keyword
https://read.qxmd.com/read/37929763/high-sensitivity-troponin-level-and-benefits-of-chronic-total-occlusion-revascularization
#1
JOURNAL ARTICLE
Daniel A Gold, Pratik B Sandesara, Vardhmaan Jain, Matthew E Gold, Nishant Vatsa, Shivang R Desai, Malika Elhage Hassan, Chenyang Yuan, Yi-An Ko, Ayman Alkhoder, Kiran Ejaz, Zain Alvi, Alireza Rahbar, Gillian Murtagh, Wissam A Jaber, William J Nicholson, Arshed A Quyyumi
Background The survival benefit of revascularization of chronic total occlusion (CTO) of the coronary arteries remains a subject of controversy. We measured high sensitivity troponin-I (hsTn-I) levels as an estimate of myocardial ischemia in patients with stable coronary artery disease, with the hypothesis that (1) patients with CTO have higher levels of hsTn-I than patients without CTO, (2) hsTn-I levels will predict adverse cardiovascular events in patients with CTO, and (3) patients with elevated hsTn-I levels will have a survival benefit from CTO revascularization...
November 6, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/36661917/a-story-of-pa-bsa-and-biomarkers-to-diagnose-pulmonary-hypertension-in-patients-with-severe-aortic-valve-stenosis-the-rise-of-igf-bp2-and-gdf-15
#2
JOURNAL ARTICLE
Joseph Kletzer, Stefan Hecht, Susanne Ramsauer, Bernhard Scharinger, Reinhard Kaufmann, Jürgen Kammler, Jörg Kellermair, Kaveh Akbari, Hermann Blessberger, Clemens Steinwender, Klaus Hergan, Uta C Hoppe, Michael Lichtenauer, Elke Boxhammer
(1) Background: Currently, echocardiography is the primary non-invasive diagnostic method used to screen patients with severe aortic valve stenosis (AS) for pulmonary hypertension (PH) by estimating systolic pulmonary artery pressure (sPAP). Other radiological methods have been a focus of research in the past couple of years, as it was shown that by determining the pulmonary artery (PA) diameter, prognostic statements concerning overall mortality could be made in these patients. This study compared established and novel cardiovascular biomarkers with the PA/BSA value to detect PH in patients with severe AS...
January 5, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/34436239/diagnostic-performance-of-serial-high-sensitivity-cardiac-troponin-measurements-in-the-emergency-setting
#3
JOURNAL ARTICLE
Peter A Kavsak, Mark K Hewitt, Shawn E Mondoux, Joshua O Cerasuolo, Jinhui Ma, Natasha Clayton, Matthew McQueen, Lauren E Griffith, Richard Perez, Hsien Seow, Craig Ainsworth, Dennis T Ko, Andrew Worster
Serial high-sensitivity cardiac troponin (hsTn) testing in the emergency department (ED) and the intensive cardiac care unit may assist physicians in ruling out or ruling in acute myocardial infarction (MI). There are three major algorithms proposed for high-sensitivity cardiac troponin I (hsTnI) using serial measurements while incorporating absolute concentration changes for MI or death following ED presentation. We sought to determine the diagnostic estimates of these three algorithms and if one was superior in two different Canadian ED patient cohorts with serial hsTnI measurements...
August 13, 2021: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/34266289/repeat-measurements-on-patient-samples-identifies-unpredictable-and-poorly-reproducible-cardiac-troponin-results-with-a-high-sensitivity-cardiac-troponin-assay
#4
LETTER
Simone Drummond, Ching-Tong Mark, Nadia Caruso, Lorna Clark, Peter A Kavsak
No abstract text is available yet for this article.
November 2021: Annals of Clinical Biochemistry
https://read.qxmd.com/read/34224384/implementation-of-a-high-sensitivity-troponin-i-assay-in-an-academic-medical-center-a-qualitative-and-quantitative-assessment
#5
JOURNAL ARTICLE
David E Winchester, Omkar Betageri, Patrick Perche, Brandon Allen, Ryan Theis
OBJECTIVES: To describe the clinical impact and lessons learned through implementation of a high sensitivity troponin (hsTn) assay. BACKGROUND: hsTn assays have received regulatory approval for use in the United States, and healthcare facilities are beginning to adopt these new assays. Questions remain about how to implement them and what effect they may have on demand for cardiovascular services. METHODS: We conducted a mixed-methods implementation science-based investigation of hsTn adoption at a single academic medical center...
July 2021: Journal of Invasive Cardiology
https://read.qxmd.com/read/34201544/hesperetin-nanocrystals-improve-mitochondrial-function-in-a-cell-model-of-early-alzheimer-disease
#6
JOURNAL ARTICLE
Lukas Babylon, Rekha Grewal, Pascal-L Stahr, Ralph W Eckert, Cornelia M Keck, Gunter P Eckert
Mitochondrial dysfunction represents a hallmark of both brain aging and age-related neurodegenerative disorders including Alzheimer disease (AD). AD-related mitochondrial dysfunction is characterized by an impaired electron transport chain (ETC), subsequent decreased adenosine triphoshpate (ATP) levels, and elevated generation of reactive oxygen species (ROS). The bioactive citrus flavanone hesperetin (Hst) is known to modulate inflammatory response, to function as an antioxidant, and to provide neuroprotective properties...
June 23, 2021: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/32375613/-control-of-ventricular-rate-in-permanent-atrial-fibrillation-cardio-protec-tion-and-tissue-hemodynamics
#7
RANDOMIZED CONTROLLED TRIAL
S G Kanorskiy, L V Polischuk
Objective To evaluate myocardial injury and tissue hemodynamics in elderly patients with permanent atrial fibrillation (AF) based on the achieved range of ventricular contraction rate (VCR).Materials and Methods This prospective, randomized, blind study included 75 patients aged ≥60 with permanent AF. All patients were prescribed bisoprolol as a VCR-reducing therapy. Patients were randomized to two groups according to the permuted-block design based on the range of resting VCR goal: group 1, 60-79 bpm (n=38) and group 2, 80-100 bpm (n=37)...
March 18, 2020: Kardiologiia
https://read.qxmd.com/read/31965160/rapid-rule-out-for-suspected-myocardial-infarction-is-the-algorithm-appropriate-for-all
#8
JOURNAL ARTICLE
Erez Marcusohn, Danny Epstein, Ariel Roguin, Robert Zukermann
AIMS: Patients presenting to the emergency department (ED) with cardiac chest pain and high-sensitive troponin I (HsTnI) less than 5 ng/L have very good prognosis and low risk for major adverse cardiovascular events. The 2015 European Society of Cardiology (ESC) guidelines for non-ST-elevation myocardial infarction (MI)/acute coronary syndrome (ACS) suggests that patients with normal high-sensitive troponin, which are free of chest pain and have a global registry of acute coronary events (GRACE) score less than 140 are eligible for discharge from the hospital for outpatient workup...
July 1, 2020: European Heart Journal. Quality of Care & Clinical Outcomes
https://read.qxmd.com/read/31743687/multi-platform-analytical-evaluation-of-the-beckman-coulter-access-high-sensitivity-troponin-i-assay-across-different-laboratory-sites-using-barricor-plasma
#9
MULTICENTER STUDY
Joshua E Raizman, Albert K Y Tsui, Bobbi-Lynn Goudreau, Anna K Füzéry, Mathew Estey, Hossein Sadrzadeh, Trefor Higgins
OBJECTIVES: Previous analytical evaluations of the Beckman Coulter Access high sensitivity troponin (hsTn) I assay have focused on single platforms and laboratory sites. The purpose of this study was to determine assay robustness across different platforms at multiple sites, platform-specific characteristics, and equivalence to other hsTn methods in a large laboratory network. METHODS: Barricor plasma was used to assess imprecision, linearity, sensitivity (limit of blank and detection, LOB/LOD), and comparability to the conventional AccuTnI+3 and other hsTn assays...
April 2020: Clinical Biochemistry
https://read.qxmd.com/read/31542905/low-risk-non-st-elevation-acute-coronary-syndrome-and-normal-troponin-do-we-need-further-evaluation
#10
JOURNAL ARTICLE
Erez Marcusohn, Danny Epstein, Anees Musallam, Zohar Keidar, Ariel Roguin
BACKGROUND: With the recent introduction of high-sensitivity troponin (hsTn), the incremental benefit of stress myocardial perfusion imaging (MPI) in the evaluation of patients who present to the emergency department (ED) with acute coronary syndrome (ACS) is unclear. OBJECTIVES: To assess the added value of stress MPI in low-risk ACS patients with normal range hsTnI. METHODS: We analyzed all patients who were hospitalized at our medical center from February 2016 to November 2017, who presented with low-risk ACS and underwent stress MPI, and in whom hsTnI was in the normal range after the introduction of hsTnI...
September 2019: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/31449619/an-atypical-cause-of-myocardial-infarction-case-report-of-an-obstructing-papillary-fibroelastoma-of-the-aortic-valve
#11
JOURNAL ARTICLE
Niamh Logan, Mohammad Sirajul Islam, Jehan Zeb Chughtai, Niamh F Murphy
BACKGROUND: Papillary fibroelastomas are rare primary cardiac tumours with a prevalence of 0.01% at autopsy. They are histologically benign tumours but have been demonstrated through case series to confer an increased risk of thrombo-embolism resulting in: transient ischaemic attack, stroke, myocardial infarction, and pulmonary and systemic embolization. CASE SUMMARY: A 54-year-old woman presented with central chest pain radiating to her left arm. At presentation there was a significant troponin rise; initial high-sensitivity troponin-I (hsTn-I) 660 pg/mL increased to 3340 pg/mL at 6 h...
June 1, 2019: European Heart Journal. Case Reports
https://read.qxmd.com/read/31308305/the-relationship-between-the-use-of-cold-and-isothermic-blood-cardioplegia-solution-for-myocardial-protection-during-cardiopulmonary-bypass-and-the-ischemia-reperfusion-injury
#12
RANDOMIZED CONTROLLED TRIAL
Hakan Saclı, Ibrahim Kara, Mevriye Serpil Diler, Bilal Percin, Ahmet Ilksoy Turan, Kaan Kırali
PURPOSE: In this study, we aimed to assess myocardial protection and ischemia-reperfusion injury in patients undergoing open heart surgery with isothermic blood cardioplegia (IBC) or hypothermic blood cardioplegia (HBC). MATERIALS AND METHODS: A total of 48 patients who underwent isolated coronary artery bypass grafting or isolated mitral valve surgery between March 2017 and October 2017 were evaluated as randomized prospective study. Study groups (HBC: Group 1, IBC: Group 2) were compared in terms of interleukin 6 (IL-6), IL-8, IL-10, and complement factor 3a (C3a) levels, metabolic parameters, creatine kinase-muscle/brain (CK-MB) and high-sensitivity Troponin I (hsTn-I), and clinical outcomes...
December 20, 2019: Annals of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/31111144/type-ii-myocardial-infarction-and-chronic-myocardial-injury-rates-invasive-management-and-4-year-mortality-among-consecutive-patients-undergoing-high-sensitivity-troponin-t-testing-in-the-emergency-department
#13
JOURNAL ARTICLE
Aisha Etaher, Oliver J Gibbs, Yousef M Saad, Steven Frost, Tuan L Nguyen, Ian Ferguson, Craig P Juergens, Derek Chew, John K French
AIMS: As assessment of patients with suspected acute coronary syndromes (ACS) in emergency departments (EDs) represents a major workload because high-sensitivity troponin (HsTn) T and I levels are frequently measured, and a minority of patients have final diagnosis of myocardial infarction (MI). We determined the relative frequencies of three patients groups: Type-I MI, Type-II MI (including acute myocardial injury). METHODS AND RESULTS: Among 2738 consecutive patients with suspected ACS presenting to ED at Liverpool Hospital, Australia, between March and June 2014...
January 1, 2020: European Heart Journal. Quality of Care & Clinical Outcomes
https://read.qxmd.com/read/31093657/cardiovascular-biomarkers-in-patients-with-acute-decompensated-heart-failure-randomized-to-sacubitril-valsartan-or-enalapril-in-the-pioneer-hf-trial
#14
RANDOMIZED CONTROLLED TRIAL
David A Morrow, Eric J Velazquez, Adam D DeVore, Margaret F Prescott, Carol I Duffy, Yared Gurmu, Kevin McCague, Ricardo Rocha, Eugene Braunwald
AIMS: Circulating high-sensitivity cardiac troponin (hsTn) and soluble ST2 (sST2) reflect myocardial stress in patients with heart failure (HF). Production of cyclic guanosine 3'5' monophosphate (cGMP) in response to activation of natriuretic peptide receptors reduces cardiac afterload and preload. We assessed the effects of sacubitril/valsartan on these biomarkers in patients with reduced ejection fraction and acute decompensated HF (ADHF). METHODS AND RESULTS: PIONEER-HF was a randomized, double-blind trial of sacubitril/valsartan vs...
October 21, 2019: European Heart Journal
https://read.qxmd.com/read/30598634/high-sensitivity-troponins-after-a-standardized-2-hour-treadmill-run
#15
JOURNAL ARTICLE
Pavel Broz, Daniel Rajdl, Jaroslav Novak, Milan Hromadka, Jaroslav Racek, Ladislav Trefil, Vaclav Zeman
BACKGROUND: The aim of this study was to examine high-sensitivity troponin T and I (hsTnT and hsTnI) after a treadmill run under laboratory conditions and to find a possible connection with echocardiographic, laboratory and other assessed parameters. METHODS: Nineteen trained men underwent a standardized 2-hour-long treadmill run. Concentrations of hsTnT and hsTnI were assessed before the run, 60, 120 and 180 minutes after the start and 24 hours after the run. Changes in troponins were tested using non-parametric analysis of variance (ANOVA)...
July 2018: Journal of Medical Biochemistry
https://read.qxmd.com/read/28978339/high-sensitivity-troponin-t-and-i-reflect-mitral-annular-plane-systolic-excursion-being-assessed-by-cardiac-magnetic-resonance-imaging
#16
JOURNAL ARTICLE
Michèle Natale, Michael Behnes, Seung-Hyun Kim, Julia Hoffmann, Nadine Reckord, Ursula Hoffmann, Johannes Budjan, Siegfried Lang, Martin Borggrefe, Theano Papavassiliu, Thomas Bertsch, Ibrahim Akin
PURPOSE: This study aims to evaluate the association between high sensitivity troponins (hsTn) and mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI). METHODS: Patients undergoing cMRI were prospectively enrolled. Patients with right ventricular dysfunction (< 50%) were excluded. Blood samples for measurements of hsTn and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected at the time of cMRI...
October 4, 2017: European Journal of Medical Research
https://read.qxmd.com/read/28656817/high-sensitivity-troponin-t-and-i-reflect-left-atrial-function-being-assessed-by-cardiac-magnetic-resonance-imaging
#17
JOURNAL ARTICLE
Michèle Natale, Michael Behnes, Seung-Hyun Kim, Julia Hoffmann, Nadine Reckord, Ursula Hoffmann, Johannes Budjan, Siegfried Lang, Martin Borggrefe, Theano Papavassiliu, Thomas Bertsch, Ibrahim Akin
Background Left atrial function (LAF) plays an interactive role between pulmonary and systemic circulation. Cardiac biomarkers, such as amino-terminal pro-brain natriuretic peptide (NT-proBNP) and troponins, might reflect cardiac function. This study aims to evaluate the association between high sensitivity troponins (hsTn) and left atrial function in patients undergoing cardiac magnetic resonance imaging (cMRI). Methods Patients undergoing cardiac magnetic resonance imaging (cMRI) were enrolled prospectively...
March 2018: Annals of Clinical Biochemistry
https://read.qxmd.com/read/28528430/risk-classification-of-highly-sensitive-troponin-i-predict-presence-of-vulnerable-plaque-assessed-by-dual-source-coronary-computed-tomography-angiography
#18
JOURNAL ARTICLE
Ting Liu, Guan Wang, Peiling Li, Xu Dai
Patients presenting to the emergency department with acute chest pain, negative conventional troponin and electrocardiogram require serial testing to rule out acute coronary syndrome (ACS). We studied the association of highly sensitive troponin (hsTn) I with vulnerable plaque features as detected by coronary dual source computed tomography angiography (DSCTA) and determined whether hsTn I at the time of presentation combined with early DSCTA could improve classification of patients as high-risk or low risk for ACS...
November 2017: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/28421838/self-reported-cocaine-use-is-not-associated-with-elevations-in-high-sensitivity-troponin-i
#19
JOURNAL ARTICLE
Candice D Jordan, Frederick K Korley, Andrew I Stolbach
OBJECTIVE: High-sensitivity troponin (hsTn) assays detect 10 times lower concentrations of cardiac troponin than conventional assays. We examined the effects of self-reported cocaine use to determine whether those with acute cocaine use being evaluated for ACS are more likely to have elevated hsTnI than those nonusers being evaluated for ACS. METHODS: We conducted a sub-analysis of a prospective cohort of ED patients evaluated for acute coronary syndrome. Recent cocaine use was determined by structured patient interviews...
June 2017: Clinical Toxicology
https://read.qxmd.com/read/28343173/fast-track-protocols-using-highly-sensitive-troponin-assays-for-ruling-out-and-ruling-in-non-st-elevation-acute-coronary-syndrome
#20
JOURNAL ARTICLE
Simona Ferraro, Alberto Dolci, Mauro Panteghini
The introduction of "highly sensitive" cardiac troponin assays (hsTn) has reinforced the evidence that only serial testing incorporated in running algorithms allows a more accurate diagnosis of acute myocardial infarction. In this report, we consider the available evidence supporting the use of fast track protocols for ruling out and ruling in non-ST elevation myocardial infarction (NSTEMI) and compare it with the content of recently released guideline by the European Society of Cardiology, noting some uncomfortable aspects that need urgent clarification and/or revision...
October 26, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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