keyword
https://read.qxmd.com/read/38453893/rapid-point-of-care-test-for-diagnosis-of-peritonitis-in-peritoneal-dialysis-patients
#1
JOURNAL ARTICLE
Htay Htay, Jason Chon Jun Choo, Dorothy Hannah Huang, Mathini Jayaballa, David W Johnson, Riece Koniman, Elizabeth Ley Oei, Tan Chieh Suai, Sin Yan Wu, Marjorie Wai Yin Foo
BACKGROUND: Periplex® is a rapid point-of-care test based on the detection of interleukin-6 (IL-6) or matrix metalloproteinase-8 (MMP-8) to diagnose peritonitis in peritoneal dialysis (PD) patients. METHODS: This single-centre study was conducted in Singapore General Hospital from 2019 to 2022. The study recruited PD patients suspected of having peritonitis. Periplex was performed at the presentation and recovery of peritonitis. Primary outcomes were sensitivity and specificity of Periplex at presentation...
March 7, 2024: Peritoneal Dialysis International
https://read.qxmd.com/read/38392887/first-case-of-human-anisakiosis-in-greece-acute-invasive-infection-mimicking-peritoneal-malignancy
#2
Sotirios Dinas, Anastasia Diakou, Konstantinos Vasiliadis, Serafeim C Chaintoutis, Eleftheria Massa, George N Konstantinou, Albion Totsi, Athanasios Xakis, Christos Papavasiliou
Consumption of raw and mildly processed seafood, in the context of modern Western world eating trends, is recognized as a major driver for human fish-borne infections. However, these zoonoses and their unfamiliar risks remain neglected and underappreciated among European diagnosticians. In contemporary Europe anisakidosis is one of the most important fish-borne zoonoses. It is caused by ingesting the third-stage infective larvae of the nematode parasites that belong to the family Anisakidae. The case described herein, is an intestinal and ectopic form of anisakiosis ( Anisakis spp...
February 6, 2024: Pathogens
https://read.qxmd.com/read/38255222/successful-introduction-of-benralizumab-for-eosinophilic-ascites
#3
Nabil Belfeki, Nouha Ghriss, Souheil Zayet, Faten El Hedhili, Cyrus Moini, Guillaume Lefevre
Eosinophilic ascites is a rare disorder, reported in both adult and pediatric patients, characterized by high eosinophil counts in the peritoneal fluid. Eosinophilic ascites appears as a manifestation of various diseases such as parasitic and fungal infections, malignancy, and hypereosinophilic syndrome. It also represents an uncommon manifestation of eosinophilic gastroenteritis, usually treated with corticosteroids. We present the case of a 16-year-old woman with abdominal distention related to abundant ascites...
January 6, 2024: Biomedicines
https://read.qxmd.com/read/38240415/enterocolic-granulomatous-phlebitis-associated-with-epidermal-growth-factor-containing-fibulin-like-extracellular-matrix-protein-1-deposition-and-focal-amyloid-properties-a-case-report
#4
Shojiro Ichimata, Akane Aikawa, Naonori Sugishita, Nagaaki Katoh, Fuyuki Kametani, Hibiki Tagawa, Yusuke Handa, Masahide Yazaki, Yoshiki Sekijima, Takashi Ehara, Naoki Nishida, Shin Ishizawa
A woman in her 60s with rheumatoid arthritis was admitted with fever and abdominal pain. Laparoscopic examination with the differential diagnosis of peritoneal neoplasm and infection revealed granulomatous phlebitis in the resected greater omentum. Amorphous eosinophilic deposits observed in the resected tissue exhibited focal, weak positivity for Congo red but were strongly positive for thioflavin S, confirming their focal amyloid properties. Marked degeneration of elastic fibers was also evident. Electron microscopy revealed deposits around the affected elastic fibers...
January 19, 2024: Pathology International
https://read.qxmd.com/read/38182939/a-case-of-non-esophageal-eosinophilic-gastrointestinal-disease-diagnosed-by-mucosal-incision-assisted-biopsy
#5
JOURNAL ARTICLE
Ryo Watanabe, Tomoyuki Yada, Ai Yoshida, Keita Odaka, Toyokazu Yagi, Yurika Ikegami, Katsunori Sekine, Takashi Oide, Naomi Uemura
A 46-year-old woman presented at our hospital with anorexia, vomiting, and diarrhea. Blood tests indicated markedly increased eosinophil counts, and esophagogastroduodenoscopy revealed slight erythema in the gastric body. Computed tomography showed edematous thickening of the stomach and small intestinal walls and peritonitis. Thus, eosinophilic gastrointestinal disease was suspected. Endoscopic biopsies from the esophagus, stomach, and duodenum were collected, but no significant increases in eosinophil counts were observed...
January 6, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38174942/characterization-of-the-immunosuppressive-environment-induced-by-larval-echinococcus-granulosus-during-chronic-experimental-infection
#6
JOURNAL ARTICLE
Leticia Grezzi, Yamila E Martínez, Anabella A Barrios, Álvaro Díaz, Cecilia Casaravilla
The larval stage of Echinococcus granulosus causes the chronic infection known as cystic echinococcosis, deploying strong inhibitory mechanisms on host immune responses. Using experimental intraperitoneal infection in C57BL/6 mice, we carried out an in-depth analysis of the local changes in macrophage populations associated with chronic infection. In addition, we analyzed T cells and relevant soluble mediators. Infected animals showed an increase in local cell numbers, mostly accounted for by eosinophils, T cells, and macrophages...
January 4, 2024: Infection and Immunity
https://read.qxmd.com/read/38144619/eosinophilic-gastroenteritis-as-an-uncommon-cause-of-ascites-recurrence-in-a-young-female
#7
Rajat Shukla, Rachana Warrier, Neeraj Sharma, Kunal Kumar, Sumeet Arora, Nalin Singh
Ascites appear as a clinical manifestation of various disorders, and the presence of raised levels of eosinophils in the peritoneal fluid characterizes eosinophilic ascites, which is an extremely rare disorder. Eosinophilic gastroenteritis is one of the uncommon causes of ascites. If not investigated thoroughly, ascites recurrence in a young female with a history of tuberculosis may be wrongly attributed to tuberculosis recurrence in an endemic country. The etiology of ascites in our case was correctly identified as the subserosal form of eosinophilic ascites...
December 2023: Medical Journal, Armed Forces India
https://read.qxmd.com/read/38016013/immunosuppressive-ability-of-trichinella-spiralis-adults-can-ameliorate-type-2-inflammation-in-a-murine-allergy-model
#8
JOURNAL ARTICLE
Wenjie Shi, Qinwei Xu, Yan Liu, Zhili Hao, Yue Liang, Isabelle Vallée, Xihuo You, Mingyuan Liu, Xiaolei Liu, Ning Xu
BACKGROUND: There is an increase in the global incidence of allergies. The hygiene hypothesis and the old friend hypothesis reveal that helminths are associated with the prevalence of allergic diseases. The therapeutic potential of Trichinella spiralis (T. spiralis) is recognized; however, the stage at which it exerts its immunomodulatory effect is unclear. METHODS: We evaluated the differentiation of bone marrow-derived macrophages stimulated with T. spiralis excretory-secretory products...
November 28, 2023: Journal of Infectious Diseases
https://read.qxmd.com/read/38003303/novel-peritoneal-sclerosis-rat-model-developed-by-administration-of-bleomycin-and-lansoprazole
#9
JOURNAL ARTICLE
Kosei Kunitatsu, Yuta Yamamoto, Shota Nasu, Akira Taniji, Shuji Kawashima, Naoko Yamagishi, Takao Ito, Shigeaki Inoue, Yoshimitsu Kanai
In our preliminary experiment, peritoneal sclerosis likely induced by peritoneal dialysis was unexpectedly observed in the livers of rats given bleomycin and lansoprazole. We examined whether this peritoneal thickening around the liver was time-dependently induced by administration of both drugs. Male Wistar rats were injected with bleomycin and/or lansoprazole for 2 or 4 weeks. The 3YB-1 cell line derived from rat fibroblasts was treated by bleomycin and/or lansoprazole for 24 h. The administration of both drugs together, but not individually, thickened the peritoneal tissue around the liver...
November 9, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37726067/alk-rearranged-epithelioid-mesenchymal-neoplasm-expanding-the-spectrum-of-tyrosine-kinase-altered-mesenchymal-tumors
#10
JOURNAL ARTICLE
Catherine K Gestrich, Jessica L Davis, Laura Biederman, Ivy John, Rita Alaggio, Isabella Giovannoni, Michael A Arnold, Archana Shenoy, Amanda Tchakarov, Alyaa Al-Ibraheemi
The anaplastic lymphoma kinase (ALK) gene encodes a receptor tyrosine kinase, and fusions involving this gene have been reported in a variety of mesenchymal neoplasms. ALK-altered tumors with epithelioid morphology have been described in epithelioid inflammatory myofibroblastic sarcoma and epithelioid fibrous histiocytoma. Herein, we describe the clinicopathologic features of 7 ALK-rearranged mesenchymal tumors with epithelioid morphology occurring predominately in the pediatric population. Tumors occurred in 4 females and 3 males with an age ranging from 1 month to 28 years...
September 17, 2023: Modern Pathology
https://read.qxmd.com/read/37720666/a-pancreatic-adenocarcinoma-mimicking-hepatoid-carcinoma-of-uncertain-histogenesis-a-case-report-and-literature-review
#11
Andreea Iliesiu, Radu-Valeriu Toma, Ana Maria Ciongariu, Radu Costea, Narcis Zarnescu, Liviu Bîlteanu
In rare cases, metastatic adenocarcinomas of different origin may exhibit the features of hepatoid carcinoma (HC), a rare malignant epithelial tumor, most commonly occurring in the ovaries and stomach, as well as in the pancreas and biliary ducts. A case of a 72-year-old female patient who developed a highly aggressive, poorly differentiated pancreatic ductal adenocarcinoma with peritoneal carcinomatosis, demonstrating hepatoid differentiation upon conventional hematoxylin and eosin staining is reported in the present study...
October 2023: Oncology Letters
https://read.qxmd.com/read/37591111/lymphocyte-immunophenotyping-and-concentration-of-mmp-9-in-transudates-and-exudates-in-horses
#12
JOURNAL ARTICLE
Pavla Hamouzová, Olga Dobešová, Kristína Řeháková, Šárka Stehlíková, Petr Čížek, Zuzana Drábková, Petr Jahn, Jaroslav Doubek
This study is the first to provide information on the lymphocyte subpopulations in peritoneal effusions in horses. Peritoneal transudates (n = 12), peritoneal exudates (n = 6) and a pleural exudate (n = 1) were analyzed. The total nucleated cell count (TNCC), total protein (TP) and matrix metalloproteinase-9 (MMP-9) concentration determined by ELISA were measured and routine cytological evaluation was performed. CD3, CD4, CD8 and CD21 positive cells were detected by flow cytometry...
August 12, 2023: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/37583293/2b4-a-potential-target-in-staphylococcus-aureus-associated-allergic-inflammation
#13
JOURNAL ARTICLE
Pratibha Gaur, Mansour Seaf, Nirit Trabelsi, Orly Marcu, Daria Gafarov, Ora Schueler-Furman, Ofer Mandelboim, Micha Ben-Zimra, Francesca Levi-Schaffer
Staphylococcus aureus (SA) and its exotoxins activate eosinophils (Eos) and mast cells (MCs) via CD48, a GPI-anchored receptor belonging to the Signaling Lymphocytes Activation Molecules (SLAM) family. 2B4 (CD244), an immuno-regulatory transmembrane receptor also belonging to the SLAM family, is the high affinity ligand for CD48. 2B4 is expressed on several leukocytes including NK cells, T cells, basophils, monocytes, dendritic cells (DCs) and Eos. In the Eos and MCs crosstalk carried out by physical and soluble interactions (named the 'Allergic Effector Unit', AEU), 2B4-CD48 binding plays a central role...
August 16, 2023: Clinical and Experimental Immunology
https://read.qxmd.com/read/37240441/eosinophil-granule-proteins-involvement-in-acute-appendicitis-an-allergic-disease
#14
JOURNAL ARTICLE
Nuno Carvalho, Elisabete Carolino, Hélder Coelho, Ana Lúcia Barreira, Luísa Moreira, Margarida André, Susana Henriques, Carlos Cardoso, Luis Moita, Paulo Matos Costa
Several pieces of evidence point to an allergic component as a trigger of acute appendicitis. As the Th2 immune response is characterized by eosinophil mobilization to the target organ and release of their cationic granule proteins, it is reasonable to investigate if the degranulation of eosinophils could be associated with the local injury. The primary aim of this study is to evaluate the participation of eosinophils granules proteins in acute appendicitis, both at local and systemic levels and the secondary aim is to evaluate the diagnostic accuracy of eosinophils granules proteins for the detection of acute appendicitis, as well as for distinguishing between complicated and uncomplicated acute appendicitis...
May 22, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37133201/pancreatic-acinar-cell-carcinoma-with-pleomorphic-and-spindle-cells-an-autopsy-proven-case
#15
Hironori Uruga, Tetsuo Tamura, Yasuro Miura, Jumpei Itonaga, Rikako Koyama, Tsunao Imamura, Yutaka Takazawa
Pancreatic acinar cell carcinomas are glandular and have amphophilic/eosinophilic cytoplasm, presenting acinar, solid, and trabecular structures. Unusual histological features of acinar cell carcinoma are known, such as oncocytic, pleomorphic, spindle, and clear cell variants, but their clinical significance has not been well described. A man in his 70s was referred to our hospital because of elevated serum pancreatic enzymes. Contrast-enhanced abdominal computed tomography revealed slight swelling of the pancreatic head and suspension of the main pancreatic duct in the pancreatic body...
May 3, 2023: Pathology International
https://read.qxmd.com/read/37111413/hgprt-and-pnp-recombinant-enzymes-from-schistosoma-mansoni-and-their-role-in-immunotherapy-during-experimental-murine-schistosomiasis
#16
JOURNAL ARTICLE
Bruna Dias de Lima Fragelli, Ana Carolina Maragno Fattori, Elisandra de Almeida Montija, Joice Margareth de Almeida Rodolpho, Cynthia Aparecida de Castro, Krissia Franco de Godoy, Camila Tita Nogueira, Vanderlei Rodrigues, Edson Garcia Soares, Larissa Romanello, Juliana R Torini, Humberto D'Muniz Pereira, Fernanda de Freitas Anibal
Schistosomiasis is a parasitic infection caused by trematode worms (also called blood flukes) of the genus Schistosoma sp., which affects over 230 million people worldwide, causing 200,000 deaths annually. There is no vaccine or new drugs available, which represents a worrying aspect, since there is loss of sensitivity of the parasite to the medication recommended by the World Health Organization, Praziquantel. The present study evaluated the effects of the recombinant enzymes of S. mansoni Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT), Purine Nucleoside Phosphorylase (PNP) and the MIX of both enzymes in the immunotherapy of schistosomiasis in murine model...
March 29, 2023: Pathogens
https://read.qxmd.com/read/36871665/mollugin-ameliorates-murine-allergic-airway-inflammation-by-inhibiting-th2-response-and-m2-macrophage-activation
#17
JOURNAL ARTICLE
Xiuru Li, Ruitao Hou, Hao Ding, Xiang Gao, Zichen Wei, Ting Qi, Lei Fang
Mollugin, isolated from Rubia cordifoliaL, is a pharmacological compound with anti-inflammatory activity. This study aimed to investigate whether mollugin protects mice against shrimp tropomyosin (ST)-induced allergic airway inflammation. Mice were sensitized with ST combined with Al(OH)3 administered intraperitoneally (i.p.) once weekly for 3 wk followed by ST challenge for 5 d. Mice were i.p.-administered daily with mollugin for 7 d. Results showed that mollugin attenuated ST-induced infiltration of eosinophils and epithelial mucus secretion in the lung tissues and suppressed lung eosinophil peroxidase activity...
March 3, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/36773709/mast-cells-contribute-to-the-resolution-of-allergic-inflammation-by-releasing-resolvin-d1
#18
JOURNAL ARTICLE
Pier Giorgio Puzzovio, Hadas Pahima, Tresa George, David Mankuta, Ron Eliashar, Ekaterini Tiligada, Bruce D Levy, Francesca Levi-Schaffer
BACKGROUND: Mast cells are initiators and main effectors of allergic inflammation, together with eosinophils, with whom they can interact in a physical and soluble cross-talk with marked pro-inflammatory features, the Allergic Effector Unit. The pro-resolution role of mast cells, alone or in co-culture with eosinophils, has not been characterized yet. OBJECTIVES: We aimed to investigate select pro-resolution pathways in mast cells in vitro and in vivo in allergic inflammation...
February 9, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/36731091/cystic-walthard-nests-of-the-peritoneal-diaphragm-a-report-of-3-cases-of-a-common-process-at-an-unusual-site-and-occurring-in-patients-with-endometriosis
#19
JOURNAL ARTICLE
Kyle M Devins, Nafisa Wilkinson, Peter Barton-Smith, Long Jaio, Robert H Young
Nests of cells resembling urothelium, eponymously named "Walthard nests," are well-known incidental findings over the fallopian tube and occasionally undergo cystification resulting in clinical detection and surgical removal. Only rarely is this process noted outside the pelvic peritoneum. Herein we describe cystic Walthard nests occurring in the diaphragmatic peritoneum of three patients (aged 25, 36, and 39 yr) undergoing surgical evaluation for presumed endometriosis. In each case, small pearly white nodules on the diaphragmatic peritoneum were noted and biopsied...
March 1, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/36678417/effects-of-immunization-with-recombinant-schistosoma-mansoni-enzymes-ak-and-hgprt-murine-infection-control
#20
JOURNAL ARTICLE
Ana Carolina Maragno Fattori, Elisandra de A Montija, Bruna D de L Fragelli, Ricardo de O Correia, Cynthia Aparecida de Castro, Larissa Romanello, Camila T Nogueira, Silmara M Allegretti, Edson G Soares, Humberto D Pereira, Fernanda de F Anibal
Schistosomiasis is one of the most important human helminthiases worldwide. Praziquantel is the current treatment, and no vaccine is available until the present. Thus, the presented study aimed to evaluate the immunization effects with recombinant Schistosoma mansoni enzymes: Adenosine Kinase (AK) and Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT), as well as a MIX of the two enzymes. Female Balb/c mice were immunized in three doses, and 15 days after the last immunization, animals were infected with S...
January 1, 2023: Pathogens
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