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https://read.qxmd.com/read/30674313/evaluation-of-a-self-retaining-distractor-for-hip-joint-arthroscopy-in-toy-breed-dogs
#1
Jihye Kim, Jaemin Jeong, Haebeom Lee
BACKGROUND: Hip arthroscopy has become a viable option over the last few years for small animal orthopedic diseases, including hip dysplasia, osteoarthritis, and joint evaluation. However, the narrow joint spaces make it difficult to manipulate the instrument, and depth of tissues make it difficult to distract the joint space. In addition, it is very difficult to maintain consistent distraction over time with a manual distraction due to hand fatigue. To overcome these difficulties, distractors are used in human medicine to improve safety and accuracy of arthroscopy...
January 23, 2019: BMC Veterinary Research
https://read.qxmd.com/read/30657760/age-related-strength-loss-affects-non-stepping-balance-recovery
#2
Hoda Koushyar, Kathleen A Bieryla, Maury A Nussbaum, Michael L Madigan
Aging is associated with a higher risk of falls, and an impaired ability to recover balance after a postural perturbation is an important contributing factor. In turn, this impaired recovery ability likely stems from age-related decrements in lower limb strength. The purpose of this study was to investigate the effects of age-related strength loss on non-stepping balance recovery capability after a perturbation while standing, without constraining movements to the ankle as in prior reports. Two experiments were conducted...
2019: PloS One
https://read.qxmd.com/read/30636973/differences-and-mechanisms-underpinning-a-change-in-the-knee-flexion-moment-while-running-in-stability-and-neutral-footwear-among-young-females
#3
Timothy A Sayer, Rana S Hinman, Kade L Paterson, Kim L Bennell, Karine Fortin, J Kasza, Adam L Bryant
Background: Higher peak external knee flexion moments (KFM) during running has been observed in healthy people wearing athletic footwear compared to barefoot, which may increase risk of knee pathologies such as patellofemoral pain. Currently, no studies have examined whether stability and neutral style athletic shoes influence the peak KFM differently, or explored the underlying biomechanical mechanisms by which footwear alters peak KFM in young females. Methods: Lower limb biomechanics of sixty girls aged between 10 and 25 years old were collected while running in footwear (both stability and neutral) and barefoot...
2019: Journal of Foot and Ankle Research
https://read.qxmd.com/read/30597057/office-based-mesenchymal-stem-cell-therapy-for-the-treatment-of-musculoskeletal-disease-a-systematic-review-of-recent-human-studies
#4
Luke Law, Christine L Hunt, Andre J van Wijnen, Ahmad Nassr, A Noelle Larson, Jason S Eldrige, William D Mauck, Mathew J Pingree, Juan Yang, Casey W Muir, Patricia J Erwin, Mohamad Bydon, Wenchun Qu
Background: The use of mesenchymal stem cells (MSCs) in clinical applications for the treatment of musculoskeletal disease is steadily increasing in office-based practice. The so-called "first generation" of MSCs is defined as autologous stem cells that have undergone minimal manipulation and are used for a homologous purpose. Systematic reviews of the clinical trials completed to date of such MSCs enable practitioners to better understand what is currently known about the outcomes and side effects of such treatments...
December 29, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://read.qxmd.com/read/30585381/oxytocin-inhibits-methamphetamine-associated-learning-and-memory-alterations-by-regulating-dna-methylation-at-the-synaptophysin-promoter
#5
Xin-Yu Fan, Jing-Yu Yang, Ying-Xu Dong, Ying Hou, Shuai Liu, Chun-Fu Wu
Methamphetamine (METH) causes memory changes, but the underlying mechanisms are poorly understood. Epigenetic mechanisms, including DNA methylation, can potentially cause synaptic changes in the brain. Oxytocin (OT) plays a central role in learning and memory, but little is known of the impact of OT on METH-associated memory changes. Here, we explored the role of OT in METH-induced epigenetic alterations that underlie spatial and cognitive memory changes. METH (2.0 mg/kg, i.p.) was administered to male C57BL/6 mice once every other day for 8 days...
December 25, 2018: Addiction Biology
https://read.qxmd.com/read/30560181/is-it-safe-outpatient-total-joint-arthroplasty-with-discharge-to-home-at-a-freestanding-ambulatory-surgical-center
#6
Ritesh R Shah, Nancy E Cipparrone, Alexander C Gordon, David J Raab, James R Bresch, Nishant A Shah
Background: Total joint arthroplasty (TJA) is trending toward shorter hospitalizations; as a result, there are many ambulatory surgical centers (ASCs) starting to perform outpatient TJA. However, there are limited studies examining the safety of outpatient TJA in the freestanding ASC setting. This study aims to evaluate 30-day and 90-day complication rates in patients who underwent outpatient TJA at a freestanding, independent ASC with direct discharge to home. Methods: A retrospective cohort review using health records was performed on the first 115 TJAs performed between August 2015 and March 2017 by one of the 4 orthopedic surgeons...
December 2018: Arthroplasty Today
https://read.qxmd.com/read/30559863/tumescent-local-infiltration-anesthesia-for-mini-abdominoplasty-with-liposuction
#7
Ahmed Abdalla Mohamed, Tamer Fayez Safan, Hamed Fathy Hamed, Maged Abdelwahab Abdelaziz Elgendy
AIM: To evaluate the feasibility and safety of mini abdominoplasty with liposuction under local tumescent anaesthesia (LA) as the sole anaesthetic modality. METHODS: The study included 60 female patients with a mean age of 33.3 ± 5.6 years. Local infiltration using a mixture of 1:1000 epinephrine (1 ml), 2% lidocaine (100 ml) and 0.5% Levobupivacaine (50 ml) in 2500 ml saline was started with Local infiltration started with the abdomen, outer thigh, hips, back, inner thighs and knees...
November 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30458428/local-dynamic-stability-of-the-lower-extremity-in-novice-and-trained-runners-while-running-intraditional-and-minimal-footwear
#8
Nicholas S Frank, Stephen D Prentice, Jack P Callaghan
BACKGROUND: Understanding how footwear cushioning influences movement stability may be helpful in reducing injuries related to repetitive loading. RESEARCH QUESTION: The purpose of this study was to identify the relationship between running experience and midsole cushioning on local dynamic stability of the ankle, knee and hip. METHODS: Twenty-four trained and novice runners were recruited to run on a treadmill for five minutes at the same relative intensity...
November 5, 2018: Gait & Posture
https://read.qxmd.com/read/30411215/a-new-affordable-and-easy-to-make-pelvic-model-for-training-in-complex-urogynecological-laparoscopic-procedures
#9
Tamara Serdinšek, Branka Žegura Andrić, Igor But
INTRODUCTION AND HYPOTHESIS: Our aim was to introduce a new affordable and easy-to-make pelvic model for training in complex urogynecological laparoscopic procedures. METHODS: We modified a commercial female pelvic model consisting of sacrum, coccyx, two hip bones, the pubic symphysis, the fifth lumbar vertebra with intervertebral disc, and certain pelvic ligaments. We used sponge foam paper, felt fabric pieces, chenille stems, foam, plastic ties, fabric glue, and a thick, coated wire to create pelvic floor, uterus/vaginal cuff, bladder, both ureters, and anterior longitudinal and pectineal ligaments...
November 8, 2018: International Urogynecology Journal
https://read.qxmd.com/read/30288961/muscle-specific-perilipin2-down-regulation-affects-lipid-metabolism-and-induces-myofiber-hypertrophy
#10
Maria Conte, Andrea Armani, Giuseppe Conte, Andrea Serra, Claudio Franceschi, Marcello Mele, Marco Sandri, Stefano Salvioli
BACKGROUND: Perilipin2 (Plin2) belongs to a family of five highly conserved proteins, known for their role in lipid storage. Recent data indicate that Plin2 has an important function in cell metabolism and is involved in several human pathologies, including liver steatosis and Type II diabetes. An association between Plin2 and lower muscle mass and strength has been found in elderly and inactive people, but its function in skeletal muscle is still unclear. Here, we addressed the role of Plin2 in adult muscle by gain and loss of function experiments...
October 4, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/30280372/cobalt-ions-stimulate-a-fibrotic-response-through-matrix-remodelling-fibroblast-contraction-and-release-of-pro-fibrotic-signals-from-macrophages
#11
J Xu, A Nyga, W Li, X Zhang, N Gavara, M M Knight, J C Shelton
Many studies report the adverse responses to metal-on-metal (MoM) hip prostheses, with tissues surrounding failed MoM hip prostheses revealing abundant tissue necrosis and fibrosis. These local effects appear to be initiated by metal ions released from the prosthesis causing the secretion of inflammatory mediators. However, little is known about the effect of the metal ions on tissue remodelling and pseudotumor formation, which are also associated with the failure of MoM hip prostheses. The peri-prosthetic soft tissue masses can lead to pain, swelling, limited range of joint movement and extensive tissue lesion...
October 2, 2018: European Cells & Materials
https://read.qxmd.com/read/30273960/novel-mutation-in-teneurin-3-found-to-co-segregate-in-all-affecteds-in-a-multi-generation-family-with-developmental-dysplasia-of-the-hip
#12
George Feldman, Dietmar Kappes, Jayati Mookerjee-Basu, Theresa Freeman, Andrzej Fertala, Javad Parvizi
DDH is a debilitating condition characterized by incomplete formation of the acetabulum leading to dislocation of the hip, suboptimal joint function and accelerated wear of the articular cartilage resulting in early onset crippling arthritis of the hip in 20-40 year olds. Current diagnostic tests in newborns using physical manipulation of the femur or ultrasound either under or over-diagnose this condition. Developing an accurate, cost effective diagnostic test is a goal of this study. To better understand the biologic pathways involved in acetabular development, DNA from severely affected individuals in a four generation family that showed inter-generational transmission of the disorder was isolated and whole exome sequenced...
October 1, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30270744/validity-of-patient-reported-complications-after-total-hip-and-knee-arthroplasty
#13
Kinh Luan Thanh Dang, Helen Badge, Ian A Harris
BACKGROUND: Evaluating the effectiveness of total hip arthroplasty (THA) and total knee arthroplasty (TKA) often relies on accurate patient reporting of postoperative complications. Despite this, there is little research regarding the accuracy of patient reports. We aimed to determine the accuracy of patient-reported significant complications after THA and TKA. METHODS: Patients were recruited prior to undergoing primary hip or knee arthroplasty at 19 high-volume hospitals...
May 2018: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/30233958/superpath-the-direct-superior-portal-assisted-total-hip-approach
#14
James Chow
The supercapsular percutaneously assisted total hip (SuperPath; MicroPort) approach is a direct superior portal-assisted approach for total hip arthroplasty (THA) that utilizes the interval between the gluteus minimus and the piriformis to access the hip capsule. The technique was developed to promote early mobilization, greater range of motion, and improved pain control. The major steps of this procedure are as follows: Step 1: Patient positioning. The patient is in the standard lateral decubitus position with the involved leg in the "home position," that is, 45° to 60° of flexion, 20° to 30° of internal rotation, and slight adduction by elevating the foot on a padded Mayo stand...
September 28, 2017: JBJS Essential Surgical Techniques
https://read.qxmd.com/read/30232854/-acupuncture-treatment-reduces-body-weight-possibly-by-down-regulating-insulin-and-leptin-resistance-and-up-regulating-soluble-leptin-receptor-level-in-prediabetic-patients
#15
Zhi-Ming Zhao, Chun-Li Liu, Qun-Yan Zhang, Bei-Bei Zhang, Jun-Hao Guo, Ai-Hong Yuan, Hui Cai
OBJECTIVE: To observe the effect of acupuncture of Feishu (BL 13), Pishu (BL 20), etc. on body weight, blood lipid, leptin (LP) and soluble leptin receptor (sOB-R) levels in prediabetic patients, so as to explore its mechanisms underlying treatment and prevention of prediabetes. METHODS: A total of 100 prediabetic patients were randomly assigned to medication (Metformin) group ( n =35), acupuncture group ( n =35) and simple lifestyle intervention group ( n =30) with random number table method...
August 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/30230052/effects-of-barbell-back-squat-stance-width-on-sagittal-and-frontal-hip-and-knee-kinetics
#16
Johan Lahti, András Hegyi, Andrew D Vigotsky, Juha P Ahtiainen
Different stance widths are commonly utilized when completing the barbell back squat during athletic general preparedness training. Width manipulation is thought to influence sagittal plane stimuli to the hip and knee extensors, the primary extensor musculature in the squat. However, how width manipulation affects frontal plane stimuli is less understood. Knowledge of hip and knee net joint moments (NJM) could improve exercise selection when aiming to improve sport-specific performance and prevent injuries...
September 19, 2018: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/30178303/injury-prevention-strategies-for-adolescent-cricket-pace-bowlers
#17
REVIEW
Mitchell R L Forrest, Brendan R Scott, Jeffrey J Hebert, Alasdair R Dempsey
Adolescent cricket pace bowlers are prone to non-contact shoulder, low back and lower-limb injuries. Exercise-based injury prevention programmes (IPPs) are effective for reducing non-contact injuries in athletes; however, a specific programme for adolescent pace bowlers has not been published. This paper therefore seeks to provide a rationale for the development of an exercise-based IPP specific for adolescent pace bowlers. It also outlines design principles and provides an example exercise programme that can be implemented at the community level...
November 2018: Sports Medicine
https://read.qxmd.com/read/30168018/amphetamine-self-administration-and-its-extinction-alter-the-5-ht-1b-receptor-protein-levels-in-designated-structures-of-the-rat-brain
#18
Joanna Miszkiel, Joanna Jastrzębska, Małgorzata Filip, Edmund Przegaliński
Manipulation of the serotonin (5-HT)1B receptors can modify the behavioral effects of amphetamine including its reinforcing properties. Focus of this study was to examine changes in 5-HT1B receptor protein expression in several brain structures linked to substance drug disorder in different stages of amphetamine addiction-single session of amphetamine self-administration, 20 consecutive days of amphetamine self-administration, and 3 and 14 days of extinction from chronic drug intake. "Yoked" procedure was employed to set apart pharmacological and motivational effects of amphetamine intoxication...
August 30, 2018: Neurotoxicity Research
https://read.qxmd.com/read/30167674/gaze-when-reaching-to-grasp-a-glass
#19
Dimitris Voudouris, Jeroen B J Smeets, Katja Fiehler, Eli Brenner
People have often been reported to look near their index finger's contact point when grasping. They have only been reported to look near the thumb's contact point when grasping an opaque object at eye height with a horizontal grip-thus when the region near the index finger's contact point is occluded. To examine to what extent being able to see the digits' final trajectories influences where people look, we compared gaze when reaching to grasp a glass of water or milk that was placed at eye or hip height. Participants grasped the glass and poured its contents into another glass on their left...
August 1, 2018: Journal of Vision
https://read.qxmd.com/read/30131208/autologous-conditioned-serum-acs-for-intra-articular-treatment-in-osteoarthritis-retrospective-report-of-28-cases
#20
Michela Tassara, Alessandro De Ponti, Lorena Barzizza, Matilde Zambelli, Cristina Parisi, Raffaella Milani, Luca Santoleri
INTRODUCTION: Autologous conditioned serum (ACS) is a novel blood product developed for intra-articular injection as a novel therapy for Osteoarthritis (OA). This study is a retrospective evaluation of 28 cases (25 Knee-OA and 3 hip-OA) treated with ACS between November 2013 and February 2016. MATERIALS AND METHODS: ACS was prepared according to standards in an accredited Cell Manipulation Lab, and applied by an expert clinician (2 ml injection once weekly over 4 weeks)...
August 2018: Transfusion and Apheresis Science
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