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Esma Saada-Bouzid, Frederic Peyrade, Joel Guigay
PURPOSE OF REVIEW: The aim of this review is to summarize the current knowledge on the genomic characterization of squamous cell carcinomas of the head and neck (HNSCC) and discusses how these abnormalities could be incorporated into a therapeutic approach. RECENT FINDINGS: Tobacco and HPV infection, the two main risk factors of HNSCC, allow the definition of two groups with distinct anatomoclinical and genetic features. As tobacco and HPV infection are not exclusive, exposure to both risk factors is associated with an intermediate prognostic...
March 15, 2019: Current Opinion in Oncology
Esma Saada-Bouzid, Frederic Peyrade, Joel Guigay
PURPOSE OF REVIEW: Checkpoint inhibitors (CPI) are revolutionizing the treatment of advanced cancers including recurrent and or metastatic squamous cell carcinoma of the head and neck (RM-SCCHN). RECENT FINDINGS: In this review, we will summarize the results of prospective trials evaluating CPI and particularly antiprogrammed death 1 (PD-1)/antiprogrammed death-ligand 1 (PD-L1) in RM-SCCHN. SUMMARY: Nivolumab and Pembrolizumab, two anti-PD-1 CPI, were associated with longer overall survival than standard chemotherapy in pretreated RM-SCCHN in two randomized phase 3 trials (respectively CHECKMATE-141 and KEYNOTE-040)...
March 15, 2019: Current Opinion in Oncology
Shiqiong Xu, Oded Sagiv, Maria Laura Rubin, Ho-Seok Sa, Michael Tetzlaff, Priyadharsini Nagarajan, Jing Ning, Bita Esmaeli
Importance: To our knowledge, there are no validation studies to date of the prognostic value of the AJCC Cancer Staging Manual, eighth edition (AJCC 8), criteria for eyelid and periocular squamous cell carcinoma. Objective: To determine the association of tumor (T) category in AJCC 8 with local recurrence, nodal metastasis, distant metastasis, and disease-specific survival (DSS) for eyelid and periocular squamous cell carcinoma. Design, Setting, and Participants: In this retrospective, single-center cohort study, 109 consecutive patients with eyelid and periocular squamous cell carcinoma treated from January 1999 to April 2018 were included...
March 14, 2019: JAMA Ophthalmology
Ho-Seok Sa, Michael T Tetzlaff, Bita Esmaeli
PURPOSE: To identify clinicopathologic factors associated with local recurrence of eyelid sebaceous carcinoma and determine whether routine conjunctival map biopsies are necessary to detect pagetoid spread. METHODS: The authors searched PubMed for articles on eyelid sebaceous carcinoma and pagetoid spread published in English during 1982 to 2018, and they reviewed 99 consecutive patients with eyelid sebaceous carcinoma who underwent surgical excision with frozen section control of margins performed by 1 author (BE) during 1999 to 2017...
March 8, 2019: Ophthalmic Plastic and Reconstructive Surgery
Yasemin Behram Kandemir, Esma Konuk, Ertan Katırcı, Feride Xxx, Mustafa Behram
OBJECTIVES: Vascular endothelial growth factor (VEGF) and its receptors play important roles in angiogenesis. Melatonin plays an important role in gonadal development; thus, its effect on the reproductive system is evident. We investigated the influence of melatonin on the expression of VEGF, vascular endothelial growth factor receptor-1 (VEGFR1) and vascular endothelial growth factor receptor-2 (VEGFR2), as well as on changes in oxidative stress markers and follicle numbers in rat ovaries...
March 7, 2019: Clinics
Esma Alp, Fehmi Damkaci, Eylem Guven, Martin Tenniswood
Background: The efficacy of epigenetic drugs, such as histone deacetylase inhibitors, is often diminished by poor aqueous solubility resulting in limited bioavailability and a low therapeutic index. To overcome the suboptimal therapeutic index, we have developed a biocompatible starch nanoparticle formulation of CG-1521, a histone deacetylase inhibitor in preclinical development for hard-to-treat breast cancers, which improves its bioavailability and half-life. Methods: The physicochemical parameters (size, zeta potential, morphology, loading, and release kinetics) of these nanoparticles (CG-NPs) have been optimized and their cytotoxic and apoptotic capacities measured in MCF-7 breast cancer cell line...
2019: International Journal of Nanomedicine
Duygu Sak, Fusun Erdenen, Cuneyt Müderrisoglu, Esma Altunoglu, Volkan Sozer, Hulya Gungel, Pınar Akca Guler, Tuncer Sak, Hafize Uzun
Background: Taurine has an active role in providing glucose homeostasis and diabetes causes a decline in taurine levels. This paper investigates the relationship between taurine and diabetic complications, patients' demographic features, and biochemical parameters. Methods: Fifty-nine patients with type 2 diabetes mellitus (T2DM), and 28 healthy control subjects between the ages of 32 and 82 were included in the study. The mean age of subjects was 55.6 ± 10.3 and mean diabetes duration was 10.2 ± 6.0 years...
March 11, 2019: Biomolecules
Alexandre Bozec, Philippe Schultz, Jocelyn Gal, Emmanuel Chamorey, Yann Chateau, Olivier Dassonville, Gilles Poissonnet, François Demard, Frédéric Peyrade, Esma Saada, Karen Benezery, Axel Leysalle, Laure Santini, Lila Messaoudi, Nicolas Fakhry
OBJECTIVES: The purposes of this study were to assess the evolution of quality of life (QoL) in patients with head and neck squamous cell carcinoma (HNSCC) undergoing oncologic surgery and to determine the predictive factors of post-therapeutic QoL. METHODS: All HNSCC patients who underwent primary surgery, between 2012 and 2014, were enrolled in this prospective multicentric study. Patients completed the EORTC QLQ-C30 and QLQ-H&N35 questionnaires before surgery and at 6 months after treatment...
March 2019: Surgical Oncology
Esma Kahraman, Özlem Akay, Ahmet Mahmut Kılıç
OBJECTIVES: Industrial advances, as a result of globalization, causes many threats to the working life. These threats are generally associated with the level of economic development of countries. While threats from industrialization are decreasing in developed countries, developing countries are still faced with these threats. Therefore, this study aims to examine the relationship between fatal work accidents (FWA), and independent variables which are national income (NI) and employment rate (ER) in a number of selected countries...
March 9, 2019: Journal of Occupational Health
Bozidaraka L Zaric, Milan Obradovic, Emina Sudar-Milovanovic, Jovan Nedeljkovic, Vesna Lazic, Esma R Isenovic
BACKGROUND: . Insulin is essential for the treatment of Type 1 diabetes mellitus (T1DM) and necessary in numerous cases of Type 2 diabetes mellitus (T2DM). Prolonged administration of anti-diabetic therapy is necessary for the maintenance of the normal glucose levels and thereby preventing vascular complications. A better understanding disease per se and the technological progress contribute the development of new approaches with the aim to achieve better glycemic control. OBJECTIVE: Current therapies for DM are faced with some challenges...
March 6, 2019: Current Pharmaceutical Design
Recep Üzek, Esma Sari, Serap Şenel, Adil Denizli, Arben Merkoçi
The authors describe a test stripe for fluorometric determination of the endocrine disruptor bisphenol A (BPA). Graphene quantum dots (GQDs) were immobilized on molecularly imprinted nanoparticles which then were placed on nitrocellulose paper. The GQDs display blue fluorescence (with excitation/emission peaks at 350/440 nm) which is reduced in the presence of BPA. The test stripe has a 43.9 ± 0.8 μg·L-1 limit of detection in case of water samples. The stripe was applied to the determination of BPA in (spiked) tap water and sea water, and the LODs were found to be 1...
March 7, 2019: Mikrochimica Acta
Melahat Melek Oguz, Gurses Sahin, Esma Altinel Acoglu, Emine Polat, Husniye Yucel, Fatma Zehra Oztek Celebi, Hilal Unsal, Meltem Akcaboy, Eyup Sari, Saliha Senel
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of excessive immune activation. Secondary HLH syndrome develops as a complication of infection, drugs, rheumatologic conditions, or malignancy. The main objectives of this work were to identify the etiology of secondary HLH and prognostic factors associated with mortality. Patients diagnosed with secondary HLH, between January 2011 and December 2016, were retrospectively included in this study. We analyzed clinical and laboratory findings as well as prognostic factors from 24 pediatric patients diagnosed with secondary HLH...
March 1, 2019: Pediatric Hematology and Oncology
Sakineh Saghaeiannejad-Isfahani, Rohollah Sheikh Abumasoudi, Nazila Esmaeli, Taherh Saberi, Narges Mahmodi
INTRODUCTION: Hospital websites are one of the most important communication and information distribution tools in hospitals. Evaluation of hospital websites based on different aspects including design, content, accessibility, and other related criteria can determine hospitals' situation in the use of novel information technologies. Therefore, this study aims to evaluate public hospital websites of Isfahan using WebMedQual approach. MATERIALS AND METHODS: This study is an applied study carried out using a survey method which evaluated the public hospital websites of Isfahan using WebMedQual scale in the year 2015...
2019: Journal of Education and Health Promotion
Esma Saada-Bouzid, Christophe Le Tourneau
Although the molecular landscape of squamous cell carcinoma of the head and neck (SCCHN) has been largely deciphered, only one targeted therapy has been approved to date without any molecular selection, namely cetuximab. Cetuximab is a monoclonal antibody targeting EGFR. It has been shown to improve overall survival in the locally advanced setting in combination with radiotherapy and the recurrent and/or metastatic setting in combination with a platinum compound and 5FU. Beside EGFR targeting agents, antiangiogenic agents have been shown to produce antitumor activity but were associated with substantial toxicity...
2019: Frontiers in Oncology
Emrah Aksakal, Ziya Simsek, Uğur Aksu, Oguzhan Birdal, Esma Selva Ateş, Kamuran Kalkan, Oktay Gulcu, Selami Demirelli, Enbiya Aksakal, Hakan Tas
PURPOSE: High-dose steroid therapy (HDST) has frequent side-effects that appear at its cessation and depend on its dose. However, there is a lack of studies about the acute effects of HDST on cardiac function in adult patients. METHODS: We included in this study 30 patients who underwent HDST (intravenously at doses ranging from 250 to 1000 mg) and 30 healthy control subjects with similar demographic and clinical characteristics, between September and December 2016...
February 20, 2019: Journal of Clinical Ultrasound: JCU
Hampartsoum B Barsoumian, Lalit Batra, Pradeep Shrestha, William S Bowen, Hong Zhao, Nejat K Egilmez, Jorge G Gomez-Gutierrez, Esma S Yolcu, Haval Shirwan
: Costimulation through 4-1BB (CD137) receptor generates robust CD8+ T-effector and memory responses. The only known ligand, 4-1BBL, is a trimeric transmembrane protein that has no costimulatory activity as a soluble molecule. Thus, agonistic antibodies to the receptor have been used for cancer immunotherapy in preclinical models and are currently being evaluated in the clinic. Here, we report that treatment with an oligomeric form of the ligand, SA-4-1BBL, as a single agent is able to protect mice against subsequent tumor challenge irrespective of the tumor type...
February 15, 2019: Cancer Research
Esma Kozan, Mert Ilhan, Ibrahim Tümen, Esra Küpeli Akkol
ETHNOPHARMACOLOGICAL RELEVANCE: This study aimed to evaluate the in vitro activity of the essential oil of Pinus nigra subsp. pallasiana against protoscoleces of Echinococcus granulosus sensu lato. In traditional Turkish folk medicine, the essential oils and resin of P. nigra and P. sylvestris are used externally for wound healing. They are also used in cattle for treating worms and as boiling essence against cold and stomachache. Protoscoleces were aseptically aspirated from sheep livers having hydatid cysts...
February 11, 2019: Journal of Ethnopharmacology
Kürşad Aydın, Ayşe Kartal, Esma Keleş Alp
Background/aim: The aim of this study was to evaluate the nutritional status of children with cerebral palsy and determine the particular characteristics of the disorder. Materials and methods: The nutritional status of the children was assessed by the Gomez classification using weight-for-age. The Gross Motor Function Classification System was used to determine the gross and fine motor functions. Results: The study was conducted with 197 children (58...
February 11, 2019: Turkish Journal of Medical Sciences
Ivana Resanovic, Zoran Gluvic, Bozidarka Zaric, Emina Sudar-Milovanovic, Aleksandra Jovanovic, Davorka Milacic, Radmilo Isakovic, Esma R Isenovic
This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. A group of 19 patients (mean age: 63 ± 2.1) with T1DM and with the peripheral arterial disease were included in this study. Patients were exposed to 10 sessions of HBOT in the duration of 1 h to 100% oxygen inhalation at 2.4 ATA. Blood samples were collected for the plasma C-reactive protein (CRP), plasma free fatty acid (FFA), serum nitrite/nitrate, and serum arginase activity measurements...
2019: International Journal of Endocrinology
Mohamed Ali Chaouch, Mohamed Wejih Dougaz, Wael Ferjaoui, Esma Leila Gouta, Ramzi Nouira, Ibtissem Bouasker, Chadli Dziri
No abstract text is available yet for this article.
February 9, 2019: Journal of Gastrointestinal Cancer
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