Ilias Attaye, Beverley Beynon-Cobb, Panayiotis Louca, Ana Nogal, Alessia Visconti, Francesca Tettamanzi, Kari Wong, Gregory Michellotti, Tim D Spector, Mario Falchi, Jordana T Bell, Cristina Menni
Chronic kidney disease (CKD) is a major public health burden, with dietary acid load (DAL) and gut microbiota playing crucial roles. As DAL can affect the host metabolome, potentially via the gut microbiota, we cross-sectionally investigated the interplay between DAL, host metabolome, gut microbiota, and early-stage CKD (TwinsUK, n = 1,453). DAL was positively associated with CKD stage G1-G2 (Beta (95% confidence interval) = 0.34 (0.007; 0.7), p = 0.046). After adjusting for covariates and multiple testing, we identified 15 serum, 14 urine, 8 stool, and 7 saliva metabolites, primarily lipids and amino acids, associated with both DAL and CKD progression...
March 15, 2024: IScience