Natsuko Nomura, Hisako Matsumoto, Akihito Yokoyama, Yoshihiro Nishimura, Koichiro Asano, Akio Niimi, Yuji Tohda, Norihiro Harada, Hiroyuki Nagase, Makoto Nagata, Hiromasa Inoue, Mitsuko Kondo, Takahiko Horiguchi, Nobuaki Miyahara, Nobuyuki Hizawa, Masayuki Hojo, Noboru Hattori, Naozumi Hashimoto, Akira Yamasaki, Toru Kadowaki, Tomoki Kimura, Mari Miki, Hirokazu Taniguchi, Mikio Toyoshima, Tetsuji Kawamura, Osamu Matsuno, Yoko Sato, Hironobu Sunadome, Tadao Nagasaki, Tsuyoshi Oguma, Toyohiro Hirai
RATIONALE: Bronchiectasis and bronchiolitis are differential diagnoses of asthma; moreover, they are factors associated with worse asthma control. OBJECTIVE: We determined clinical courses of bronchiectasis/bronchiolitis-complicated asthma by inflammatory subtypes as well as factors affecting them. METHODS: We conducted a survey of refractory asthma with non-cystic fibrosis bronchiectasis/bronchiolitis in Japan. Cases were classified into three groups, based on the latest fractional exhaled NO (FeNO) level (32 ppb for the threshold) and blood eosinophil counts (320/µL for the threshold): high (type 2-high) or low (type 2-low) FeNO and eosinophil and high FeNO or eosinophil (type 2-intermediate)...
December 20, 2022: Respiratory Research