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CCN1 TGF-beta

Erawan Borkham-Kamphorst, Christian Schaffrath, Eddy Van de Leur, Ute Haas, Lidia Tihaa, Steffen K Meurer, Yulia A Nevzorova, Christian Liedtke, Ralf Weiskirchen
UNLABELLED: Cysteine-rich protein 61 (CCN1/CYR61) is a CCN (CYR61, CTGF (connective tissue growth factor), and NOV (Nephroblastoma overexpressed gene)) family matricellular protein comprising six secreted CCN proteins in mammals. CCN1/CYR61 expression is associated with inflammation and injury repair. Recent studies show that CCN1/CYR61 limits fibrosis in models of cutaneous wound healing by inducing cellular senescence in myofibroblasts of the granulation tissue which thereby transforms into an extracellular matrix-degrading phenotype...
May 2014: Biochimica et Biophysica Acta
Marie-Fran├žoise Ritz, Ursula Graumann, Bertha Gutierrez, Oliver Hausmann
Traumatic spinal cord injury (SCI) disrupts the blood-spinal cord barrier and reduces the blood supply caused by microvascular changes. Vessel regression and neovascularization have been observed in the course of secondary injury contributing to microvascular remodeling after trauma. Spatio-temporal distribution of blood vessels and modulation of gene expression of several angiogenic factors have been investigated in rats after spinal cord compression injury. Rarefaction of vessels was detectable at the injury site 2 days after SCI before they disappeared in the developing cavity after 2 and 4 weeks, whereas no changes were observed in the penumbra...
November 2010: Current Neurovascular Research
Nadine Wolf, Wei Yang, Caroline E Dunk, Isabella Gashaw, Stephen J Lye, Thomas Ring, Markus Schmidt, Elke Winterhager, Alexandra Gellhaus
It is known that a hypoxic environment is critical for trophoblast migration and invasion and is fundamental for appropriate placental perfusion. Because cysteine-rich 61 (CYR61, CCN1) and nephroblastoma overexpressed (NOV, CCN3) are expressed in the extravillous trophoblast and expression levels are deregulated in preeclampsia, we investigated their regulation properties in first-trimester placental explants and in JEG3 choriocarcinoma cells upon a physiological low oxygen tension of 1-3%. In placental explants, both proteins were expressed in the extravillous trophoblast cells and were increased upon hypoxia...
June 2010: Endocrinology
Tao Bai, Chih-Chiun Chen, Lester F Lau
CCN1 (CYR61) is a matricellular protein that is highly expressed at sites of inflammation and wound repair. In these contexts, CCN1 can modify the activities of specific cytokines, enabling TNF-alpha to be cytotoxic without blocking NF-kappaB activity and enhancing the apoptotic activity of Fas ligand and TRAIL. In this paper, we show that CCN1 supports the adhesion of macrophages through integrin alpha(M)beta(2) and syndecan-4, activates NFkappaB-mediated transcription, and induces a proinflammatory genetic program characteristic of classically activated M1 macrophages that participates in Th1 responses...
March 15, 2010: Journal of Immunology
Norifumi H Moritani, Satoshi Kubota, Toshio Sugahara, Masaharu Takigawa
BACKGROUND: The chondrosarcoma-derived HCS-2/8 has been known to be an excellent model of human articular chondrocytes. By mimicking the arthritic conditions through the treatment of HCS-2/8 cells with cytokines, we estimated the gene expression response of ccn1 and ccn2 during the course of joint inflammation in vitro. RESULTS: In order to mimic the initiation of inflammation, HCS-2/8 cells were treated with tumor necrosis factor (TNF)-alpha. To induce pro-inflammatory or reparative responses, TGF-beta was employed...
April 15, 2005: Cell Communication and Signaling: CCS
Cristiane G Lin, Chih-Chiun Chen, Shr-Jeng Leu, Tatiana M Grzeszkiewicz, Lester F Lau
The novel angiogenic inducer CCN3 (NOV, nephroblastoma overexpressed) is a matricellular protein of the CCN family, which also includes CCN1 (CYR61), CCN2 (CTGF), CCN4 (WISP-1), CCN5 (WISP-2), and CCN6 (WISP-3). CCN3 is broadly expressed in derivatives of all three germ layers during mammalian development, and its deranged expression is associated with vascular injury and a broad range of tumors. We have shown that CCN3 promotes proangiogenic activities in vascular endothelial cells through integrin receptors and induces neovascularization in vivo (Lin, C...
March 4, 2005: Journal of Biological Chemistry
Shinji Sakamoto, Masahiro Yokoyama, Michiko Aoki, Kensuke Suzuki, Yoshiyuki Kakehi, Yutaka Saito
BACKGROUND: CYR61 is an extracellular matrix-associated protein that promotes adhesion, migration, and proliferation of endothelial cells and fibroblasts. Prostate enlargement, which frequently causes the urethral compression, is often histologically observed as stromal and epithelial hyperplasia in an enlarged gland. To determine whether or not CYR61 has relevance to the progression of benign prostatic hyperplasia (BPH), we investigated the induction of CYR61, and also examined its function in both prostatic stromal and epithelial cells...
December 1, 2004: Prostate
Kazutomo Sawai, Kiyoshi Mori, Masashi Mukoyama, Akira Sugawara, Takayoshi Suganami, Masao Koshikawa, Kensei Yahata, Hisashi Makino, Tetsuya Nagae, Yuriko Fujinaga, Hideki Yokoi, Tetsuro Yoshioka, Akihiro Yoshimoto, Issei Tanaka, Kazuwa Nakao
Dynamic recovery of glomerular structure occurs after severe glomerular damage in anti-Thy-1 glomerulonephritis (Thy-1 GN), but its mechanism remains to be investigated. To identify candidate genes possibly involved in glomerular reconstruction, screening was performed for genes that are specifically expressed by podocytes and are upregulated in glomeruli of Thy-1 GN. Among them, cysteine-rich protein 61 (Cyr61 or CCN1), a soluble angiogenic protein belonging to the CCN family, was identified. By Northern blot analysis, Cyr61 mRNA was markedly upregulated in glomeruli of Thy-1 GN from day 3 through day 7, when mesangial cell migration was most prominent...
May 2003: Journal of the American Society of Nephrology: JASN
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