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'Multiple Sclerosis'

Ayelet Armon-Omer, Chen Waldman, Naaem Simaan, Hadar Neuman, Snait Tamir, Radi Shahien
BACKGROUND: Multiple sclerosis (MS) is a multifactorial disease with unknown etiology. It is assumed to result from interplay between genetic and environmental factors, including nutrition. We hypothesized that there are differences in nutritional parameters between MS patients and healthy controls. METHODS: We examined 63 MS patients and 83 healthy controls. Nutritional status was determined by a dietary questionnaire, blood tests, quantification of cell membrane fatty acids, and serum antioxidant capacity...
February 18, 2019: Nutrients
M Hasan Mohajeri
In the last decade, the microbiome in general and the gut microbiome in particular have been associated not only to brain development and function, but also to the pathophysiology of brain aging and to neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, or multiple sclerosis (MS) [...].
February 18, 2019: Nutrients
Sarah Patrick, Peter Connick
BACKGROUND: Depression affects approximately 25% of people with MS (pwMS) at any given time. It is however under recognised in clinical practice, in part due to a lack of uptake for brief assessment tools and uncertainty about their psychometric properties. The 9-item Patient Health Questionnaire (PHQ-9) is an attractive candidate for this role. OBJECTIVE: To synthesise published findings on the psychometric properties of the 9-item Patient Health Questionnaire (PHQ-9) when applied to people with multiple sclerosis (pwMS)...
2019: PloS One
Dustin R Allen, M U Huang, Nathan B Morris, Georgia K Chaseling, Elliot M Frohman, Ollie Jay, Scott L Davis
INTRODUCTION: Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared with healthy controls (CON) exercising at similar rates of metabolic heat production...
March 2019: Medicine and Science in Sports and Exercise
Shang-De Guo, Chun-Yun Liu, Jing-Wen Yu, Zhi Chai, Qing Wang, Xi-Ting Mi, Guo-Bin Song, Yan-Hua Li, Peng-Wei Yang, Ling Feng, Bao-Guo Xiao, Cun-Gen Ma
AIM: Multiple sclerosis (MS) is a relapsing-remitting inflammatory demyelinating disease that requires long-term treatment. Although Rho kinase inhibitor Fasudil shows good therapeutic effect in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, certain side effects may limit its clinical use. This study aimed at observing the therapeutic potential of Fasudil-modified encephalitogenic mononuclear cells (MNCs) via nasal delivery in EAE and exploring possible mechanisms of action...
February 18, 2019: CNS Neuroscience & Therapeutics
Rebecca Persson, Sally Lee, Marianne Ulcickas Yood, Michael Wagner, Neil Minton, Steve Niemcryk, Anders Lindholm, Amber Evans, Susan Jick
OBJECTIVE: To describe the resources and methods used to identify and validate multiple sclerosis (MS) and match non-MS patients in each of the two databases, and to characterize their demographics, comorbidities and concomitant medications. METHODS: This study was conducted in two separate electronic medical databases, the United States Department of Defense (DOD) military health care system and the United Kingdom's Clinical Practice Research Datalink (CPRD) GOLD...
February 18, 2019: Journal of Neurology
Andrea Rodrigues Vasconcelos, Nilton Barreto Dos Santos, Cristoforo Scavone, Carolina Demarchi Munhoz
Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the expression of an array of enzymes with important detoxifying and antioxidant functions. Current findings support the role of high levels of oxidative stress in the pathogenesis of neurological disorders. Given the central role played by Nrf2 in counteracting oxidative damage, a number of studies have targeted the modulation of this transcription factor in order to confer neuroprotection. Nrf2 activity is tightly regulated by oxidative stress and energy-based stimuli...
2019: Frontiers in Pharmacology
Rebecca Kelsey
No abstract text is available yet for this article.
February 18, 2019: Nature Reviews. Neurology
Shahrzad Talebian, Jalal Gharesouran, Soudeh Ghafouri-Fard, Behnaz Salek Esfahani, Shahram Arsang-Jang, Mir Davood Omrani, Mohammad Taheri, Maryam Rezazadeh
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Nearly 85% of MS patients are recognized with relapsing-remitting MS (RRMS), a typical clinical course of disease which is distinguished by several episodes of relapses, separated by remissions of neurological impairment. Failure of repair mechanisms is a main factor in progression of neurological dysfunction in MS. Several lines of evidence suggest that Reelin (RELN) signaling pathway can contribute in the regulation of repair mechanisms in MS patients...
February 12, 2019: Immunobiology
Giuseppa Mudò, Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Fulvio Plescia, Maria F Massenti, Marta Di Carlo, Carla Cannizzaro, Giovanni Cassata, Luca Cicero, Maria Ruscica, Natale Belluardo, Luigi M Grimaldi
BACKGROUND: Aβ1-42 peptide abnormal production is associated with the development and maintenance of neuroinflammation and oxidative stress in brains from Alzheimer disease (AD) patients. Suppression of neuroinflammation may then represent a suitable therapeutic target in AD. We evaluated the efficacy of IFNβ1a in attenuating cognitive impairment and inflammation in an animal model of AD. METHODS: A rat model of AD was obtained by intra-hippocampal injection of Aβ1-42 peptide (23 μg/2 μl)...
February 18, 2019: Journal of Neuroinflammation
Bisera Stepanovska, Andrea Huwiler
The past two decades of intense research have revealed a key role of the sphingolipid molecule sphingosine 1-phosphate (S1P) in regulating multiple physiological and pathophysiological processes including cell proliferation and survival, cell migration, inflammatory mediator synthesis and tissue remodeling. S1P mainly acts through five high-affinity G protein-coupled S1P receptors, which are ubiquitously expressed and mediate a complex network of signaling in a cell type dependent manner. S1P receptors have become an attractive pharmacological target to interfere with S1P-mediated cellular responses, which contribute to various autoimmune and inflammatory diseases...
February 15, 2019: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Katharine Harding, Owain Williams, Mark Willis, James Hrastelj, Anthony Rimmer, Fady Joseph, Valentina Tomassini, Mark Wardle, Trevor Pickersgill, Neil Robertson, Emma Tallantyre
Importance: Uncertainty remains about how aggressively to treat early multiple sclerosis. High-efficacy disease-modifying therapies (DMTs) are often reserved for individuals expressing poor prognostic features at baseline. Objective: To analyze long-term outcomes in a population-based cohort according to initial treatment strategy. Design, Setting and Participants: In this cohort study, data were derived from January 1998 to December 2016, and analysis was performed in January 2017...
February 18, 2019: JAMA Neurology
Sarah C Conner, Laurent Benayoun, Jayandra J Himali, Stephanie L Adams, Qiong Yang, Charles DeCarli, Jan K Blusztajn, Alexa Beiser, Sudha Seshadri, Ivana Delalle
Genome-wide association studies identified a single nucleotide polymorphism (SNP) in the MSRB3 gene encoding Methionine Sulfoxide Reductase-B3 (MsrB3) to be associated with the risk for low hippocampal volume and late onset Alzheimer's disease (AD). Subsequently, we identified AD-associated abnormal patterns of neuronal and vascular MsrB3 expression in postmortem hippocampi. The present study investigated the relationship between the MSRB3 SNP rs61921502, G (minor/risk allele) and MRI measures of brain injury including total brain volume, hippocampal volume, and white matter hyperintensities using linear regression models; the presence of brain infarcts using logistic regression models; and the incidence of stroke, dementia, and AD using Cox proportional hazards models in 2,038 Framingham Heart Study Offspring participants with MRI administered close to examination cycle 7 (1998-2001)...
February 11, 2019: Journal of Alzheimer's Disease: JAD
Ingo Mrosewski, Ilka Neumann, Rafael Switkowski
BACKGROUND: Automated immunoassays utilizing the interaction between streptavidin and biotin are widely used. Nonetheless, biotin remains an often overlooked confounder. METHODS: We report the case of a 54-year-old female patient with progressive multiple sclerosis and Hashimoto's thyroiditis who presented herself for a follow-up. Measurements on Roche's cobas® 8000 modular analyzer series suggested severe hyperthyroidism. Initially, no relevant confounders could be identified...
January 1, 2019: Clinical Laboratory
Nitya Beriwal, Tashi Namgyal, Pema Sangay, Asmaa Monther Al Quraan
The anti-oxidant effects of melatonin and the immune-pineal axis are well established. However, how they play a role in the pathogenesis of neurodegenerative diseases is not well elucidated. A better understanding of this neuro-immuno-endocrinological link can help in the development of novel therapies with higher efficacy to alleviate symptomatology, slow disease progression and improve the quality of life. Recent studies have shown that the immune-pineal axis acts as an immunological buffer, neurohormonal switch and it also intricately links the pathogenesis of neurodegenerative diseases (like Multiple sclerosis, Alzheimer's disease, Parkinson's disease) and inflammation at a molecular level...
January 2019: Heliyon
Daniel R Wynn
Multiple sclerosis (MS) is a chronic progressive neurodegenerative demyelinating disease affecting the central nervous system. Glatiramer acetate (GA; Copaxone®) was the first disease-modifying treatment (DMT) for MS successfully tested in humans (1977) and was approved by the US Food and Drug Administration in December 1996. Since then, there have been numerous developments in the MS field: advances in neuroimaging allowing more rapid and accurate diagnosis; the availability of a range of DMTs including immunosuppressant monoclonal antibodies and oral agents; a more holistic approach to treatment by multidisciplinary teams; and an improved awareness of the need to consider a patient's preferences and patient-reported outcomes such as quality of life...
2019: Multiple Sclerosis International
Dharmaraja Allimuthu, Zita Hubler, Fadi J Najm, Hong Tang, Ilya Bederman, William Seibel, Paul J Tesar, Drew J Adams
Small molecules that promote oligodendrocyte formation have been identified in "drug repurposing" screens to nominate candidate therapeutics for diseases in which myelin is lost, including multiple sclerosis. We recently reported that many such molecules enhance oligodendrocyte formation not by their canonical targets but by inhibiting a narrow range of enzymes in cholesterol biosynthesis. Here we identify enhancers of oligodendrocyte formation obtained by screening a structurally diverse library of 10,000 small molecules...
January 31, 2019: Cell Chemical Biology
Kazuki Kunieda, Mitsuyasu Kawaguchi, Naoya Ieda, Hidehiko Nakagawa
Peptidyl arginine deiminases (PADs) catalyze the post-translational deimination of arginine residues to citrulline residues. Aberrant levels of PAD activity are associated with various diseases, such as rheumatoid arthritis, Alzheimer's disease, and multiple sclerosis, so there is a need for simple and convenient high-throughput screening systems to discover PAD inhibitors as candidate therapeutic agents. Here, we report a highly sensitive off/on-type fluorescence probe for PAD activity based on the donor-excited photoinduced electron transfer (d-PeT) mechanism, utilizing the specific cycloaddition reaction between the benzil group of the probe and the ureido group of the PAD product, citrulline, under acidic conditions...
January 25, 2019: Bioorganic & Medicinal Chemistry Letters
Steffen Bollmann, Matilde Holm Kristensen, Morten Skaarup Larsen, Mathias Vassard Olsen, Mads Jozwiak Pedersen, Lasse Riis Østergaard, Kieran O'Brien, Christian Langkammer, Amir Fazlollahi, Markus Barth
Quantitative susceptibility mapping (QSM) reveals pathological changes in widespread diseases such as Parkinson's disease, Multiple Sclerosis, or hepatic iron overload. QSM requires multiple processing steps after the acquisition of magnetic resonance imaging (MRI) phase measurements such as unwrapping, background field removal and the solution of an ill-posed field-to-source-inversion. Current techniques utilize iterative optimization procedures to solve the inversion and background field correction, which are computationally expensive and lead to suboptimal or over-regularized solutions requiring a careful choice of parameters that make a clinical application of QSM challenging...
February 14, 2019: Zeitschrift Für Medizinische Physik
Daniel Golan, Jeffrey Wilken, Glen M Doniger, Timothy Fratto, Robert Kane, Jared Srinivasan, Myassar Zarif, Barbara Bumstead, Marijean Buhse, Lori Fafard, Ilir Topalli, Mark Gudesblatt
BACKGROUND: Computerized cognitive batteries may facilitate the integration of neuropsychological assessments into routine clinical care of patients with multiple sclerosis (PwMS). OBJECTIVE: To assess the construct and criterion validity of a computerized, multi-domain cognitive assessment battery (CAB, NeuroTrax) in MS. METHODS: 81 PwMS and 15 healthy controls (HC) completed the CAB and a set of traditional neuropsychological tests recommended for MS on the same day...
January 30, 2019: Multiple Sclerosis and related Disorders
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