keyword
https://read.qxmd.com/read/38531923/geneai-3-0-powerful-novel-generalized-hybrid-and-ensemble-deep-learning-frameworks-for-mirna-species-classification-of-stationary-patterns-from-nucleotides
#1
JOURNAL ARTICLE
Jaskaran Singh, Narendra N Khanna, Ranjeet K Rout, Narpinder Singh, John R Laird, Inder M Singh, Mannudeep K Kalra, Laura E Mantella, Amer M Johri, Esma R Isenovic, Mostafa M Fouda, Luca Saba, Mostafa Fatemi, Jasjit S Suri
Due to the intricate relationship between the small non-coding ribonucleic acid (miRNA) sequences, the classification of miRNA species, namely Human, Gorilla, Rat, and Mouse is challenging. Previous methods are not robust and accurate. In this study, we present AtheroPoint's GeneAI 3.0, a powerful, novel, and generalized method for extracting features from the fixed patterns of purines and pyrimidines in each miRNA sequence in ensemble paradigms in machine learning (EML) and convolutional neural network (CNN)-based deep learning (EDL) frameworks...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38500295/neoadjuvant-chemotherapy-alone-or-combined-with-egfr-directed-targeted-therapy-or-anti-pd-1-immunotherapy-for-locally-advanced-lacrimal-sac-and-nasolacrimal-duct-carcinomas
#2
JOURNAL ARTICLE
Jeremy Goldfarb, Janet Fan, Luana Guimaraes de Sousa, Neal Akhave, Jeffrey Myers, Ryan Goepfert, Krish Manisundaram, Jiawei Zhao, Steven J Frank, Amy Moreno, Renata Ferrarotto, Bita Esmaeli
BACKGROUND/AIMS: We describe our findings in patients with locally advanced lacrimal sac and nasolacrimal duct (NLD) carcinoma who received neoadjuvant systemic therapy. METHODS: We identified patients with locally advanced primary lacrimal sac/NLD carcinoma treated with neoadjuvant systemic intravenous therapy at our institution during 2017-2019. RESULTS: The study included seven patients, four men and three women; the mean age was 60.4 years (range: 43-76)...
March 18, 2024: Seminars in Ophthalmology
https://read.qxmd.com/read/38486968/sensorimotor-content-of-multi-unit-activity-recorded-in-the-paramedian-lobule-of-the-cerebellum-using-carbon-fiber-microelectrode-arrays
#3
JOURNAL ARTICLE
Esma Cetinkaya, Eric J Lang, Mesut Sahin
The cerebellum takes in a great deal of sensory information from the periphery and descending signals from the cerebral cortices. It has been debated whether the paramedian lobule (PML) in the rat and its paravermal regions that project to the interpositus nucleus (IPN) are primarily involved in motor execution or motor planning. Studies that have relied on single spike recordings in behaving animals have led to conflicting conclusions regarding this issue. In this study, we tried a different approach and investigated the correlation of field potentials and multi-unit signals recorded with multi-electrode arrays from the PML cortex along with the forelimb electromyography (EMG) signals in rats during behavior...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38470560/an-updated-view-of-the-effect-of-probiotic-supplement-on-sports-performance-a-detailed-review
#4
REVIEW
Miray Nur Aykut, Esma Nur Erdoğan, Menşure Nur Çelik, Murat Gürbüz
PURPOSE OF REVIEW: Modulation of the host microbiota through probiotics has been shown to have beneficial effects on health in the growing body of research. Exercise increases the amount and diversity of beneficial microorganisms in the host microbiome. Although low- and moderate-intensity exercise has been shown to reduce physiological stress and improve immune function, high-intensity prolonged exercise can suppress immune function and reduce microbial diversity due to intestinal hypoperfusion...
March 12, 2024: Current Nutrition Reports
https://read.qxmd.com/read/38444692/pleomorphic-adenoma-of-the-parotid-gland-concomitant-with-tuberculosis-infection-a-case-report-and-review-of-the-literature
#5
Dorra Chiboub, Nadia Romdhane, Esma Jameleddine, Emna Rejeb, Fatma Khanchel, Raja Jouini, Imen Zoghlami, Safa Nefzaoui, Ines Hariga, Chiraz Mbarek
Tuberculosis of the salivary glands and particularly of the parotid gland is a localization that remains rare even in endemic countries. The association of intra parotid tuberculosis with a benign tumor has been found only in rare cases in literature. A 50-year-old woman with a history of normal pressure hydrocephalus treated surgically, non-smoker, presented with a right parotid swelling progressively increasing in size for 3 years. Clinical examination revealed a 4 cm long, firm, mobile, painless parotid swelling without inflammatory signs and without accessory lymphadenopathy...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38433274/the-clinical-features-treatment-and-prognosis-of-neutropenic-fever-and-coronavirus-disease-2019-results-of-the-multicentre-teos-study
#6
MULTICENTER STUDY
Dilşah Başkol Elik, Şafak Kaya, Sevil Alkan, Tuna Demirdal, Alper Sener, Selçuk Kaya, Özlem Güzel Tunçcan, Bircan Kayaaslan, Rahmet Güner, Fatma Eser, Hasip Kahraman, Serhat Birengel, Elif Mukime Sarıcaoğlu, Esma Eroğlu, Fatma Çölkesen, Erman Öztürk, Hande Berk Cam, Çiğdem Mermutluoğlu, Şafak Özer Balin, Gülden Sincan, Nilgün Altın, Uluhan Sili, Bedia Mutay Suntur, Tuğba Arslan Gülen, Burak Deveci, Rabin Saba, Şaban İncecik, Gülden Eser Karlıdağ, Elif Hakko, Damla Akdağ, Hüseyin Aytaç Erdem, Hilal Sipahi, Candan Çicek, Mehmet Sezai Taşbakan, Meltem Taşbakan, Hüsnü Pullukçu, Tansu Yamazhan, Bilgin Arda, Sercan Ulusoy, Oguz Resat Sipahi
This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020-15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0...
March 3, 2024: Scientific Reports
https://read.qxmd.com/read/38432247/cetuximab-versus-methotrexate-in-first-line-treatment-of-older-frail-patients-with-inoperable-recurrent-or-metastatic-head-and-neck-cancer-elan-unfit-a-randomised-open-label-phase-3-trial
#7
RANDOMIZED CONTROLLED TRIAL
Joël Guigay, Cécile Ortholan, Damien Vansteene, Didier Cupissol, Caroline Even, Marie-Christine Kaminsky, Christian Sire, Emmanuel Blot, Philippe Debourdeau, Laurence Bozec, Esma Saada-Bouzid, Jérôme Fayette, Pierre Dalloz, Yoann Pointreau, Hervé Le Caer, Claire Falandry, Laurence Digue, Antoine Braccini, Stéphane Lopez, Pierre Guillet, Cécile Michel, Nadir Cheurfa, Dominique Schwob, Jean Bourhis, Cécile Mertens, Anne Aupérin
BACKGROUND: At present, there is no established standard treatment for frail older patients with recurrent or metastatic head and neck squamous cell carcinoma. We aimed to compare the efficacy and safety of cetuximab to those of methotrexate (the reference regimen) in this population. METHODS: This randomised, open-label, phase 3 trial was done at 20 hospitals in France. Patients aged 70 years or older, assessed as frail by the ELAN Geriatric Evaluation, with recurrent or metastatic head and neck squamous cell carcinoma in the first-line setting and with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 were eligible for inclusion...
March 2024: The Lancet. Healthy longevity
https://read.qxmd.com/read/38420832/aigener-1-0-an-artificial-intelligence-technique-for-the-revelation-of-informative-and-antibiotic-resistant-genes-in-escherichia-coli
#8
JOURNAL ARTICLE
Debasish Swapnesh Kumar Nayak, Saswati Mahapatra, Sweta Padma Routray, Swayamprabha Sahoo, Santanu Kumar Sahoo, Mostafa M Fouda, Narpinder Singh, Esma R Isenovic, Luca Saba, Jasjit S Suri, Tripti Swarnkar
BACKGROUND: There are several antibiotic resistance genes (ARG) for the Escherichia coli (E. coli) bacteria that cause urinary tract infections (UTI), and it is therefore important to identify these ARG. Artificial Intelligence (AI) has been used previously in the field of gene expression data, but never adopted for the detection and classification of bacterial ARG. We hypothesize, if the data is correctly conferred, right features are selected, and Deep Learning (DL) classification models are optimized, then (i) non-linear DL models would perform better than Machine Learning (ML) models, (ii) leads to higher accuracy, (iii) can identify the hub genes, and, (iv) can identify gene pathways accurately...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38418558/improved-tactile-speech-perception-using-audio-to-tactile-sensory-substitution-with-formant-frequency-focusing
#9
JOURNAL ARTICLE
Mark D Fletcher, Esma Akis, Carl A Verschuur, Samuel W Perry
Haptic hearing aids, which provide speech information through tactile stimulation, could substantially improve outcomes for both cochlear implant users and for those unable to access cochlear implants. Recent advances in wide-band haptic actuator technology have made new audio-to-tactile conversion strategies viable for wearable devices. One such strategy filters the audio into eight frequency bands, which are evenly distributed across the speech frequency range. The amplitude envelopes from the eight bands modulate the amplitudes of eight low-frequency tones, which are delivered through vibration to a single site on the wrist...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38407794/maternal-fed-zinc-deficient-diet-effects-on-relaxin-family-peptides-and-oxidant-system-in-the-testis-and-liver-tissue-of-male-offspring
#10
JOURNAL ARTICLE
Hamiyet Kose, Abdullah Sivrikaya, Esma Menevse
Today, the studies are limited on roles of insulin-like peptide 3 (INSL3), insulin-like peptide 7 (INSL7), and relaxin family peptide receptor 1 (RXFP1) which are synthesized by the testis. It is aimed to investigate the levels of the sex hormone as testosterone and the family of insulin-like proteins (relaxin family peptides), which are important in the puberty transition, in the testicular and liver tissues of male offspring born to female rats fed a zinc-deficient diet during the pregnancy, and in the changes in lipid peroxidation markers...
February 26, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38404596/a-novel-rapid-bioluminescence-based-antimicrobial-susceptibility-testing-method-based-on-adenosine-triphosphate-consumption
#11
JOURNAL ARTICLE
Elif Arik Sever, Esma Aybakan, Yeşim Beşli, Onur Karatuna, Tanil Kocagoz
INTRODUCTION: Standard, phenotypic antimicrobial susceptibility testing (AST) methods require 16-20 h of incubation and are considered as the bottleneck in providing timely input for appropriate antimicrobial treatment. In this study, a novel adenosine triphosphate (ATP)-bioluminescence-based method which allows rapid AST within 3 h was described. METHODS: Standard AST was performed for 56 Enterobacterales isolates using EUCAST disk diffusion (DD) methodology...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38400609/utilizing-fab-fragment-conjugated-surface-plasmon-resonance-based-biosensor-for-detection-of-salmonella-enteritidis
#12
JOURNAL ARTICLE
Esma Eser, Okan Öner Ekiz, H İbrahim Ekiz
Although antibodies, a key element of biorecognition, are frequently used as biosensor probes, the use of these large molecules can lead to adverse effects. Fab fragments can be reduced to allow proper antigen-binding orientation via thiol groups containing Fab sites that can directly penetrate Au sites chemically. In this study, the ability of the surface plasmon resonance (SPR) sensor to detect Salmonella was studied. Tris(2-carboxyethyl)phosphine was used as a reducing agent to obtain half antibody fragments...
February 23, 2024: Journal of Molecular Recognition: JMR
https://read.qxmd.com/read/38399379/bioavailability-of-oral-curcumin-in-systematic-reviews-a-methodological-study
#13
JOURNAL ARTICLE
Viljemka Bučević Popović, Esma Karahmet Farhat, Ines Banjari, Antonia Jeličić Kadić, Livia Puljak
Curcumin is a natural compound found in turmeric that exhibits diverse biological activities. However, its poor bioavailability limits its therapeutic application, which has led to the development of various bioavailability-improved formulations. In this methodological study, we analyzed whether systematic reviews on curcumin considered the bioavailability of systemic oral curcumin formulations when synthesizing evidence from human clinical trials. A total of 171 systematic reviews published between 2003 and 2022 were included in the study...
January 28, 2024: Pharmaceuticals
https://read.qxmd.com/read/38399027/effect-of-oxidation-process-on-mechanical-and-tribological-behaviour-of-titanium-grade-5-alloy
#14
JOURNAL ARTICLE
Abdulsalam Saier, Ismail Esen, Hayrettin Ahlatci, Esma Keskin
In this study, microstructural characterization, mechanical (tensile and compressive) properties, and tribological (wear) properties of Titanium Grade 5 alloy after the oxidation process were examined. While it is observed that the grey contrast coloured α grains are coaxial in the microstructures, it is seen that there are black contrast coloured β grains at the grain boundaries. However, in oxidised Titanium Grade 5, it is possible to observe that the α structure becomes larger, and the number and density of the structure increases...
February 6, 2024: Materials
https://read.qxmd.com/read/38393422/juglone-ascorbate-treatment-enhances-reactive-oxygen-species-mediated-mitochondrial-apoptosis-in-pancreatic-cancer
#15
JOURNAL ARTICLE
Dudu Erkoc-Kaya, Hilal Arikoglu, Ebru Guclu, Duygu Dursunoglu, Esma Menevse
BACKGROUND: Treatment of Pancreatic Cancer (PC) is challenging due to its aggressiveness and acquired resistance to conventional chemotherapy and radiotherapy. Therefore, the discovery of new therapeutic agents and strategies is essential. Juglone, a naphthoquinone, is a secondary metabolite produced naturally in walnut-type trees having allelopathic features in its native environment. Juglone was shown to prevent cell proliferation and induce ROS-mediated mitochondrial apoptosis. Ascorbate with both antioxidant and oxidant features, shows selective cytotoxicity in cancer cells...
February 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38388876/the-effects-of-cannabidiol-against-methotrexate-induced-lung-damage
#16
JOURNAL ARTICLE
Ozlem Ozmen, Adem Milletsever, Serife Tasan, Esma Selcuk, Mehtap Savran
Methotrexate (MTX) is a widely used medication for various cancers, yet its use is associated with adverse effects on organs, notably the lungs. Cannabidiol (CBD), known for its antioxidant and anti-inflammatory properties, was investigated for its potential protective effects against MTX-induced lung injury. Thirty-two female Wistar Albino rats were divided into four groups: control, MTX (single 20 mg/kg intraperitoneal dose), MTX + CBD (single 20 mg/kg MTX with 0.1 ml of 5 mg/kg CBD for 7 days intraperitoneally) and CBD only (for 7 days)...
February 22, 2024: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/38382650/double-side-2-dimensional-3-dimensional-heterojunctions-for-inverted-perovskite-solar-cells
#17
JOURNAL ARTICLE
Randi Azmi, Drajad Satrio Utomo, Badri Vishal, Shynggys Zhumagali, Pia Dally, Andi Muhammad Risqi, Adi Prasetio, Esma Ugur, Fangfang Cao, Imil Fadli Imran, Ahmed Ali Said, Anil Reddy Pininti, Anand Selvin Subbiah, Erkan Aydin, Chuanxiao Xiao, Sang Il Seok, Stefaan De Wolf
Defects at the top and bottom interfaces of three-dimensional (3D) perovskite photo-absorbers diminish the performance and operational stability of perovskite solar cells (PSCs) due to charge recombination, ion migration, and electric-field inhomogeneities.1-5 Here, we demonstrate that long alkyl-amine ligands can generate near-phase pure two-dimensional (2D) perovskites at the top and bottom 3D perovskite interfaces and effectively resolves these issues. At the rear-contact side, we find that the employed alkyl-amine ligand strengthens the interactions with the substrate through acid-base reactions with the phosphonic acid group from the employed organic hole-transporting self-assembled monolayer molecule, thus regulating the 2D perovskite formation...
February 21, 2024: Nature
https://read.qxmd.com/read/38364587/quantitative-evaluation-of-saliency-based-explainable-artificial-intelligence-xai-methods-in-deep-learning-based-mammogram-analysis
#18
JOURNAL ARTICLE
Esma Cerekci, Deniz Alis, Nurper Denizoglu, Ozden Camurdan, Mustafa Ege Seker, Caner Ozer, Muhammed Yusuf Hansu, Toygar Tanyel, Ilkay Oksuz, Ercan Karaarslan
BACKGROUND: Explainable Artificial Intelligence (XAI) is prominent in the diagnostics of opaque deep learning (DL) models, especially in medical imaging. Saliency methods are commonly used, yet there's a lack of quantitative evidence regarding their performance. OBJECTIVES: To quantitatively evaluate the performance of widely utilized saliency XAI methods in the task of breast cancer detection on mammograms. METHODS: Three radiologists drew ground-truth boxes on a balanced mammogram dataset of women (n = 1496 cancer-positive and negative scans) from three centers...
February 5, 2024: European Journal of Radiology
https://read.qxmd.com/read/38349662/influence-of-multiple-sterilization-on-performance-of-titanium-pegs-when-measuring-implant-stability-with-resonance-frequency-analyses
#19
JOURNAL ARTICLE
Gokcen Ates, Esma Sönmez, Süleyman Çağatay Dayan, Canan Bural, Onur Geckili
This in vitro study was conducted to investigate the repeatability of the implant stability quotients (ISQ) measured with multipegs after numerous sterilizations and to detect the exact time when the readings start to deviate. Multipegs were sterilized with 3 different methods (autoclaved, autoclaved + ultrasonic cleaner, chemical disinfection + autoclaved) and grouped according to the method applied. All specimens were put into the autoclave with sealed packages every time they were sterilized. Each specimen was sterilized 50 times according to the technique described in its group after an ISQ measurement was performed...
October 1, 2023: Journal of Oral Implantology
https://read.qxmd.com/read/38340045/capillary-manganese-halide-needle-like-array-scintillator-with-isolated-light-crosstalk-for-micro-x-ray-imaging
#20
JOURNAL ARTICLE
Wenyi Shao, Tengyue He, Lijie Wang, Jian-Xin Wang, Yang Zhou, Bingyao Shao, Esma Ugur, Wentao Wu, Zhenzhong Zhang, Hongwei Liang, Stefaan De Wolf, Osman M Bakr, Omar F Mohammed
The exacerbation of inherent light scattering with increasing scintillator thickness poses a major challenge for balancing the thickness-dependent spatial resolution and scintillation brightness in X-ray imaging scintillators. Herein, we fabricated a thick pixelated needle-like array scintillator capable of micrometer resolution via waveguide structure engineering. Specifically, this involves integrating a straightforward low-temperature melting process of manganese halide with an aluminum-clad capillary template...
February 10, 2024: Advanced Materials
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