keyword
https://read.qxmd.com/read/38537225/a-randomized-noninferiority-trial-to-compare-enteral-to-parenteral-phosphate-replacement-on-biochemistry-waste-and-environmental-impact-and-healthcare-cost-in-critically-ill-patients-with-mild-to-moderate-hypophosphatemia
#1
JOURNAL ARTICLE
Chinh D Nguyen, Haustine P Panganiban, Timothy Fazio, Amalia Karahalios, Melissa Akravs, Christopher M MacIsaac, Thomas Rechnitzer, Lucy Arno, An Tran-Duy, Scott McAlister, Yasmine Ali Abdelhamid, Adam M Deane
OBJECTIVES: Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste. DESIGN: Prospective, randomized, parallel group, noninferiority clinical trial. SETTING: Single center, 42-bed state trauma, medical and surgical ICUs, from April 20, 2022, to July 1, 2022. PATIENTS: Patients with serum phosphate concentration between 0.3 and 0.75 mmol/L. INTERVENTIONS: We randomized patients to either enteral or IV phosphate replacement using electronic medical record-embedded program...
March 25, 2024: Critical Care Medicine
https://read.qxmd.com/read/38537201/prospective-evaluation-of-serum-free-thiols-in-inflammatory-bowel-disease-a-candidate-to-replace-c-reactive-protein-for-disease-activity-assessment
#2
JOURNAL ARTICLE
Anuj Bohra, Nicholas Batt, Krishneel Dutt, Pavel Sluka, Olga Niewiadomski, Abhinav Vasudevan, Daniel R Van Langenberg
BACKGROUND: Serum free thiols (SFTs) reflecting oxidative stress appear to correlate with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of SFTs concentrations vs endoscopic and histological activity, compare SFTs with established biomarkers, and identify clinical and laboratory parameters independently associated with SFT levels in IBD patients. METHODS: Patients with confirmed IBD undergoing routine ileocolonoscopy for activity assessment were prospectively recruited, with serum samples obtained concurrently for SFTs and routine bloods, plus fecal calprotectin and immunochemical tests were collected ±30 days from ileocolonoscopy...
March 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38537174/preparation-of-antibacterial-biobased-fibers-by-triaxial-microfluidic-spinning-technology-using-ionic-liquids-as-the-solvents
#3
JOURNAL ARTICLE
Zhimin Zhao, Junlei Wang, Hanmeng Yuan, Jie Xu, Hongshuai Gao, Yi Nie
Bacterial infections have become a serious threat to public health. The utilization of antibacterial textiles offers an effective way to combat bacterial infections at the source, instead of relying solely on antibiotic consumption. Herein, efficient and durable antibacterial fibers based on quercetin and cellulose were prepared by a triaxial microfluidic spinning technology using ionic liquids (ILs) as the solvents. It was indicated that the structure and properties of the antibacterial fibers were affected by the type of IL and the flow rates during the triaxial microfluidic spinning process...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38537137/development-of-a-long-amplicon-pma-qpcr-assay-for-detection-of-viable-xanthomonas-arboricola-pv-pruni-cells-in-peach-trees
#4
JOURNAL ARTICLE
Milan Panth, Enoch Noh, Guido Schnabel, Hehe Wang
Bacterial spot is one of the most serious diseases of peach caused by the pathogen Xanthomonas arboricola pv. pruni (XAP), leading to early defoliation and unmarketable fruit. The pathogen can overwinter in peach twigs and form spring cankers, which are considered the primary inoculum source for early season leaf and fruitlet infection. The amount of overwintering bacterial inoculum plays a critical role for the bacterial spot development, but no reliable quantification method is available. Thus, we developed a long-amplicon propidium monoazide (PMA)-qPCR assay for specific detection of viable XAP cells...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537125/efficacy-of-a-novel-antibiotic-drug-combination-toward-multidrug-resistant-ocular-pathogens
#5
JOURNAL ARTICLE
Lakshminarayanan Gowtham, Rachel A F Wozniak, Paul M Dunman, Esther Sheba, Prashant Garg, Joveeta Joseph
PURPOSE: Antimicrobial resistance is a global health threat, compounded by the reduction in the discovery of new antibiotics. A repurposed drugs-based approach could provide a viable alternative for the treatment of multidrug-resistant (MDR) bacterial infections. In this study, we sought to evaluate the in vitro efficacy of a novel drug combination, polymyxin B/trimethoprim (PT) + rifampin on MDR isolates from patients with bacterial keratitis in India. METHODS: Forty-three isolates, which included 20 Staphylococcus aureus, 19 Pseudomonas aeruginosa, 3 Pseudomonas stutzeri, and 1 Acinetobacter baumannii, were evaluated for their antibiotic resistance by minimum inhibitory concentration (MIC)...
March 26, 2024: Cornea
https://read.qxmd.com/read/38537121/influence-of-low-level-tannin-supplementation-on-comparative-growth-performance-of-holstein-and-angus-x-holstein-cross-calf-fed-concentrate-based-finishing-diets-for-328-days
#6
JOURNAL ARTICLE
Pedro H V Carvalho, Brooke C Latack, Marcos V C Ferraz, Lester J R P Nolasco, Willi R Meireles, Heitor O M Oliveira, Richard A Zinn
The objective of the current study was to evaluate the effects of tannin and monensin supplementation in feedlot diets and breed (Holstein vs. Angus × Holstein) on growth performance, energetic efficiency, and carcass characteristics. Eighty purebred Holstein calves (HOL; initial body weight (BW) = 130 ± 5 kg) and eighty Angus × Holstein calves (AXH; initial BW = 129 ± 6 kg) were blocked by initial BW and randomly assigned to 40 pens. Dietary treatments consisted of a steam-flaked corn-based diet supplemented with 1) no feed additive (CON); 2) 30 mg of monensin/ kg of dry matter (DM) (MON; Rumensin 90, Elanco, Greenfield, IN); 3) 1...
March 27, 2024: Journal of Animal Science
https://read.qxmd.com/read/38537053/characterizing-the-opioidergic-mechanisms-of-repetitive-transcranial-magnetic-stimulation-induced-analgesia-a-randomized-controlled-trial
#7
JOURNAL ARTICLE
Ying Liu, Junfeng Sun, Chaomin Wu, Jinxuan Ren, Yanni He, Na Sun, Hao Huang, QunShan Chen, Dan Liu, Yangyuxin Huang, Feng Xu, Lina Yu, Bernadette M Fitzgibbon, Robin F H Cash, Paul B Fitzgerald, Min Yan, Xianwei Che
Repetitive transcranial magnetic stimulation (rTMS) is a promising technology to reduce chronic pain. Investigating the mechanisms of rTMS analgesia holds the potential to improve treatment efficacy. Using a double-blind and placebo-controlled design at both stimulation and pharmacologic ends, this study investigated the opioidergic mechanisms of rTMS analgesia by abolishing and recovering analgesia in 2 separate stages across brain regions and TMS doses. A group of 45 healthy participants were equally randomized to the primary motor cortex (M1), the dorsolateral prefrontal cortex (DLPFC), and the Sham group...
March 26, 2024: Pain
https://read.qxmd.com/read/38537030/longitudinal-bond-strength-of-a-universal-adhesive-and-chemical-dentin-characterization-under-different-acid-etching-protocols
#8
JOURNAL ARTICLE
Lucélia Lemes Gonçalves, Anuradha Prakki, Tânia Mara da Silva, Arwa Bafail, Janaína Bortolatto, Alexander Terry Stavroullakis, Sérgio Eduardo de Paiva Gonçalves
OBJECTIVE: This study aimed to analyze the longitudinal bond strength of a universal adhesive and chemically characterize the dentin substrate under different acid etching protocols. METHODOLOGY: Dentin samples were etched with polyacrylic acid 25% (PAA) for 10 seconds (n=3) and phosphoric acid 32% (PA) for 15 seconds (n=3) and analyzed by Fourier transform infrared spectroscopy - attenuated total reflectance (FTIR-ATR) before and after treatment. For collagen degradation, samples (n=12) were divided into 3 groups: PAA, PA, and Deionized water (control), and analyzed by the quantity of solubilized type I collagen C-terminal cross-linked telopeptides and solubilized C-terminal peptide in relation to total protein concentration (ICTPtp and CTXtp) and by their ultimate tensile strength (UTS)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536995/in-office-dental-bleaching-in-adolescents-using-6-hydrogen-peroxide-with-and-without-gingival-barrier-a-randomized-double-blind-clinical-trial
#9
JOURNAL ARTICLE
Taynara de Souza Carneiro, Michael Willian Favoreto, João Pedro Ferreira Rodrigues, Elisama Sutil, Gabrielle Gomes Centenaro, Isabela de Matos de Freitas, Alessandra Reis, Laura Ceballos García, Alessandro Dourado Loguercio
BACKGROUND: At low concentrations used for in-office bleaching gels, such as 6% HP, gingival barrier continues to be performed. If we take into account that, in the at-home bleaching technique, no barrier is indicated, it seems that the use of a gingival barrier fails to make much sense when bleaching gel in low concentration is used for in-office bleaching. OBJECTIVE: This double-blind, split-mouth, randomized clinical trial evaluated the gingival irritation (GI) of in-office bleaching using 6% hydrogen peroxide (HP) with and without a gingival barrier in adolescents, as well as color change and the impact of oral condition on quality of life...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536992/ozone-therapy-improves-early-stages-of-osseointegration-in-ovariectomized-rats
#10
JOURNAL ARTICLE
William Phillip Pereira da Silva, João Matheus Fonseca E Santos, Mônica Caroline de Souza, Stéfany Barbosa, Anderson Maikon de Souza Santos, Edilson Ervolino, Ana Paula Farnezi Bassi, Cortino Sukotjo, Leonardo P Faverani
OBJECTIVE: the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats. METHODOLOGY: ovariectomy was performed on 30 Wistar rats, aged six months (Rattus novergicus), and, after 90 days, osseointegrated implants were installed in each tibial metaphysis. The study groups were divided into the animals that received intraperitoneal ozone at a concentration of 700 mcg/kg - OZ Group (n=15) - and a control group that received an intraperitoneal saline solution and, for this reason, was named the SAL group (n=15)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536968/manganese-nanoparticles-synthesis-mechanisms-of-influence-on-plant-resistance-to-stress-and-prospects-for-application-in-agricultural-chemistry
#11
REVIEW
Alla I Perfileva, Konstantin V Krutovsky
Manganese (Mn) is an important microelement for the mineral nutrition of plants, but it is not effectively absorbed from the soil and mineral salts added thereto and can also be toxic in high concentrations. Mn nanoparticles (NPs) are less toxic, more effective, and economical than Mn salts due to their nanosize. This article critically reviews the current publications on Mn NPs, focusing on their effects on plant health, growth, and stress tolerance, and explaining possible mechanisms of their effects. This review also provides basic information and examples of chemical, physical, and ecological ("green") methods for the synthesis of Mn NPs...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38536960/unveiling-the-molecular-characteristics-origins-and-formation-mechanism-of-reduced-nitrogen-organic-compounds-in-the-urban-atmosphere-of-shanghai-using-a-versatile-aerosol-concentration-enrichment-system
#12
JOURNAL ARTICLE
Munila Abudumutailifu, Xiaona Shang, Lina Wang, Miaomiao Zhang, Huihui Kang, Yunqian Chen, Ling Li, Ruiting Ju, Bo Li, Huiling Ouyang, Xu Tang, Chunlin Li, Lin Wang, Xinke Wang, Christian George, Yinon Rudich, Renhe Zhang, Jianmin Chen
Reduced nitrogen-containing organic compounds (NOCs) in aerosols play a crucial role in altering their light-absorption properties, thereby impacting regional haze and climate. Due to the low concentration levels of individual NOCs in the air, the utilization of accurate detection and quantification technologies becomes essential. For the first time, this study investigated the diurnal variation, chemical characteristics, and potential formation pathways of NOCs in urban ambient aerosols in Shanghai using a versatile aerosol concentration enrichment system (VACES) coupled with HPLC-Q-TOF-MS...
March 27, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38536935/the-gut-microbiota-posttranslationally-modifies-iga1-in-autoimmune-glomerulonephritis
#13
JOURNAL ARTICLE
Patrick J Gleeson, Nicolas Benech, Jonathan Chemouny, Eleftheria Metallinou, Laureline Berthelot, Jennifer da Silva, Julie Bex-Coudrat, Erwan Boedec, Fanny Canesi, Carine Bounaix, Willy Morelle, Maryse Moya-Nilges, John Kenny, Liam O'Mahony, Loredana Saveanu, Bertrand Arnulf, Aurélie Sannier, Eric Daugas, François Vrtovsnik, Patricia Lepage, Harry Sokol, Renato C Monteiro
Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where deglycosylated IgA1 (IgA subclass 1) auto-antigens are recognized by IgG auto-antibodies, forming immune complexes that are deposited in the kidneys, leading to glomerulonephritis. In the intestinal microbiota of patients with IgA nephropathy, there was increased relative abundance of mucin-degrading bacteria, including Akkermansia muciniphila ...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536930/a-case-for-a-binary-black-hole-system-revealed-via-quasi-periodic-outflows
#14
JOURNAL ARTICLE
Dheeraj R Pasham, Francesco Tombesi, Petra Suková, Michal Zajaček, Suvendu Rakshit, Eric Coughlin, Peter Kosec, Vladimír Karas, Megan Masterson, Andrew Mummery, Thomas W-S Holoien, Muryel Guolo, Jason Hinkle, Bart Ripperda, Vojtěch Witzany, Ben Shappee, Erin Kara, Assaf Horesh, Sjoert van Velzen, Itai Sfaradi, David Kaplan, Noam Burger, Tara Murphy, Ronald Remillard, James F Steiner, Thomas Wevers, Riccardo Arcodia, Johannes Buchner, Andrea Merloni, Adam Malyali, Andy Fabian, Michael Fausnaugh, Tansu Daylan, Diego Altamirano, Anna Payne, Elizabeth C Ferraraa
Binaries containing a compact object orbiting a supermassive black hole are thought to be precursors of gravitational wave events, but their identification has been extremely challenging. Here, we report quasi-periodic variability in x-ray absorption, which we interpret as quasi-periodic outflows (QPOuts) from a previously low-luminosity active galactic nucleus after an outburst, likely caused by a stellar tidal disruption. We rule out several models based on observed properties and instead show using general relativistic magnetohydrodynamic simulations that QPOuts, separated by roughly 8...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536917/sensitive-detection-of-multiple-blood-biomarkers-via-immunomagnetic-exosomal-pcr-for-the-diagnosis-of-alzheimer-s-disease
#15
JOURNAL ARTICLE
Shun Hu, Liding Zhang, Ying Su, Xiaohan Liang, Jie Yang, Qingming Luo, Haiming Luo
Blood exosomes are emerging as potential biomarkers for diagnosing brain diseases such as Alzheimer's disease (AD). There is currently a lack of an ultrasensitive technology for identifying core AD biomarkers in blood exosomes to optimize the utility of biomarkers in clinical practice. Here, an immunomagnetic exosomal polymerase chain reaction (iMEP) platform was developed using DNA-conjugated antibodies for the rapid detection of amyloid-β (Aβ1-40 and Aβ1-42 ) and phosphorylated tau (p-tau396,404 and p-tau181 ) in clinical blood exosomes...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536838/comparative-evaluation-of-different-modalities-for-measuring-in-vivo-carnosine-levels
#16
JOURNAL ARTICLE
Alok R Amraotkar, David Hoetker, Mohammad J Negahdar, Chin K Ng, Pawel Lorkiewicz, Ugochukwu S Owolabi, Shahid P Baba, Aruni Bhatnagar, Timothy E O'Toole
Carnosine is an endogenous di-peptide (β-alanine -L- histidine) involved in maintaining tissue homeostasis. It is most abundant in skeletal muscle where its concentration has been determined in biopsy samples using tandem mass spectrometry (MS-MS). Carnosine levels can also be assessed in intact leg muscles by proton magnetic resonance spectroscopy (1H-MRS) or in blood and urine samples using mass spectrometry. Nevertheless, it remains uncertain how carnosine levels from these distinct compartments are correlated with each other when measured in the same individual...
2024: PloS One
https://read.qxmd.com/read/38536829/the-effects-of-gases-from-food-waste-on-human-health-a-systematic-review
#17
JOURNAL ARTICLE
Paulina Rudziak, Evans Batung, Isaac Luginaah
Food waste is a routine and increasingly growing global concern that has drawn significant attention from policymakers, climate change activists and health practitioners. Amid the plurality of discourses on food waste-health linkages, however, the health risks from food waste induced emissions have remained under explored. This lack of evidence is partly because of the lack of complete understanding of the effects of food waste emissions from household food waste on human health either directly through physiological mechanisms or indirectly through environmental exposure effects...
2024: PloS One
https://read.qxmd.com/read/38536793/comparison-of-blood-and-urine-concentrations-of-equol-by-lc%C3%A2-ms-ms-method-and-factors-associated-with-equol-production-in-466-japanese-men-and-women
#18
JOURNAL ARTICLE
Remi Yoshikata, Khin Zay Yar Myint, Junichi Taguchi
Equol is produced from daidzein by the action of gut bacteria on soy isoflavones. However, not all people can produce equol, and metabolism differs even among the producers. We aimed to examine the equol producer status in both men and women, and investigate the relationships among the serum and urinary isoflavones as well as to other biomedical parameters. In this study, we measured the equol and daidzein concentrations from the blood and urine of 292 men and 174 women aged between 22 and 88 years by liquid chromatography-tandem mass spectrometry (LC‒MS/MS)...
2024: PloS One
https://read.qxmd.com/read/38536780/thc-and-sperm-impact-on-fertilization-capability-pre-implantation-in-vitro-development-and-epigenetic-modifications
#19
JOURNAL ARTICLE
Alexander G Kuzma-Hunt, Reem Sabry, Ola S Davis, Vivien B Truong, Jibran Y Khokhar, Laura A Favetta
Global cannabis use has risen 23% since 2010, with 209 million reported users, most of whom are males of reproductive age. Delta-9-tetrahydrocannabinol (THC), the main psychoactive phytocannabinoid in cannabis, disrupts pro-homeostatic functions of the endocannabinoid system (ECS) within the male reproductive system. The ECS is highly involved in regulating morpho-functional and intrinsic sperm features that are required for fertilization and pre-implantation embryo development. Previous work by our group demonstrated that THC altered sperm capacitation and the transcriptome, including several fertility-associated microRNAs (miRs)...
2024: PloS One
https://read.qxmd.com/read/38536776/electroacupuncture-stimulation-enhances-the-permeability-of-the-blood-brain-barrier-a-systematic-review-and-meta-analysis-of-preclinical-evidence-and-possible-mechanisms
#20
JOURNAL ARTICLE
Nuo Xu, Peng Gong, Shiting Xu, Yangyun Chen, Mengyuan Dai, Zhaoxing Jia, Xianming Lin
An important cellular barrier to maintain the stability of the brain's internal and external environment is the blood-brain barrier (BBB). It also prevents harmful substances from entering brain tissue through blood circulation while providing protection for the central nervous system. It should be noted, however, that the intact BBB can be a barrier to the transport of most drugs into the brain via the conventional route of administration, which can prevent them from reaching effective concentrations for the treatment of disorders affecting the central nervous system...
2024: PloS One
keyword
keyword
163919
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.