keyword
https://read.qxmd.com/read/38526926/the-2023-ao-spine-praxis-guidelines-in-acute-spinal-cord-injury-what-have-we-learned-what-are-the-critical-knowledge-gaps-and-barriers-to-implementation
#21
JOURNAL ARTICLE
Michael G Fehlings, Ali Moghaddamjou, Nathan Evaniew, Lindsay A Tetreault, Mohammed Ali Alvi, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Narrative summary of the 2023 AO Spine-Praxis clinical practice guidelines for management in acute spinal cord injury (SCI). OBJECTIVES: The objective of this article is to summarize the key findings of the clinical practice guidelines for the optimal management of traumatic and intraoperative SCI (ISCI). This article will also highlight potential knowledge translation opportunities for each recommendation and discuss important knowledge gaps and areas of future research...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526923/a-clinical-practice-guideline-for-the-management-of-patients-with-acute-spinal-cord-injury-recommendations-on-hemodynamic-management
#22
JOURNAL ARTICLE
Brian K Kwon, Lindsay A Tetreault, Allan R Martin, Paul M Arnold, Rex A W Marco, Virginia F J Newcombe, Carl M Zipser, Stephen L McKenna, Radha Korupolu, Chris J Neal, Rajiv Saigal, Nina E Glass, Sam Douglas, Mario Ganau, Vafa Rahimi-Movaghar, James S Harrop, Bizhan Aarabi, Jefferson R Wilson, Nathan Evaniew, Andrea C Skelly, Michael G Fehlings
STUDY DESIGN: Clinical practice guideline development following the GRADE process. OBJECTIVES: Hemodynamic management is one of the only available treatment options that likely improves neurologic outcomes in patients with acute traumatic spinal cord injury (SCI). Augmenting mean arterial pressure (MAP) aims to improve blood perfusion and oxygen delivery to the injured spinal cord in order to minimize secondary ischemic damage to neural tissue. The objective of this guideline was to update the 2013 AANS/CNS recommendations on the hemodynamic management of patients with acute traumatic SCI, acknowledging that much has been published in this area since its publication...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526922/an-update-of-a-clinical-practice-guideline-for-the-management-of-patients-with-acute-spinal-cord-injury-recommendations-on-the-role-and-timing-of-decompressive-surgery
#23
JOURNAL ARTICLE
Michael G Fehlings, Lindsay A Tetreault, Laureen Hachem, Nathan Evaniew, Mario Ganau, Stephen L McKenna, Chris J Neal, Narihito Nagoshi, Vafa Rahimi-Movaghar, Bizhan Aarabi, Christoph P Hofstetter, Valerie Ter Wengel, Hiroaki Nakashima, Allan R Martin, Steven Kirshblum, Ricardo Rodrigues Pinto, Rex A W Marco, Jefferson R Wilson, David E Kahn, Virginia F J Newcombe, Carl M Zipser, Sam Douglas, Shekar N Kurpad, Yi Lu, Rajiv Saigal, Uzma Samadani, Paul M Arnold, Gregory W J Hawryluk, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Clinical practice guideline development. OBJECTIVES: Acute spinal cord injury (SCI) can result in devastating motor, sensory, and autonomic impairment; loss of independence; and reduced quality of life. Preclinical evidence suggests that early decompression of the spinal cord may help to limit secondary injury, reduce damage to the neural tissue, and improve functional outcomes. Emerging evidence indicates that "early" surgical decompression completed within 24 hours of injury also improves neurological recovery in patients with acute SCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526644/a-systematic-review-of-sandifer-syndrome-in-children-with-severe-gastroesophageal-reflux
#24
JOURNAL ARTICLE
Daiki Kato, Hiroo Uchida, Hizuru Amano, Kazuki Yokota, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Akihiro Yasui, Yousuke Gohda, Takuya Maeda, Akinari Hinoki
PURPOSE: Sandifer syndrome (SS), which combines gastroesophageal reflux (GER) and a neurological or psychiatric disorder, is an uncommon condition that often takes a long time to diagnosis. We aimed to systematically review available papers regarding SS. METHODS: After presenting our two cases of SS, we systematically reviewed articles published in MEDILINE/PubMed, Cochrane Library, and Web of Science. RESULTS: The meta-analysis included 54 reported cases and 2 of our own cases...
March 25, 2024: Pediatric Surgery International
https://read.qxmd.com/read/38526628/clinical-features-and-surgical-treatments-of-scoliosis-in-neurofibromatosis-type-1-a-systemic-review-and-meta-analysis
#25
REVIEW
Dun Wang, Bo-Han Zhang, Xue Wen, Kun-Hao Chen, Hai-Tao Xiao, Xue-Wen Xu, Qing-Feng Li
BACKGROUND: Neurofibromatosis type 1 (NF 1) is an autosomal-dominant tumor predisposition genetic disease affecting approximately 1 in 3000 live births. The condition could present various manifestations ranging from skin abnormalities to neurological tumors. The musculoskeletal system could also be frequently affected, and scoliosis is the most common orthopedic manifestation. Characterized by the early-onset and rapid progression tendency, NF 1-related dystrophic scoliosis presented discrepancies from idiopathic scoliosis in terms of natural history, clinical features, and management outcomes and thus required special attention...
March 25, 2024: European Spine Journal
https://read.qxmd.com/read/38526313/social-isolation-and-post-weaning-environmental-enrichment-effects-on-rat-emotional-behavior-and-serotonergic-system
#26
REVIEW
Roxana Patrícia Bezerra da Silva, Isabeli Lins Pinheiro, Regina Katiuska Bezerra da Silva, Eduarda Correia Moretti, Olavo Barbosa de Oliveira Neto, Kelli Ferraz-Pereira, Lígia Cristina Monteiro Galindo
Social isolation (SI) is related to adverse neurobehavioral effects and neurochemical changes when it occurs early in development. On the other hand, environmental enrichment (EE) is associated with a reduction in anxiety-like and depression-like behavior, as well as an increase in serotonin (5-HT) levels in the prefrontal cortex and hippocampus in rodents. This study systematically reviewed the effects of SI and EE on emotional behavior and serotonergic system components in rats after weaning. Primary experimental studies that used subgroups of rats subjected to SI, EE, and normal social conditions after weaning were considered eligible...
March 25, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38526275/human-brain-organoid-trends-evolution-and-remaining-challenges
#27
JOURNAL ARTICLE
Minghui Li, Yuhan Yuan, Zongkun Hou, Shilei Hao, Liang Jin, Bochu Wang
Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases. Although various studies and reviews have described developments and advancements in brain organoids, few studies have comprehensively summarized and analyzed the global trends in this area of neuroscience. To identify and further facilitate the development of cerebral organoids, we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 years...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38523977/interventions-to-improve-medication-adherence-in-children-with-epilepsy-a-systematic-review
#28
REVIEW
Karishma Godara, Nisha Phakey, Divyani Garg, Suvasini Sharma, Rashmi R Das
Low medication adherence remains a major challenge in the treatment of epilepsy, particularly in children. In recent years, several approaches and interventions have been employed to promote medication adherence in children with epilepsy (CWE). In this study, we aimed to summarize the evidence on these interventions. In this systematic review, major medical electronic databases were searched for relevant literature from January 2005 till July 2023, including PsycINFO, Medline (via PubMed), Google Scholar, Taylor & Francis databases, and CENTRAL by the Cochrane Library...
February 2024: Curēus
https://read.qxmd.com/read/38523419/expert-consensus-recommendations-for-improving-and-standardising-the-assessment-of-patients-with-generalised-myasthenia-gravis
#29
JOURNAL ARTICLE
Andreas Meisel, Francesco Saccà, Jennifer Spillane, John Vissing
BACKGROUND: Regular and consistent disease assessment could provide a clearer picture of burden in generalised myasthenia gravis (gMG) and improve patient care; however, the use of assessment tools in practice lacks standardisation. This modified Delphi approach was taken to review current evidence on assessment tool use in gMG and develop expert-derived consensus recommendations for good practice. METHODS: A European expert panel of 15 experienced gMG neurologists contributed to development of this consensus, four of whom formed a lead Sub-committee...
March 24, 2024: European Journal of Neurology
https://read.qxmd.com/read/38523141/identifying-factors-predicting-outcomes-after-major-trauma-in-older-patients-prognostic-systematic-review-and-meta-analysis
#30
JOURNAL ARTICLE
Mayura Thilanka Iddagoda, Michelle Trevenen, Claire Meaton, Christopher Etherton-Beer, Leon Flicker
INTRODUCTION: Trauma is the most common cause of morbidity and mortality in older people and it is important to determine the predictors of outcomes after major trauma in older people. METHODS: MEDLINE, Embase, Web of Science and manual search of relevant papers since 1987 to February 2023 was searched. Random effects meta-analyses were performed. The primary outcome of interest was mortality and secondary outcomes were medical complications, length of stay, discharge destination, readmission, and intensive care requirement...
March 25, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38523025/-effectiveness-of-psychotherapy-on-dissociative-symptoms-in-adult-populations-a-prisma-systematic-review
#31
JOURNAL ARTICLE
Camille Aujoulat, Alexis Vancappel, Géraldine Tapia
INTRODUCTION: Dissociation is a psychological process in reaction to threat which can be found in many psychiatric conditions. Dissociative symptoms can become very disabling, whether in daily life or in care. Nevertheless, few studies seem to have examined the efficacy of psychotherapy on the latter and its relevance as a therapeutic target. METHOD: A systematic review of the literature (PRISMA) on the efficacy of psychotherapy on dissociative symptoms in adults with mental disorders was conducted...
March 23, 2024: L'Encéphale
https://read.qxmd.com/read/38522911/the-clinical-practice-guideline-for-the-management-of-amyotrophic-lateral-sclerosis-in-japan-update-2023
#32
JOURNAL ARTICLE
Makoto Urushitani, Hitoshi Warita, Naoki Atsuta, Yuishin Izumi, Osamu Kano, Toshio Shimizu, Yuki Nakayama, Yugo Narita, Hiroyuki Nodera, Takuji Fujita, Koichi Mizoguchi, Mitsuya Morita, Masashi Aoki
Amyotrophic lateral sclerosis (ALS) is an adult-onset intractable motor neuron disease characterized by selective degeneration of cortical neurons in the frontotemporal lobe and motor neurons in the brainstem and spinal cord. Impairment of these neural networks causes progressive muscle atrophy and weakness that spreads throughout the body, resulting in life-threatening bulbar palsy and respiratory muscle paralysis. However, no therapeutic strategy has yet been established to halt ALS progression. Although evidence for clinical practice in ALS remains insufficient, novel research findings have steadily accumulated in recent years...
March 23, 2024: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/38522790/acute-macrocystic-thoracic-schwannoma-systematic-review-and-illustrative-case-example
#33
REVIEW
Grace R Fassina, Spencer J Oslin, Helen H Shi, John F Burke, Caple A Spence, Christopher S Graffeo
BACKGROUND: Schwannomas are benign peripheral nerve sheath tumors arising from myelinating Schwann cells. Although macrocystic changes are regularly encountered in schwannoma variants such as vestibular nerve tumors, they are exceedingly rare among spinal neoplasms. METHODS: Case report and systematic review of four databases (Ovid Medline, PubMed, Science Direct, and SCOPUS) from inception to present. All peer-reviewed publications reporting intradural cystic thoracic schwannoma were included...
March 22, 2024: World Neurosurgery
https://read.qxmd.com/read/38521933/a-systematic-review-of-high-impact-cpg-sites-and-regions-for-mgmt-methylation-in-glioblastoma-a-systematic-review-of-mgmt-methylation-in-gbm
#34
JOURNAL ARTICLE
David Gibson, Anh Huan Vo, Hannah Lambing, Prithanjan Bhattacharya, Peggy Tahir, Farid F Chehab, Nicholas Butowski
BACKGROUND: MGMT (O 6 -methylguanine-DNA methyltransferase) promoter methylation is a commonly assessed prognostic marker in glioblastoma (GBM). Epigenetic silencing of the MGMT gene by promoter methylation is associated with greater overall and progression free survival with alkylating agent regimens. To date, there is marked heterogeneity in how MGMT promoter methylation is tested and which CpG sites are interrogated. METHODS: To further elucidate which MGMT promoter CpG sites are of greatest interest, we performed comprehensive searches in PubMed, Web of Science, and Embase and reviewed 2,925 article abstracts...
March 23, 2024: BMC Neurology
https://read.qxmd.com/read/38520940/the-role-of-genetics-in-the-treatment-of-dystonia-with-deep-brain-stimulation-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Harini Sarva, Federico Rodriguez-Porcel, Francisco Rivera, Claudio Daniel Gonzalez, Samantha Barkan, Susmit Tripathi, Emilia Gatto, Pedro Garcia Ruiz
BACKGROUND: Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions that lead to involuntary postures or repetitive movements. Genetic mutations are being increasingly recognized as a cause of dystonia. Deep brain stimulation (DBS) is one of the limited treatment options available. However, there are varying reports on its efficacy in genetic dystonias. This systematic review of the characteristics of genetic dystonias treated with DBS and their outcomes aims to aid in the evaluation of eligibility for such treatment...
March 20, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38520792/vitamin-d-status-and-neuromyelitis-optica-spectrum-disease-a-systematic-review-and-meta-analysis
#36
REVIEW
Yunfei Zhu, Shugang Cao, Fangzhou Hu, Xiaoling Zhou, Qun Xue
BACKGROUND AND OBJECTIVE: There's an increasing body of evidence on vitamin D deficiency and the risk of neuromyelitis optica spectrum disorder (NMOSD). The aim of this meta-analysis was to assess serum vitamin D levels in patients with NMOSD versus healthy controls. METHODS: We searched PubMed, EMBASE, Cochrane Library, Web of Science and CNKI for publications up to November 2022 and explored the relationship between NMOSD and serum vitamin D levels. The standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated using a random-effects model...
March 8, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38520640/intraoperative-mapping-and-preservation-of-executive-functions-in-awake-craniotomy-a-systematic-review
#37
REVIEW
Rabeet Tariq, Hafiza Fatima Aziz, Shahier Paracha, Noman Ahmed, Muhammad Waqas Saeed Baqai, Saqib Kamran Bakhshi, Annabel McAtee, Timothy J Ainger, Farhan A Mirza, Syed Ather Enam
Awake craniotomy (AC) allows intraoperative brain mapping (ioBM) for maximum lesion resection while monitoring and preserving neurological function. Conventionally, language, visuospatial assessment, and motor functions are mapped, while the assessment of executive functions (EF) is uncommon. Impaired EF may lead to occupational, personal, and social limitations, thus, a compromised quality of life. A comprehensive literature search was conducted through Scopus, Medline, and Cochrane Library using a pre-defined search strategy...
March 23, 2024: Neurological Sciences
https://read.qxmd.com/read/38520639/comparative-efficacy-of-different-noninvasive-brain-stimulation-protocols-on-upper-extremity-motor-function-and-activities-of-daily-living-after-stroke-a-systematic-review-and-network-meta-analysis
#38
REVIEW
Ling-Ling Li, Jia-Jia Wu, Kun-Peng Li, Jing Jin, Yun-Ting Xiang, Xu-Yun Hua, Mou-Xiong Zheng, Jian-Guang Xu
The objectives of the study were to systematically evaluate the rehabilitation effect of noninvasive brain stimulation (NIBS) on upper extremity motor function and activities of daily living in stroke patients and to prioritize various stimulation protocols for reliable evidence-based medical recommendations in patients with upper extremity motor dysfunction after stroke. Web of Science, PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP, and CBM were searched to collect all randomized controlled trials (RCTs) of NIBS to improve upper extremity motor function in stroke patients...
March 23, 2024: Neurological Sciences
https://read.qxmd.com/read/38519310/the-impact-of-internet-pornography-on-children-and-adolescents-a-systematic-review
#39
JOURNAL ARTICLE
Frank W Paulus, Foujan Nouri, Susanne Ohmann, Eva Möhler, Christian Popow
OBJECTIVES: Young people's exposure to online pornographic material has increased in the past years. Its impact is a complex topic but an important issue due to growing concerns. Therefore, we reviewed the literature on Internet pornography consumption and its impact on children and adolescents. Furthermore, we examined young people's thoughts about pornography and their reasons for consumption. METHOD: We performed a systematic literature search in the online databases ERIC, PsycARTICLES, PsycINFO, and PSYNDEX for peer-reviewed articles in English, published between 2000 and 2022 and additionally identified secondary references...
March 21, 2024: L'Encéphale
https://read.qxmd.com/read/38519277/chinese-herbal-medicine-ginkgo-biloba-l-preparations-for-ischemic-stroke-an-overview-of-systematic-reviews-and-meta-analyses
#40
REVIEW
Tian-Tian Meng, Ya-Ping You, Min Li, Jian-Bo Guo, Xin-Bin Song, Jing-Yi Ding, Xiao-Long Xie, An-Qi Li, Shang-Jin Li, Xiang-Jun Yin, Peng Wang, Zhe Wang, Bao-Liang Wang, Qing-Yong He
BACKGROUND: Ginkgo biloba L. preparations (GBLPs) are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke (IS). Recently, several systematic reviews (SRs) and meta-analyses (MAs) of GBLPs for IS have been published. OBJECTIVE: This overview aims to assess the quality of related SRs and MAs. SEARCH STRATEGY: PubMed, Embase, Cochrane Library, Web of Science, Chinese Biological Medicine, China National Knowledge Infrastructure, Wanfang, and Chinese Science and Technology Journals databases were searched from their inception to December 31, 2022...
March 6, 2024: Journal of Integrative Medicine
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