Luis V Herrera-Marcos, Roberto Martínez-Beamonte, Carmen Arnal, Cristina Barranquero, Juan J Puente-Lanzarote, Tania Herrero-Continente, José M Lou-Bonafonte, Gonzalo Gonzalo-Romeo, Gabriele Mocciaro, Benjamin Jenkins, Joaquín C Surra, María J Rodríguez-Yoldi, Juan Carlos Burillo, Roberto Lasheras, Agustín García-Gil, Antonio Güemes, Albert Koulman, Jesús Osada
Squalene is a key minor component of virgin olive oil, the main source of fat in the Mediterranean diet, and had shown to improve the liver metabolism in rabbits and mice. The present research was carried out to find out whether this effect was conserved in a porcine model of hepatic steatohepatitis and to search for the lipidomic changes involved. The current study revealed that a 0.5% squalene supplementation to a steatotic diet for a month led to hepatic accumulation of squalene and decreased triglyceride content as well as area of hepatic lipid droplets without influencing cholesterol content or fiber areas...
November 17, 2022: Journal of Nutritional Biochemistry