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Microbiota And Chronic Kidney Disease

https://read.qxmd.com/read/38510931/-bacillus-coagulans-tci711-supplementation-improved-nonalcoholic-fatty-liver-by-modulating-gut-microbiota-a-randomized-placebo-controlled-clinical-trial
#1
JOURNAL ARTICLE
Rong-Hong Hsieh, Yu-Ju Chien, Wen-Yi Lan, Yung-Kai Lin, Yung-Hsiang Lin, Chi-Fu Chiang, Ming-Ta Yang
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has become one of the major problems of chronic liver disease worldwide. It not only causes damage to the liver but also engenders chronic hepatitis and cirrhosis. Recent studies have shown that regulating Bacillus coagulans can improve NAFLD. OBJECTIVES: This trial explores whether B. coagulans TCI711 (BCT) could ameliorate NAFLD. METHODS: A total of 57 patients with NAFLD were recruited through FibroScan liver fibrosis scanner and divided into placebo ( n = 28) and BCT-supplemented groups ( n = 29)...
March 2024: Current Developments in Nutrition
https://read.qxmd.com/read/38503362/pathophysiology-and-management-of-enteric-hyperoxaluria
#2
REVIEW
Jordan Desenclos, Valentine Forté, Cécile Clément, Michel Daudon, Emmanuel Letavernier
Enteric hyperoxaluria is a metabolic disorder resulting from conditions associated with fatty acid malabsorption and characterized by an increased urinary output of oxalate. Oxalate is excessively absorbed in the gut and then excreted in urine where it forms calcium oxalate crystals, inducing kidney stones formation and crystalline nephropathies. Enteric hyperoxaluria is probably underdiagnosed and may silently damage kidney function of patients affected by bowel diseases. Moreover, the prevalence of enteric hyperoxaluria has increased because of the development of bariatric surgical procedures...
March 17, 2024: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/38481512/targeting-gut-microbiome-with-prebiotic-in-patients-with-ckd-the-targut-ckd-study
#3
JOURNAL ARTICLE
Michael B Sohn, Bei Gao, Cynthia Kendrick, Anvesha Srivastava, Tamara Isakova, Jennifer J Gassman, Linda F Fried, Myles Wolf, Alfred K Cheung, Kalani L Raphael, Patricia Centron Vinales, John P Middleton, Ana Pabalan, Dominic S Raj
INTRODUCTION: Disruption of gut microbiota underpins some of the metabolic alterations observed in chronic kidney disease (CKD). METHODS: In a nonrandomized, open-label, 3-phase pilot trial, with repeated measures within each phase, we examined the efficacy of oligofructose-enriched inulin (p-inulin) in changing the gut microbiome and their metabolic products in 15 patients with CKD. The stability of microbiome and metabolome was studied during the pretreatment phase (8 weeks), a p-inulin treatment phase (12 weeks), and a post treatment phase (8 weeks) of the study...
March 2024: KI Reports
https://read.qxmd.com/read/38477209/relationship-between-compound-%C3%AE-ketoacid-and-microinflammation-in-patients-with-chronic-kidney-disease
#4
JOURNAL ARTICLE
Zaobin Chen, Yongda Lin, Jiali Wang, Kaijin Yao, Yina Xie, Xiutian Chen, Tianbiao Zhou
Chronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory state has been recognized as an important component of CKD, which can lead to renal fibrosis and loss of renal function, and plays a crucial role in the pathophysiology and progression of the disease...
February 19, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38474799/the-role-of-probiotics-in-the-prevention-of-clostridioides-difficile-infection-in-patients-with-chronic-kidney-disease
#5
REVIEW
Sylwia Dudzicz-Gojowy, Andrzej Więcek, Marcin Adamczak
In patients suffering from chronic kidney disease (CKD), substantial unfavourable alterations in the intestinal microbiota composition, i.e., dysbiosis, have been noted. The main causes of such dysbiosis among others are insufficient dietary fibre content in the diet, fluid restrictions, medications used, and physical activity limitation. One clinically important consequence of dysbiosis in CKD patients is high risk of Clostridioides difficile infection (CDI). In observational studies, it was found that CDI is more frequent in CKD patients than in the general population...
February 27, 2024: Nutrients
https://read.qxmd.com/read/38474744/food-to-prevent-vascular-calcification-in-chronic-kidney-disease
#6
REVIEW
Diana Moldovan, Crina Rusu, Alina Potra, Dacian Tirinescu, Maria Ticala, Ina Kacso
Vascular calcification (VC) is a consequence of chronic kidney disease (CKD) which is of paramount importance regarding the survival of CKD patients. VC is far from being controlled with actual medication; as a result, in recent years, diet modulation has become more compelling. The concept of medical nutritional therapy points out the idea that food may prevent or treat diseases. The aim of this review was to evaluate the influence of food habits and nutritional intervention in the occurrence and progression of VC in CKD...
February 23, 2024: Nutrients
https://read.qxmd.com/read/38474703/-dieta-de-la-milpa-a-culturally-concordant-plant-based-dietary-pattern-for-hispanic-latine-people-with-chronic-kidney-disease
#7
REVIEW
Annabel Biruete, Gabriela Leal-Escobar, Ángeles Espinosa-Cuevas, Luis Mojica, Brandon M Kistler
Chronic kidney disease (CKD) disproportionately affects minorities in the United States, including the Hispanic/Latine population, and is a public health concern in Latin American countries. An emphasis on healthy dietary patterns, including the Mediterranean and the Dietary Approaches to Stop Hypertension (DASH) diets, has been suggested as they are associated with a lower incidence of CKD, slower CKD progression, and lower mortality in kidney failure. However, their applicability may be limited in people from Latin America...
February 20, 2024: Nutrients
https://read.qxmd.com/read/38472984/diagnosing-and-treating-igan-steroids-budesonide-or-maybe-both
#8
REVIEW
Christodoulos Keskinis, Eleni Moysidou, Michalis Christodoulou, Panagiotis Pateinakis, Maria Stangou
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, is characterized by a mesangial IgA deposit and a variety of histological lesions, as described by the Oxford classification system. Despite the well-described "four-hit hypothesis", there are still plenty of less or undescribed mechanisms that participate in the disease pathogenesis, such as B-cell priming, which seems to be initiated by different antigens in the intestinal microbiota. Diagnosis of the disease is currently based on kidney biopsy findings, as the sensitivity and specificity of the many serum and urinary biomarkers described so far do not seem to have diagnostic accuracy...
February 28, 2024: Diagnostics
https://read.qxmd.com/read/38458480/tangshen-formula-alleviates-inflammatory-injury-against-aged-diabetic-kidney-disease-through-modulating-gut-microbiota-composition-and-related-amino-acid-metabolism
#9
JOURNAL ARTICLE
Dan-Qian Chen, Hao-Jun Zhang, Wen Zhang, Kai Feng, Hui Liu, Hai-Ling Zhao, Ping Li
Diabetic kidney disease (DKD) is leading causes and one of the fastest growing causes of chronic kidney disease worldwide, and leads to high morbidity and mortality. Emerging evidences have revealed gut microbiota dysbiosis and related metabolism dysfunction play a dominant role in DKD progression and treatment through modulating inflammation. Our previous studies showed that Tangshen Formula (TSF), a Chinese herbal prescription, exhibited anti-inflammatory effect on DKD, but underlying mechanism that involved gut microbiota and related metabolism in aged model remained obscure...
March 9, 2024: Experimental Gerontology
https://read.qxmd.com/read/38433906/cross-sectional-analyses-of-metabolites-across-biological-samples-mediating-dietary-acid-load-and-chronic-kidney-disease
#10
JOURNAL ARTICLE
Ilias Attaye, Beverley Beynon-Cobb, Panayiotis Louca, Ana Nogal, Alessia Visconti, Francesca Tettamanzi, Kari Wong, Gregory Michellotti, Tim D Spector, Mario Falchi, Jordana T Bell, Cristina Menni
Chronic kidney disease (CKD) is a major public health burden, with dietary acid load (DAL) and gut microbiota playing crucial roles. As DAL can affect the host metabolome, potentially via the gut microbiota, we cross-sectionally investigated the interplay between DAL, host metabolome, gut microbiota, and early-stage CKD (TwinsUK, n = 1,453). DAL was positively associated with CKD stage G1-G2 (Beta (95% confidence interval) = 0.34 (0.007; 0.7), p = 0.046). After adjusting for covariates and multiple testing, we identified 15 serum, 14 urine, 8 stool, and 7 saliva metabolites, primarily lipids and amino acids, associated with both DAL and CKD progression...
March 15, 2024: IScience
https://read.qxmd.com/read/38427291/the-interplay-between-dietary-choline-and-cardiometabolic-disorders-a-review-of-current-evidence
#11
REVIEW
Natalia G Vallianou, Dimitris Kounatidis, Sotiria Psallida, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Dimitrios Tsilingiris, Maria Dalamaga
PURPOSE OF REVIEW: Choline is an essential nutrient for human health and cellular homeostasis as it is necessary for the synthesis of lipid cell membranes, lipoproteins, and the synthesis of the neurotransmitter acetylcholine. The aim of this review is to analyze the beneficial effects of choline and its significance in cellular metabolism and various inflammatory pathways, such as the inflammasome. We will discuss the significance of dietary choline in cardiometabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and chronic kidney disease (CKD) as well as in cognitive function and associated neuropsychiatric disorders...
March 1, 2024: Current Nutrition Reports
https://read.qxmd.com/read/38412632/metabolome-evidence-of-ckdu-risks-after-chronic-exposure-to-simulated-sri-lanka-drinking-water-in-zebrafish
#12
JOURNAL ARTICLE
Pan-Pan Jia, Yan Li, Lan-Chen Zhang, Ming-Fei Wu, Tian-Yun Li, De-Sheng Pei
It is still a serious public health issue that chronic kidney disease of uncertain etiology (CKDu) in Sri Lanka poses challenges in identification, prevention, and treatment. What environmental factors in drinking water cause kidney damage remains unclear. This study aimed to investigate the risks of various environmental factors that may induce CKDu, including water hardness, fluoride (HF), heavy metals (HM), microcystin-LR (MC-LR), and their combined exposure (HFMM). The research focused on comprehensive metabolome analysis, and correlation with transcriptomic and gut microbiota changes...
February 26, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38396596/investigating-the-efficacy-of-kidney-protective-lactobacillus-mixture-containing-pet-treats-in-feline-chronic-kidney-disease-and-its-possible-mechanism
#13
JOURNAL ARTICLE
Ching-Wen Tsai, Hsiao-Wen Huang, Ya-Jane Lee, Ming-Ju Chen
Microbiota-based strategies are a novel auxiliary therapeutic and preventative way of moderating chronic kidney disease (CKD). Lactobacillus mixture (Lm) was previously demonstrated to exert a renal-protective function in the CKD mice model. The efficacy of probiotics in pet foods is a relatively new area of study, and thus verifying the potential health benefits is necessary. This study evaluated the efficacy of Lm treats in feline CKD and elucidated the mechanisms underlying host-microbe interactions. CKD cats (2 and 3 stages) were administrated probiotic pet treats daily (10 g) for 8 weeks...
February 16, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38389147/pharmacologic-therapeutics-in-sarcopenia-with-chronic-kidney-disease
#14
JOURNAL ARTICLE
Ran-Hui Cha
Inflammation, metabolic acidosis, renin-angiotensin system activation, insulin resistance, and impaired perfusion to skeletal muscles, among others, are possible causes of uremic sarcopenia. These conditions induce the activation of the nuclear factor-kappa B and mitogen-activated protein kinase pathways, adenosine triphosphate ubiquitin-proteasome system, and reactive oxygen species system, resulting in protein catabolism. Strategies for the prevention and treatment of sarcopenia in chronic kidney disease (CKD) are aerobic and resistance exercises along with nutritional interventions...
February 19, 2024: Kidney Research and Clinical Practice
https://read.qxmd.com/read/38376748/stroke-and-distal-organ-damage-exploring-brain-kidney-crosstalk
#15
REVIEW
Vandana Dulam, Sireesha Katta, Venkata Prasuja Nakka
Stroke and kidney dysfunction represent significant public health challenges, yet the precise mechanisms connecting these conditions and their severe consequences remain unclear. Individuals experiencing chronic kidney disease (CKD) and acute kidney injury (AKI) are at heightened susceptibility to experiencing repeated strokes. Similarly, a reduced glomerular filtration rate is associated with an elevated risk of suffering a stroke. Prior strokes independently contribute to mortality, end-stage kidney disease, and cardiovascular complications, underscoring the pathological connection between the brain and the kidneys...
February 20, 2024: Neurochemical Research
https://read.qxmd.com/read/38369469/gut-microbial-metabolites-scfas-and-chronic-kidney-disease
#16
REVIEW
Meng He, Wenqian Wei, Yichen Zhang, Zhouxia Xiang, Dan Peng, Ayijiaken Kasimumali, Shu Rong
The global incidence of Chronic Kidney Disease (CKD) is steadily escalating, with discernible linkage to the intricate terrain of intestinal microecology. The intestinal microbiota orchestrates a dynamic equilibrium in the organism, metabolizing dietary-derived compounds, a process which profoundly impacts human health. Among these compounds, short-chain fatty acids (SCFAs), which result from microbial metabolic processes, play a versatile role in influencing host energy homeostasis, immune function, and intermicrobial signaling, etc...
February 18, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38360205/protein-rich-foods-sea-foods-and-gut-microbiota-amplify-immune-responses-in-chronic-diseases-and-cancers-targeting-perk-as-a-novel-therapeutic-strategy-for-chronic-inflammatory-diseases-neurodegenerative-disorders-and-cancer
#17
REVIEW
Fatma Saaoud, Yifan Lu, Keman Xu, Ying Shao, Domenico Praticò, Roberto I Vazquez-Padron, Hong Wang, Xiaofeng Yang
The endoplasmic reticulum (ER) is a cellular organelle that is physiologically responsible for protein folding, calcium homeostasis, and lipid biosynthesis. Pathological stimuli such as oxidative stress, ischemia, disruptions in calcium homeostasis, and increased production of normal and/or folding-defective proteins all contribute to the accumulation of misfolded proteins in the ER, causing ER stress. The adaptive response to ER stress is the activation of unfolded protein response (UPR), which affect a wide variety of cellular functions to maintain ER homeostasis or lead to apoptosis...
February 13, 2024: Pharmacology & Therapeutics
https://read.qxmd.com/read/38338891/perinatal-use-of-citrulline-rescues-hypertension-in-adult-male-offspring-born-to-pregnant-uremic-rats
#18
JOURNAL ARTICLE
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
The growing recognition of the association between maternal chronic kidney disease (CKD) and fetal programming highlights the increased vulnerability of hypertension in offspring. Potential mechanisms involve oxidative stress, dysbiosis in gut microbiota, and activation of the renin-angiotensin system (RAS). Our prior investigation showed that the administration of adenine to pregnant rats resulted in the development of CKD, ultimately causing hypertension in their adult offspring. Citrulline, known for enhancing nitric oxide (NO) production and possessing antioxidant and antihypertensive properties, was explored for its potential to reverse high blood pressure (BP) in offspring born to CKD dams...
January 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38333870/colonic-microflora-and-plasma-metabolite-based-comparative-analysis-of-unilateral-ureteral-obstruction-induced-chronic-kidney-disease-after-treatment-with-the-chinese-medicine-fuzhenghuayujiangzhutongluo-and-ast-120
#19
JOURNAL ARTICLE
Ziwei Chen, Shaobo Wu, Li Huang, Jing Li, Xueying Li, Yu Zeng, Zejun Chen, Ming Chen
BACKGROUND: Many researchers have investigated the use of Chinese herbs to delay the progression of chronic kidney disease (CKD) through their effects on colonic microflora and microbiota-derived metabolites. However, whether FuZhengHuaYuJiangZhuTongLuo (FZHY) has effects that are similar to those of AST-120 on CKD needs to be elucidated. METHODS: In this study, we compared the effects of FZHY and AST-120 on the colonic microbiota and plasma metabolites in the CKD rat model...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38310315/integrated-traditional-chinese-and-western-medicine-in-the-prevention-and-treatment-of-non-alcoholic-fatty-liver-disease-future-directions-and-strategies
#20
REVIEW
Xin Ding, Xu He, Bulang Tang, Tian Lan
Traditional Chinese medicine (TCM) has been widely used for several centuries for metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). At present, NAFLD has become the most prevalent form of chronic liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma. However, there is still a lack of effective treatment strategies in Western medicine. The development of NAFLD is driven by multiple mechanisms, including genetic factors, insulin resistance, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, gut microbiota dysbiosis, and adipose tissue dysfunction...
February 3, 2024: Chinese Medicine
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