verplaetse, Gustavo A Angarita, Walter Roberts, Sherry A McKee
OBJECTIVE: Current knowledge regarding the intersection of psychiatric disorders and crime in the United States is limited to psychiatric, forensic, and youth samples. This study presents nationally representative data on the relationship of DSM-5 psychiatric disorders, comorbid substance and mental health disorders, and multimorbidity (number of disorders) with criminal behavior and justice involvement among non-institutionalized US adults. METHODS: Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions Wave III (NESARC-III; 2012-2013; N = 36,309)...
February 12, 2019: Journal of Clinical Psychiatry
Júlio César Acosta-Navarro, Adriana Midori Oki, Luiza Antoniazzi, Maria Aparecida Carlos Bonfim, Valeria Hong, Maria Cristina de Almeida Gaspar, Valeria Cristina Sandrim, Adriana Nogueira
OBJECTIVE: To evaluate the frequency of food consumption in apparently healthy men and their association with cardiovascular risk factors and biomarkers of subclinical atherosclerosis. METHODS: In this observational study, 88 men had their food standard obtained through the food frequency questionnaire (FFQ). Associations of dietary patterns with cardiovascular risk factors, such as anthropometric data, laboratory and clinical evaluations, carotid-femoral arterial stiffness (IMT) and pulse wave velocity were evaluated...
January 2019: Revista da Associação Médica Brasileira
Jennifer A Noble, Christian Aupetit, Dominique Descamps, Stéphane Petit, Aude Simon, Joëlle Mascetti, Nadia Ben Amor, Valérie Blanchet
The ultrafast relaxation occurring in pyrene upon excitation at 4.68 eV was studied in a supersonic gas-jet fs pump-probe experiment. Mass spectrometry and velocity map imaging of photoelectrons produced by probing via multiphoton ionisation at 800 nm reveal that the initially prepared wave packet exhibits a fast relaxation (<80 fs), followed by a slower one of 200 fs. By comparing the propensity rules of photoionisation observed at one color with ab initio calculations, we tentatively assign these two timescales to a first internal conversion to the dark bB3g state followed by a second one to the long lived aB2u first excited state...
February 13, 2019: Physical Chemistry Chemical Physics: PCCP
Sonja E Siennick, Mayra Picon
Adolescents with depression have lower peer status overall, but tend to befriend each other. We examined the "tightknittedness" of their friendship groups by testing whether adolescent friendship groups' average levels of or variability in internalizing symptoms predict group cohesiveness. We used four waves (9th-12th grades) of survey and social network data on 3,013 friendship groups from the PROmoting School-Community-University Partnerships to Enhance Resilience study. Friendship groups with higher average depressive symptoms were less cohesive; groups with higher average anxiety symptoms had greater reciprocity...
February 13, 2019: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
Qi Li, Xiaoguang Peng, Gregory B McKenna
Diffusing wave spectroscopy (DWS)-based micro-rheology has been used in different optical geometries (backscattering and transmission) as well as different sample thicknesses in order to probe system dynamics at different length scales [D. J. Pine, D. A. Weitz, J. X. Zhu, E. Herbolzheimer. J. Phys., 1990, 51(18), 2101-2127]. Previous study from this lab [Q. Li, X. Peng, G. B. McKenna. Soft Matter, 2017, 13(7), 1396-1404] indicates the DWS-based micro-rheology observes the system non-equilibrium behaviors differently from macro-rheology...
February 13, 2019: Soft Matter
Charlie Gréboval, Eva Izquierdo, Clément Livache, Bertille Martinez, Marion Dufour, Nicolas Goubet, Nicolas Moghaddam, Junling Qu, Audrey Chu, Julien Ramade, Hervé Aubin, Hervé Cruguel, Mathieu Silly, Emmanuel Lhuillier, Sandrine Ithurria
We demonstrate the growth of 2D nanoplatelets (NPLs) made of a HgTe/CdS heterostructure, with an optical absorption reaching the shortwave infrared range. The material is an interesting platform to investigate the effect of dimensionality (0D vs. 2D) and confinement on the electronic spectrum and carrier dynamics in colloidal materials. We bring consistent evidence for the p-type nature of this material from transport and photoemission measurements. The majority carrier dynamics probed using pump-probe photoemission is found to be mostly dependent on the presence of a confinement barrier at the surface rather than on the material dimensionality...
February 13, 2019: Nanoscale
Tingting Zhang, Liang Zhang, Xianchun Liu, Zhongcheng Mu, Shuangxi Xing
The design and synthesis of cheaper and more stable catalysts with comparable electrocatalytic performance to commercial Pt/C towards the oxygen reduction reaction is of importance for their application in fuel cells and metal-air batteries. Herein, we report the generation of nitrogen-doped carbon/MnO2 nanocomposites via pyrolyzing the polypyrrole/MnO2 precursor that is obtained based on the direct redox reaction between polypyrrole and KMnO4. The achieved sample presents an onset and half-wave potential of -0...
February 13, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Sammi Ali, Sarah A Signor, Konstantin Kozlov, Sergey V Nuzhdin
Robustness in development allows for the accumulation of genetically based variation in expression. However, this variation is usually examined in response to large perturbations, and examination of this variation has been limited to being spatial, or quantitative, but because of technical restrictions not both. Here we bridge these gaps by investigating replicated quantitative spatial gene expression using rigorous statistical models, in different genotypes, sexes, and species (Drosophila melanogaster and D...
February 12, 2019: Evolution & Development
Alexander Grimm, Hannah Oertl, Eva Auffenberg, Victoria Schubert, Christoph Ruschil, Hubertus Axer, Natalie Winter
Differentiation of Guillain-Barré syndrome (GBS) and acute-onset chronic inflammatory demyelinating polyradiculoneuritis (CIDP) might be intricate in early stages. We compared electrodiagnostics (EDx) and nerve ultrasound (NUS) as tools for early distinction and follow-up. NUS and EDx have been performed at first visitation and after 6 months. The nerve conduction study score (NCSS), the ultrasound pattern sum score (UPSS), and clinical scores were used for comparison. Compared with the 33 GBS patients, the 34 CIDP patients (50% with symptoms < 4 weeks) revealed significant nerve enlargement in ultrasound (p < 0...
February 12, 2019: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Yuko Saito, Hirotsugu Yamada, Kenya Kusunose, Ken Saito, Masataka Sata
BACKGROUND: There is a need to stratify patients who may develop heart failure because of the current "heart failure pandemic". We hypothesized that noninvasive assessment of diastolic electromechanical coupling by electrocardiography and Doppler echocardiography may be clinically useful for risk stratification of hypertensive patients who may develop heart failure. METHODS: We measured the time from the peak to end of the T wave (TpTe) as an electrophysiological parameter, and peak early diastolic mitral flow (E) and lateral annular (e') velocities as mechanical parameters in 109 patients with hypertension...
February 12, 2019: Journal of Echocardiography
Han-Tao Li, Chih-Hong Lee, Tony Wu, Mei-Yun Cheng, Wei-En Johnny Tseng, Chun-Wei Chang, Hsiang-Yao Hsieh, Hsing-I Chiang, Chih-Yin Lin, Bao-Luen Chang, Wey-Ran Lin, Siew-Na Lim
BACKGROUND: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures. METHODS: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed...
February 12, 2019: Neurocritical Care
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