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Keywords Microbiota And Chronic Kidney ...

Microbiota And Chronic Kidney Disease

https://read.qxmd.com/read/38286361/longitudinal-pilot-evaluation-of-the-gut-microbiota-comparing-patients-with-and-without-chronic-kidney-disease
#21
JOURNAL ARTICLE
Shirin Pourafshar, Binu Sharma, Jenifer Allen, Madeleine Hoang, Hannah Lee, Holly Dressman, Crystal C Tyson, Indika Mallawaarachchi, Pankaj Kumar, Jennie Z Ma, Pao-Hwa Lin, Julia J Scialla
OBJECTIVE: The gut microbiota contributes to metabolic diseases, such as diabetes and hypertension, but is poorly characterized in chronic kidney disease (CKD). DESIGN AND METHODS: We enrolled 24 adults within household pairs, in which at least one member had self-reported kidney disease, diabetes, or hypertension. CKD was classified based on estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2 or urine-albumin-to-creatinine ratio (UACR) of ≥30 mg/g...
January 27, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38276548/anti-obesity-effect-of-combining-white-kidney-bean-extract-propolis-ethanolic-extract-and-crpi-3-on-sprague-dawley-rats-fed-a-high-fat-diet
#22
JOURNAL ARTICLE
Doaa Salah Eldin Abdelfattah, Mervat A Fouad, Aliaa N Elmeshad, Mohamed A El-Nabarawi, Sammar Fathy Elhabal
Obesity has been associated with the occurrence and prevalence of various chronic metabolic diseases. The management of obesity has evolved to focus not only on reducing weight, but also on preventing obesity-related complications. Studies have shown that bioactive components in natural products like white kidney bean extract (WKBE), propolis ethanolic extract (PEE), and chromium picolinate (CrPi3 ) showed anti-obesity properties. However, no studies have examined the outcomes of combining any of these nutraceutical supplements...
January 20, 2024: Nutrients
https://read.qxmd.com/read/38276313/the-kidney-gut-axis-as-a-novel-target-for-nutritional-intervention-to-counteract-chronic-kidney-disease-progression
#23
REVIEW
Sandra Cabała, Małgorzata Ożgo, Agnieszka Herosimczyk
A well-balanced diet is integral for overall health, aiding in managing key risk factors for kidney damage like hypertension while supplying necessary precursors for metabolite production. Dietary choices directly influence the composition and metabolic patterns of the gut microbiota, showing promise as therapeutic tools for addressing various health conditions, including chronic kidney diseases (CKD). CKD pathogenesis involves a decline in the glomerular filtration rate and the retention of nitrogen waste, fostering gut dysbiosis and the excessive production of bacterial metabolites...
January 22, 2024: Metabolites
https://read.qxmd.com/read/38275035/association-between-gut-microbiota-compositions-with-microvascular-complications-in-individuals-with-diabetes-a-systematic-review
#24
JOURNAL ARTICLE
Motahareh Hasani, Zahra Asadi Pilerud, Atefe Kami, Amir Abbas Vaezi, Sahar Sobhani, Hanieh-Sadat Ejtahed, Mostafa Qorbani
BACKGROUND: Diabetes is one of the chronic and very complex diseases that can lead to microvascular complications. Recent evidence demonstrates that dysbiosis of the microbiota composition might result in low-grade, local, and systemic inflammation, which contributes directly to the development of diabetes mellitus and its microvascular consequences. OBJECTIVE: The aim of this systematic review was to investigate the association between diabetes microvascular complications, including retinopathy, neuropathy, nephropathy, and gut microbiota composition...
January 24, 2024: Current Diabetes Reviews
https://read.qxmd.com/read/38255253/exploring-the-relationship-between-gut-microbiome-composition-and-blood-indole-3-acetic-acid-in-hemodialysis-patients
#25
JOURNAL ARTICLE
Ping-Hsun Wu, Yu-Fang Tseng, Wangta Liu, Yun-Shiuan Chuang, Chi-Jung Tai, Chun-Wei Tung, Kean-Yee Lai, Mei-Chuan Kuo, Yi-Wen Chiu, Shang-Jyh Hwang, Wei-Chun Hung, Yi-Ting Lin
Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating cardiovascular and cognitive risk in HD patients. However, research on the microbiome-IAA association is limited. This study aimed to explore the gut microbiome's relationship with plasma IAA levels in 72 chronic HD patients aged over 18 (August 2016-January 2017). IAA levels were measured using tandem mass spectrometry, and gut microbiome analysis utilized 16s rRNA next-generation sequencing...
January 10, 2024: Biomedicines
https://read.qxmd.com/read/38244232/gut-flora-metagenomic-analysis-coupled-with-metabolic-and-deep-immune-profiling-in-chronic-kidney-disease
#26
JOURNAL ARTICLE
I-Wen Wu, Lun-Ching Chang, Yi-Lun Wu, Huang-Yu Yang, Yuh-Ching Twu, Po-Yu Tsai, Skyler Paulus, Rhian Resnick, Wen-Hung Chung, Chih-Wei Yang, Wen-Ping Hsieh, Shih-Chi Su
BACKGROUND AND HYPOTHESIS: Perturbation of gut microbiota has been linked to chronic kidney disease (CKD), which was correlated with a sophisticated milieu of metabolic and immune dysregulation. METHODS: To clarify the underlying host-microbe interaction in CKD, we performed multi-omics measurements, including systems-level gut microbiome, targeted serum metabolome, and deep immunotyping, in a cohort of patients and non-CKD controls. RESULTS: Our analyses on functional profiles of gut microbiome showed a decrease in the diversity and abundance of carbohydrate-active enzyme (CAZyme) genes but an increase in the abundance of antibiotic resistance, nitrogen cycling enzyme, and virulence factor genes in CKD...
January 19, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38237547/a-novel-enzyme-based-functional-correlation-algorithm-for-multi-omics-reveals-the-potential-mechanisms-of-traditional-chinese-medicines-taking-jian-pi-yi-shen-formula-as-an-example
#27
JOURNAL ARTICLE
Ying-Hao Yin, Chang-Hui Li, Hai-Piao Huang, Chi Zhang, Shang-Bin Zhang, Shun-Min Li, Jianping Chen
The integrated analysis of host metabolome and intestinal microbiome is an opportunity to explore the complex therapeutic mechanisms of traditional Chinese medicines. Currently, researchers mainly employ various statistical correlation analytical methods to investigate metabolome-microbiome correlations. However, these conventional correlation techniques often focus on statistical correlations and their biological meanings are always ignored, especially the functional relevance between them. Here, we developed a novel enzyme-based functional correlation (EBFC) algorithm to further improve the interpretability and the identified scope of microbe-metabolite correlations based on the conventional Spearman's analysis...
January 11, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38220540/bladder-cancer-and-the-urinary-microbiome-new-insights-and-future-directions-a-review
#28
REVIEW
Angela E Russo, Areeba Memon, Shahid Ahmed
The presence of a microbiome in the urinary system has been established through recent advancements in technology and investigation of microbial communities in the human body. The study of the taxonomic and genomic ecology of microbial communities has been greatly improved by the use of metagenomics. The research in this area has expanded our understanding of microbial ecosystems and shows that the urinary tract contains over 100 species from over 50 genera, with Lactobacillus, Gardnerella, and Streptococcus being the most common...
January 9, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38220413/can-curcumin-supplementation-break-the-vicious-cycle-of-inflammation-oxidative-stress-and-uremia-in-patients-undergoing-peritoneal-dialysis
#29
RANDOMIZED CONTROLLED TRIAL
Drielly C M V Reis, Livia Alvarenga, Ludmila F M F Cardozo, Beatriz G Baptista, Susane Fanton, Bruna R Paiva, Marcelo Ribeiro-Alves, Rodrigo S Fortunato, Andressa L Vasconcelos, Lia S Nakao, Carmen Lucia Sanz, Andresa A Berretta, Maurilo Leite, Denise Mafra
BACKGROUND & AIMS: Turmeric (a source of curcumin) is an excellent food to modulate oxidative stress, inflammation, and gut dysbiosis in patients with chronic kidney disease (CKD). However, no studies report the benefits of curcumin in patients undergoing peritoneal dialysis (PD). This study aims to evaluate the effects of curcuminoid supplementation on oxidative stress, inflammatory markers, and uremic toxins originating from gut microbiota in patients with CKD undergoing PD. METHODS: This longitudinal, randomized, single-blind, placebo-controlled trial evaluated 48 patients who were randomized into two groups: Curcumin (three capsules of 500 mg of Curcuma longa extract, with 98...
February 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38205394/huang-gan-formula-alleviates-systemic-inflammation-and-uremia-in-adenine-induced-chronic-kidney-disease-rats-may-associate-with-modification-of-gut-microbiota-and-colonic-microenvironment
#30
JOURNAL ARTICLE
Jingqian Zhao, Chenyu Zhao, Tianrong Xun, Xiaokang Wang, Sui Wei, Chunxiao Ye, Mimi Zhang, Dan Guo, Xixiao Yang
PURPOSE: This study aims to investigate the effects of Huang Gan formula (HGF), a Chinese herbal prescription used for chronic kidney disease (CKD), on the regulation of the gut microbiota and colonic microenvironment of CKD. METHODS: CKD rats were induced by 150 mg/kg adenine gavage for 4 weeks, then orally treated with or without 3.6 g/kg or 7.2 g/kg of HGF for 8 weeks. The renal function and structure were analyzed by biochemical detection, hematoxylin and eosin, Masson's trichrome, Sirius red and immunochemical staining...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38163858/using-the-concept-of-food-as-medicine-to-mitigate-inflammation-in-patients-undergoing-peritoneal-dialysis
#31
REVIEW
Livia Alvarenga, Drielly C M V Reis, Julie Ann Kemp, Karla Thais Resende Teixeira, Denis Fouque, Denise Mafra
The most common kidney replacement therapy (KRT) worldwide is hemodialysis (HD), and only 5%-10% of patients are prescribed peritoneal dialysis (PD) as KRT. Despite PD being a different method, these patients also present particular complications, such as oxidative stress, gut dysbiosis, premature aging, and mitochondrial dysfunction, leading to an inflammation process and high cardiovascular mortality risk. Although recent studies have reported nutritional strategies in patients undergoing HD with attempts to mitigate these complications, more information must be needed for PD patients...
January 1, 2024: Therapeutic Apheresis and Dialysis
https://read.qxmd.com/read/38162058/-sichuan-dark-tea-based-medicated-dietary-formula-improves-obesity-induced-renal-lipid-metabolism-disorder-in-mice-by-remodeling-gut-microbiota-and-short-chain-fatty-acid-metabolism
#32
JOURNAL ARTICLE
Hui Li, Lihan Zhang, Rongshuang Huang, Qian Ren, Fan Guo, Min Shi, Letian Yang, Yang Yu, Liang Ma, Ping Fu
OBJECTIVE: To investigate the renoprotective effects of a Sichuan dark tea-based medicated dietary formula (alternatively referred to as Qing, or clarity in Chinese) on mice with diet-induced obesity (DIO) and to explore the specific mechanisms involved. METHODS: Male C57BL/6 mice were randomly assigned to three groups, a control group, a DIO group, and a Qing treatment group, or the Qing group, with 8 mice in each group. The mice in the control group were given normal maintenance feed and purified water, and the other two groups were fed a high-fat diet for 12 weeks to establish the DIO model...
November 20, 2023: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/38149555/the-pan-liver-network-theory-from-traditional-chinese-medicine-to-western-medicine
#33
REVIEW
Yaxing Zhang, Xian-Ming Fang
In traditional Chinese medicine (TCM), the liver is the "general organ" that is responsible for governing/maintaining the free flow of qi over the entire body and storing blood. According to the classic five elements theory, zang-xiang theory, yin-yang theory, meridians and collaterals theory, and the five-viscera correlation theory, the liver has essential relationships with many extrahepatic organs or tissues, such as the mother-child relationships between the liver and the heart, and the yin-yang and exterior-interior relationships between the liver and the gallbladder...
2023: Chinese Journal of Physiology
https://read.qxmd.com/read/38136178/protective-role-of-taurine-on-rat-offspring-hypertension-in-the-setting-of-maternal-chronic-kidney-disease
#34
JOURNAL ARTICLE
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Taurine is a natural antioxidant with antihypertensive properties. Maternal chronic kidney disease (CKD) has an impact on renal programming and increases the risk of offspring hypertension in later life. The underlying mechanisms cover oxidative stress, a dysregulated hydrogen sulfide (H2 S) system, dysbiotic gut microbiota, and inappropriate activation of the renin-angiotensin-aldosterone system (RAAS). We investigated whether perinatal taurine administration enables us to prevent high blood pressure (BP) in offspring complicated by maternal CKD...
November 29, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38130753/the-dietary-fiber-inulin-slows-progression-of-chronic-kidney-disease-mineral-bone-disorder-ckd-mbd-in-a-rat-model-of-ckd
#35
JOURNAL ARTICLE
Annabel Biruete, Neal X Chen, Corinne E Metzger, Shruthi Srinivasan, Kalisha O'Neill, Paul B Fallen, Austin Fonseca, Hannah E Wilson, Henriette de Loor, Pieter Evenepoel, Kelly S Swanson, Matthew R Allen, Sharon M Moe
Chronic kidney disease (CKD)-mineral bone disorder (CKD-MBD) leads to fractures and cardiovascular disease. Observational studies suggest beneficial effects of dietary fiber on both bone and cardiovascular outcomes, but the effect of fiber on CKD-MBD is unknown. To determine the effect of fiber on CKD-MBD, we fed the Cy/+ rat with progressive CKD a casein-based diet of 0.7% phosphate with 10% inulin (fermentable fiber) or cellulose (non-fermentable fiber) from 22 weeks to either 30 or 32 weeks of age (~30% and ~15% of normal kidney function; CKD 4 and 5)...
December 2023: JBMR Plus
https://read.qxmd.com/read/38111708/corn-silk-polysaccharides-attenuate-diabetic-nephropathy-through-restoration-of-the-gut-microbial-ecosystem-and-metabolic-homeostasis
#36
JOURNAL ARTICLE
Wenting Dong, Yuanyuan Zhao, Xiuwei Li, Jinhai Huo, Weiming Wang
INTRODUCTION: The pathogenesis of diabetic nephropathy (DN) is complex, inflammation is the central link among the inducing factors in the existing research, and the gutkidney axis could scientifically explain the reasons for the accumulation of chronic low-grade inflammation. As both a medicine and food, corn silk contains abundant polysaccharides. Historical studies and modern research have both confirmed its intervention effect on diabetes and DN, but the mechanism of action is unclear...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38093822/-a-series-of-unfortunate-events-a-case-report-of-infective-endocarditis-resulting-from-ventricular-arrhythmia-ablation
#37
Maria Stec, Dominika Dziadosz, Katarzyna Mizia-Stec
BACKGROUND: Radiofrequency ablation (RFA) is the most effective non-pharmacological approach in the reduction of ventricular tachycardia (VT) recurrence. However, it is crucial to thoroughly screen every patient for contraindications for RFA and provide appropriate pharmacological prophylaxis, if needed, since adverse effects may be fatal. CASE SUMMARY: A 77-year-old male with multi-vessel coronary artery disease, heart failure with reduced ejection fraction (New York Heart Association (NYHA) Class III), with implantable cardioverter-defibrillator was admitted to our clinic due to recurrent life-threatening VT...
December 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/38085410/characterization-of-gut-microbiota-in-patients-with-stage-3-4-chronic-kidney-disease-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Xiali Yang, Shiying Cai, Jinsheng Gong, Jun Zhang, Minling Lian, Rufu Chen, Linghui Zhou, Peijin Bai, Bo Liu, Minting Zhuang, Honghong Tan, Juan Xu, Meizhen Li
PURPOSE: Multiple factors, such as dietary patterns, pharmaceutical interventions, and exposure to harmful substances, possess the capacity to influence gut microbiota composition. Gut microbiota dysbiosis has emerged as a significant contributor to the progression of chronic kidney disease (CKD) and its associated complications. By comprehending the intricacies of the intestinal microbiota, this research endeavor holds the potential to offer novel perspectives on potential strategies for mitigating CKD progression...
December 12, 2023: International Urology and Nephrology
https://read.qxmd.com/read/38074146/from-heart-failure-and-kidney-dysfunction-to-cardiorenal-syndrome-tmao-may-be-a-bridge
#39
REVIEW
Jialun Zhang, Peining Zhu, Siyu Li, Yufei Gao, Yue Xing
The study of trimethylamine oxide (TMAO), a metabolite of gut microbiota, and heart failure and chronic kidney disease has made preliminary achievements and been summarized by many researchers, but its research in the field of cardiorenal syndrome is just beginning. TMAO is derived from the trimethylamine (TMA) that is produced by the gut microbiota after consumption of carnitine and choline and is then transformed by flavin-containing monooxygenase (FMO) in the liver. Numerous research results have shown that TMAO not only participates in the pathophysiological progression of heart and renal diseases but also significantly affects outcomes in chronic heart failure (CHF) and chronic kidney disease (CKD), besides influencing the general health of populations...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38022571/intestinal-homeostasis-in-the-gut-lung-kidney-axis-a-prospective-therapeutic-target-in-immune-related-chronic-kidney-diseases
#40
REVIEW
Xinyin Liu, Xiaoran Wang, Peipei Zhang, Yiwen Fang, Yanyan Liu, Yueyue Ding, Wen Zhang
In recent years, the role of intestinal homeostasis in health has received increasing interest, significantly improving our understanding of the complex pathophysiological interactions of the gut with other organs. Microbiota dysbiosis, impaired intestinal barrier, and aberrant intestinal immunity appear to contribute to the pathogenesis of immune-related chronic kidney diseases (CKD). Meanwhile, the relationship between the pathological changes in the respiratory tract (e.g., infection, fibrosis, granuloma) and immune-related CKD cannot be ignored...
2023: Frontiers in Immunology
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