I-Wen Wu, Lun-Ching Chang, Yi-Lun Wu, Huang-Yu Yang, Yuh-Ching Twu, Po-Yu Tsai, Skyler Paulus, Rhian Resnick, Wen-Hung Chung, Chih-Wei Yang, Wen-Ping Hsieh, Shih-Chi Su
BACKGROUND AND HYPOTHESIS: Perturbation of gut microbiota has been linked to chronic kidney disease (CKD), which was correlated with a sophisticated milieu of metabolic and immune dysregulation. METHODS: To clarify the underlying host-microbe interaction in CKD, we performed multi-omics measurements, including systems-level gut microbiome, targeted serum metabolome, and deep immunotyping, in a cohort of patients and non-CKD controls. RESULTS: Our analyses on functional profiles of gut microbiome showed a decrease in the diversity and abundance of carbohydrate-active enzyme (CAZyme) genes but an increase in the abundance of antibiotic resistance, nitrogen cycling enzyme, and virulence factor genes in CKD...
January 19, 2024: Nephrology, Dialysis, Transplantation