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OCT retina

Alisa T Thavikulwat, Dingcai Cao, Thasarat S Vajaranant, Jennifer I Lim
PURPOSE: To determine the rate of retinal nerve fiber layer (RNFL) thinning in patients with sickle cell hemoglobinopathies. Design; Prospective cohort study METHODS: Sixty-seven patients averaging 35.8±11.5 years old at enrollment with electrophoretically-confirmed sickle cell hemoglobinopathies followed by the University of Illinois at Chicago retina clinic for ≥1 year were included. Exclusion criteria included a history of diabetes, uncontrolled hypertension, glaucoma, ocular opacities, other retinopathies, and previous retinal procedures...
February 13, 2019: American Journal of Ophthalmology
Dao-Yi Yu, Stephen J Cringle, Paula K Yu, Chandrakumar Balaratnasingam, Andrew Mehnert, Marinko V Sarunic, Dong An, Er-Ning Su
The central role of the cardiovascular system is to maintain adequate capillary perfusion. The spatially and temporally heterogeneous nature of capillary perfusion has been reported in some organs. However, such heterogeneous perfusion properties have not been sufficiently explored in the retina. Arguably, spatial and temporal heterogeneity of capillary perfusion could be more predominant in the retina than that in other organs. This is because the retina is one of the highest metabolic demand neural tissues yet it has a limited blood supply due to optical requirements...
February 12, 2019: Progress in Retinal and Eye Research
Francis L Munier, Alejandra Daruich
A 17-year-old boy, previously diagnosed with familial exudative vitreoretinopathy (FEVR) due to LRP5 mutation, complained of left eye decreased vision. Serial imaging by optical coherence tomography showed vitreomacular traction that progressed to lamellar macular hole (MH), and further evolved to full-thickness MH 3 weeks later. Visual acuity (VA) was 20/200. Pars plana vitrectomy with encircling buckle, internal limiting membrane peeling, and gas tamponade were performed. Three months postoperatively, VA had increased to 20/25 and the MH remained closed...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Peter H Tang, Ruben Jauregui, Stephen H Tsang, Alexander G Bassuk, Vinit B Mahajan
RPGR-associated retinitis pigmentosa (RP) is a progressive disease with retina degeneration. Optical coherence tomography angiography (OCTA) is an imaging technique that provides novel insights. The authors report two affected male siblings who underwent OCTA imaging. The area of the foveal avascular zone (FAZ) was measured. Although the younger sibling exhibited more advanced clinical disease, his visual acuity was superior to his older sibling. OCTA imaging revealed a better preserved FAZ in the younger sibling as the reason for this...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Rupesh Agrawal, Sophia Seen, Shiva Vaishnavi, Kiran Kumar Vupparaboina, Abhilash Goud, Mohammed Abdul Rasheed, Jay Chhablani
BACKGROUND AND OBJECTIVE: Choroidal vascularity index (CVI) is a noninvasive tool to assess choroidal structure. The objective of the current study was to compare the CVI measurements on swept-source optical coherence tomography (SS-OCT) and spectral-domain OCT (SD-OCT) scans using the same image binarization protocol. PATIENTS AND METHODS: This prospective study was conducted from July 2016 through January 2017 and involved 54 healthy volunteers at a tertiary referral eye care institute in Southern India...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Andrew W Stacey, Maria Pefkianaki, Tomas Ilginis, Michael Michaelides, Phill Hykin, Andrew Webster, Anthony T Moore, Mandeep S Sagoo
BACKGROUND AND OBJECTIVE: To identify the clinical and imaging characteristics of isolated retinal astrocytic hamartomas (IRAH). PATIENTS AND METHODS: A case series of eight patients diagnosed with IRAH. RESULTS: The average age at diagnosis was 32 years (range: 9 years to 80 years). After a median follow-up time of 59 months, none of the lesions had demonstrated any change or growth. Fundus fluorescein angiogram identified hyperfluorescence in five of six imaged lesions...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Elie Motulsky, Fang Zheng, Yingying Shi, José M B Garcia, Giovanni Gregori, Philip J Rosenfeld
BACKGROUND AND OBJECTIVE: Swept-source optical coherence tomography (SS-OCT) imaging was performed on eyes with epiretinal membranes (ERMs), and the extent of the ERMs were compared between the 12 mm × 12 mm scans and the more routine 6 mm × 6 mm field of view (FOV). PATIENTS AND METHODS: Eyes containing ERMs were imaged using a 12 mm × 12 mm SS-OCT scan. En face images derived from vitreoretinal interface (VRI) slabs were reviewed to assess the full extent of the ERM...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Kai Suzuki, Kiyoko Gocho, Keiichiro Akeo, Sachiko Kikuchi, Daiki Kubota, Satoshi Katagiri, Kaoru Fujinami, Kazushige Tsunoda, Takeshi Iwata, Kunihiko Yamaki, Tsutomu Igarashi, Tadashi Nakano, Hiroshi Takahashi, Takaaki Hayashi, Shuhei Kameya
BACKGROUND AND OBJECTIVE: To characterize the photoreceptors and choroidal morphology of heterozygous female carriers of choroideremia who typically do not have any visual defects but can have severe funduscopic changes. PATIENTS AND METHODS: This was a clinical case series study. Detailed ophthalmic examinations were performed on six female carriers from four families with choroideremia. The subfoveal choroidal thickness (SFCT) was determined by spectral-domain optical coherence tomography (SD-OCT) and the cone photoreceptor density by adaptive optics (AO) retinal imaging...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Shih-Chun Chao, Shang-Jung Yang, Hung-Chi Chen, Chi-Chin Sun, Chin-Hsin Liu, Chia-Yi Lee
Purpose: To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods: A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. The ophthalmic data including best-corrected visual acuity, spherical equivalent, intraocular pressure, central corneal thickness, central foveal thickness, visual field deviation, retinal nerve fiber layers thickness, and ganglion cell complex thickness were obtained from medical documents...
2019: Journal of Ophthalmology
Andrea Scupola, Gabriela Grimaldi, Maria G Sammarco, Paola Sasso, Michele Marullo, Maria A Blasi
PURPOSE: Combined hamartoma of the retina and retinal pigment epithelium is a rare benign tumor characterized by a variable combination of glial, vascular, and pigmented components. The purpose of our study was to analyze the features of combined hamartoma of the retina and retinal pigment epithelium on optical coherence tomography angiography. METHODS: Small case series of two cases of combined hamartoma of the retina and retinal pigment epithelium with macular and optic nerve involvement, evaluated with multimodal imaging including optical coherence tomography, fluorescein angiography, and optical coherence tomography angiography...
February 14, 2019: European Journal of Ophthalmology
Alexander Barash, Toco Y P Chui, Patricia Garcia, Richard B Rosen
PURPOSE: Intravitreal injections acutely and temporarily increase intraocular pressure (IOP), and this may have cumulative long-term effects including an increased risk for glaucoma surgery. This study was designed to measure retinal perfusion density changes on optical coherence tomography (OCT) angiography and OCT thickness alterations associated with acutely increased IOP after intravitreal injections. METHODS: Retrospective observational clinical study of 40 eyes (39 patients) with various retinopathies from October 2016 to June 2017 at a tertiary care retina clinic in NYC...
February 11, 2019: Retina
D Martín-Iglesias, J Artaraz, A Fonollosa, A Ugarte, A Arteagabeitia, G Ruiz-Irastorza
OBJECTIVE: The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces cohort treated with hydroxychloroquine (HCQ). METHODS: SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer thickness (GCLT) and qualitative data of retinal pigment epithelium (RPE) and external retina (ExtR) were collected prospectively...
February 12, 2019: Lupus
San Seong, Hun Goo Choo, Yang Jae Kim, Ju Young Kim, Jin Hae Lee, Hyun Sup Oh, Yong Sung You, Soon Hyun Kim, Oh Woong Kwon
PURPOSE: To introduce novel findings of polypoidal choroidal vasculopathy (PCV) via optical coherence tomography angiography (OCTA). METHODS: This study is a retrospective chart review of 16 patients (16 eyes) with PCV. OCTA (Avanti RTVue XR) findings were evaluated and selected for analysis after agreement by two retina specialists . RESULTS: Twenty one polyps in 16 eyes (16 patients) with PCV were included in this study. The mean patient age was 67 years (13 men and three women)...
February 2019: Korean Journal of Ophthalmology: KJO
Travis W Sawyer, Photini F S Rice, David M Sawyer, Jennifer W Koevary, Jennifer K Barton
Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to quantitatively assess the diagnostic potential of OCT for ovarian cancer imaging; however, due to small organ size, the ovaries must first be separated from the image background using the process of segmentation...
January 2019: Journal of Medical Imaging
Ruichan Li, Yanli Liu, Jing Xie, Xudong Huang, Li Zhang, Hua Liu, Lihua Li
Hydrogen possesses antioxidative effects and cures numerous types of ophthalmopathy, but the mechanism of hydrogen on ROS-induced retinal senescence remains elusive. In this study, retinal morphology revealed that hydrogen reduced the number and size of vitreous black deposits in Bruch's membrane in NaIO3 mice. Hydrogen also reduced ROS levels in the retina as assessed by DHE staining. Moreover, this result was consistent with the downregulation of expression of the oxidative stress hallmark OGG1. These findings suggested that hydrogen can reduce retinal oxidative stress induced by NaIO3, and this result was further verified using the antioxidant ALCAR...
February 5, 2019: Free Radical Biology & Medicine
Yuka Kihara, Tjebo F C Heeren, Cecilia S Lee, Yue Wu, Sa Xiao, Simone Tzaridis, Frank G Holz, Peter Charbel Issa, Catherine A Egan, Aaron Y Lee
Importance: As currently used, microperimetry is a burdensome clinical testing modality for testing retinal sensitivity requiring long testing times and trained technicians. Objective: To create a deep-learning network that could directly estimate function from structure de novo to provide an en face high-resolution map of estimated retinal sensitivity. Design, Setting, and Participants: A cross-sectional imaging study using data collected between January 1, 2016, and November 30, 2017, from the Natural History Observation and Registry of macular telangiectasia type 2 (MacTel) evaluated 38 participants with confirmed MacTel from 2 centers...
February 1, 2019: JAMA network open
Juliette Hugo, Marie Beylerian, Eric Denion, Aurore Aziz, Pierre Gascon, Danièle Denis, Frédéric Matonti
PURPOSE: The etiology of torpedo maculopathy remains unknown, but it has been recently suggested that it could represent a persistent defect in the development of the retinal pigment epithelium. As retinal pigment epithelium and photoreceptors form a functional unit, an alteration of photoreceptor distribution or function is predictable. The aim of this study is to describe multimodal imaging, including adaptive optics, in three cases of torpedo maculopathy, and discuss its pathogenesis...
February 8, 2019: European Journal of Ophthalmology
Rae Young Kim, Ho Ra
RATIONALE: Increases in cosmetic laser use have led to recent reports of accidental retinal injuries, most of which are limited to the posterior pole. We report a case of peripheral retinal injury caused by a 1064-nm Nd:YAG: neodymium-doped yttrium aluminum garnet. PATIENT CONCERNS: A 27-year-old Asian woman was admitted with scotoma symptoms in her right eye. The patient was a skin care technician. Three days before admission, a laser beam had struck her eye while she was preparing for a laser procedure...
February 2019: Medicine (Baltimore)
Yuyi You, Ling Zhu, Ting Zhang, Ting Shen, Ariadna Fontes, Con Yiannikas, John Parratt, Joshua Barton, Angela Schulz, Vivek Gupta, Michael H Barnett, Clare L Fraser, Mark Gillies, Stuart L Graham, Alexander Klistorner
PURPOSE: To compare functional and structural changes in the retina in patients with aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). DESIGN: Cross-sectional study; biochemical study of human retinas. PARTICIPANTS: A total of 181 participants, including 22 consecutive patients (44 eyes) with NMOSD, 131 patients (262 eyes) with multiple sclerosis (MS), and 28 normal subjects (56 eyes)...
January 31, 2019: Ophthalmology
Delu Song, Yoshiyasu Ueda, Rupak Bhuyan, Imran Mohammed, Takashi Miwa, Damodar Gullipali, Hangsoo Kim, Lin Zhou, Ying Song, Hannah Schultz, Albert Bargoud, Joshua L Dunaief, Wen-Chao Song
Single nucleotide polymorphisms and rare mutations in Factor H (FH; official name CFH) are associated with age-related macular degeneration and atypical hemolytic uremic syndrome, a form of thrombotic microangiopathy. Mice with the FH W1206R mutation (FHR/R ) share features with human atypical hemolytic uremic syndrome. Here, we report that FHR/R mice exhibited retinal vascular occlusion and ischemia. Retinal fluorescein angiography demonstrated delayed perfusion and vascular leakage in FHR/R mice. Optical coherence tomography imaging of FHR/R mice showed retinal degeneration, edema, and detachment...
January 31, 2019: American Journal of Pathology
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