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Termination of pregnancy

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https://read.qxmd.com/read/30767287/a-next-generation-sequencing-custom-gene-panel-designed-to-distinguish-isolated-polydactyly-from-syndromic-polydactyly-during-prenatal-diagnosis
#1
Stefano Paolacci, Flavio Faletra, Paolo Enrico Maltese, Mariachiara Quadrifoglio, Matteo Bertelli
Here we report a case of posthumous genetic testing on an aborted fetus. Voluntary termination of pregnancy was chosen after prenatal ultrasound examination showed polydactyly and renal cysts. This article is protected by copyright. All rights reserved.
February 15, 2019: Congenital Anomalies
https://read.qxmd.com/read/30764544/early-pregnancy-human-decidua-is-enriched-with-activated-fully-differentiated-and-pro-inflammatory-gamma-delta-t-cells-with-diverse-tcr-repertoires
#2
Antonia Terzieva, Violeta Dimitrova, Lyubomir Djerov, Petya Dimitrova, Silvina Zapryanova, Iana Hristova, Ivaylo Vangelov, Tanya Dimova
Pregnancy is a state where high and stage-dependent plasticity of the maternal immune system is necessary in order to equilibrate between immunosuppression of harmful responses towards the fetus and ability to fight infections. TCR γδ cells have been implicated in the responses in infectious diseases, in the regulation of immune responses, and in tissue homeostasis and repair. The variety of functions makes γδ T cells a particularly interesting population during pregnancy. In this study, we investigated the proportion, phenotype and TCR γ and δ repertoires of γδ T cells at the maternal⁻fetal interface and in the blood of pregnant women using FACS, immunohistochemistry and spectratyping...
February 5, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30763542/risk-factors-for-surgical-intervention-of-early-medical-abortion
#3
Amani Meaidi, Sarah Friedrich, Thomas Alexander Gerds, Oejvind Lidegaard
BACKGROUND: By being non-invasive, medical termination of pregnancy has increased worldwide access to abortion and improved safety of unsafe abortion. However, secondary surgical intervention is the most frequent complication to medical abortion. OBJECTIVE: We aimed to identify and quantify risk factors for surgical intervention in women undergoing medically induced termination of pregnancy before nine completed weeks of gestation. STUDY DESIGN: We conducted a nationwide cohort study, including all pregnancies terminated before 63 gestational days in women aged 15-49 years during the period 2005-2015...
February 11, 2019: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/30761679/single-versus-multiple-cervical-dilation-by-osmotic-dilator-before-induction-of-labor-for-second-trimester-abortion
#4
Misooja Lee, Kazuya Mimura, Masayuki Endoh, Yoko Kawanishi, Tatsuya Miyake, Aiko Kakigano, Tsuyoshi Takiuchi, Shinya Matsuzaki, Takuji Tomimatsu, Tadashi Kimura
AIM: In this study, we aimed to investigate whether there was a significant prognostic difference between single and multiple cervical dilations when inducing second-trimester abortion. METHODS: We conducted a retrospective review of 238 pregnant women who underwent termination of pregnancy at 12-21 weeks of gestation at Osaka University Hospital in Osaka, Japan, between January 2010 and May 2018. Termination of pregnancy was performed by vaginal administration of 1 mg gemeprost every 3 h for up to five doses per day after uterine cervical dilation using lamicel...
February 13, 2019: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/30755084/comparison-of-cultured-human-cardiomyocyte-clusters-obtained-from-embryos-fetuses-or-derived-from-human-embryonic-stem-cells
#5
Søren J Grubb, Maj Linea Vestergaard, Astrid Sten Andersen, Karen Koefod Rasmussen, Linn Mamsen, Greta Tuckute, Kristina Grunnet-Lauridsen, Kjeld Møllgård, Erik Ernst, Søren T Christensen, Kirstine Calloe, Claus Yding Andersen
Cardiomyocytes (CM) derived from human embryonic stem cells (hESC) or induced pluripotent stem cells (iPSC) are used to study cardiogenesis and mechanisms of heart disease and are advancing as a method for toxicological screening of drugs. The phenotype of stem cell-derived CMs should ideally resemble native CMs. Here we compare embryonic/fetal CMs with hESC-derived CMs according to function and morphology. CM clusters were obtained from human embryonic/fetal hearts from elective terminated pregnancies before gestational week 12 and separated into atrial and ventricular tissues...
February 13, 2019: Stem Cells and Development
https://read.qxmd.com/read/30747547/sublingual-vs-vaginal-misoprostol-for-completion-of-first-trimester-missed-abortion-a-randomised-controlled-trial
#6
Ahmed Abdelshafy, Hassan Awwad, Amgad Abo-Gamra, Ahmed Alanwar, Ahmed M Elkotb, Mohamed Shahin, Maya Abd El-Razek, Ahmed M Abbas
OBJECTIVE: The study aimed to compare the efficacy and safety of sublingual and vaginal misoprostol for termination of pregnancy in women with first trimester missed abortion. METHODS: A single-blind, parallel group, randomised clinical trial (ClinicalTrials.gov NCT02686840) was conducted in a university hospital between 1 February 2016 and 31 January 2017. All women who presented with first trimester missed abortion were invited to participate in the study and were randomised to one of two groups: one group received sublingual misoprostol in three doses of 800 μg every 4 h, while a second group received vaginal misoprostol in the same dosage regimen...
February 12, 2019: European Journal of Contraception & Reproductive Health Care
https://read.qxmd.com/read/30746853/knowledge-attitude-and-ethical-consideration-of-chinese-couples-requesting-preimplantation-genetic-testing-in-hong-kong
#7
Sophelia H S Chan, Raymond H W Li, Vivian C Y Lee, Mary H Y Tang, Ernest H Y Ng
AIM: Increasing preimplantation genetic testing (PGT) cycles are being performed in Hong Kong. This study aims to evaluate the knowledge, attitude and ethical consideration of Chinese couples toward PGT. METHODS: Couples requesting PGT between June 2013 and March 2014 were invited to complete a questionnaire. RESULTS: Total 49 couples (49 women, 47 men) completed the questionnaires. Eighteen couples (37%) were waiting for PGT (pre-PGT group), 15 couples (31%) were undergoing PGT (PGT group) and 16 couples (32%) had completed at least one PGT cycle (post-PGT group)...
February 11, 2019: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/30739992/twist1-was-detected-in-mesenchymal-cells-of-mammary-fibroadenoma-and-invasive-components-of-breast-carcinoma-in-rats
#8
Satomi Funahashi, Yasumasa Okazaki, Hirotaka Nagai, Shan Hwu Chew, Kumiko Ogawa, Takeshi Toyoda, Young-Man Cho, Shinya Toyokuni
Fibroadenoma (FA) is a common mammary fibroepithelial tumor. The tumor size of the FA is increased by estrogen, progesterone, prolactin, and pregnancy, whereas it decreases after menopause. These observations in humans indicate that FA is hormone dependent. In rats, the most common mammary neoplasm is also FA. Expression levels of Twist1, a transcriptional regulator of epithelial-mesenchymal transition, were examined in paraffin-embedded tissue sections of an experimental rat breast model to find physiological alternations coincident with reproductive hormonal changes...
January 2019: Journal of Toxicologic Pathology
https://read.qxmd.com/read/30738954/pregnancy-outcomes-following-quinolone-and-fluoroquinolone-exposure-during-pregnancy-a-systematic-review-and-meta-analysis
#9
Selin Acar, Elif Keskin-Arslan, Hilal Erol-Coskun, Tijen Kaya-Temiz, Yusuf Cem Kaplan
OBJECTIVE: To investigate whether maternal exposure to quinolones, fluoroquinolones and specifically ciprofloxacin is associated with major malformations and other adverse pregnancy outcomes. METHODS: MEDLINE/PubMed, Embase and Reprotox® databases were searched. Observational studies with an exposed and control group were included. RESULTS: Analysis of 8 cohort and 2 case-control studies showed no significant increases in rates of major malformations for quinolone (OR, 1...
February 7, 2019: Reproductive Toxicology
https://read.qxmd.com/read/30734373/the-aims-of-expanded-universal-carrier-screening-autonomy-prevention-and-responsible-parenthood
#10
Sanne van der Hout, Wybo Dondorp, Guido de Wert
Expanded universal carrier screening (EUCS) entails a population-wide screening offer for multiple disease-causing mutations simultaneously. Although there is much debate about the conditions under which EUCS can responsibly be introduced, there seems to be little discussion about its aim: providing carrier couples with options for autonomous reproductive choice. While this links in with current accounts of the aim of foetal anomaly screening, it is different from how the aim of ancestry-based carrier screening has traditionally been understood: reducing the disease burden in the population...
February 7, 2019: Bioethics
https://read.qxmd.com/read/30722979/prognosis-of-severe-congenital-heart-diseases-do-we-overestimate-the-impact-of-prenatal-diagnosis
#11
Marie Vincenti, Sophie Guillaumont, Beatrice Clarivet, Valerie Macioce, Thibault Mura, Pierre Boulot, Gilles Cambonie, Pascal Amedro
BACKGROUND: Prenatal diagnosis of congenital heart disease (CHD) is controversial because of unclear benefits in terms of morbidity and mortality, and issues with healthcare costs and organization. AIM: To compare, in children with severe CHD, 1-year morbidity and mortality between prenatal and postnatal diagnosis groups. METHODS: All pregnancies and children aged<1 year with a diagnosis of severe CHD were collected over a 5-year period from our database...
February 2, 2019: Archives of Cardiovascular Diseases
https://read.qxmd.com/read/30717783/policy-for-reducing-unplanned-pregnancies-and-repeat-unplanned-pregnancies-rates-in-israeli-defense-force
#12
Adi Kuperman-Shani, Tarif Bader, Elon Glassberg, Vered Klaitman
Israel has compulsory military service, beginning at the age of 18. Women serve about two years and men for about three years. However, de facto only some of the potential service entrants are recruited. Among women, those who enlist are mainly secular Jews who are unmarried; among men, most of the ultra-Orthodox Jews do not enlist. In addition, only a fraction of the recruits chooses to turn the military service into a career and sign up for additional service as professional military personal (officers and non-commissioned officers)...
February 4, 2019: Israel Journal of Health Policy Research
https://read.qxmd.com/read/30713751/efficacy-of-second-trimester-termination-procedure-medical-mechanic-or-combine
#13
Tuncay Yüce, Dilek Yüksel, Erkan Kalafat, Acar Koç
Objectives: During mid-trimester, it is necessary to terminate pregnancy due to some fetal anomalies and intrauterine death. Therefore, in this study, we aimed to compare abortion induction methods and combined use retrospectively. Methods: About 112 out of 223 pregnant patients were included in the study. The groups were determined as follows: Group 1 including pregnant patients who were administered misoprostol only (50 patients), Group 2 including pregnant patients who were administered single dose misoprostol (according to FIGO) and subsequently received cervical Foley catheter (30 patients), and Group 3 including pregnant patients who received Foley catheter only (32 patients)...
September 2018: Interventional Medicine & Applied Science
https://read.qxmd.com/read/30709546/direct-toxicity-of-insulin-on-the-human-placenta-and-protection-by-metformin
#14
Mario Vega, Maurizio Mauro, Zev Williams
OBJECTIVE: To study the effects of insulin and metformin on primary trophoblasts from early pregnancies. DESIGN: Experimental in vitro study. SETTING: Academic research institute. PATIENT(S): Trophoblasts from healthy patients undergoing first trimester elective termination of pregnancy and primary lung fibroblasts (IMR-90). INTERVENTION(S): Culture and treatment with insulin and metformin of primary trophoblasts and primary lung fibroblasts (IMR-90)...
January 14, 2019: Fertility and Sterility
https://read.qxmd.com/read/30707968/deregulation-of-mir-324-kiss1-kisspeptin-in-early-ectopic-pregnancy-mechanistic-findings-with-clinical-and-diagnostic-implications
#15
Antonio Romero-Ruiz, Maria S Avendaño, Francisco Dominguez, Teresa Lozoya, Helena Molina-Abril, Susana Sangiao-Alvarellos, Marta Gurrea, Maribel Lara-Chica, Manuel Fernandez-Sanchez, Encarnación Torres, Cecilia Perdices-Lopez, Ali Abbara, Liliana Steffani, Marco A Calzado, Waljit S Dhillo, Antonio Pellicer, Manuel Tena-Sempere
BACKGROUND: Ectopic pregnancy (EP) is a life-threatening condition, for which novel screening tools enabling early accurate diagnosis would improve clinical outcomes. Kisspeptins, encoded by KISS1, play an essential role in human reproduction, at least partially by regulating placental function and possibly embryo implantation. Kisspeptin levels are massively elevated in normal pregnancy and reportedly altered in various gestational pathologies. Yet, the pathophysiological role of KISS1/kisspeptin in EP has not been investigated previously...
January 29, 2019: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/30706883/neu-laxova-syndrome
#16
Tanima Dwivedi, Manasi Gosavi
NeuLaxova syndrome (NLS) is a rare congenital abnormality involving multiple systems. Until date, only 60 cases of this syndrome have been reported in the literature. A stillborn fetus from a 23-year-old female with bad obstetrics history and consanguinity marriage, presented at 41 weeks gestation and not appreciating fetal movements for the past 3 days. Ultrasound examination revealed the absence of fetal cardiac activity and features of growth retardation. The fetus was sent for pathological examination. At autopsy, fetus had ichthyosis over the scalp and face, depressed nasal bridge, low set ears, microcephaly, slopping forehead, wide interdigital spaces, edema of hands and feet, hypoplastic penis, right leg showed congenital talipes equinovarus and left leg showed rocker bottom foot...
January 2019: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/30706183/prenatal-detection-of-right-aortic-arch
#17
Gülen Yerlikaya, Tünay Efetürk, Stephanie Springer, Theresa Reischer
PURPOSE: To examine an unselective population of fetuses with right aortic arch (RAA) and suggest perinatal management. Second, to evaluate the importance and possible implication of fetal MRI in those cases. METHODS: Retrospective study of 36 patients with RAA diagnosed prenatally between 2006 and 2017 in a tertiary referral center. RESULTS: 32 fetuses were diagnosed with RAA and 4 with double aortic arch (DAA). 7 (19, 5%) cases had intracardiac abnormalities...
January 31, 2019: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/30703717/placental-mesenchymal-dysplasia-an-underdiagnosed-placental-pathology-with-various-clinical-outcomes
#18
Cécile Guenot, John Kingdom, Maud De Rham, Maria Osterheld, Sarah Keating, Yvan Vial, Tim Van Mieghem, Nicole Jastrow, Luigi Raio, Marialuigia Spinelli, Letizia Di Meglio, Gihad Chalouhi, David Baud
BACKGROUND: Placental mesenchymal dysplasia (PMD) is a rare vascular and connective placental anomaly, which is often associated with severe fetal and/or maternal complications. The diversity of presentation of PMD challenges diagnosis and effective pregnancy management. OBJECTIVE: We aimed to review cases presenting at 7 tertiary centers worldwide over the last decade and to study the occurrence of obstetric and neonatal complications. STUDY DESIGN: Pathology databases from 7 tertiary hospitals were screened for cases of PMD (between 2007-2017)...
January 17, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/30703286/intra-amniotic-digoxin-for-feticide-between-21-and-30-weeks-of-gestation-a-prospective-study
#19
Merav Sharvit, Zvi Klein, Michal Silber, Meir Pomeranz, Regina Agizim, Ron Schonman, Ami Fishman
OBJECTIVE: Intra-amniotic injection of digoxin is a well-known method for feticide before inducing termination of pregnancy (TOP) at 17-24 weeks of gestation. Information on its effectiveness when administered after 24 weeks of gestation is limited. This study evaluated the efficacy of intra-amniotic digoxin injection for inducing fetal demise within 18 to 24 hours, at 21 to 30 weeks of gestation and its safety. DESIGN: Prospective cohort study. SETTING: Tertiary university medical canter...
January 31, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/30702074/the-restless-legs-syndrome-review
#20
G Japaridze, S Kasradze, L Maisuradze, R Popp, Th Wetter
The restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a common sleep related neurological disorder with prevalence between 1 and 10%, increasing with age. Women are more frequently affected than men. RLS is characterized by an urge to move the legs accompanied by uncomfortable and unpleasant sensations in the legs, worsening of complaints during periods of rest, improvement by movement and an increase of symptoms in the evening or at night. In addition, affected patients may also suffer from severe sleep disorders and negative effects on daily activities...
December 2018: Georgian Medical News
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