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Stephanie Valerie Weissleder, Maren Klemm
The simultaneous occurrence of sleeping disorders and glaucoma is caused by multiple factors and, until today, the underlying mechanisms are not completely understood. There seems to be correlations, either between sleeping disorders in patients with a diagnosed glaucoma and between the onset of a glaucoma in patients with certain sleeping habits, but no precise data has been collected so far.
February 2019: Klinische Monatsblätter Für Augenheilkunde
Ulrich J Sachs
Although the detection of a characteristic autoantibody can prove immune thrombocytopenia (ITP), this diagnosis is often based on the exclusion of other causes of thrombocytopenia. Direct glycoprotein (GP)-specific tests have the property required to demonstrate such a characteristic autoantibody. In contrast, platelet-associated immunoglobulin G or antibody detection in plasma or serum is an insufficient diagnostic test. Moreover, data for commercial capture assays are sparse and their use is currently not recommended...
February 14, 2019: Hämostaseologie
Florian Zweipfenning, Sandra P Toelle, Christina Gerth-Kahlert
BACKGROUND: Evaluation and comparison of the ocular phenotype in patients diagnosed with tuberous sclerosis complex (TSC). Analysis of ocular complications during follow-up. PATIENTS AND METHODS: A retrospective chart review was performed of patients with TSC who had received an ocular examination at the eye clinic of the University Hospital Zurich. Data were analysed on visual acuity (VA) assessment, refraction, anterior and posterior eye examination including the distinction of different types of hamartomas and, when available, visual fields...
February 14, 2019: Klinische Monatsblätter Für Augenheilkunde
Gang Seok Jeon, Jae Ryong Han
PURPOSE: To assess treatment efficacy of scleral buckling surgery with wide-field surgical microscope and 27-gauge (G) chandelier illumination for rhegmatogenous retinal detachment (RRD). METHODS: This study is a retrospective chart review of 29 eyes in 29 patients with RRD who underwent scleral buckling surgery with a wide-field surgical microscope and 27-G chandelier illumination fiber inserted into the sclera at the pars plana. Results are expressed as mean ± standard deviation...
February 14, 2019: Ophthalmologica. Journal International D'ophtalmologie
Tae-Hyung Kim, Soon Ho Yoon, Hyunsook Hong, Hye-Ryun Kang, Sang-Heon Cho, Suh-Young Lee
BACKGROUND: We conducted a meta-analysis to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction. METHODS: A systematic literature search identified studies on adult patients with anaphylaxis and a subsequent biphasic reaction due to various causes that contained sufficient data to extract outcomes. The outcomes were pooled using a random-effects model. RESULTS: Twelve studies with a total of 2,890 adult patients with anaphylaxis and 143 patients with a biphasic reaction were included...
February 14, 2019: International Archives of Allergy and Immunology
Clara Rodriguez-Sabate, Ingrid Morales, Jesus N Lorenzo, Manuel Rodriguez
The motor symptoms in Parkinson's disease (PD) have been linked to changes in the excitatory/inhibitory interactions of centers involved in the cortical-subcortical closed-loop circuits which connect basal ganglia (BG) and the brain cortex. This approach may explain some motor symptoms of PD but not others, which has driven the study of BG from new perspectives. Besides their cortical-subcortical linear circuits, BG have a number of subcortical circuits which directly or indirectly connect each BG with all the others...
February 3, 2019: NeuroImage: Clinical
Corinna Pietsch, Uwe G Liebert
BACKGROUND: Sapovirus is a common cause of self-limiting diarrhea. In immunocompromised individuals chronic infections occur, but are incompletely investigated. OBJECTIVES: To investigate viral evolution in immunocompromised hosts during chronic sapovirus infection. STUDY DESIGN: From January 2010 to September 2018 stool samples of 5333 in-patients were analyzed for the presence of sapovirus RNA by real-time RT-PCR. In follow-up samples of chronic diarrhea cases nucleic acid sequencing of sapovirus genomes was performed...
February 7, 2019: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Liwei Liao, Zhiguo Wu, David Mellor, Daihui Peng, Chen Zhang, Jingjing Xu, Chenglei Wang, Lvchun Cui, Yiru Fang
BACKGROUND: This study aimed to explore subtypes of treatment-resistant depression (TRD). METHODS: Latent class analysis (LCA) was performed on clinical and demographic data collected from 375 patients with TRD. Clinical variables were compared across subtypes. Treatment outcomes across subtypes of TRD were compared separately for those within each subtype with anxiety (those with a HRSD-17 anxiety/somatization factor score ≥ 7) and those without anxiety. LCA subtypes were compared using Cochran's and Mantel-Haenszel χ2 test, respectively...
February 6, 2019: Journal of Affective Disorders
I T Mendes, A L M Ruela, F C Carvalho, J T J Freitas, R Bonfilio, G R Pereira
Donepezil is one of the main compounds used in the therapy of Alzheimer's disease. Oral administration of this drug presents many drawbacks, resulting in treatment non-adherence among patients. Thus, the development of transdermal formulations for donepezil delivery is important. The aim of this study was to prepare and to evaluate nanostructured lipid carrier-based gels (NLC gel) able to improve the skin delivery of donepezil free base (DPB). The components of nanostructured lipid carriers (NLCs) were selected after evaluating their enhancing effects using in vitro DPB skin delivery assays...
February 6, 2019: Colloids and Surfaces. B, Biointerfaces
F Girinon, S Ketoff, Q Hennocq, N Kogane, N Ullman, N Kadlub, E Galliani, C Neiva-Vaz, M P Vazquez, A Picard, R H Khonsari
AIM AND SCOPE: Result assessment in cleft surgery is a technical challenge and requires the development of dedicated morphometric tools. Two cohorts of patients managed according to two different protocols were assessed at similar ages and their palatal shape was compared using geometric morphometrics. Material and Methods Ten patients (protocol №1) benefited from early lip closure (1-3 months) and secondary combined soft and hard palate closure (6-9 months); 11 patients (protocol №2) benefited from later combined lip and soft palate closure (6 months) followed by hard palate closure (18 months)...
February 11, 2019: Journal of Stomatology, Oral and Maxillofacial Surgery
Timothy A Dinh, Mark L Jewell, Matt Kanke, Adam Francisco, Ramja Sritharan, Rigney E Turnham, Seona Lee, Edward R Kastenhuber, Eliane Wauthier, Cynthia D Guy, Raymond S Yeung, Scott W Lowe, Lola M Reid, John D Scott, Anna M Diehl, Praveen Sethupathy
BACKGROUND & AIMS: Fibrolamellar carcinoma is a rare liver cancer that primarily affects adolescents and young adults. It is characterized by a heterozygous ∼400 kb deletion on chromosome 19 that results in a unique DNAJB1-PRKACA fusion. The role of microRNAs (miRNAs) in FLC remains unclear. We identified dysregulated miRNAs in FLC and investigated whether dysregulation of one key miRNA contributes to FLC pathogenesis. METHODS: We analyzed small RNA sequencing (smRNA-seq) data from The Cancer Genome Atlas (TCGA) to identified dysregulated miRNAs in primary FLC tumors and validated the findings in three independent FLC cohorts...
February 11, 2019: Cellular and Molecular Gastroenterology and Hepatology
Marta Olivé-Gadea, Manuel Requena, Elena Fonseca Hernández, Manuel Quintana, Estevo Santamarina, Laura Abraira Del Fresno, Jose Álvarez-Sabín, Xavier Salas-Puig, Manuel Toledo
Epileptic seizures are a common reason for emergency department (ED) admittance. We aimed to describe the etiological distribution of epileptic seizures and the relationships between etiology and semiology in patients admitted to the emergency room, and to identify early prognostic factors for recurrence and mortality. METHODS: A retrospective observational study was conducted in adult patients consecutively attended in the emergency room with epileptic seizures over a 2-year period. We recorded data on the etiological and syndromic classification of the seizure, and on recurrence and mortality at 1 year of follow-up...
February 11, 2019: Epilepsy & Behavior: E&B
Yong Ahn, Han Joong Keum, Sang-Gu Lee, Sheen-Woo Lee
OBJECTIVE: The clinical application of endoscopic technique for lumbar lateral recess stenosis (LRS) is still challenging. This study aimed to describe a transforaminal endoscopic decompression (TED) technique for LRS and to demonstrate its clinical results. METHODS: Two-year follow-up data were collected from 45 consecutive patients who underwent TED for LRS. Full-scale endoscopic decompression can be performed in the dorsal and ventral aspects of the lateral recess with combined partial pediculectomy using an articulating bone burr and endoscopic instruments...
February 11, 2019: World Neurosurgery
Francesco Doglietto, Francesco Belotti, Carlotta Ginevra Nucci, Elena Roca, Pier Paolo Mattogno, Francesca Zappa, Karol Migliorati, Pier Paolo Panciani, Giannantonio Spena, Claudio Cereda, Claudio Cornali, Marco Maria Fontanella
BACKGROUND: Three-dimensional (3D), high-definition (HD) endoscopy has been recently introduced in neurosurgery and its value extensively discussed in endonasal skull base surgery. There is no reported clinical series on the use of a recent 3D-HD ventriculoscope. OBJECTIVE: Aim of this study is to describe our initial experience with this novel device. METHODS: Patients consecutively operated on from June 2016 to June 2018 with a 3D-HD ventriculoscope were prospectively collected...
February 11, 2019: World Neurosurgery
Faliang Gao, Min Li, Zheng Wang, Lingfei Shi, Lin Lou, Jia Zhou
OBJECTIVE: To explore the efficacy and safety of Gamma Knife Radiosurgery (GKRS) for meningiomas in neurofibromatosis Type 2 (NF2) patients . METHODS: A series of 35 consecutive patients with 99 meningiomas in our department were retrospectively included from Jan 2000 to Dec 2015. Clinical records, MR image and follow-up data were reviewed. RESULTS: A total of 35 patients(25 females and 10 males) with 99 NF2-associated meningiomas were identified...
February 11, 2019: World Neurosurgery
Atul Goel, Ravikiran Vutha, Abhidha Shah, Pralhad Dharurkar, Neha Jadhav, Dikpal Jadhav
OBJECTIVE: Immediate postoperative and early clinical outcome of treatment of spinal kyphoscoliosis associated with Chiari formation and syringomyelia and treated by atlantoaxial fixation is described. MATERIAL AND METHODS: During the period April 2016 to March 2018, 11patients having spinal kyphosciolosis (SKS) as a major presenting symptom in association with Chiari formation and syringomyelia were surgically treated and are analysed retrospectively. There were 6 males and 5 females and their ages ranged from 11 to 17 years (average 14 years)...
February 11, 2019: World Neurosurgery
Zhengda Yu, Nan Zhang, N U Farrukh Hameed, Tianming Qiu, Dongxiao Zhuang, Junfeng Lu, Jinsong Wu
OBJECTIVE: To evaluate the risk factors of tumor related epilepsy (TRE) and the relationship between TRE and functional/survival outcomes in high-grade glioma (HGG) patients. METHOD: The clinical data of 587 patients with HGG were retrospectively analyzed. Chi-square test and logistic multiple regression analysis were used to analyze factors associated with TRE. Logistic and Cox regression were used to analyze factors that may influence functional and survival outcomes...
February 11, 2019: World Neurosurgery
Stuart B Mazzone, Michael J Farrell
Cough is an important protective mechanism for clearing the airways but becomes a troublesome, and often difficult to treat, symptom in respiratory disease. Although cough can be produced as a reflex in response to the presence of irritants within the airways, emerging research demonstrates an unappreciated complexity in the peripheral and central neural systems that regulate cough. This complexity includes multiple primary sensory neurons that can induce or facilitate reflex coughing, different ascending central circuits in the brain that contribute to cough sensory discrimination and the perception of the urge-to-cough, and several descending brain systems for inducing, facilitating and inhibiting cough responses...
February 11, 2019: Pulmonary Pharmacology & Therapeutics
E Gallitto, G L Faggioli, R Pini, C Mascoli, A Freyrie, V Vento, S Ancetti, A Stella, M Gargiulo
OBJECTIVE: To report perioperative and 1-year results of total endovascular repair of contained ruptured thoracoabdominal aortic aneurysms (TAAAs). METHODS: Between 2015 and 2017, pre-operative, procedural and post-operative data of patients with radiographic evidence of contained ruptured TAAAs treated by endovascular repair, were prospectively collected. Only patients with stable hemodynamic parameters were enclosed. Primary endpoints were: 30-day / in-hospital mortality, spinal cord ischemia (SCI), post-operative cardio-pulmonary complications and new onset of hemodialysis...
February 11, 2019: Annals of Vascular Surgery
Pauline Marteau, Divi Cornec, Maelenn Gouillou, Sandrine Jousse-Joulin, Dewi Guellec, Sebastian Costa, Thierry Marhadour, Guillermo Carvajal Alegria, Sophie Varache, Yves Gauvin, Sylvie Boisramé, Laetitia Le Pottier, Yves Renaudineau, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec
OBJECTIVE: Parotidomegaly is a criterion of the EULAR Primary Sjögren Syndrome Disease Activity Index (ESSDAI). The cut-off value was set at 3 cm in length for the parotid gland, 2 cm for the submandibular glands. However, clinical appreciation of salivary glands size remains hazardous. The objective is to evaluate inter-observer reproducibility of parotid gland measurement by palpation, and to secondary evaluate its reliability compared to US assessment. METHODS: Outpatients with primary Sjögren Syndrome (pSS) or with a diagnostic suspicion, in a single reference centre, were included...
February 11, 2019: Joint, Bone, Spine: Revue du Rhumatisme
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