Jing-Si Jiang, Jie Zang, Yi Ru, Ying Luo, Jian-Kun Song, Yue Luo, Xiao-Ya Fei, Zhan Zhang, Ying Zhang, Dan Yang, Mi Zhou, Qi-Long Chen, Yun Bai, Yong-Yong Li, Le Kuai, Bin Li
Diabetic ulcers (DUs), a devastating complication of diabetes, are intractable for limited effective interventions in clinic. Based on the clinical samples and bioinformatic analysis, we found lower level of CCN1 in DU individuals. Considering the accelerated proliferation effect in keratinocytes, we propose the therapeutic role of CCN1 supplementation in DU microenvironment. To address the challenge of rapid degradation of CCN1 in protease-rich diabetic healing condition, we fabricated a nanoformulation of CCN1 (CCN1-NP), which protected CCN1 from degradation and significantly raised CCN1 intracellular delivery efficiency to 6...
September 2022: Biomaterials