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Meghna S Jayaraman, Kaitlin Graham, Evan C Unger
The aim of this paper was to create an in vitro setup to quantify the oxygen offloading capabilities of dodecafluoropentane emulsion (DDFPe) in a hypoxic environment. Oxygen offloading from DDFPe was characterized under different gaseous environments and under pre-oxygenated conditions. Results of this study showed that (1) oxygen offloading is inversely related to the solubility of the selected sparging gas in saline and (2) both pre-oxygenated and simultaneously oxygenated DDFPe display similar magnitudes of oxygen transport...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Hollis E Krug, Christopher Dorman, Nicole Blanshan, Sandra Frizelle, Maren Mahowald
Pain is the main cause of disability from arthritis. There is currently an unmet need for adequate treatments for arthritis pain. Pre-clinical models are necessary and useful for studying the mechanisms of pain and for evaluating efficacy of arthritis therapies. Measuring pain in animal models of arthritis is challenging. We have developed methods for measuring evoked and spontaneous pain in three models of murine arthritis. We quantitate the evoked pain responses of mice subjected to firm palpation of a painful knee...
February 22, 2019: Journal of Visualized Experiments: JoVE
Mohamad Motawea, Mamdouh El-Nahas, David G Armstrong
BACKGROUND: The total contact cast has been recognized as the "gold standard" for treatment of Charcot neuro-osteoarthropathy (CN). However, removable cast walkers (RCWs) became an alternative option especially after resolution of the acute stage. RCWs with an elevated sole construction often induce leg length discrepancy (LLD) that could significantly affects plantar pressure (PP) distribution in diabetic patients with neuropathy. AIM: To study the additional effect of walking speed on PP abnormalities induced by LLD...
January 17, 2019: Foot
Sumarno Adi Subrata, Rutja Phuphaibul, Nirobol Kanogsunthornrat, Apinya Siripitayakunkit
BACKGROUND AND AIMS: Diabetic foot ulcer is recognized as the consequence of peripheral neuropathy and peripheral arterial disease amid individuals with diabetes. As is well known, this situation still remains a crucial problem in nursing practice. Available studies describing an algorithm of inter-related nursing interventions concerned with diabetic foot ulcers are limited. Therefore, this integrative review was aimed to present evidence-based practice for overcoming the complications of diabetic foot ulcer as well as preventing lower extremity amputation...
March 7, 2019: Current Diabetes Reviews
Dana Stewart, Eddy Lang, Dongmei Wang, Grant Innes
OBJECTIVE: Emergency department (ED) and hospital overcrowding cause offload delays that remove emergency medical services (EMS) crews from service and compromise care delivery. Prolonged ED boarding and delays to inpatient care are associated with increased hospital length of stay (LOS) and patient mortality, but the effects of EMS offload delays have not been well studied. METHODS: We used administrative data to study all high-acuity Canadian Triage Acuity Scale 2-3 EMS arrivals to Calgary adult EDs from July 2013 to June 2016...
March 7, 2019: CJEM
Fagui Liu, Zhenxi Huang, Liangming Wang
As an emerging and promising computing paradigm in the Internet of things (IoT),edge computing can significantly reduce energy consumption and enhance computation capabilityfor resource-constrained IoT devices. Computation offloading has recently received considerableattention in edge computing. Many existing studies have investigated the computation offloadingproblem with independent computing tasks. However, due to the inter-task dependency in variousdevices that commonly happens in IoT systems, achieving energy-efficient computation offloadingdecisions remains a challengeable problem...
March 4, 2019: Sensors
Benedikt Stolz, Casper Grim, Christoph Lutter, Kolja Gelse, Monika Schell, Bernd Swoboda, Hans-Dieter Carl, Thilo Hotfiel
BACKGROUND:  Continuous passive motion (CPM) and active knee joint motion devices are commonly applied after various surgical procedures. Despite the growing use of active motion devices, there is a paucity of data comparing plantar loads between the different mobilization techniques. The aim of this study was to investigate foot loads during knee joint mobilization in continuous passive and active knee joint motion devices and to compare this data to the physiological load of full weight-bearing...
February 21, 2019: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
Xiayan Fan, Taiping Cui, Chunyan Cao, Qianbin Chen, Kyung Sup Kwak
In this paper, we study the offloading decision of collaborative task execution between platoon and Mobile Edge Computing (MEC) server. The mobile application is represented by a series of fine-grained tasks that form a linear topology, each of which is either executed on a local vehicle, offloaded to other members of the platoon, or offloaded to a MEC server. The objective of the design is to minimize the cost of tasks offloading and meets the deadline of tasks execution. The cost minimized task decision problem is transformed into the shortest path problem, which is limited by the deadline of the tasks on a directed acyclic graph...
February 18, 2019: Sensors
Jiheon Kang, Doo-Seop Eom
We present a machine and deep learning method to offload trained deep learning model and transmit packets efficiently on resource-constrained internet of things (IoT) edge devices and networks. Recently, the types of IoT devices have become diverse and the volume of data has been increasing, such as images, voice, and time-series sensory signals generated by various devices. However, transmitting large amounts of data to a server or cloud becomes expensive owing to limited bandwidth, and leads to latency for time-sensitive operations...
February 18, 2019: Sensors
Danielle L Eastick, Glenn J Tattersall, Simon J Watson, John A Lesku, Kylie A Robert
Many ideas have been put forward for the adaptive value of the cassowary casque; and yet, its purpose remains speculative. Homeothermic animals elevate body temperature through metabolic heat production. Heat gain must be offset by heat loss to maintain internal temperatures within a range for optimal performance. Living in a tropical climate, cassowaries, being large bodied, dark feathered birds, are under thermal pressure to offload heat. We tested the original hypothesis that the casque acts as a thermal window...
February 13, 2019: Scientific Reports
Chongwu Dong, Wushao Wen
The mobile edge computing (MEC) paradigm provides a promising solution to solve the resource-insufficiency problem in mobile terminals by offloading computation-intensive and delay-sensitive tasks to nearby edge nodes. However, limited computation resources in edge nodes may not be sufficient to serve excessive offloading tasks exceeding the computation capacities of edge nodes. Therefore, multiple edge clouds with a complementary central cloud coordinated to serve users is the efficient architecture to satisfy users' Quality-of-Service (QoS) requirements while trying to minimize some network service providers' cost...
February 12, 2019: Sensors
Andrew N Rosenbaum, Robert P Frantz, Sudhir S Kushwaha, John M Stulak, Simon Maltais, Atta Behfar
Background Left ventricular (LV) hemodynamic assessment has been sparsely performed in patients supported on continuous-flow LV assist devices (cf LVADs ). Insight into dynamic changes of left heart parameters during ramp studies may improve LV assist device optimization and evaluate pathology. Methods and Results To complement right heart catheterization, a novel technique for left heart catheterization in patients with a cf LVAD was developed. Patients implanted with cf LVAD s underwent hemodynamic ramp left heart catheterization and right heart catheterization with transthoracic echocardiography...
February 19, 2019: Journal of the American Heart Association
William Tettelbach, Jonathan Arnold, Alberto Aviles, Christopher Barrett, Animesh Bhatia, Michael Desvigne, Lisa J Gould, Marcus S Speyrer, Mark Suski, Colin J Traynor, Lucian Vlad
Use of ultra-portable, mechanically powered disposable negative pressure wound therapy (dNPWT) has grown as an adjunctive modality to manage wounds in outpatient care and to expedite transition of inpatients to an outpatient setting. This technology has demonstrated similar efficacy and usability for mobile outpatients when compared with electrically powered negative pressure wound therapy devices. It was designed for patients with smaller, low to moderately exudating wounds and does not require batteries or a power source...
February 2019: Wounds: a Compendium of Clinical Research and Practice
Marios Avgeris, Dimitrios Spatharakis, Dimitrios Dechouniotis, Nikos Kalatzis, Ioanna Roussaki, Symeon Papavassiliou
A Cyber-Physical Social System (CPSS) tightly integrates computer systems with the physical world and human activities. In this article, a three-level CPSS for early fire detection is presented to assist public authorities to promptly identify and act on emergency situations. At the bottom level, the system's architecture involves IoT nodes enabled with sensing and forest monitoring capabilities. Additionally, in this level, the crowd sensing paradigm is exploited to aggregate environmental information collected by end user devices present in the area of interest...
February 3, 2019: Sensors
Dafna Schwartz, Amit Gefen
Patients who are immobile endure prolonged bodyweight-related compressive, tensional and shear loads at their body-support contact areas that over time may lead to the onset of pressure ulcers (PUs). Approximately, one-third of the common sacral PUs are severe and classified as category 3 or 4. If a PU has occurred, off-loading is the basic, commonly accepted clinical intervention; however, in many situations, complete off-loading of sacral PUs is not possible. Minimising the exposure of wounds and their surroundings to elevated mechanical loads is crucial for healing...
January 29, 2019: International Wound Journal
Kimberly Bartosiak, Jeremy J McCormick
Avascular necrosis (AVN) of the sesamoid is pathology of the medial or lateral hallucal sesamoid resulting in pain under the first metatarsophalangeal joint often presenting in young female athletes. There is overlap of stress fracture, nonunion, and AVN that makes defining the diagnosis difficult but the treatment and outcomes are similar. The most reliable operative treatment used for AVN of the sesamoid is an accumulation of anatomic and mechanical factors with repetitive microtrauma. Nonoperative modalities are designed to offload the sesamoid...
March 2019: Foot and Ankle Clinics
Michele Nitti, George Alex Stelea, Vlad Popescu, Mauro Fadda
In the last few years, one of the main characteristics of the current technological development is the constantly increasing need for data exchange among various types of devices, both mobile and fixed. Within this context, the direct communications between devices has the potential to create new, location-based peer-to-peer applications and services, as well as to help offload traffic from the congested traditional cellular networks. The main hurdles for this kind of Device to Device (D2D) communications are throughput, spectral efficiency, latency and fairness...
January 18, 2019: Sensors
Lauren D Olsen
In their attempt to address racial disparities in the provision of health care, the U.S. medical profession has reproduced racial inequalities of their own. In this article, I draw upon interview data with medical educators and students to detail how medical educators routinely offload the instruction on the social underpinnings and consequences of race onto students, particularly students of color. I develop the concept of the conscripted curriculum to capture how students' social identities are utilized by educators in the professionalization process...
January 17, 2019: Journal of Health and Social Behavior
Mille Nabsen Marwaa, Charlotte Ytterberg, Susanne Guidetti
AIM: The aim of this study was to explore significant others' perspectives on how information and communication technology can support the rehabilitation process after stroke and facilitate participation in everyday life. METHOD: Thirteen significant others were included in the study, and to capture their perspectives, two focus groups, and five individual interviews were carried out in Denmark and Sweden 6-12 months after the stroke incident. A grounded theory approach was used throughout the study and a constant comparative method was used in the analysis...
January 16, 2019: Disability and Rehabilitation
Kenichi Matsuda, Masakazu Kobayashi, Takefumi Kuranaga, Kentaro Takada, Haruo Ikeda, Shigeki Matsunaga, Toshiyuki Wakimoto
SurE is a new, stand-alone thioesterase (TE) offloading the non-ribosomal peptide (NRP) assembly line found in surugamide biosynthesis. It is homologous to penicillin binding protein (PBP) and capable of cyclizing two structurally unrelated substrates derived from two different NRP assembly lines, highlighting the broad substrate tolerance of the SurE offloading cyclase.
January 14, 2019: Organic & Biomolecular Chemistry
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