Bruna Dias de Lima Fragelli, Ana Carolina Maragno Fattori, Elisandra de Almeida Montija, Joice Margareth de Almeida Rodolpho, Cynthia Aparecida de Castro, Krissia Franco de Godoy, Camila Tita Nogueira, Vanderlei Rodrigues, Edson Garcia Soares, Larissa Romanello, Juliana R Torini, Humberto D'Muniz Pereira, Fernanda de Freitas Anibal
Schistosomiasis is a parasitic infection caused by trematode worms (also called blood flukes) of the genus Schistosoma sp., which affects over 230 million people worldwide, causing 200,000 deaths annually. There is no vaccine or new drugs available, which represents a worrying aspect, since there is loss of sensitivity of the parasite to the medication recommended by the World Health Organization, Praziquantel. The present study evaluated the effects of the recombinant enzymes of S. mansoni Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT), Purine Nucleoside Phosphorylase (PNP) and the MIX of both enzymes in the immunotherapy of schistosomiasis in murine model...
March 29, 2023: Pathogens