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Tahmina Ajmal, Tochukwu Kene Anyachebelu, Marc Conrad, David M Rawson
Using a single numerical value to indicate the quality of water, a so-called Water Quality Index (WQI) is a well-established way of rating the overall water quality status of a given water body. During the last few years, researchers in the water sector have developed different such indices to address their specific needs. In this study, we attempt to obtain a WQI formula suited for evaluating the water quality of the River Lea. We have selected four different sites on the River Lea and explore the possibility of monitoring using a minimum number of parameters only...
February 9, 2019: Environmental Monitoring and Assessment
Julien Lepage, Pierre Francois Ceccaldi, Sid Ahmed Remini, Patrick Plaisance, Audrey Voulgaropoulos, Dominique Luton
BACKGROUND: Although most societies of obstetrics advocate vaginal delivery of twins, there has been a steady rise in the rate of twin cesarean sections. We risk perhaps losing in a single generation our obstetrical learning and skills because of medicolegal and emotionally charged issues. METHODS: We have therefore designed a realistic as possible simulation model of second twin delivery and tested it on residents in obstetrics. FINDINGS: Between two trials, we noted a significant improvement in the time required for internal podalic version and breech extraction...
January 24, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Julia Pescheny, Gurch Randhawa, Yannis Pappas
Background: Social prescription is an initiative that aims to link patients in primary care with sources of support within the community and voluntary sector to improve their health, wellbeing, and care experience. Such programmes usually include navigators, who work with referred patients and issue onward referrals to sources of non-medical support. Most research on social prescribing (SP) has focused on outcome evaluations, resulting in a knowledge gap of factors affecting uptake and adherence...
October 2018: BJGP Open
Fidelia Bature, Barbara Guinn, Dong Pang, Yannis Pappas
We set out to investigate the insights general practitioners (GPs) have into the early signs and symptoms of Alzheimer's disease (AD), factors that may be responsible for the late diagnosis, as well as their recommendations for early diagnosis of AD. This was a semi-structured, qualitative and audio-recorded interview of seven GPs, from five GP surgeries in Milton Keynes and Luton, using the framework analysis. GPs reported challenges with the current patient's consultation time, a lack of continuity of care, inadequate training, limited support for patients after diagnosis, and poor treatment of the UK's aging population...
November 15, 2018: JAD Reports
Fabienne Delay, Vincent Dochez, Florence Biquard, Marie-Thérèse Cheve, Philippe Gillard, Chloe Arthuis, Norbert Winer
INTRODUCTION: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. OBJECTIVES: The principal objective of this retrospective study was to analyze the data that enabled the physicians to assess whether the goiter was hypo- or hyperthyroid and then to analyze the obstetric practices used in the Pays de Loire network to describe in detail the tools used to diagnose and characterize the goiters and the management chosen in these cases...
December 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
Jennifer Arnold, Alexandra Luton, Jonathan Davies
No abstract text is available yet for this article.
October 2018: Seminars in Perinatology
Werner F Blum, Jürgen Klammt, Serge Amselem, Heike M Pfäffle, Marie Legendre, Marie-Laure Sobrier, Marie-Pierre Luton, Christopher J Child, Christine Jones, Alan G Zimmermann, Charmian A Quigley, Gordon B Cutler, Cheri L Deal, Jan Lebl, Ron G Rosenfeld, John S Parks, Roland W Pfäffle
No abstract text is available yet for this article.
October 2018: EBioMedicine
Frédéric Illouz, Dominique Luton, Michel Polak, Alix Besançon, Claire Bournaud
This section deals with the specificities of managing Graves' disease during pregnancy. Graves' disease incurs risks of fetal, neonatal and maternal complications that are rare but may be severe: fetal hyper- or hypothyroidism, usually first showing as fetal goiter, neonatal dysthyroidism, premature birth and pre-eclampsia. Treatment during pregnancy is based on antithyroid drugs alone, without association to levothyroxine. An history of Graves' disease, whether treated radically or not, with persistent maternal anti-TSH-receptor antibodies must be well identified...
August 16, 2018: Annales D'endocrinologie
Alexandra Luton, Nidia Estrada, Kalynn Barrientez, Jennifer McGinnis, Jennifer Pitlik, Alexandra Carter, Lisa Davenport, Jonathan Davies
Traditional nursing care strategies may require modification to meet the unique needs of conjoined twins. Here we discuss the strategies found to be useful in planning for and responding to distinctive circumstances encountered throughout hospitalization, as well as lessons learned. Areas of focus include ensuring privacy, designing adequate unit accommodations to meet space and equipment needs, staffing considerations and adaptations to typical neonatal intensive care nursing interventions. The utility of a team-based approach to interdisciplinary care coordination is also discussed...
July 27, 2018: Seminars in Perinatology
Katie E J Hann, Nasreen Ali, Sue Gessler, Lindsay Sarah Macduff Fraser, Lucy Side, Jo Waller, Saskia C Sanderson, Anne Lanceley
OBJECTIVE: Population-based risk assessment, using genetic testing and the provision of appropriate risk management, could lead to prevention, early detection and improved clinical management of ovarian cancer (OC). Previous research with mostly white British participants found positive attitudes towards such a programme. The current study aimed to explore the attitudes of South Asian (SA) women and men in the UK with the aim of identifying how best to implement such a programme to minimise distress and maximise uptake...
July 18, 2018: BMJ Open
Rebecca Garcia, Nasreen Ali, Malcolm Griffiths, Gurch Randhawa
BACKGROUND: To review the similarities and differences in Pakistani, Bangladeshi and White British mothers health beliefs (attitudes, knowledge and perceptions) and health behaviour regarding their consumption of folic acid pre-conception, to reduce the risk of neural tube defects. METHODS: Our study used a descriptive qualitative research approach, implementing face-to-face focus group discussions with Pakistani, Bangladeshi or White British mothers (normal birth outcomes and mothers with poor birth outcomes) and semi-structured interviews or focus groups with service providers using semi-structured topic guides...
June 15, 2018: BMC Pregnancy and Childbirth
Olivier Poujade, Elie Azria, Pierre-François Ceccaldi, Carine Davitian, Carine Khater, Paul Chatel, Emilie Pernin, Nizar Aflak, Martin Koskas, Agnès Bourgeois-Moine, Laurence Hamou-Plotkine, Morgane Valentin, Jean-Paul Renner, Carine Roy, Candice Estellat, Dominique Luton
OBJECTIVE: Shoulder dystocia is a major obstetric emergency defined as a failure of delivery of the fetal shoulder(s). This study evaluated whether an obstetric maneuver, the push back maneuver performed gently on the fetal head during delivery, could reduce the risk of shoulder dystocia. STUDY DESIGN: We performed a multicenter, randomized, single-blind trial to compare the push back maneuver with usual care in parturient women at term. The primary outcome, shoulder dystocia, was considered to have occurred if, after delivery of the fetal head, any additional obstetric maneuver, beginning with the McRoberts maneuver, other than gentle downward traction and episiotomy was required...
August 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Julien Lepage, Gwenola Keromnes, Sylvie Epelboin, Dominique Luton, Chadi Yazbeck
OBJECTIVE: To investigate the relationship between serum P levels on the day of hCG administration and pregnancy outcomes in patients undergoing IVF. DESIGN: Retrospective study. SETTING: Teaching hospital. PATIENTS: A total of 1022 IVF-ICSI cycles, frozen embryo transfer excluded. INTERVENTION(S): Patients-all types of responder - underwent IVF with agonist or antagonist protocols. Clinical outcomes of IVF were analyzed according to plasma P levels...
May 18, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Fidelia Bature, Dong Pang, Anthea Robinson, Norma Polson, Yannis Pappas, Barbara Guinn
OBJECTIVE: Evidence suggests that individuals with Alzheimer's disease (AD) are often diagnosed in the later stages of their disease with a poor prognosis. This study is aimed to identify patterns in signs and symptoms preceding the clinical diagnosis of AD to suggest a predictive model for earlier diagnosis of the disease in the primary care. DESIGN: A retrospective medical record review; nested case control design. PARTICIPANTS: Participants included one hundred and nine patients from three general practice (GP) surgeries in Milton Keynes and Luton Clinical Commissioning Groups (CCG) (37 cases with AD and 72 controls without AD)...
2018: Current Alzheimer Research
Maïa Banigé, Michel Polak, Dominique Luton
OBJECTIVES: To assess whether it is possible to identify the neonatal predictors of neonatal hyperthyroidism at the presymptomatic stage of the disease. STUDY DESIGN: This retrospective multicenter study in 10 maternity units was based on the medical records of all patients monitored for a pregnancy between January 1, 2007, and January 1, 2014. Among 280 000 births, 2288 medical records of women with thyroid dysfunction were selected and screened. Of these, 415 women had Graves disease and were positive for thyrotropin receptor antibody during pregnancy, and were included...
June 2018: Journal of Pediatrics
Morgane Valentin, Perrine Coste Mazeau, Michel Zerah, Pierre François Ceccaldi, Alexandra Benachi, Dominique Luton
Neural tube defects (NTD) occur in 0.5 to 2 per 1000 pregnancies with various handicaps for the affected child. It is now well established that folic acid deficiency (absolute or relative) is a predisposing factor to this type of malformation. Several randomized controlled trials showed that high-dose folic acid (4mg) is an essential factor for prevention of neural tube defects recurrence and significantly prevents the first occurrence of neural tube defects with a lower dose (0.4mg). Other etiologies can favor the occurrence of NTD such as MTHFR polymorphism, some antiepileptic therapies, obesity and pregestational mellitus diabetes...
April 2018: Annales D'endocrinologie
Julie Milanini, Racha Fayad, Mariagrazia Partisani, Patrick Lecine, Jean-Paul Borg, Michel Franco, Frédéric Luton
A key step of epithelial morphogenesis is the creation of the lumen. Luminogenesis by hollowing proceeds through the fusion of apical vesicles at cell-cell contacts. The small nascent lumens grow through extension, coalescence and enlargement, coordinated with cell division, to give rise to a single central lumen. Here, by using MDCK cells grown in 3D-culture, we show that EFA6A (also known as PSD) participates in luminogenesis. EFA6A recruits α-actinin 1 (ACTN1) through direct binding. In polarized cells, ACTN1 was found to be enriched at the tight junction where it acts as a primary effector of EFA6A for normal luminogenesis...
February 8, 2018: Journal of Cell Science
P-H Jarreau, L Allal, F Autret, E Azria, O Anselem, L Boujenah, C Crenn-Hebert, L Desfrere, G Girard, F Goffinet, C Huon, G Kayem, M-C Lamau, H Legardeur, D Luton, S Menard, J Patkai, M Rajguru-Kasemi, V Tessier
Decisions regarding whether to initiate or forgo intensive care for extremely premature infants are often based on gestational age alone. However, other factors also affect the prognosis for these patients and must be taken into account. After a short review of these factors, we present the thoughts and proposals of the Risks and Pregnancy department. The proposals are to limit emergency decisions, to better take into account other factors than gestational age and prenatal predicted fetal weight in assessing the prognosis, to introduce multidisciplinary consultation in the evaluation and proposals that will be discussed with the parents, and to separate prenatal steroid therapy from decision-making regarding whether or not to administer intensive care...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Maïa Banigé, Candice Estellat, Valerie Biran, Luc Desfrere, Valerie Champion, Alexandra Benachi, Yves Ville, Marc Dommergues, Pierre-Henri Jarreau, Mostafa Mokhtari, Claire Boithias, Frederic Brioude, Laurent Mandelbrot, Pierre-François Ceccaldi, Delphine Mitanchez, Michel Polak, Dominique Luton
Context: Neonatal hyperthyroidism was first described in 1912 and in 1964 was shown to be linked to transplacental passage of maternal antibodies. Few multicenter studies have described the perinatal factors leading to fetal and neonatal dysthyroidism. Objective: To show how fetal dysthyroidism (FD) and neonatal dysthyroidism (ND) can be predicted from perinatal variables, in particular, the levels of anti-thyrotropin receptor antibodies (TRAbs) circulating in the mother and child...
June 2017: Journal of the Endocrine Society
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