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stenosis tracheal

Giulio Porcedda, Alice Brambilla, Silvia Favilli, Bruno Murzi, Lorenzo Mirabile, Roberto Baggi, Luigi Arcieri
BACKGROUND:  Left pulmonary artery (LPA) sling (PAS) is a vascular ring, which is frequently associated with long-segment tracheal stenosis (TS). Mortality rate in operated children is still high, especially in cases of severe tracheal hypoplasia and/or associated congenital heart defects (CHDs). We report our experience of treatment and follow-up in a pediatric cohort of patients affected by PAS with severe tracheobronchial involvement. METHODS:  From 2005 to 2017, we enrolled 11 children diagnosed with PAS and congenital TS requiring surgical intervention...
February 11, 2019: Thoracic and Cardiovascular Surgeon
Francesco Puma, Mattia Meattelli, Miroslawa Kolodziejek, Marina Giuliana Properzi, Rosanna Capozzi, Alberto Matricardi, Lucio Cagini, Jacopo Vannucci
An innovative technique for airway management, utilizing a small diameter, short-cuffed, orotracheal tube for assisting rigid bronchoscopy in critical airway obstruction is reported. The device, part of Translaryngeal Tracheostomy KIT, was placed beyond the stenosis and used in combination with the rigid bronchoscope. This procedure improves safety during the management of critical tracheal stenoses, because the airway is constantly under the anesthesiologist's control. Consequently, inhalation anesthesia is feasible, use of neuromuscular blockage is possible, end-tidal CO2 monitoring is reliable and the distal airway is protected by blood and debris soilage during the tumor debulking...
February 7, 2019: Annals of Thoracic Surgery
Robert E Seegmiller, Cameron Foster, Jared L Burnham
BACKGROUND: The mutant chondrodysplasia (cho) is a cartilage-targeting disorder in C57BL mice that results in dwarfing and other malformations stemming from this collagenopathy. Clarke Fraser made the discovery of the mutation accidentally in the early 1960s during the thalidomide tragedy. METHODS: For this review we identified key research on cho as since its discovery. Relevant data were compiled to make a comprehensive review that details discoveries associated with the cho mutation, that describes the associated phenotypes and molecular mechanisms, and that provides a discussion surrounding its current clinical relevance...
February 4, 2019: Birth Defects Research
Matthew S Yong, Michael Z L Zhu, Douglas Bell, Nelson Alphonso, Johann Brink, Yves d'Udekem, Igor E Konstantinov
OBJECTIVES: Pulmonary artery (PA) sling is a rare vascular anomaly often associated with congenital tracheal stenosis. We describe the long-term outcomes with repair of this condition. METHODS: A retrospective study was conducted at 2 institutions. From 1984 to 2018, 33 patients with PA sling underwent repair. RESULTS: The median age at the time of surgery was 5.9 months (quartile 1-3: 2.5-12 months). Concomitant tracheal surgery was required in 21 patients (64%) where slide tracheoplasty was used in 11 patients (52%)...
January 31, 2019: European Journal of Cardio-thoracic Surgery
Susan C Shelmerdine, Michael T Ashworth, Alistair D Calder, Nagarajan Muthialu, Owen J Arthurs
No abstract text is available yet for this article.
February 2, 2019: Thorax
A Aleksanyan, E Stoelben
INTRODUCTION:  Cervical stenosis of the trachea caused by tracheotomy, tumor or without defined reason (idiopathic) can be treated by resection and anastomosis with good early and long-term results. Involvement of the ring cartilage makes the procedure technically demanding and increases the risk of morbidity. We describe our technique of laryngotracheal resection and reconstruction and compare the perioperative results with standard tracheal resection. PATIENTS AND METHODS:  Between January 2005 and December 2015, we performed about 800 procedures on the trachea including 76 standard cervical tracheal resections and 35 laryngotracheal resection...
January 31, 2019: Pneumologie
Sayali Dharmadhikari, Cameron A Best, Nakesha King, Michaela Henderson, Jed Johnson, Christopher K Breuer, Tendy Chiang
OBJECTIVES: The clinical experience with tissue-engineered tracheal grafts (TETGs) has been fraught with graft stenosis and delayed epithelialization. A mouse model of orthotopic replacement that recapitulates the clinical findings would facilitate the study of the cellular and molecular mechanisms underlying graft stenosis. METHODS: Electrospun nanofiber tracheal scaffolds were created using nonresorbable (polyethylene terephthalate + polyurethane) and co-electrospun resorbable (polylactide-co-caprolactone/polyglycolic acid) polymers (n = 10/group)...
January 30, 2019: Annals of Otology, Rhinology, and Laryngology
I Issoufou, L Belliraj, H Harmouchi, F Z Ammor, M Lakranbi, Y Ouadnouni, M Smahi
INTRODUCTION: Primary tumours of the trachea are very rare and may develop from the tracheal salivary glands. CASE REPORTS: We describe four patients operated on in our service between 2010 and 2017 of whom two had an adenocystic carcinoma, one a mucoepidermoid carcinoma and one a pleomorphic adenoma of the trachea. All were treated by resection and tracheal anastomosis with clear margins in three cases. The malignant cases received adjuvant treatment consisting of radiotherapy in one case and radiochemotherapy in the second...
January 25, 2019: Revue des Maladies Respiratoires
Eric C Mason, Samuel McGhee, Kai Zhao, Tendy Chiang, Laura Matrka
OBJECTIVES: Laryngotracheal stenosis and obstruction can be challenging to manage. Traditional assessment tools are limited in clinical correlation. Three-dimensional computational fluid dynamics (CFD) modeling is a novel technique used to analyze airflow dynamics. The objective of this study was to apply CFD to the human upper airway to explore its utility. METHODS: CFD models were constructed on an adult patient with an obstructive tracheal lesion before and after intervention and on an adult with normal airway anatomy, using computed tomographic imaging obtained retrospectively...
January 28, 2019: Annals of Otology, Rhinology, and Laryngology
N Ezemba, C P Echieh, E N Chime, C O Okorie, F G Okonna, F L Idoko, O A Arua
Postintubation tracheal stenosis (PITS) is a known complication of endotracheal intubation or tracheostomy. It is the most common indication for tracheal resection/reconstructive surgery. Despite technological improvement and skilled patient care in the ICU, PITS still constitutes an important group of iatrogenic sequela after intubation. With increasing number of patients requiring ICU admission and mechanical ventilation in Nigeria, it is important that this complication is prevented from occurring. The care of such patients often is technically challenging...
January 2019: Nigerian Journal of Clinical Practice
Si-Yeon Park, Hong Seok Choi, Ji-Young Yoon, Eun-Jung Kim, Ji-Uk Yoon, Hee Young Kim, Ji-Hye Ahn
Endotracheal intubation is commonly associated with laryngeal injury that often resolves spontaneously without any complication. However, stenosis or granulomatous lesions are generally found on the tracheal wall or vocal process at the tube cuff level, caused by excessive cuff pressure. We present a case of fatal vocal cord granuloma leading to dyspnea following orthognathic surgery and sustained intubation for 14 hours.
December 2018: Journal of Dental Anesthesia and Pain Medicine
J J Li, J Chu, M Hu
Objective: To discuss the surgical safeness of the cleft palate children with airway stenosis by means of analyzing characteristics of the shape of the upper airway and comparing clinical data of cleft palate children with airway stenosis and non-airway stenosis. Methods: Tracing back from Apirl 2015 to Apirl 2017, 126 cleft palate children treated in Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, were included (46 male and 80 female, age of 7 to 74 months, median age 18 months)...
January 9, 2019: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Tong Qiu, Yandong Zhao, Jianfang Song, Wenjie Jiao
Robotic surgery for circumferential tracheal resection and reconstruction has not previously been reported. Herein we describe the case of a 48-year-old man with primary extra-luminal tracheal leiomyosarcoma. A preoperative bronchoscopy exam and chest computed tomography revealed a tracheal neoplasm, which derived from lower membranous trachea and nearly obstructed the orifice of the left main bronchus. The patient underwent circumferential tracheal resection and reconstruction via a completely portal robotic approach with four arms...
December 29, 2018: Thoracic Cancer
Andrew J Redmann, Michael J Rutter, Alessandro deAlarcon, Catherine K Hart, Amy Manning, Matthew Smith, Sid M Khosla
OBJECTIVES: 1) Evaluate success rates for adults undergoing cervical slide tracheoplasty. 2) Examine complication rates of slide tracheoplasty in adults. METHODS: A retrospective cohort of adults > 21 years of age undergoing cervical slide tracheoplasty for tracheal stenosis between October 2011 and August 2017 was reviewed. Comorbidities, stenosis grade, etiology of stenosis, primary versus revision surgery, complications, and number of adjunct endoscopic procedures required postoperatively were evaluated...
December 28, 2018: Laryngoscope
Jae Yeon Lee, Soo Jin Son, Seok Hwa Choi, Dong-Woo Cho
BACKGROUND/AIM: Tracheal anastomosis is commonly indicated for patients with tracheal tumor, stenosis and tracheoesophageal fistula. This study was designed to evaluate the healing activity of topical application of platelet-rich plasma (PRP) jelly for tracheal reconstruction in a rabbit model. MATERIALS AND METHODS: Thirty-six healthy New Zealand White rabbits were assigned to three groups of 12 animals each. The control group underwent tracheal resection and anastomosis...
January 2019: In Vivo
Emre Türkmen, Yavuz Selim Pata
OBJECTIVES: In this study, pirfenidone's role about reducing tracheal stenosis by suppressing fibrosis and inflammation was examined. METHODS: Tracheotomy was performed on 14 rats, and their cannulas were fixed to tracheotomy area by stoma suture. Two working groups were established. Rats in the first group were given 15 mg/kg/day (1 mL pirfenidone solution) pirfenidone intraperitoneally for 10 days. In the second group as a control group, 1 mL saline solution was applied intraperitoneally...
December 25, 2018: Laryngoscope
Bangde Xue, Beibei Liang, Guangyin Yuan, Limin Zhu, Hao Wang, Zhaohui Lu, Zhiwei Xu
OBJECTIVE: To preliminarily investigate the feasibility of bioabsorption tracheal stenting for the therapeutic application of congenital tracheal stenosis (CTS). STUDY DESIGN: Experimental research. SETTING: Shanghai Children Medical Center, National Children's Medical Center. SUBJECTS AND METHODS: Five kinds of magnesium alloys with different compositions were studied in this paper, a patented Mg-Nd-Zn-Zr alloy series namely JDBM (JiaoDa BioMg) and four Mg-Ca-Zn alloys...
November 22, 2018: International Journal of Pediatric Otorhinolaryngology
Rachel Kaye, Todd Goldstein, Daniel A Grande, David Zeltsman, Lee P Smith
OBJECTIVES: Surgical reconstruction of tracheal disease has expanded to include bioengineering and three dimensional (3D) printing. This pilot study investigates the viability of introducing a living functional tracheal replacement graft in a rabbit animal model. METHODS: Seven New Zealand White rabbits were enrolled and six completed participation (one intraoperative mortality). Tracheal replacement grafts were created by impregnating 3D printed biodegradable polycaprolactone (PCL) tracheal scaffolds with rabbit tracheal hyaline chondrocytes...
November 10, 2018: International Journal of Pediatric Otorhinolaryngology
Kamran Asif Syed, P Naina, Apar Pokharel, Mary John, Ajoy Mathew Varghese
STUDY OBJECTIVES: To review the key parameters related to the proposed modified pediatric tracheostomy technique with to determine the efficacy, safety and outcomes in a tertiary hospital in south India. Patients and Methods A retrospective chart review of all children aged below 16 years who underwent tracheostomy at a tertiary hospital in south India during the period of August 2014 to August 2016. Data on age, gender, indication for tracheostomy, primary disease condition, duration of intubation, complications and decannulation rate were recorded...
March 2019: International Journal of Pediatric Otorhinolaryngology
Romaine F Johnson, Charles Saadeh
OBJECTIVES: Tracheal stenosis is a recognized complication of tracheostomy. Yet, the incidence and demographics of tracheal stenosis due to tracheostomies have infrequently been studied. METHODS: We performed a cross-sectional analysis of U.S. emergency department (ED) visits, hospital discharges, and readmissions using the 2013 National Emergency Department Sample, 2013 National Inpatient Sample, and 2013 Nationwide Readmission Database for patients with tracheal stenosis due to tracheostomies...
December 19, 2018: Laryngoscope
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