Josephine K Dermawan, Dianne Torrence, Cheng-Han Lee, Liliana Villafania, Kerry A Mullaney, Sara DiNapoli, Purvil Sukhadia, Ryma Benayed, Laetitia Borsu, Narasimhan P Agaram, Garrett M Nash, Brendan C Dickson, Jamal Benhamida, Cristina R Antonescu
Mesothelioma is a rare, aggressive malignant neoplasm of mesothelial origin. A small subset of peritoneal mesothelioma is driven by recurrent gene fusions, mostly EWSR1/FUS::ATF1 fusions, with predilection for young adults. To date, only two cases of mesothelioma harboring EWSR1::YY1 fusions have been described. We present three additional cases of EWSR1::YY1-fused peritoneal mesotheliomas, two localized and one diffuse, all occurring in the peritoneum of middle-aged adults (2 females and 1 male), and discovered incidentally by imaging or during surgery performed for unrelated reasons...
October 2022: Genes, Chromosomes & Cancer